KEGG   PATHWAY: sce04113
Entry
sce04113                    Pathway                                

Name
Meiosis - yeast - Saccharomyces cerevisiae (budding yeast)
Description
During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, then segregates from, its homologous pair, while the sister chromatids segregate from each other at meoisis II. In yeast, the switch to enter growth phase or meiosis phase is controlled by nutritional signals. At the onset of meiosis, nutritional signaling pathways converge on transcriptional regulation of Ime1. Ime1 is a transcriptional activator to promote expression of early meiosis-specific genes required for pre-meiotic DNA replication and meiotic recombination. Two of the early meiosis-specific genes, a transcriptional activator, Ndt80, and a CDK2 homolog, Ime2, are required for the transcription of middle meiosis-specific genes, which includes B-type cyclin genes and genes involved in spore wall formation. Polo-like kinase Cdc5, whose expression is activated by Ndt80, is required for the critical step in meiotic progression. Cdc5 regulates sister-kinetochore co-orientation by promoting the localization of Mam1 and Lrs4, components of the co-orientation complex, to kinetochores. Cdc5 also phosphorylates the meiotic cohesin subunit Rec8, which is essential for its cleavage and removal by separase. Moreover, Cdc5 promotes the release of protein phosphatase Cdc14 from the nuclezus, which is required for anaphase I spindle disassembly and exit from meiosis I. The centromeric protein Sgo1 is a key regulator of meiotic chromosome segregation. Sgo1 with PP2A may protect pericentromeric but not arm cohesion of sister chromatids during meiosis I. Sgo1 then disappears at meiosis II to allow sister chromatids to separate.
Class
Cellular Processes; Cell growth and death
Pathway map
sce04113  Meiosis - yeast
sce04113

Other DBs
GO: 0051321
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YJR066W  TOR1; phosphatidylinositol kinase-related protein kinase TOR1 [KO:K07203] [EC:2.7.11.1]
YKL203C  TOR2; phosphatidylinositol kinase-related protein kinase TOR2 [KO:K07203] [EC:2.7.11.1]
YAL040C  CLN3; cyclin CLN3 [KO:K06646]
YBR160W  CDC28; cyclin-dependent serine/threonine-protein kinase CDC28 [KO:K04563] [EC:2.7.11.22]
YER111C  SWI4; SBF complex DNA-binding subunit SWI4 [KO:K06649]
YLR182W  SWI6; transcriptional regulator SWI6 [KO:K06648]
YPL256C  CLN2; cyclin CLN2 [KO:K06650]
YCR097W  HMRA1; Hmra1p [KO:K09358]
YCL067C  HMLALPHA2; homeodomain mating type protein alpha2 [KO:K09359]
YCR039C  MATALPHA2; homeodomain mating type protein alpha2 [KO:K09359]
YCR096C  HMRA2; homeodomain mating type protein A2 [KO:K09359]
YGR044C  RME1; Rme1p [KO:K09235]
YDL245C  HXT15; hexose transporter HXT15 [KO:K08139]
YDR342C  HXT7; hexose transporter HXT7 [KO:K08139]
YDR343C  HXT6; hexose transporter HXT6 [KO:K08139]
YDR345C  HXT3; hexose transporter HXT3 [KO:K08139]
YEL069C  HXT13; hexose transporter HXT13 [KO:K08139]
YFL011W  HXT10; hexose transporter HXT10 [KO:K08139]
YHR092C  HXT4; hexose transporter HXT4 [KO:K08139]
YHR094C  HXT1; hexose transporter HXT1 [KO:K08139]
YHR096C  HXT5; hexose transporter HXT5 [KO:K08139]
YJL214W  HXT8; hexose transporter HXT8 [KO:K08139]
YJL219W  HXT9; hexose transporter HXT9 [KO:K08139]
YJR158W  HXT16; hexose transporter HXT16 [KO:K08139]
YLR081W  GAL2; galactose permease GAL2 [KO:K08139]
YMR011W  HXT2; hexose transporter HXT2 [KO:K08139]
YNR072W  HXT17; hexose transporter HXT17 [KO:K08139]
YOL156W  HXT11; hexose transporter HXT11 [KO:K08139]
YDL138W  RGT2; glucose sensor [KO:K08139]
YDL194W  SNF3; glucose sensor [KO:K08139]
YNL318C  HXT14; Hxt14p [KO:K08139]
YDR477W  SNF1; AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 [KO:K12761] [EC:2.7.11.1]
YDL035C  GPR1; Gpr1p [KO:K12762]
YER020W  GPA2; guanine nucleotide-binding protein subunit alpha [KO:K04630]
YNL098C  RAS2; Ras family GTPase RAS2 [KO:K07827]
YOR101W  RAS1; Ras family GTPase RAS1 [KO:K07827]
YJL005W  CYR1; adenylate cyclase [KO:K01768] [EC:4.6.1.1]
YJL164C  TPK1; cAMP-dependent protein kinase catalytic subunit TPK1 [KO:K04345] [EC:2.7.11.11]
YPL203W  TPK2; cAMP-dependent protein kinase catalytic subunit TPK2 [KO:K04345] [EC:2.7.11.11]
YKL166C  TPK3; cAMP-dependent protein kinase catalytic subunit TPK3 [KO:K04345] [EC:2.7.11.11]
YKL062W  MSN4; stress-responsive transcriptional activator MSN4 [KO:K09468]
YMR037C  MSN2; stress-responsive transcriptional activator MSN2 [KO:K09468]
YMR016C  SOK2; Sok2p [KO:K12763]
YJR094C  IME1; transcription factor IME1 [KO:K12764]
YJL106W  IME2; protein kinase IME2 [KO:K12765] [EC:2.7.11.1]
YLR079W  SIC1; cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 [KO:K03085]
YGR109C  CLB6; B-type cyclin CLB6 [KO:K06651]
YPR120C  CLB5; B-type cyclin CLB5 [KO:K06651]
YJL194W  CDC6; AAA family ATPase CDC6 [KO:K02213]
YJR046W  TAH11; Tah11p [KO:K12414]
YML065W  ORC1; origin recognition complex subunit 1 [KO:K02603]
YBR060C  ORC2; origin recognition complex subunit 2 [KO:K02604]
YLL004W  ORC3; origin recognition complex subunit 3 [KO:K02605]
YPR162C  ORC4; origin recognition complex subunit 4 [KO:K02606]
YNL261W  ORC5; origin recognition complex subunit 5 [KO:K02607]
YHR118C  ORC6; origin recognition complex subunit 6 [KO:K02608]
YBL023C  MCM2; MCM DNA helicase complex subunit MCM2 [KO:K02540] [EC:3.6.4.12]
YEL032W  MCM3; MCM DNA helicase complex subunit MCM3 [KO:K02541] [EC:3.6.4.12]
YPR019W  MCM4; MCM DNA helicase complex subunit MCM4 [KO:K02212] [EC:3.6.4.12]
YLR274W  MCM5; MCM DNA helicase complex subunit MCM5 [KO:K02209] [EC:3.6.4.12]
YGL201C  MCM6; MCM DNA helicase complex subunit MCM6 [KO:K02542] [EC:3.6.4.12]
YBR202W  MCM7; mini-chromosome maintenance complex protein 7 [KO:K02210] [EC:3.6.4.12]
YLR103C  CDC45; DNA replication initiation factor CDC45 [KO:K06628]
YDL017W  CDC7; serine/threonine protein kinase CDC7 [KO:K02214] [EC:2.7.11.1]
YDR052C  DBF4; protein serine/threonine kinase activating protein DBF4 [KO:K02309]
YMR139W  RIM11; serine/threonine protein kinase RIM11 [KO:K12766] [EC:2.7.11.1]
YFL033C  RIM15; protein kinase RIM15 [KO:K12767] [EC:2.7.11.1]
YDR207C  UME6; DNA-binding transcriptional regulator UME6 [KO:K09243]
YHL022C  SPO11; DNA topoisomerase (ATP-hydrolyzing) [KO:K10878]
YER179W  DMC1; recombinase DMC1 [KO:K10872]
YDR285W  ZIP1; Zip1p [KO:K12768]
YHR124W  NDT80; transcription factor NDT80 [KO:K12769]
YBR045C  GIP1; protein phosphatase regulator GIP1 [KO:K12770]
YDR523C  SPS1; putative serine/threonine protein kinase SPS1 [KO:K12771] [EC:2.7.11.1]
YOR313C  SPS4; Sps4p [KO:K12772]
YGR059W  SPR3; septin SPR3 [KO:K12773]
YGR108W  CLB1; B-type cyclin CLB1 [KO:K02220]
YDL155W  CLB3; B-type cyclin CLB3 [KO:K06659]
YLR210W  CLB4; B-type cyclin CLB4 [KO:K06659]
YMR001C  CDC5; polo kinase CDC5 [KO:K06660] [EC:2.7.11.21]
YHR152W  SPO12; Spo12p [KO:K12576]
YOR195W  SLK19; Slk19p [KO:K12575]
YFR028C  CDC14; phosphoprotein phosphatase CDC14 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
YER106W  MAM1; Mam1p [KO:K12774]
YDR439W  LRS4; Lrs4p [KO:K12775]
YER133W  GLC7; type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 [KO:K06269] [EC:3.1.3.16]
YDR436W  PPZ2; salt homeostasis regulator [KO:K06269] [EC:3.1.3.16]
YML016C  PPZ1; salt homeostasis regulator [KO:K06269] [EC:3.1.3.16]
YPL179W  PPQ1; protein-serine/threonine phosphatase [KO:K06269] [EC:3.1.3.16]
YOR351C  MEK1; serine/threonine protein kinase MEK1 [KO:K12776] [EC:2.7.11.1]
YLR263W  RED1; Red1p [KO:K12777]
YIL072W  HOP1; Hop1p [KO:K12778]
YDR310C  SUM1; Sum1p [KO:K12779]
YJL187C  SWE1; tyrosine protein kinase SWE1 [KO:K03114] [EC:2.7.11.1]
YLR288C  MEC3; Mec3p [KO:K02544]
YPL194W  DDC1; Ddc1p [KO:K06663]
YOR368W  RAD17; Rad17p [KO:K02830] [EC:3.1.11.2]
YER173W  RAD24; Rad24p [KO:K06662]
YBR136W  MEC1; protein kinase MEC1 [KO:K02543]
YDR217C  RAD9; chromatin-binding protein RAD9 [KO:K06661]
YPL153C  RAD53; serine/threonine/tyrosine protein kinase RAD53 [KO:K02831] [EC:2.7.11.-]
YBR274W  CHK1; serine/threonine protein kinase CHK1 [KO:K02216] [EC:2.7.11.1]
YDR113C  PDS1; securin [KO:K02627]
YGR098C  ESP1; separase [KO:K02365] [EC:3.4.22.49]
YFL008W  SMC1; cohesin subunit SMC1 [KO:K06636]
YJL074C  SMC3; cohesin subunit SMC3 [KO:K06669]
YPR007C  REC8; Rec8p [KO:K12780]
YIL026C  IRR1; Irr1p [KO:K06671]
YJL030W  MAD2; spindle checkpoint protein MAD2 [KO:K02537]
YGL086W  MAD1; coiled-coil domain-containing protein MAD1 [KO:K06679]
YNL172W  APC1; anaphase promoting complex subunit 1 [KO:K03348]
YLR127C  APC2; anaphase promoting complex subunit 2 [KO:K03349]
YBL084C  CDC27; anaphase promoting complex subunit CDC27 [KO:K03350]
YDR118W  APC4; anaphase promoting complex subunit 4 [KO:K03351]
YOR249C  APC5; anaphase promoting complex subunit 5 [KO:K03352]
YKL022C  CDC16; anaphase promoting complex subunit CDC16 [KO:K03353]
YHR166C  CDC23; anaphase promoting complex subunit CDC23 [KO:K03355]
YLR102C  APC9; anaphase promoting complex subunit 9 [KO:K03356]
YGL240W  DOC1; anaphase promoting complex subunit DOC1 [KO:K03357]
YDL008W  APC11; anaphase promoting complex subunit 11 [KO:K03358]
YFR036W  CDC26; anaphase promoting complex subunit CDC26 [KO:K03359]
YDR260C  SWM1; Swm1p [KO:K12416]
YGL116W  CDC20; ubiquitin-protein transferase activating protein CDC20 [KO:K03363]
YGR188C  BUB1; protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
YOR073W  SGO1; Sgo1p [KO:K11582]
YOR014W  RTS1; protein phosphatase 2A regulatory subunit RTS1 [KO:K11584]
YDL134C  PPH21; phosphoprotein phosphatase 2A catalytic subunit PPH21 [KO:K04382] [EC:3.1.3.16]
YDL188C  PPH22; phosphoprotein phosphatase 2A catalytic subunit PPH22 [KO:K04382] [EC:3.1.3.16]
YAL016W  TPD3; protein phosphatase 2A structural subunit TPD3 [KO:K03456]
YIR025W  MND2; Mnd2p [KO:K12781]
YGR225W  AMA1; Ama1p [KO:K12782]
YHR184W  SSP1; Ssp1p [KO:K12783]
YAR019C  CDC15; serine/threonine protein kinase CDC15 [KO:K06683] [EC:2.7.11.1]
Compound
C00031  D-Glucose
C00288  HCO3-
C00575  3',5'-Cyclic AMP
Reference
  Authors
Honigberg SM, Purnapatre K
  Title
Signal pathway integration in the switch from the mitotic cell cycle to meiosis in yeast.
  Journal
J Cell Sci 116:2137-47 (2003)
DOI:10.1242/jcs.00460
Reference
  Authors
Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G
  Title
Transcriptional regulation of meiosis in budding yeast.
  Journal
Int Rev Cytol 224:111-71 (2003)
DOI:10.1016/S0074-7696(05)24004-4
Reference
  Authors
Honigberg SM
  Title
Ime2p and Cdc28p: co-pilots driving meiotic development.
  Journal
J Cell Biochem 92:1025-33 (2004)
DOI:10.1002/jcb.20131
Reference
  Authors
Hochwagen A, Amon A
  Title
Checking your breaks: surveillance mechanisms of meiotic recombination.
  Journal
Curr Biol 16:R217-28 (2006)
DOI:10.1016/j.cub.2006.03.009
Reference
  Authors
Hollingsworth NM
  Title
Deconstructing meiosis one kinase at a time: polo pushes past pachytene.
  Journal
Genes Dev 22:2596-600 (2008)
DOI:10.1101/gad.1727508
Reference
  Authors
Sourirajan A, Lichten M
  Title
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosis.
  Journal
Genes Dev 22:2627-32 (2008)
DOI:10.1101/gad.1711408
Reference
  Authors
Roeder GS, Bailis JM
  Title
The pachytene checkpoint.
  Journal
Trends Genet 16:395-403 (2000)
DOI:10.1016/S0168-9525(00)02080-1
Reference
  Authors
Barr FA, Sillje HH, Nigg EA
  Title
Polo-like kinases and the orchestration of cell division.
  Journal
Nat Rev Mol Cell Biol 5:429-40 (2004)
DOI:10.1038/nrm1401
Reference
  Authors
Lee BH, Amon A
  Title
Polo kinase--meiotic cell cycle coordinator.
  Journal
Cell Cycle 2:400-2 (2003)
DOI:10.4161/cc.2.5.475
Reference
  Authors
Buonomo SB, Rabitsch KP, Fuchs J, Gruber S, Sullivan M, Uhlmann F, Petronczki M, Toth A, Nasmyth K
  Title
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19.
  Journal
Dev Cell 4:727-39 (2003)
DOI:10.1016/S1534-5807(03)00129-1
Reference
  Authors
Oelschlaegel T, Schwickart M, Matos J, Bogdanova A, Camasses A, Havlis J, Shevchenko A, Zachariae W
  Title
The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
  Journal
Cell 120:773-88 (2005)
DOI:10.1016/j.cell.2005.01.032
Reference
  Authors
Dai W, Wang X
  Title
The Yin and Yang of centromeric cohesion of sister chromatids: mitotic kinases meet protein phosphatase 2A.
  Journal
Cell Div 1:9 (2006)
DOI:10.1186/1747-1028-1-9
Reference
  Authors
Clift D, Bizzari F, Marston AL
  Title
Shugoshin prevents cohesin cleavage by PP2A(Cdc55)-dependent inhibition of separase.
  Journal
Genes Dev 23:766-80 (2009)
DOI:10.1101/gad.507509
Reference
  Authors
Pesin JA, Orr-Weaver TL
  Title
Regulation of APC/C activators in mitosis and meiosis.
  Journal
Annu Rev Cell Dev Biol 24:475-99 (2008)
DOI:10.1146/annurev.cellbio.041408.115949
Reference
  Authors
Diamond AE, Park JS, Inoue I, Tachikawa H, Neiman AM
  Title
The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
  Journal
Mol Biol Cell 20:134-45 (2009)
DOI:10.1091/mbc.E08-06-0615
Related
pathway
sce04111  Cell cycle - yeast
sce04120  Ubiquitin mediated proteolysis
KO pathway
ko04113   
LinkDB

DBGET integrated database retrieval system