KEGG   PATHWAY: skh00550
Entry
skh00550                    Pathway                                

Name
Peptidoglycan biosynthesis - Shewanella khirikhana
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
skh00550  Peptidoglycan biosynthesis
skh00550

Organism
Shewanella khirikhana [GN:skh]
Gene
STH12_02996  murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
STH12_03891  murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
STH12_04045  murC; UDP-N-acetylmuramate--L-alanine ligase [KO:K01924] [EC:6.3.2.8]
STH12_04042  murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [KO:K01925] [EC:6.3.2.9]
STH12_04039  murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [KO:K01928] [EC:6.3.2.13]
STH12_01593  ddl_1; D-alanine--D-alanine ligase [KO:K01921] [EC:6.3.2.4]
STH12_04040  murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [KO:K01929] [EC:6.3.2.10]
STH12_00698  ispU; Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [KO:K00806] [EC:2.5.1.31]
STH12_00359  uppP; Undecaprenyl-diphosphatase [KO:K06153] [EC:3.6.1.27]
STH12_03114  undecaprenyl pyrophosphate phosphatase [KO:K19302] [EC:3.6.1.27]
STH12_04041  mraY; Phospho-N-acetylmuramoyl-pentapeptide-transferase [KO:K01000] [EC:2.7.8.13]
STH12_04044  murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563] [EC:2.4.1.227]
STH12_00265  pbpG_1; Penicillin-binding protein 2D [KO:K03814] [EC:2.4.1.129]
STH12_03306  mrcA; Penicillin-binding protein 1A [KO:K05366] [EC:2.4.1.129 3.4.16.4]
STH12_02874  mrcB; Penicillin-binding protein 1B [KO:K05365] [EC:2.4.1.129 3.4.16.4]
STH12_02391  spoVD; Stage V sporulation protein D [KO:K05515] [EC:3.4.16.4]
STH12_04038  ftsI; Peptidoglycan synthase FtsI precursor [KO:K03587] [EC:3.4.16.4]
STH12_02395  dacA; D-alanyl-D-alanine carboxypeptidase DacA precursor [KO:K07258] [EC:3.4.16.4]
STH12_01421  dacB; D-alanyl-D-alanine carboxypeptidase DacB precursor [KO:K07259] [EC:3.4.16.4 3.4.21.-]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00133  D-Alanine
C00448  trans,trans-Farnesyl diphosphate
C00692  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C00993  D-Alanyl-D-alanine
C01050  UDP-N-acetylmuramate
C01212  UDP-N-acetylmuramoyl-L-alanine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702  UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851  MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896  Crosslinked peptidoglycan
C05897  Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556  di-trans,poly-cis-Undecaprenyl phosphate
C17558  di-trans,poly-cis-Undecaprenol
Reference
  Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
  Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
  Journal
FEMS Microbiol Rev 32:208-33 (2008)
DOI:10.1111/j.1574-6976.2007.00089.x
Reference
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
  Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
  Title
Cytoplasmic steps of peptidoglycan biosynthesis.
  Journal
FEMS Microbiol Rev 32:168-207 (2008)
DOI:10.1111/j.1574-6976.2008.00104.x
Reference
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Reference
  Authors
van Heijenoort  J
  Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
  Journal
Glycobiology 11:25R-36R (2001)
DOI:10.1093/glycob/11.3.25R
Related
pathway
skh00520  Amino sugar and nucleotide sugar metabolism
skh00900  Terpenoid backbone biosynthesis
KO pathway
ko00550   
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