KEGG   PATHWAY: sbq04630
sbq04630                    Pathway                                

JAK-STAT signaling pathway - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
sbq04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
101028427  IL2; interleukin-2 [KO:K05429]
101043897  IL3; interleukin-3 [KO:K04736]
101038267  IL4; interleukin-4 isoform X1 [KO:K05430]
101039737  IL5; interleukin-5 [KO:K05428]
101034757  IL6; interleukin-6 [KO:K05405]
101048813  IL7; interleukin-7 [KO:K05431]
101047729  IL9; interleukin-9 [KO:K05432]
101052580  IL10; interleukin-10 [KO:K05443]
101048956  IL11; interleukin-11 isoform X1 [KO:K05417]
101044358  IL12A; interleukin-12 subunit alpha [KO:K05406]
101049311  IL12B; interleukin-12 subunit beta [KO:K05425]
101038789  IL13; interleukin-13 [KO:K05435]
101043435  IL15; interleukin-15 [KO:K05433]
101053421  IL17D; interleukin-17D [KO:K05492]
101051941  IL19; interleukin-19 [KO:K05444]
101051615  IL20; interleukin-20 isoform X1 [KO:K22667]
101029390  IL21; interleukin-21 [KO:K05434]
101034093  IL22; interleukin-22 [KO:K05445]
101034582  IL23A; interleukin-23 subunit alpha [KO:K05426]
101051084  IL24; LOW QUALITY PROTEIN: interleukin-24 [KO:K22668]
101032308  interferon alpha-8-like [KO:K05414]
101032622  interferon alpha-2-like [KO:K05414]
101032943  IFNA13; interferon alpha-1/13 [KO:K05414]
104649849  interferon alpha-5-like [KO:K05414]
101034105  interferon alpha-8-like [KO:K05414]
101034416  interferon alpha-5-like [KO:K05414]
101034728  IFNA21; interferon alpha-21 [KO:K05414]
101035681  IFNB1; interferon beta [KO:K05415]
101033464  IFNG; interferon gamma [KO:K04687]
101051559  IFNK; interferon kappa [KO:K05441]
101032182  IFNL1; interferon lambda-1 [KO:K05447]
101034825  IFNL3; interferon lambda-3 [KO:K22669]
101035047  IFNW1; interferon omega-1 [KO:K05440]
101043909  OSM; oncostatin-M [KO:K05418]
101044227  LIF; leukemia inhibitory factor [KO:K05419]
101053895  TSLP; thymic stromal lymphopoietin [KO:K05436]
101039706  CTF1; cardiotrophin-1 [KO:K24382]
101043583  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101033312  CNTF; ciliary neurotrophic factor [KO:K05420]
101040223  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
101049694  EPO; erythropoietin isoform X1 [KO:K05437]
104649998  uncharacterized protein LOC104649998 [KO:K05438]
104649999  somatotropin-like [KO:K05438]
101053411  somatotropin-like [KO:K05438]
101053718  somatotropin-like [KO:K05438]
101039453  somatotropin-like isoform X1 [KO:K05438]
101041089  somatotropin-like [KO:K05438]
101053083  somatotropin-like [KO:K05438]
101048464  LEP; leptin isoform X1 [KO:K05424]
101047352  THPO; LOW QUALITY PROTEIN: thrombopoietin [KO:K06854]
101037800  PRL; prolactin [KO:K05439]
101052478  EGF; pro-epidermal growth factor [KO:K04357]
101034511  PDGFA; platelet-derived growth factor subunit A isoform X6 [KO:K04359]
101043776  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101036589  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
101030332  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101047979  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101039092  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
101044733  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101032072  IL5RA; interleukin-5 receptor subunit alpha isoform X2 [KO:K05067]
101037958  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101044161  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101038590  IL9R; interleukin-9 receptor [KO:K05073]
101032801  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
101035361  interleukin-10 receptor subunit beta isoform X4 [KO:K05135]
101035136  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
101032718  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
101048468  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
101045372  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101049403  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
101036913  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
101053121  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
101048007  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
101045058  IL21R; LOW QUALITY PROTEIN: interleukin-21 receptor [KO:K05075]
101035704  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
101027739  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
101049947  IL23R; interleukin-23 receptor [KO:K05065]
101044811  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
101029979  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101035044  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101054160  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
101050965  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101035348  OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057]
101035973  LIFR; leukemia inhibitory factor receptor [KO:K05058]
101038323  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
101038788  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
101033804  CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738]
101042318  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101035236  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
101042350  GHR; growth hormone receptor [KO:K05080]
101027698  LEPR; leptin receptor [KO:K05062]
101046140  MPL; thrombopoietin receptor [KO:K05082]
101045141  PRLR; prolactin receptor isoform X1 [KO:K05081]
101047461  EGFR; epidermal growth factor receptor [KO:K04361] [EC:]
101040156  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:]
101040158  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:]
101031615  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
101034707  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:]
101028662  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:]
101030811  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101029836  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101049662  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
101030273  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
101049987  signal transducer and activator of transcription 5A [KO:K11223]
101043203  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101029869  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
101035612  CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701]
101050866  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
101040467  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
101046533  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101034850  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
101050319  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
101043236  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
101030923  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
101051366  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101046604  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
101039294  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101047113  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:]
101047066  MYC; myc proto-oncogene protein isoform X2 [KO:K04377]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101049141  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101047749  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101041919  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101032494  aldehyde oxidase 2 [KO:K00157] [EC:]
101033246  aldehyde oxidase [KO:K00157] [EC:]
101042764  LOW QUALITY PROTEIN: aldehyde oxidase 4-like [KO:K00157] [EC:]
101048514  GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640]
101046949  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
101031112  STAM2; signal transducing adapter molecule 2 [KO:K04705]
101027825  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X3 [KO:K18026] [EC:]
101032306  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X4 [KO:K05697] [EC:]
101051991  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
101033803  EP300; histone acetyltransferase p300 [KO:K04498] [EC:]
101050224  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:]
101036739  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
101035858  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
101041839  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
101035001  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:]
101052630  FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365]
101031381  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:]
101033019  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:]
101038666  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101036943  SOS1; son of sevenless homolog 1 [KO:K03099]
101046427  SOS2; son of sevenless homolog 2 [KO:K03099]
101047663  HRAS; GTPase HRas isoform X2 [KO:K02833]
101054052  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:]
101029768  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
101052779  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:]
101027982  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
101032496  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101033359  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101050592  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101034861  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
101045714  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
101040766  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
101047083  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
sbq04010  MAPK signaling pathway
sbq04060  Cytokine-cytokine receptor interaction
sbq04110  Cell cycle
sbq04120  Ubiquitin mediated proteolysis
sbq04151  PI3K-Akt signaling pathway
sbq04210  Apoptosis
KO pathway

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