KEGG   PATHWAY: shr04310
shr04310                    Pathway                                

Wnt signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Environmental Information Processing; Signal transduction
Pathway map
shr04310  Wnt signaling pathway

Other DBs
GO: 0016055
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
100930661  PORCN; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:]
100928059  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100918306  WNT2; protein Wnt-2 isoform X3 [KO:K00182]
100918389  WNT2B; protein Wnt-2b [KO:K00182]
100914628  WNT3A; protein Wnt-3a [KO:K00312]
100935307  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100925510  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100917926  WNT5A; protein Wnt-5a [KO:K00444]
100924415  WNT5B; protein Wnt-5b [KO:K00444]
100933826  WNT6; protein Wnt-6 [KO:K00445]
100925362  WNT7B; protein Wnt-7b [KO:K00572]
100931119  WNT7A; protein Wnt-7a [KO:K00572]
100934290  WNT8B; protein Wnt-8b [KO:K00714]
100923381  WNT8A; protein Wnt-8a [KO:K00714]
100914365  WNT9A; protein Wnt-9a [KO:K01064]
100919162  WNT9B; LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
100917765  WNT10A; protein Wnt-10a [KO:K01357]
100932979  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
100913767  WNT11; protein Wnt-11 [KO:K01384]
100921973  WNT16; protein Wnt-16 [KO:K01558]
100935288  CER1; cerberus [KO:K01645]
100919692  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:]
100924944  WIF1; wnt inhibitory factor 1 [KO:K01691]
100928565  SERPINF1; pigment epithelium-derived factor [KO:K19614]
100929236  SOST; sclerostin [KO:K16834]
100929007  DKK1; dickkopf-related protein 1 [KO:K02165]
100934376  DKK2; dickkopf-related protein 2 isoform X2 [KO:K02165]
100922864  DKK4; dickkopf-related protein 4 [KO:K02165]
100920776  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
100932723  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
100921057  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
100928665  SFRP5; secreted frizzled-related protein 5 [KO:K02222]
100929659  RSPO1; R-spondin-1 [KO:K19471]
100923136  RSPO2; R-spondin-2 [KO:K23097]
100919075  RSPO3; R-spondin-3 [KO:K23098]
100920862  RSPO4; R-spondin-4 [KO:K23099]
100934289  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
100925009  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
100914726  RNF43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:]
100915841  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 isoform X1 [KO:K16273] [EC:]
100921540  FZD1; frizzled-1 [KO:K02432]
100923425  FZD7; frizzled-7 [KO:K02432]
100932536  FZD2; frizzled-2 [KO:K02235]
100919821  FZD3; frizzled-3 isoform X1 [KO:K02329]
100919498  FZD4; frizzled-4 [KO:K02354]
100916636  FZD5; frizzled-5 [KO:K02375]
111721152  FZD8; frizzled-8 [KO:K02375]
100919476  FZD6; frizzled-6 isoform X1 [KO:K02376]
100914963  FZD10; frizzled-10 [KO:K02842]
100930633  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100916936  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
116419459  BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
100915794  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:]
100932600  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
100932119  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
100931932  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
105749059  proto-oncogene FRAT1 [KO:K03069]
100930993  GSK-3-binding protein FRAT2 [KO:K03096]
100919559  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:]
100917554  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:]
100922225  CSNK2B; casein kinase II subunit beta isoform X2 [KO:K03115]
100913385  NKD2; protein naked cuticle homolog 2 isoform X1 [KO:K03213]
100929536  NKD1; protein naked cuticle homolog 1 [KO:K03213]
100916317  CXXC4; CXXC-type zinc finger protein 4 isoform X3 [KO:K03344]
100914061  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:]
100920192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:]
100930636  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100923576  AXIN1; axin-1 isoform X1 [KO:K02157]
100933740  AXIN2; axin-2 isoform X1 [KO:K04385]
100925931  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100915224  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
100915381  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:]
100924173  casein kinase I-like [KO:K08957] [EC:]
100919354  casein kinase I-like [KO:K08957] [EC:]
105751130  LOW QUALITY PROTEIN: casein kinase I [KO:K08957] [EC:]
100930141  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100922609  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100922675  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100934638  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100919586  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
100919701  protein chibby homolog 1 isoform X1 [KO:K23402]
100919437  CBY1; protein chibby homolog 1 [KO:K23402]
100917114  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:]
100932423  transcription factor SOX-17 [KO:K04495]
100932678  transcription factor SOX-17-like [KO:K04495]
100915704  CTBP1; C-terminal-binding protein 1 isoform X3 [KO:K04496]
116421565  CTNND2; catenin delta-2 isoform X1 [KO:K23491]
100921187  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:]
100926283  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:]
100927489  RUVBL1; ruvB-like 1 isoform X1 [KO:K04499] [EC:]
100923569  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100923201  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
100920997  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:]
100928564  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
116423739  JUN; transcription factor AP-1 [KO:K04448]
100930035  FOSL1; fos-related antigen 1 [KO:K04502]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100915359  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100921166  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100927316  CCN4; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
100920568  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
100933647  MMP7; matrilysin [KO:K01397] [EC:]
100914418  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
100929360  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:]
100913731  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100922952  SIAH1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:]
100929832  CACYBP; calcyclin-binding protein [KO:K04507]
100927300  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100927158  TBL1X; F-box-like/WD repeat-containing protein TBL1X isoform X1 [KO:K04508]
100930778  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
100923383  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
100925642  BTRC; F-box/WD repeat-containing protein 1A isoform X4 [KO:K03362]
100926417  CUL1; cullin-1 [KO:K03347]
100918404  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:]
100925212  GPC4; LOW QUALITY PROTEIN: glypican-4 [KO:K08110]
100918028  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:]
100922785  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:]
100921061  RYK; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:]
100930535  VANGL1; vang-like protein 1 isoform X1 [KO:K04510]
100934878  VANGL2; vang-like protein 2 isoform X1 [KO:K04510]
100916841  PRICKLE1; prickle-like protein 1 [KO:K04511]
100925938  PRICKLE2; prickle-like protein 2 [KO:K04511]
100920422  PRICKLE3; prickle planar cell polarity protein 3 isoform X1 [KO:K04511]
100920125  PRICKLE4; prickle-like protein 4 [KO:K04511]
100934498  INVS; inversin [KO:K19626]
100914526  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X2 [KO:K04512]
100935054  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X2 [KO:K04512]
100921931  RHOA; transforming protein RhoA [KO:K04513]
100916865  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100932383  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100924669  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100930815  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:]
100928480  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:]
100924267  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:]
100922938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:]
100934049  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:]
100934311  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:]
100929015  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:]
100934917  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:]
100916233  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:]
100913975  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:]
100918427  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:]
100917281  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:]
100915297  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:]
100918408  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:]
100918689  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:]
100926364  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100920251  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100917473  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100920502  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
C00076  Calcium cation
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Beta-catenin and Tcfs in mammary development and cancer.
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Yang Y.
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Kalderon D.
Similarities between the Hedgehog and Wnt signaling pathways.
Trends Cell Biol 12:523-31 (2002)
Nusse R.
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development 130:5297-305 (2003)
Jope RS, Johnson GV.
The glamour and gloom of glycogen synthase kinase-3.
Trends Biochem Sci 29:95-102 (2004)
Veeman MT, Axelrod JD, Moon RT.
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Dev Cell 5:367-77 (2003)
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Nat Cell Biol 3:628-36 (2001)
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
The way Wnt works: Components and mechanism.
Growth Factors 31:1-31 (2013)
Carethers JM
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Gastroenterology 137:33-6 (2009)
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
J Biol Chem 283:33053-8 (2008)
Niehrs C
The complex world of WNT receptor signalling.
Nat Rev Mol Cell Biol 13:767-79 (2012)
Abou Ziki MD, Mani A
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Atherosclerosis 262:171-178 (2017)
He Y, Ki H, Kim H, Kim K
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Cell Biol Int 39:954-61 (2015)
shr04010  MAPK signaling pathway
shr04110  Cell cycle
shr04115  p53 signaling pathway
shr04120  Ubiquitin mediated proteolysis
shr04350  TGF-beta signaling pathway
shr04510  Focal adhesion
shr04520  Adherens junction
shr05010  Alzheimer disease
KO pathway

DBGET integrated database retrieval system