KEGG   PATHWAY: ssa00290Help
Entry
ssa00290                    Pathway                                

Name
Valine, leucine and isoleucine biosynthesis - Streptococcus sanguinis
Class
Metabolism; Amino acid metabolism
BRITE hierarchy
Pathway map
ssa00290  Valine, leucine and isoleucine biosynthesis
ssa00290

Ortholog table
Module
ssa_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ssa00290]
ssa_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ssa00290]
ssa_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ssa00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Streptococcus sanguinis [GN:ssa]
Gene
SSA_1967  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SSA_0980  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
SSA_0981  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
SSA_0977  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
SSA_1970  ilvB; acetolactate synthase catalytic subunit [KO:K01652] [EC:2.2.1.6]
SSA_1969  ilvH; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
SSA_1968  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
SSA_2286  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
SSA_1225  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SSA_0564  aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
SSA_0975  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ssa00260  Glycine, serine and threonine metabolism
ssa00280  Valine, leucine and isoleucine degradation
ssa00620  Pyruvate metabolism
KO pathway
ko00290   
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