KEGG   PATHWAY: shr04115
shr04115                    Pathway                                

p53 signaling pathway - Sarcophilus harrisii (Tasmanian devil)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
shr04115  p53 signaling pathway

Sarcophilus harrisii (Tasmanian devil) [GN:shr]
100925167  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:]
100932330  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:]
100934350  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:]
100933648  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:]
100922647  GORAB; RAB6-interacting golgin isoform X2 [KO:K19748]
100919874  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:]
100920321  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:]
100930617  MDM4; protein Mdm4 isoform X1 [KO:K10127]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100926666  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100915359  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100921166  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100932899  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
100924154  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
100920942  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100924454  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100925631  CDK2; cyclin-dependent kinase 2 isoform X4 [KO:K02206] [EC:]
116422809  SFN; 14-3-3 protein sigma [KO:K06644]
100926735  RPRM; protein reprimo [KO:K10128]
100925753  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100931176  CCNB2; G2/mitotic-specific cyclin-B2 isoform X2 [KO:K21770]
100924163  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:]
100926902  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100920439  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116423727  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100917873  GTSE1; LOW QUALITY PROTEIN: G2 and S phase-expressed protein 1 [KO:K10129]
105749219  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105750981  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
105749071  tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
100931580  CASP8; caspase-8 [KO:K04398] [EC:]
100929676  BID; BH3-interacting domain death agonist [KO:K04726]
116423037  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
100918247  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
100915548  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100934666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100915213  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
100923153  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
100922884  SHISA5; protein shisa-5 isoform X4 [KO:K10135]
100925270  PERP; p53 apoptosis effector related to PMP-22 isoform X1 [KO:K10136]
100931841  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
100922952  SIAH1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:]
100919671  cytochrome c 2 [KO:K08738]
111721251  cytochrome c [KO:K08738]
100932636  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100931481  CASP9; caspase-9 [KO:K04399] [EC:]
100922757  caspase-3-like [KO:K02187] [EC:]
100922500  CASP3; caspase-3 [KO:K02187] [EC:]
100916406  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
100921412  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
100918816  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100922915  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
100914356  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
100922941  CD82; CD82 antigen [KO:K06509]
100926698  THBS1; thrombospondin-1 [KO:K16857]
100915477  SERPINB5; serpin B5 [KO:K10139]
100916232  DDB2; DNA damage-binding protein 2 [KO:K10140]
100934573  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:]
100914438  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:]
100920975  SESN3; sestrin-3 isoform X1 [KO:K10141]
100918388  SESN1; sestrin-1 isoform X1 [KO:K10141]
100914636  SESN2; sestrin-2 isoform X1 [KO:K20394]
100927199  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:]
100918445  TSC2; tuberin isoform X1 [KO:K07207]
100923851  STEAP3; metalloreductase STEAP3 isoform X5 [KO:K10142] [EC:1.16.1.-]
100930616  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:]
100916490  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:]
100914510  CCNG1; cyclin-G1 [KO:K10145]
100926942  CCNG2; cyclin-G2 [KO:K10146]
100933058  PPM1D; protein phosphatase 1D isoform X1 [KO:K10147] [EC:]
100918460  TP73; tumor protein p73 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
shr04110  Cell cycle
shr04210  Apoptosis
shr04218  Cellular senescence
KO pathway

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