KEGG   PATHWAY: tup05217
Entry
tup05217                    Pathway                                

Name
Basal cell carcinoma - Tupaia chinensis (Chinese tree shrew)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancer: specific types
Pathway map
tup05217  Basal cell carcinoma
tup05217

Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102503238  TP53; tumor protein p53 [KO:K04451]
102490159  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102496861  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102476523  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102502813  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102471776  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102476690  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102472614  DDB2; damage specific DNA binding protein 2 [KO:K10140]
102479454  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
102483981  SHH; sonic hedgehog [KO:K11988]
102471693  PTCH1; patched 1 [KO:K06225]
102498407  SMO; smoothened, frizzled class receptor [KO:K06226]
102484063  KIF7; kinesin family member 7 [KO:K18806]
102499034  SUFU; SUFU negative regulator of hedgehog signaling [KO:K06229]
102501300  GLI1; GLI family zinc finger 1 [KO:K16797]
102500191  GLI2; GLI family zinc finger 2 [KO:K16798]
102475580  GLI3; GLI family zinc finger 3 [KO:K06230]
102469552  BMP2; bone morphogenetic protein 2 [KO:K21283]
102497487  BMP4; bone morphogenetic protein 4 [KO:K04662]
102502697  HHIP; hedgehog interacting protein [KO:K06231]
102502271  PTCH2; patched 2 [KO:K11101]
102499190  WNT1; Wnt family member 1 [KO:K03209]
102479831  WNT2B; Wnt family member 2B [KO:K00182]
102483867  WNT2; Wnt family member 2 [KO:K00182]
102501628  WNT3A; Wnt family member 3A [KO:K00312]
102489001  WNT3; Wnt family member 3 [KO:K00312]
102493340  WNT4; Wnt family member 4 [KO:K00408]
102489573  WNT5A; Wnt family member 5A [KO:K00444]
102467720  WNT5B; Wnt family member 5B [KO:K00444]
102483667  WNT6; Wnt family member 6 [KO:K00445]
102484353  WNT7A; Wnt family member 7A [KO:K00572]
102500004  WNT7B; Wnt family member 7B [KO:K00572]
102468229  WNT8B; Wnt family member 8B [KO:K00714]
102490209  WNT8A; Wnt family member 8A [KO:K00714]
102496226  WNT9A; Wnt family member 9A [KO:K01064]
102489417  WNT9B; Wnt family member 9B [KO:K01064]
102481567  WNT10B; Wnt family member 10B [KO:K01357]
102483253  WNT10A; Wnt family member 10A [KO:K01357]
102494826  WNT11; Wnt family member 11 [KO:K01384]
102497530  WNT16; Wnt family member 16 [KO:K01558]
102492163  FZD7; frizzled class receptor 7 [KO:K02432]
102499195  FZD1; frizzled class receptor 1 [KO:K02432]
102479307  FZD2; frizzled class receptor 2 [KO:K02235]
102474963  FZD3; frizzled class receptor 3 [KO:K02329]
102491949  FZD4; frizzled class receptor 4 [KO:K02354]
102475157  FZD5; frizzled class receptor 5 [KO:K02375]
102487480  FZD8; frizzled class receptor 8 [KO:K02375]
102492375  FZD6; frizzled class receptor 6 [KO:K02376]
102479813  FZD10; frizzled class receptor 10 [KO:K02842]
102481011  FZD9; frizzled class receptor 9 [KO:K02842]
102485749  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102472352  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102468994  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102476038  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102469399  AXIN1; axin 1 [KO:K02157]
102493766  AXIN2; axin 2 [KO:K04385]
102484859  APC; APC, WNT signaling pathway regulator [KO:K02085]
102470052  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102472740  CTNNB1; catenin beta 1 [KO:K02105]
102484318  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
102481394  TCF7L1; transcription factor 7 like 1 [KO:K04490]
102472810  TCF7L2; transcription factor 7 like 2 [KO:K04491]
102474621  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
Compound
C00187  Cholesterol
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Wu F, Zhang Y, Sun B, McMahon AP, Wang Y
  Title
Hedgehog Signaling: From Basic Biology to Cancer Therapy.
  Journal
Cell Chem Biol 24:252-280 (2017)
DOI:10.1016/j.chembiol.2017.02.010
Reference
  Authors
Otsuka A, Levesque MP, Dummer R, Kabashima K
  Title
Hedgehog signaling in basal cell carcinoma.
  Journal
J Dermatol Sci 78:95-100 (2015)
DOI:10.1016/j.jdermsci.2015.02.007
Related
pathway
tup04110  Cell cycle
tup04115  p53 signaling pathway
tup04310  Wnt signaling pathway
tup04340  Hedgehog signaling pathway
tup04350  TGF-beta signaling pathway
KO pathway
ko05217   
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