Tupaia chinensis (Chinese tree shrew): 102485262 Help Entry 102485262         CDS       T02978                                  Gene name MTOR Definition (RefSeq) mechanistic target of rapamycin   KO K07203   serine/threonine-protein kinase mTOR [EC:2.7.11.1] Organism tup  Tupaia chinensis (Chinese tree shrew) Pathway tup01521   EGFR tyrosine kinase inhibitor resistance tup01522   Endocrine resistance tup04012   ErbB signaling pathway tup04066   HIF-1 signaling pathway tup04072   Phospholipase D signaling pathway tup04136   Autophagy - other tup04140   Autophagy - animal tup04150   mTOR signaling pathway tup04151   PI3K-Akt signaling pathway tup04152   AMPK signaling pathway tup04211   Longevity regulating pathway tup04213   Longevity regulating pathway - multiple species tup04218   Cellular senescence tup04371   Apelin signaling pathway tup04613   Neutrophil extracellular trap formation tup04630   JAK-STAT signaling pathway tup04659   Th17 cell differentiation tup04714   Thermogenesis tup04910   Insulin signaling pathway tup04919   Thyroid hormone signaling pathway tup04920   Adipocytokine signaling pathway tup04930   Type II diabetes mellitus tup04931   Insulin resistance tup04935   Growth hormone synthesis, secretion and action tup05010   Alzheimer disease tup05014   Amyotrophic lateral sclerosis tup05016   Huntington disease tup05017   Spinocerebellar ataxia tup05022   Pathways of neurodegeneration - multiple diseases tup05163   Human cytomegalovirus infection tup05165   Human papillomavirus infection tup05167   Kaposi sarcoma-associated herpesvirus infection tup05168   Herpes simplex virus 1 infection tup05170   Human immunodeficiency virus 1 infection tup05200   Pathways in cancer tup05205   Proteoglycans in cancer tup05206   MicroRNAs in cancer tup05210   Colorectal cancer tup05212   Pancreatic cancer tup05214   Glioma tup05215   Prostate cancer tup05221   Acute myeloid leukemia tup05224   Breast cancer tup05225   Hepatocellular carcinoma tup05226   Gastric cancer tup05230   Central carbon metabolism in cancer tup05231   Choline metabolism in cancer tup05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:tup00001]  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     102485262 (MTOR)    04371 Apelin signaling pathway     102485262 (MTOR)    04630 JAK-STAT signaling pathway     102485262 (MTOR)    04066 HIF-1 signaling pathway     102485262 (MTOR)    04072 Phospholipase D signaling pathway     102485262 (MTOR)    04151 PI3K-Akt signaling pathway     102485262 (MTOR)    04152 AMPK signaling pathway     102485262 (MTOR)    04150 mTOR signaling pathway     102485262 (MTOR)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102485262 (MTOR)    04136 Autophagy - other     102485262 (MTOR)   09143 Cell growth and death    04218 Cellular senescence     102485262 (MTOR)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102485262 (MTOR)    04659 Th17 cell differentiation     102485262 (MTOR)   09152 Endocrine system    04910 Insulin signaling pathway     102485262 (MTOR)    04920 Adipocytokine signaling pathway     102485262 (MTOR)    04935 Growth hormone synthesis, secretion and action     102485262 (MTOR)    04919 Thyroid hormone signaling pathway     102485262 (MTOR)   09149 Aging    04211 Longevity regulating pathway     102485262 (MTOR)    04213 Longevity regulating pathway - multiple species     102485262 (MTOR)   09159 Environmental adaptation    04714 Thermogenesis     102485262 (MTOR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102485262 (MTOR)    05206 MicroRNAs in cancer     102485262 (MTOR)    05205 Proteoglycans in cancer     102485262 (MTOR)    05230 Central carbon metabolism in cancer     102485262 (MTOR)    05231 Choline metabolism in cancer     102485262 (MTOR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102485262 (MTOR)   09162 Cancer: specific types    05210 Colorectal cancer     102485262 (MTOR)    05212 Pancreatic cancer     102485262 (MTOR)    05225 Hepatocellular carcinoma     102485262 (MTOR)    05226 Gastric cancer     102485262 (MTOR)    05214 Glioma     102485262 (MTOR)    05221 Acute myeloid leukemia     102485262 (MTOR)    05215 Prostate cancer     102485262 (MTOR)    05224 Breast cancer     102485262 (MTOR)   09164 Neurodegenerative disease    05010 Alzheimer disease     102485262 (MTOR)    05014 Amyotrophic lateral sclerosis     102485262 (MTOR)    05016 Huntington disease     102485262 (MTOR)    05017 Spinocerebellar ataxia     102485262 (MTOR)    05022 Pathways of neurodegeneration - multiple diseases     102485262 (MTOR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102485262 (MTOR)    04931 Insulin resistance     102485262 (MTOR)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102485262 (MTOR)    05168 Herpes simplex virus 1 infection     102485262 (MTOR)    05163 Human cytomegalovirus infection     102485262 (MTOR)    05167 Kaposi sarcoma-associated herpesvirus infection     102485262 (MTOR)    05165 Human papillomavirus infection     102485262 (MTOR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102485262 (MTOR)    01522 Endocrine resistance     102485262 (MTOR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:tup01001]     102485262 (MTOR)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:tup04131]     102485262 (MTOR) Enzymes [BR:tup01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      102485262 (MTOR) Protein kinases [BR:tup01001]  Serine/threonine kinases: Other   PIKK family [OT]    102485262 (MTOR) Membrane trafficking [BR:tup04131]  Autophagy   Other autophagy associated proteins    mTORC1 complex     102485262 (MTOR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  FAT PI3_PI4_kinase DUF3385 FRB_dom FATC HEAT_2 UME V-ATPase_H_N EPSP_synthase HEAT_EZ Nipped-B_C Motif Other DBs NCBI-GeneID:  102485262 NCBI-ProteinID:  XP_006145394 LinkDB All DBs Position Un AA seq 2549 aa AA seqDB search MLGTGPAAATAATTTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESR CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW ERLQGCQRIVEDWQKILMVRSLVVNPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA VLHYKHQNQARDEKKKLRHASGANITSATTTATTAATAAATASTEGSNSESEAESTENSP TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD VPTQVELLIKQATSHENLCQCYIGWCPFW NT seq 7650 nt NT seq  +upstreamnt  +downstreamnt atgcttggaactggacctgccgccgccaccgcagccaccaccacatctagcaatgtgagc gttctgcagcagtttgccagtggcctgaagagccgaaatgaggagaccagagccaaagct gccaaggagctccagcactatgtcaccatggagcttcgagagatgagtcaagaggaatct actcgcttctatgatcagctaaaccatcacatttttgaactggtttccagctctgatgcc aatgagaggaaaggtggcatcttggccatagccagcctcataggagtggaaggtggaaat gccacccgaattggcagatttgcgaactatcttcggaacctcctcccctctaatgaccca gttgtcatggaaatggcatccaaggccattggacgcctcgccatggcaggggacactttc acggctgagtacgtggagtttgaggtgaagcgagccctggaatggctgggtgctgaccgc aacgaaggccggagacacgcagctgtcctggttctccgtgagctggccatcagtgttccc accttcttcttccagcaagtgcagcccttctttgacaacatttttgtggccgtgtgggat cccaaacaggccattcgtgagggagctgtggctgcccttcgtgcctgtctaattctcacc acccagcgtgagccaaaggagatgcagaagcctcagtggtacaggcacacgtttgaagaa gcagaaaaagggtttgatgagacgttggccaaagagaagggcatgaatcgggatgatcgg atccatggagccttgctgatcctcaacgagctggtccgaatcagcagcatggaaggagag cgtctgagagaagaaatggaagaaatcacacagcagcagctggtacatgacaaatactgc aaagatctcatgggctttgggacaaaacctcgtcacattactcccttcaccagcttccag gctgtacagccccaacagtcaaatgccctggtggggctgctggggtacagctctcaccaa ggccttatgggatttggggcttctccaagcccagcaaagtccaccctagtggagagccga tgttgcagagacttgatggaggagaagtttgatcaggtgtgccagtgggtgctgaaatgc aggaatagcaagaactcgctgatccaaatgacaatccttaatctgttgccccgcttggct gcattccgaccttctgccttcacagatacccagtacctccaggataccatgaatcatgtc ctcagctgtgtcaagaaggagaaagaacgtacagcggccttccaagccctggggctactc tctgtggctgtgaggtccgaatttaaggtctatttgcctcgtgtgctggatatcattcga gcagccctgcctcctaaggacttcgcccataagaggcagaaggcaatgcaggtggatgcc acagtgttcacttgcatcagcatgctggctcgagcaatggggccaggcatccagcaggat atcaaggagctgctggagcccatgctggcagtgggactaagccctgccctcactgctgta ctctatgacctgagccgtcaaattccgcagctgaagaaggacatccaagacgggctactg aagatgctctctctggtccttatgcacaaacccctccggcacccaggcatgcccaagggc ctggcccatcagctggcctctcctggcctcacgactcttcctgaggccagtgatgtgggg agtatcactcttgccctccgaactcttggcagctttgaattcgaaggccattctctgacc caatttgtccgccactgtgcggatcatttcctgaacagtgagcacaaggagatccgcatg gaagctgctcgcacctgttcacgcctgctcacaccctccatccacctcatcagtggccat gctcatgtggttagccagactgcagtgcaagtggtagcagacgtgctcagcaaactgctc gtggttggcataacagatcctgaccccgacatccgctactgtgtcttggcatccctggat gagcgctttgatgcacacctggcccaggcagagaatttgcaggccctgtttgtagcactg aatgaccaggtgtttgagatccgggaactggccatctgcactgtaggccggcttagtagc atgaacccagcctttgtcatgcctttcctgcgcaagatgctcatccagattttgacagaa ctggagcacagtggcattgggagaatcaaagagcagagcgcccgcatgctggggcacctg gtctccaatgccccacgactcatccgcccctacatggagcctattctgaaggctttaatt ttgaaactgaaagatccagatcctgatccaaacccaggggtgatcaataatgtcttggct acaataggagaattggctcaagttagtggcctagaaatgaggaagtgggttgatgaactt tttatcatcatcatggacatgctccaggattcctctctgttggccaaaaggcaggtggct ctatggaccctgggacagttggtggccagtactggctatgtagtggagccctacaggaag taccccactttgcttgaggtgctgctgaattttttaaagactgaacagaatcagggtaca cggagagaggctatccgtgtgttggggctgttaggggctttggatccctataaacacaaa gtgaacatcggcatgattgaccaatcccgggatgcctctgctgtcagcctatcagaatcc aagtcaagtcaagactcctctgactacagcaccagtgaaatgctggtcaatatgggcaac ctgcctctggatgagttctacccagctgtgtccatggtggccttgatgcggatcttccga gaccagtctctctctcaccatcacaccatggtcgtccaggccattaccttcatcttcaag tccctaggactcaagtgtgtacagttcctgccccaggtcatgcccacattcctgaatgtc attagggtctgtgacggggccatccgagaatttctattccagcagttgggaatgttggtg tccttcgtcaagagccacatcagaccttatatggatgaaatagtcaccctcatgagagaa ttctgggtcatgaacacatcaatccagagcacgatcattcttctcattgagcagatcgtg gtagctcttgggggtgaatttaagctctacctcccccagctaatcccacacatgctgcgt gtcttcatgcacgacaacagcccaggccgcatcgtctccatcaagttgttggcggcaatc cagctgtttggcgccaatctagatgactatctgcatttgttgttgcctcctattgtgaag ttgtttgatgcccctgaagtcccactgccatctcgaaaggcagcattagagacagtggac cgcctgacagaatccctggatttcactgactatgcctcccggatcattcaccctattgtt cgaacactggaccagagcccagaactgcgttccacagccatggacacgttgtcctcactt gtctttcaactggggaagaagtaccaaattttcattccaatggtgaataaagttctggtg cgacaccgaatcaaccatcagcgctatgatgtgctcatctgcaggattgtcaaggggtac acccttgctgatgaagaggaagatcctttgatttaccagcatcgcatgctgagaagtggc caaggagatgcattggctagtggaccagtagaaacaggacccatgaagaaattgcacgtc agcaccatcaacctccaaaaggcctggggagcggccaggagggtctccaaagatgactgg ctggagtggctgagacggctgagcctggagctgctgaaggactcctcgtcaccctccctg cgctcgtgctgggctctggcgcaggcttacaacccaatggccagggatctcttcaatgct gcatttgtgtcctgctggtctgaactgaatgaagaccagcaggatgagcttattagaagc atcgagttggccctcacctcacaggacatcgctgaagttacccaaacccttttaaacttg gccgaattcatggaacacagtgacaagggccccctgccactgagagatgacaacggcatt gttctgctgggtgagagagcagccaagtgccgagcatatgccaaagcactacactacaag gagctggagttccagaagggtcccacccccgccattctggagtctctgatcagcattaat aataagctacagcagcccgaggcagctgctggggtgttggaatatgccatgaaacacttt ggagagctggagatccaggctacctggtatgagaaactgcatgagtgggaggatgctctt gtagcctatgacaagaaaatggacaccaacaaggatgacccggagctgatgctgggccgc atgcgctgcctcgaggccctgggggaatgggggcagctccaccagcagtgctgtgaaaag tggaccctggttaatgatgagacccaagccaagatggcccggatggctgctgcagctgca tggggtttaggtcaatgggacagcatggaggagtacacctgcatgatcccacgggacacc catgacggggcattttacagagctgtgctggcactacaccaagacctcttctccttggca caacagtgcatcgacaaggccagggacctgctggatgcggagttgactgcaatggcagga gagagctacagtcgggcatacggggccatggtttcatgccacatgctctctgagctggag gaggttatccagtacaaacttgtccctgagcgacgagagatcatccgccagatctggtgg gagagactacagggttgccagcgtattgtagaggattggcagaaaatcctcatggtgcgg tcccttgtggtcaaccctcatgaggacatgagaacctggctcaagtatgcaagcttgtgt ggcaagagcggcaggctggctcttgcgcacaaaaccttagtgttgctcctgggagttgat ccatctcggcaacttgatcatcccctgccaacagttcaccctcaggtgacttatgcctac atgaaaaacatgtggaagagtgctcgcaagattgatgccttccagcacatgcagcacttc gtccagactatgcagcagcaggcccagcatgccattgctaccgaggaccagcagcacaag caggagctacacaagctcatggcccggtgttttctgaaactgggggagtggcagttgaac ctacagggcatcaacgagagcacaatccccaaagtgctgcagtactacagcgccgccacg gagcacgaccgcagctggtacaaggcctggcatgcgtgggcagtgatgaactttgaggct gtgctacactacaaacatcaaaaccaagcccgtgatgagaagaagaaactgcgtcatgcc agcggggccaacatcaccagtgccaccactactgccaccacagctgctaccgctgctgcc actgccagcactgaaggcagcaacagcgagagtgaggccgagagcaccgagaacagcccc accccatctcctctgcagaagaaggtcactgaggatttgtccaaaacgctcttgatgtac actgtccctgccgtccagggcttcttccgttctatctcattgtcacgaggcaacaacctc caggatacactcagagtccttacattatggtttgattatggtcactggcctgacgtcaac gaagccttagtggaaggggtgaaagcaatccagattgatacttggttacaggttatacct cagctcattgcaagaattgatacgcccagacccttggtgggacgcctcattcaccagctt ctcacagacattggtcggtaccacccccaggccctcatctaccccttgactgtggcttct aagtctaccaccacagcccgtcacaatgcagccaacaagatcctgaagaacatgtgtgag cacagtaacaccctggtccagcaggccatgatggtgagtgaggagctgatccgagtggcc atcctctggcacgagatgtggcacgaaggcctggaagaggcatctcgtttgtactttggg gagaggaatgtgaaaggcatgtttgaggtgctggagcctctgcatgctatgatggaacgg ggcccccagactctgaaagaaacgtcatttaatcaggcctatggtcgagatttaatggag gcacaagaatggtgtaggaagtacatgaaatcaggaaatgtcaaggacctcacccaagcc tgggacctctattatcacgtgttcagacgaatctcaaaacagctgcctcagctcacatcc ttagagctgcaatatgtttccccaaaacttctgatgtgccgggaccttgagttggctgtg ccaggaacctatgaccccaaccagccgatcattcgcattcagtccatagcaccatctttg caagtcattacatccaagcagaggccccggaagttgacactgatgggcagcaatggacat gagtttgttttcctcctgaaaggccacgaagatctgaggcaggatgaacgggtgatgcag ctctttggcctggttaacactcttctggccaatgacccaacatctcttcggaaaaacctc agcatccaaagatatgccgtcattcctctgtcgaccaactctggcctcattggctgggtc cctcactgcgacacactgcatgccctcatccgagactacagggagaaaaagaagattctt ctcaacattgagcatcgcataatgttgcggatggctccagactatgaccacttgactctg atgcagaaggtggaggtatttgagcacgctgtcaataacaccgccggagacgacctggcc aagctgctgtggctgaagagccctagctcagaggtttggtttgaccgaagaaccaattat acccgctcattagcagtcatgtcaatggttgggtatattctgggcctaggagataggcac ccatcaaacctgatgctggacaggctgagtgggaaaatcctgcacattgactttggggac tgctttgaggttgctatgaccagagagaagtttccagagaagattccatttagactaaca agaatgttgaccaatgctatggaggttactggcctagatggcaactataggatcacatgc cacacggtgatggaagtacttcgggagcacaaggacagcgtcatggctgtgctggaagcc ttcgtctatgaccccttgctgaactggaggctgatggacacaaataccaaaggcaataag agatcccgaacgaggacagattcctactctgctggccagtcagtagaaattttggacggt gtggaacttggagaaccagcccataagaaaacggggaccacagtgccagaatccattcat tcgttcattggagatggtttggtgaagccagaggccctaaataagaaagctattcaaatt attaacagggttcgagataagctcactggtcgggatttctctcatgatgatactttggat gttcccacacaagttgagctgctcatcaaacaagcaacatcccatgaaaacctctgtcag tgctacattggctggtgtcctttctggtaa

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