KEGG   Tupaia chinensis (Chinese tree shrew): 102500069
Entry
102500069         CDS       T02978                                 

Gene name
KRAS
Definition
(RefSeq) KRAS proto-oncogene, GTPase
  KO
K07827  GTPase KRas
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup01521  EGFR tyrosine kinase inhibitor resistance
tup01522  Endocrine resistance
tup04010  MAPK signaling pathway
tup04012  ErbB signaling pathway
tup04014  Ras signaling pathway
tup04015  Rap1 signaling pathway
tup04062  Chemokine signaling pathway
tup04068  FoxO signaling pathway
tup04071  Sphingolipid signaling pathway
tup04072  Phospholipase D signaling pathway
tup04137  Mitophagy - animal
tup04140  Autophagy - animal
tup04150  mTOR signaling pathway
tup04151  PI3K-Akt signaling pathway
tup04210  Apoptosis
tup04211  Longevity regulating pathway
tup04213  Longevity regulating pathway - multiple species
tup04218  Cellular senescence
tup04360  Axon guidance
tup04370  VEGF signaling pathway
tup04371  Apelin signaling pathway
tup04540  Gap junction
tup04550  Signaling pathways regulating pluripotency of stem cells
tup04625  C-type lectin receptor signaling pathway
tup04650  Natural killer cell mediated cytotoxicity
tup04660  T cell receptor signaling pathway
tup04662  B cell receptor signaling pathway
tup04664  Fc epsilon RI signaling pathway
tup04714  Thermogenesis
tup04720  Long-term potentiation
tup04722  Neurotrophin signaling pathway
tup04725  Cholinergic synapse
tup04726  Serotonergic synapse
tup04730  Long-term depression
tup04810  Regulation of actin cytoskeleton
tup04910  Insulin signaling pathway
tup04912  GnRH signaling pathway
tup04914  Progesterone-mediated oocyte maturation
tup04915  Estrogen signaling pathway
tup04916  Melanogenesis
tup04917  Prolactin signaling pathway
tup04919  Thyroid hormone signaling pathway
tup04921  Oxytocin signaling pathway
tup04926  Relaxin signaling pathway
tup04929  GnRH secretion
tup04933  AGE-RAGE signaling pathway in diabetic complications
tup04935  Growth hormone synthesis, secretion and action
tup04960  Aldosterone-regulated sodium reabsorption
tup05010  Alzheimer disease
tup05022  Pathways of neurodegeneration - multiple diseases
tup05034  Alcoholism
tup05160  Hepatitis C
tup05161  Hepatitis B
tup05163  Human cytomegalovirus infection
tup05165  Human papillomavirus infection
tup05166  Human T-cell leukemia virus 1 infection
tup05167  Kaposi sarcoma-associated herpesvirus infection
tup05170  Human immunodeficiency virus 1 infection
tup05200  Pathways in cancer
tup05203  Viral carcinogenesis
tup05205  Proteoglycans in cancer
tup05206  MicroRNAs in cancer
tup05210  Colorectal cancer
tup05211  Renal cell carcinoma
tup05212  Pancreatic cancer
tup05213  Endometrial cancer
tup05214  Glioma
tup05215  Prostate cancer
tup05216  Thyroid cancer
tup05218  Melanoma
tup05219  Bladder cancer
tup05220  Chronic myeloid leukemia
tup05221  Acute myeloid leukemia
tup05223  Non-small cell lung cancer
tup05224  Breast cancer
tup05225  Hepatocellular carcinoma
tup05226  Gastric cancer
tup05230  Central carbon metabolism in cancer
tup05231  Choline metabolism in cancer
tup05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:tup00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102500069 (KRAS)
   04012 ErbB signaling pathway
    102500069 (KRAS)
   04014 Ras signaling pathway
    102500069 (KRAS)
   04015 Rap1 signaling pathway
    102500069 (KRAS)
   04370 VEGF signaling pathway
    102500069 (KRAS)
   04371 Apelin signaling pathway
    102500069 (KRAS)
   04068 FoxO signaling pathway
    102500069 (KRAS)
   04072 Phospholipase D signaling pathway
    102500069 (KRAS)
   04071 Sphingolipid signaling pathway
    102500069 (KRAS)
   04151 PI3K-Akt signaling pathway
    102500069 (KRAS)
   04150 mTOR signaling pathway
    102500069 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102500069 (KRAS)
   04137 Mitophagy - animal
    102500069 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    102500069 (KRAS)
   04218 Cellular senescence
    102500069 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102500069 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    102500069 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102500069 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    102500069 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    102500069 (KRAS)
   04660 T cell receptor signaling pathway
    102500069 (KRAS)
   04662 B cell receptor signaling pathway
    102500069 (KRAS)
   04664 Fc epsilon RI signaling pathway
    102500069 (KRAS)
   04062 Chemokine signaling pathway
    102500069 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102500069 (KRAS)
   04929 GnRH secretion
    102500069 (KRAS)
   04912 GnRH signaling pathway
    102500069 (KRAS)
   04915 Estrogen signaling pathway
    102500069 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    102500069 (KRAS)
   04917 Prolactin signaling pathway
    102500069 (KRAS)
   04921 Oxytocin signaling pathway
    102500069 (KRAS)
   04926 Relaxin signaling pathway
    102500069 (KRAS)
   04935 Growth hormone synthesis, secretion and action
    102500069 (KRAS)
   04919 Thyroid hormone signaling pathway
    102500069 (KRAS)
   04916 Melanogenesis
    102500069 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102500069 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    102500069 (KRAS)
   04726 Serotonergic synapse
    102500069 (KRAS)
   04720 Long-term potentiation
    102500069 (KRAS)
   04730 Long-term depression
    102500069 (KRAS)
   04722 Neurotrophin signaling pathway
    102500069 (KRAS)
  09158 Development and regeneration
   04360 Axon guidance
    102500069 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    102500069 (KRAS)
   04213 Longevity regulating pathway - multiple species
    102500069 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    102500069 (KRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102500069 (KRAS)
   05206 MicroRNAs in cancer
    102500069 (KRAS)
   05205 Proteoglycans in cancer
    102500069 (KRAS)
   05203 Viral carcinogenesis
    102500069 (KRAS)
   05230 Central carbon metabolism in cancer
    102500069 (KRAS)
   05231 Choline metabolism in cancer
    102500069 (KRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102500069 (KRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102500069 (KRAS)
   05212 Pancreatic cancer
    102500069 (KRAS)
   05225 Hepatocellular carcinoma
    102500069 (KRAS)
   05226 Gastric cancer
    102500069 (KRAS)
   05214 Glioma
    102500069 (KRAS)
   05216 Thyroid cancer
    102500069 (KRAS)
   05221 Acute myeloid leukemia
    102500069 (KRAS)
   05220 Chronic myeloid leukemia
    102500069 (KRAS)
   05218 Melanoma
    102500069 (KRAS)
   05211 Renal cell carcinoma
    102500069 (KRAS)
   05219 Bladder cancer
    102500069 (KRAS)
   05215 Prostate cancer
    102500069 (KRAS)
   05213 Endometrial cancer
    102500069 (KRAS)
   05224 Breast cancer
    102500069 (KRAS)
   05223 Non-small cell lung cancer
    102500069 (KRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102500069 (KRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    102500069 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    102500069 (KRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102500069 (KRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102500069 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    102500069 (KRAS)
   05161 Hepatitis B
    102500069 (KRAS)
   05160 Hepatitis C
    102500069 (KRAS)
   05163 Human cytomegalovirus infection
    102500069 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102500069 (KRAS)
   05165 Human papillomavirus infection
    102500069 (KRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102500069 (KRAS)
   01522 Endocrine resistance
    102500069 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tup04131]
    102500069 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:tup04031]
    102500069 (KRAS)
Membrane trafficking [BR:tup04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    102500069 (KRAS)
GTP-binding proteins [BR:tup04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    102500069 (KRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 G-alpha FeoB_N Gtr1_RagA ATP_bind_1 Septin DUF1413 NB-ARC AAA_25
Other DBs
NCBI-GeneID: 102500069
NCBI-ProteinID: XP_006140353
LinkDB
Position
Un
AA seq 241 aa
MARGGGRGGGGFSGGCGGGGGGCGGGCLASSEGGGGGQRLGGSQVRERGLLKMTEYKLVV
VGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMR
DQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTK
QAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKIISKEEKTPGCVKIKKCII
M
NT seq 726 nt   +upstreamnt  +downstreamnt
atggcgcgaggcggcggccgcggcggcggaggctttagcggcggctgtggcggcggcggc
ggcggctgtggcggcggctgcttggccagctctgaaggcggcggcgggggccagaggctc
ggcggctcccaggtgcgggagagaggcctgctgaaaatgactgaatataaacttgtggta
gttggagctggtggcgtaggcaagagtgccttgacgatacagcttattcagaatcacttt
gtggatgaatatgatcctacaatagaggattcctacaggaaacaagtagtaattgatgga
gaaacctgtctcttggatattctcgacacagcaggtcaagaggagtacagtgcaatgagg
gaccagtacatgaggactggggagggctttctttgtgtatttgccataaataatactaaa
tcatttgaagatattcaccattatagagaacagattaaaagagttaaagactctgaagat
gtacccatggtcctcgtaggaaataaatgtgatttgccttctagaacagtagatacaaaa
caggctcaggacttagcaagaagttatggaattcctttcattgaaacatcagcaaagaca
agacagagagtggaggatgctttttatacattggtgagagagatccgacaatacagattg
aaaataatcagcaaagaagaaaagactcctggctgtgtgaaaattaaaaaatgcattata
atgtaa

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