KEGG   Tupaia chinensis (Chinese tree shrew): 102494943Help
Entry
102494943         CDS       T02978                                 

Gene name
DOT1L
Definition
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup00310  Lysine degradation
tup05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:tup00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    102494943 (DOT1L)
 09160 Human Diseases
  09161 Cancers
   05202 Transcriptional misregulation in cancers
    102494943 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:tup03036]
    102494943 (DOT1L)
Enzymes [BR:tup01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     102494943 (DOT1L)
Chromosome and associated proteins [BR:tup03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     102494943 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DOT1
Motif
Other DBs
NCBI-GeneID: 102494943
NCBI-ProteinID: XP_014441023
LinkDB All DBs
Position
Un
AA seq 1526 aa AA seqDB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHVLQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCR
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNATTPTKVP
ESRVAGPVDAPVDSGAEDDKAGATTVKKPSPSKARKKKLNKKGRKLAGRKRGRPKKLSTA
NPERKPKKSQAALELLHAQTVSQTAPSSPQDAYRSPHSPFYQLPPSAPRPCPTPLLAAPT
PPALQKLLESFKIQYLQFLAYTKTPQYRANLQQLLDQEKERNAQLLGAAQQLLSHCQAQK
EEIRGLFQQKLDELGVKALTYDDLIQAQKEISAHNQQLQEQSEQLEKDNCQLRSRSLQLL
KARCEELRLDWSTLSLESLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLR
SCVPPDDGLVPPPRGKGALGRELEAEAGRLHLELDCAKFSLPPFSVSPELSMNGHGAGYE
LGGPLSRPASKQSTPQYLASPPDQEVVPCTPSHGSRPRLEKLSSLALPDYTRLSPAKIVL
RRHLSQDPAGAGKTGTGELHSRAEHAKENGLTYQSPGVPSVKLSPQDPRPPSPGPTQAAG
EKGGEKPAKERGHGSSGEPITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAEKLRSTPS
PVPQPRDSSALEKPGGANAHGAGSKSLAAAPAGFYAGSVAISGALSGSPAPLAPGAELAA
FDESSSSGSLLGAVGSRSSTPQHPPPLAQPRPPGQASPVHRLAASPRLGGAAPGLLPEPG
KADLPSDAGFSDPEGEAKRRIVFTISAAAASARQSPSSKHSPLPSGARGDCGQGYGQDSR
KRGRRKRASAGTPSLSTGVSPKRRALPAVAGLFTQSSGSPLNLSSMVSTINQPLEITAIS
SPEDSRKSSPVPCQDHDQPPVLKKERPLSQANGAHYSPLTSDEEPGSEDEPSSARIERKI
ATISLESKSPPKTLETGGGMAGRRPTPASEPVVSSKWKSTFSPISDVGPAKPADGPLQAP
TLGQASLLAFRPTLDEPAAAEAKLVAHPRKSFPGALAGADGLSPGTNPXNGLAFGGGLAA
DLSLHSFNDGAPLPLRVPEASLSFPAPRGREGPSEANPFLNKRQLDGLCGLKAEAGKGRE
AAEDFRSGRNLFISAAAVPSGGLLGGPGLATAASSAGSTPPSAQTHRPFLGAFPPGPQFS
LGPVSLQANLSSVAGSSVLQSLFSTVPAAAGLAPATSATTRLTNSHAVGSFSGVTGGAVG
AGRKDAASTVNGGAPGGAGLAQLYCP
NT seq 4581 nt NT seq  +upstreamnt  +downstreamnt
atgggcgagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaagcaccacgatgctgctcacgagatcatcgagacc
atccggtgggtctgcgaggagatcccggatcttaaactcgccatggagaactacgtcctg
atcgactacgacaccaagagcttcgagagcatgcagcggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg
aggccgtccaccgggctgctgcggcacgtcctgcagcaggtgtacaaccactcggtcacc
gaccccgagaaactcaacaactacgagcccttctcccccgaggtctatggcgagacctcc
ttcgacctggtggcccagatgatcgacgagatcaagatgaccgaggacgacctcttcgtg
gacctgggcagcggtgtgggccaggtcgtgctccaggttgctgccgccaccaactgcaga
caccactacggcgtcgagaaagccgacatcccagccaagtacgcggagaccatggaccgc
gaattcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggtgacttcctctccgaggagtggcgggagcggatcgccaacacaagtgttatctttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcgcttcgcaaacatg
aaggagggtggcagaatcgtgtcctcgaaaccctttgcacctctaaacttcaggataaac
agccggaacttgagtgacattggcaccatcatgcgtgtggtggagctgtcgcccctgaag
ggctccgtgtcgtggacggggaagccggtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaagaggcg
gcccggcgccggcagcagcgggagagcaagagcaacgccaccactccgaccaaggtcccc
gagagccgggtggccggccccgtggacgcccccgtggattctggtgctgaggacgacaag
gcgggagcgaccaccgtcaagaagccgtctccctccaaagctcgcaagaagaagctgaac
aagaaggggaggaagctggctggccggaagcgcgggcgcccgaagaagctgagcaccgcg
aaccccgagcgcaagcccaagaagagccaagctgcactggagctgctgcacgcacagacg
gtgtcccagacggccccctcctcgccccaggacgcctacaggtccccgcacagcccgttc
taccagctacctccgagcgcaccacggccgtgccccaccccactgctggcggcgcccacc
ccacctgcactgcagaagctgctagagtcctttaagatccagtacctgcagttcctggcc
tacaccaagaccccccagtacagagccaacctgcagcagctgctggaccaggagaaggag
aggaacgcccagctgctgggtgccgcgcagcagctcctcagccactgccaggcccagaag
gaggagatccgggggctgttccagcagaaactggacgagctgggcgtgaaggccttgacc
tacgatgacctgatccaagcgcagaaggagatctctgcgcacaaccagcagctgcaggag
cagtcggagcagctggagaaggacaactgtcagctccgcagccgcagcctgcagctgctc
aaggctcggtgcgaggagctgaggctggactggtccacgctgtccctggagagcctgctg
aaggagaagcaggccctgaagagccagatctccgagaagcagcgtcactgcctggagctg
cagatcagcatcgtggagctcgagaagagccagcggcagcaggagctgctgcagctcagg
tcctgcgtgccgcccgacgatgggctggtgccgcccccgcgcgggaagggtgccttgggc
cgcgagctggaggccgaggcgggccggctgcacctggagctggactgcgccaagttctcc
ctgccacccttcagcgtgagccccgagctgtccatgaacggccacggggcgggctacgag
ctgggcggcccgctgagccggccggcgtccaagcagagcaccccgcagtacctggcctcc
ccgcccgaccaggaggtggtgccctgcacgcccagccacggcagccggccccggctggag
aagctgtccagcctggccctgcctgactacaccaggctctcgccggccaagatcgtgctg
cggcggcacctgagccaggaccctgcgggtgctggcaagacgggaaccggcgagctccac
tctcgagctgagcacgccaaggagaacggcctcacctaccagagccccggcgtgccgagt
gtgaagctgagccctcaggacccgcggcccccgtccccagggcccacgcaggctgcaggg
gagaagggcggtgagaagcctgcgaaggagcgcggccacggcagcagcggcgagcccatc
accagcttgcccatcagcatcccgctcagcaccgtgcagcccaacaagctcccggtcagc
attcccctggctagcgtggttctgcccagccgcgccgagaagctgaggagcacgcccagc
cccgtgccgcagccccgagactcatctgcgctcgagaaaccgggcggcgctaatgcccat
ggggccgggagcaagagcttggccgcggcccccgcaggcttctacgccggctccgtggcc
atcagtggggccctgtccggcagcccggcacccctggcccccggagccgagctggccgcc
ttcgacgagtcctccagttcagggagcctcctcggtgccgtggggtcccggagctcgacg
ccgcagcacccgcccccgctggcgcagccccgcccccctggccaggcctcgcccgtgcac
cggctggccgccagtccccggctgggtggggccgccccgggcctcctccccgaacccggc
aaggccgacctgccctctgatgccggcttctcggacccggagggcgaagccaagcggagg
atcgtcttcaccatctcagccgcggctgccagcgccaggcagtcaccctccagcaagcac
agccctctgccctcgggagcccgaggggactgtggtcagggctacgggcaggacagccgc
aagcggggccgcaggaagagggcgtcggccgggacaccgagcctgagcacaggcgtgtct
cccaagcgccgtgccctgccagctgtcgccgggctcttcacgcagtcctcggggtcgccc
ctcaacctctcctccatggtcagcaccatcaaccagcccctggagatcacggcgatctcc
tcccccgaggactcacggaagagctcccctgtgccctgccaggaccacgaccagccgcct
gtgctcaagaaggagcggcccctgagccaggccaacggggcgcactactccccgctgacc
tccgacgaggagccgggctccgaggacgagcccagcagtgcccgaattgaaaggaaaatc
gcgacgatttccttggagagcaagtctcccccgaagaccttggagactgggggtggcatg
gcgggccggaggccgacacccgccagcgagcctgtcgtcagcagcaagtggaagtccacc
ttctcgcccatctccgacgtcggcccggccaagcccgcggacggccctctgcaggccccc
accctgggccaggcctccctgctcgccttccggcccaccctggacgagccggcggccgcg
gaggccaagctcgtcgcgcaccccaggaagagctttcccggcgccttggcgggggccgac
gggctcagccccggcaccaaccccngcaacggcttggccttcggcggcggtctggccgcg
gacctcagtttacacagcttcaacgatggtgctcccctccccctccgggtccccgaggcc
tcgctcagcttccccgccccgcggggcagggagggcccctcggaagccaacccctttctg
aacaagcggcagctggacggcctgtgcggcctgaaggccgaggcgggcaagggcagggag
gcggccgaggacttcaggagcggccgcaacctcttcatctccgccgccgccgtgccctcc
gggggcctcctgggcggccctggcctggccacagcggcgtcgtccgcgggcagcacgccg
ccctccgcacagacgcaccggcctttcctgggtgcctttccgcctggaccgcagttctcc
ctggggcccgtgtccctgcaggccaacctcagctctgtggccggctcgtcggtgctgcag
tccctgttcagcaccgtgccggccgccgcgggcctggcgcccgccacctctgccacgacc
agactgaccaactcccacgccgtgggcagcttctccggggtgacgggcggagcagtcgga
gcaggacggaaggacgcggcctctactgtgaacggcggcgctcccggaggcgccgggctg
gcccagctgtactgtccatag

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