KEGG   PATHWAY: shr05216
Entry
shr05216                    Pathway                                

Name
Thyroid cancer - Sarcophilus harrisii (Tasmanian devil)
Description
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
Class
Human Diseases; Cancer: specific types
Pathway map
shr05216  Thyroid cancer
shr05216

Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100927200  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100926427  CCDC6; LOW QUALITY PROTEIN: coiled-coil domain-containing protein 6 [KO:K09288]
100918319  NCOA4; nuclear receptor coactivator 4 [KO:K09289]
100916388  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100916994  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
100926491  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
100916189  TFG; protein TFG isoform X1 [KO:K09292]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100928986  NRAS; GTPase NRas [KO:K07828]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100927252  ras-related protein Rab-26-like [KO:K07827]
100929426  ras protein let-60-like [KO:K07827]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100924183  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
100934154  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100926708  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
100914649  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100932014  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100926666  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100926902  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100920439  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116423727  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100916731  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100916232  DDB2; DNA damage-binding protein 2 [KO:K10140]
100923657  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
100920258  CDH1; cadherin-1 [KO:K05689]
100930636  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
100930141  TCF7; transcription factor 7 isoform X1 [KO:K02620]
100922609  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100922675  TCF7L2; transcription factor 7-like 2 isoform X11 [KO:K04491]
100934638  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Chiloeches A, Marais R.
  Title
Is BRAF the Achilles' Heel of thyroid cancer?
  Journal
Clin Cancer Res 12:1661-4 (2006)
DOI:10.1158/1078-0432.CCR-06-0051
Reference
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
  Authors
Santoro M, Melillo RM, Fusco A.
  Title
RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture.
  Journal
Eur J Endocrinol 155:645-653 (2006)
DOI:10.1530/eje.1.02289
Reference
  Authors
Pierotti MA, Greco A.
  Title
Oncogenic rearrangements of the NTRK1/NGF receptor.
  Journal
Cancer Lett 232:90-8 (2006)
DOI:10.1016/j.canlet.2005.07.043
Reference
  Authors
Sobrinho-Simoes M, Preto A, Rocha AS, Castro P, Maximo V, Fonseca E, Soares P.
  Title
Molecular pathology of well-differentiated thyroid carcinomas.
  Journal
Virchows Arch 447:787-93 (2005)
DOI:10.1007/s00428-005-0065-5
Reference
  Authors
Gimm O.
  Title
Thyroid cancer.
  Journal
Cancer Lett 163:143-56 (2001)
DOI:10.1016/S0304-3835(00)00697-2
Reference
  Authors
Williams D.
  Title
Cancer after nuclear fallout: lessons from the Chernobyl accident.
  Journal
Nat Rev Cancer 2:543-9 (2002)
DOI:10.1038/nrc845
Related
pathway
shr03320  PPAR signaling pathway
shr04010  MAPK signaling pathway
shr04115  p53 signaling pathway
shr04310  Wnt signaling pathway
shr04520  Adherens junction
KO pathway
ko05216   
LinkDB

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