KEGG   PATHWAY: tng04115
Entry
tng04115                    Pathway                                

Name
p53 signaling pathway - Tetraodon nigroviridis (spotted green pufferfish)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
tng04115  p53 signaling pathway
tng04115

Organism
Tetraodon nigroviridis (spotted green pufferfish) [GN:tng]
Gene
GSTEN00005388G001  unnamed protein product [KO:K04728] [EC:2.7.11.1]
GSTEN00007555G001  unnamed protein product [KO:K06641] [EC:2.7.11.1]
GSTEN00035967G001  unnamed protein product [KO:K06640] [EC:2.7.11.1]
GSTEN00018969G001  unnamed protein product [KO:K02216] [EC:2.7.11.1]
GSTEN00010050G001  unnamed protein product [KO:K19748]
GSTEN00035854G001  unnamed protein product [KO:K06643] [EC:2.3.2.27]
GSTEN00013984G001  unnamed protein product [KO:K10127]
GSTEN00019217G001  unnamed protein product [KO:K04451]
GSTEN00027332G001  unnamed protein product [KO:K06625]
GSTEN00026524G001  unnamed protein product [KO:K04503]
GSTEN00021540G001  unnamed protein product [KO:K10151]
GSTEN00016773G001  unnamed protein product [KO:K10151]
GSTEN00027337G001  unnamed protein product [KO:K10151]
GSTEN00033818G001  unnamed protein product [KO:K02089] [EC:2.7.11.22]
GSTEN00032981G001  unnamed protein product [KO:K02091] [EC:2.7.11.22]
GSTEN00027855G001  unnamed protein product [KO:K02091] [EC:2.7.11.22]
GSTEN00024300G001  unnamed protein product [KO:K06626]
GSTEN00011727G001  unnamed protein product [KO:K06626]
GSTEN00033829G001  unnamed protein product [KO:K02206] [EC:2.7.11.22]
GSTEN00030547G001  unnamed protein product [KO:K10128]
GSTEN00022069G001  unnamed protein product [KO:K10128]
GSTEN00009252G001  unnamed protein product [KO:K05868]
GSTEN00008349G001  unnamed protein product [KO:K21770]
GSTEN00004705G001  unnamed protein product [KO:K02087] [EC:2.7.11.22 2.7.11.23]
GSTEN00013393G001  unnamed protein product [KO:K04402]
GSTEN00030892G001  unnamed protein product [KO:K04402]
GSTEN00004743G001  unnamed protein product [KO:K04402]
GSTEN00004790G001  unnamed protein product [KO:K04402]
GSTEN00031910G001  unnamed protein product [KO:K04402]
GSTEN00029862G001  unnamed protein product [KO:K10130]
GSTEN00031473G001  unnamed protein product [KO:K04398] [EC:3.4.22.61]
GSTEN00021995G001  unnamed protein product [KO:K02159]
GSTEN00014459G001  unnamed protein product [KO:K10131]
GSTEN00032404G001  unnamed protein product [KO:K22744]
GSTEN00020506G001  unnamed protein product [KO:K04570]
GSTEN00008621G001  unnamed protein product [KO:K04570]
GSTEN00014059G001  unnamed protein product [KO:K04570]
GSTEN00001048G001  unnamed protein product [KO:K10133] [EC:1.-.-.-]
GSTEN00004275G001  unnamed protein product [KO:K10134]
GSTEN00002716G001  unnamed protein product [KO:K10136]
GSTEN00014357G001  unnamed protein product [KO:K10136]
GSTEN00013010G001  unnamed protein product [KO:K10137]
GSTEN00006442G001  unnamed protein product [KO:K04506] [EC:2.3.2.27]
GSTEN00018747G001  unnamed protein product [KO:K08738]
GSTEN00020796G001  unnamed protein product [KO:K02084]
GSTEN00020648G001  unnamed protein product [KO:K04399] [EC:3.4.22.62]
GSTEN00013715G001  unnamed protein product [KO:K02187] [EC:3.4.22.56]
GSTEN00025004G001  unnamed protein product [KO:K22745]
GSTEN00012277G001  unnamed protein product [KO:K10138]
GSTEN00004782G001  unnamed protein product [KO:K10138]
GSTEN00023793G001  unnamed protein product [KO:K05459]
GSTEN00003787G001  unnamed protein product [KO:K03982]
GSTEN00005207G001  unnamed protein product [KO:K06509]
GSTEN00005209G001  unnamed protein product [KO:K06509]
GSTEN00029791G001  unnamed protein product [KO:K06509]
GSTEN00032374G001  unnamed protein product [KO:K16857]
GSTEN00022976G001  unnamed protein product [KO:K16857]
GSTEN00012482G001  unnamed protein product [KO:K10140]
GSTEN00000721G001  unnamed protein product [KO:K10808] [EC:1.17.4.1]
GSTEN00003455G001  unnamed protein product [KO:K10808] [EC:1.17.4.1]
GSTEN00003453G001  unnamed protein product [KO:K10808] [EC:1.17.4.1]
GSTEN00003458G001  unnamed protein product [KO:K10808] [EC:1.17.4.1]
GSTEN00012923G001  unnamed protein product [KO:K10808] [EC:1.17.4.1]
GSTEN00023089G001  unnamed protein product [KO:K10141]
GSTEN00031208G001  unnamed protein product [KO:K10141]
GSTEN00024921G001  unnamed protein product [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
GSTEN00011294G001  unnamed protein product [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
GSTEN00026281G001  unnamed protein product [KO:K07207]
GSTEN00035277G001  unnamed protein product [KO:K10142] [EC:1.16.1.-]
GSTEN00032680G001  unnamed protein product [KO:K10143] [EC:2.3.2.27]
GSTEN00021580G001  unnamed protein product [KO:K10144] [EC:2.3.2.27]
GSTEN00017018G001  unnamed protein product [KO:K10145]
GSTEN00006787G001  unnamed protein product [KO:K10146]
GSTEN00004609G001  unnamed protein product [KO:K10146]
GSTEN00020336G001  unnamed protein product [KO:K10147] [EC:3.1.3.16]
GSTEN00026869G001  unnamed protein product [KO:K10147] [EC:3.1.3.16]
GSTEN00022527G001  unnamed protein product [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
tng04110  Cell cycle
tng04210  Apoptosis
tng04218  Cellular senescence
KO pathway
ko04115   
LinkDB

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