Shigella flexneri 2002017 (serotype Fxv): SFxv_4455
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Entry
SFxv_4455 CDS
T01883
Symbol
metH
Name
(GenBank) B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
sfe
Shigella flexneri 2002017 (serotype Fxv)
Pathway
sfe00270
Cysteine and methionine metabolism
sfe00450
Selenocompound metabolism
sfe00670
One carbon pool by folate
sfe01100
Metabolic pathways
sfe01110
Biosynthesis of secondary metabolites
sfe01230
Biosynthesis of amino acids
sfe04980
Cobalamin transport and metabolism
Module
sfe_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
sfe00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
SFxv_4455 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
SFxv_4455 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
SFxv_4455 (metH)
09150 Organismal Systems
09154 Digestive system
04980 Cobalamin transport and metabolism
SFxv_4455 (metH)
Enzymes [BR:
sfe01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
SFxv_4455 (metH)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ADA76380
UniProt:
D2AD89
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All DBs
Position
4282040..4285723
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AA seq
1227 aa
AA seq
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MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLAAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKADDTANAQQAEWRSWDVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRIAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFAIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTCKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDHARRKGMSVSDVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgttggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgacctcaaaggcaacaacgacctgctggtactcagtaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgcgcctgtgctgacgagtggaccgcg
cgcacgccggagaaaccgcgctacgttgccggtgttcttggcccaaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggcg
gcggcctatcgcgaatccaccaaagcgctggtggaaggtggtgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtctttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggcccgatgaactgcgccagtacgtgcaggaa
ctatcacggattgcggaatgctacgtcaccgcccacccgaacgccgggctgcctaacgcc
tttggtgaatacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggctttctcaatatcgtcggtggttgctgcgggaccacgccgcaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgccggaaattcccgtagcctgc
cgtttgtctggcctggagccgctgaacattggcgacgatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggctctgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcgcgtcagcaggtggaaaacggcgcgcagattatcgatatc
aacatggatgaagggatgctcgatgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggatgtc
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggcgtcgacgcctttatccatcacgcgaaattgttgcgtcgctacggtgcggcagtg
gtggtgatggcctttgacgaacagggacaggccgatactcgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
ttcgacccgaacatcttcgcggtcgccaccggtattgaagagcacaacaactacgcgcag
gactttatcggcgcgtgtgaagacatcaaacgcgaactgccgcacgcgctgatttccggc
ggcgtatctaacgtttctttctcattccgtggcaacgatccggtgcgcgaagccattcac
gcagtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctacccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgtgacgatggcactgagcgtttactggagcttgccgagaaatatcgcggc
agtaaagcggacgacactgctaacgcccagcaagcggagtggcgctcgtgggacgtgaat
aaacgtctggaatactcgctggtcaaaggcataaccgagtttatcgagcaggatactgaa
gaagcccgccagcaggctacgcgcccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgatctgtttggcgaaggcaaaatgttcctgccacaggtggtcaaa
tcggcgcgcgtcatgaaacaggcagtggcgtatctcgaaccgtttattgaagccagcaaa
gagcagggtaaaaccaacggcaagatggtgatcgccaccgtgaaaggcgatgtccacgac
atcggtaaaaatatcgttggtgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgttatggtgcctgcggaaaaaattctccgtatcgccaaagaagtgaatgctgatttg
attggcctttcggggcttatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcgccattccgttactgattggcggcgcgaccacctcaaaagcg
cacacggcggtgaaaatcgagcagaactacagcggccctacggtgtatgtgcagaatgcc
tcgcgcaccgttggtgtggtagcggcgctgctttccgatactcagcgtgatgattttgtc
gctcgtacctgcaaggagtacgaaaccgtgcgtattcagcacgggcgcaagaaaccacgc
acaccaccggtcacgctggaagcggcgcgcgataacgatttcgcatttgactggcaggct
tacacgccgccggtggcgcaccgtctcggcgtgcaggaagtggaagccagcatcgaaacg
ctgcgtaattacatcgactggacaccgttctttatgacctggtcgctggccgggaagtat
cctcgcattctggaagatgaagtggtgggcgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgagaaaacgctgaatccgcgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgcacc
catgtgatcaacgtcagccaccatctgcgtcaacagaccgaaaaaacgggattcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcgcagcac
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgtttagccgaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagaactgatccgcgaaaactaccagggcatccgtccggcaccgggctatccg
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggaagtggaaaaacat
actggcatgaaactcacagaatctttcgcgatgtggcctggtgcatcggtttcgggttgg
tatttcagtcatccggacagcaagtactacgcggtggcgcaaattcagcgcgatcaggtt
gaagaccatgcccgccgtaaaggtatgagcgtctccgatgttgagcgctggctggcaccg
aatctggggtatgacgcggactga
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