KEGG   PATHWAY: uah04151
Entry
uah04151                    Pathway                                

Name
PI3K-Akt signaling pathway - Ursus arctos horribilis
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
uah04151  PI3K-Akt signaling pathway
uah04151

Other DBs
GO: 0043491
Organism
Ursus arctos horribilis [GN:uah]
Gene
113255562  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
113268295  TGFA; protransforming growth factor alpha [KO:K08774]
113263086  EREG; proepiregulin [KO:K09784]
113263049  AREG; amphiregulin [KO:K09782]
113255360  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113255677  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
113242141  FGF16; fibroblast growth factor 16 [KO:K04358]
113270070  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
113269603  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
113243917  FGF4; fibroblast growth factor 4 [KO:K04358]
113243934  FGF3; fibroblast growth factor 3 [KO:K04358]
113257435  FGF6; fibroblast growth factor 6 [KO:K04358]
113260960  FGF10; fibroblast growth factor 10 [KO:K04358]
113264085  FGF18; fibroblast growth factor 18 [KO:K04358]
113263042  FGF5; fibroblast growth factor 5 [KO:K04358]
113262031  FGF20; fibroblast growth factor 20 [KO:K04358]
113242699  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
113251181  FGF9; fibroblast growth factor 9 [KO:K04358]
113251656  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
113243935  FGF19; fibroblast growth factor 19 [KO:K22603]
113243199  FGF21; fibroblast growth factor 21 [KO:K22429]
113258001  FGF23; fibroblast growth factor 23 [KO:K22428]
113244387  NGF; beta-nerve growth factor [KO:K02582]
113265088  BDNF; brain-derived neurotrophic factor [KO:K04355]
113257991  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
113243198  NTF4; neurotrophin-4 [KO:K12457]
113243960  insulin-like [KO:K04526]
113256079  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
113243959  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
113248512  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113248525  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113241764  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
113260127  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
113255787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
113244914  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
113256194  KITLG; kit ligand isoform X1 [KO:K05461]
113243298  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
113261040  VEGFA; vascular endothelial growth factor A [KO:K05448]
113244181  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
113270324  PGF; placenta growth factor isoform X1 [KO:K16859]
113262230  VEGFC; vascular endothelial growth factor C [KO:K05449]
113240706  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
113259246  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
113252830  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
113262190  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
113258433  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
113245152  EFNA3; ephrin-A3 [KO:K05462]
113255018  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
113245285  EFNA1; ephrin-A1 [KO:K05462]
113245292  EFNA4; ephrin-A4 [KO:K05462]
113242727  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
113257444  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113265512  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
113256440  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
113250501  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
113262086  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
113252011  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113245744  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
113264137  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113265602  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113245211  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
113269802  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113242935  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113263646  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113262493  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113263944  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113263940  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
113262502  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
113251210  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
113251212  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
113261544  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
113262503  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
113263211  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
113260555  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
113270459  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
113244637  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113266205  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113241630  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113257418  GTPase HRas-like [KO:K02833]
113257792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113244394  NRAS; GTPase NRas [KO:K07828]
113257190  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113240885  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113242822  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113267646  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
113247020  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113250390  IRS1; insulin receptor substrate 1 [KO:K16172]
113255769  TLR2; toll-like receptor 2 [KO:K10159]
113266343  TLR4; toll-like receptor 4 [KO:K10160]
113267943  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113267145  uncharacterized protein LOC113267145 [KO:K06856]
113270132  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
113267624  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
113251772  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
113265156  somatotropin [KO:K05438]
113264523  PRL; prolactin [KO:K05439]
113245027  OSM; oncostatin-M isoform X1 [KO:K05418]
113255635  IL2; interleukin-2 [KO:K05429]
113261704  interleukin-3-like [KO:K04736]
113261280  IL6; interleukin-6 [KO:K05405]
113261716  IL4; interleukin-4 [KO:K05430]
113253022  IL7; interleukin-7 [KO:K05431]
113260290  interferon alpha-1/2-like [KO:K05414]
113260291  interferon alpha-1/2-like [KO:K05414]
113260293  interferon alpha-1/2-like [KO:K05414]
113260294  interferon alpha-2-like [KO:K05414]
113260295  IFNB1; interferon beta [KO:K05415]
113267523  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
113265687  CSF3; granulocyte colony-stimulating factor [KO:K05423]
113260944  GHR; growth hormone receptor isoform X1 [KO:K05080]
113260881  PRLR; prolactin receptor isoform X1 [KO:K05081]
113260912  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
113241140  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
113249383  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
113249385  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
113245610  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
113240790  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
113245310  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
113267608  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
113260884  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
113264796  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
113243022  EPOR; erythropoietin receptor [KO:K05079]
113268281  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
113254577  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113270160  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
113256691  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
113265614  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
113260108  COL1A2; collagen alpha-2(I) chain [KO:K06236]
113257484  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
113251538  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
113251539  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
113250384  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
113250386  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
113241173  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
113241234  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
113263194  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
113250298  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
113260915  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
113253922  collagen alpha-4(VI) chain-like [KO:K06238]
113253923  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
113253925  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
113258151  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
113261138  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
113268232  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
113259434  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
113253229  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
113253294  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
113258790  LAMA5; laminin subunit alpha-5 [KO:K06240]
113264714  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
113258474  LAMB1; laminin subunit beta-1 [KO:K05636]
113256862  LAMB2; laminin subunit beta-2 [KO:K06243]
113262643  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
113258464  LAMB4; laminin subunit beta-4 [KO:K06245]
113262733  LAMC1; laminin subunit gamma-1 [KO:K05635]
113262734  LAMC2; laminin subunit gamma-2 [KO:K06246]
113266526  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
113265620  CHAD; chondroadherin [KO:K06248]
113258887  RELN; reelin [KO:K06249] [EC:3.4.21.-]
113242050  THBS1; thrombospondin-1 [KO:K16857]
113247125  THBS2; thrombospondin-2 [KO:K04659]
113255163  THBS4; thrombospondin-4 [KO:K04659]
113256730  COMP; cartilage oligomeric matrix protein [KO:K04659]
113245270  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
113250491  FN1; fibronectin isoform X1 [KO:K05717]
113263166  SPP1; osteopontin isoform X1 [KO:K06250]
113269030  VTN; vitronectin [KO:K06251]
113262587  TNN; tenascin-N [KO:K06252]
113243732  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
113262794  TNR; tenascin-R [KO:K06252]
113266339  TNC; tenascin isoform X1 [KO:K06252]
113257990  VWF; von Willebrand factor [KO:K03900]
113263032  IBSP; bone sialoprotein 2 [KO:K06253]
113263868  ITGA1; integrin alpha-1 [KO:K06480]
113263908  ITGA2; integrin alpha-2 [KO:K06481]
113265351  ITGA2B; integrin alpha-IIb [KO:K06476]
113265609  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
113250699  ITGA4; integrin alpha-4 [KO:K06483]
113257516  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
113250771  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
113256462  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
113241382  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
113253775  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
113247748  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
113240906  ITGA11; integrin alpha-11 [KO:K06587]
113250684  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
113244232  ITGB1; integrin beta-1 [KO:K05719]
113265309  ITGB3; integrin beta-3 [KO:K06493]
113244620  ITGB4; integrin beta-4 [KO:K06525]
113252506  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
113250846  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
113257564  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
113261164  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113248466  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113254799  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113270537  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113253989  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113256705  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113254730  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113255266  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113255187  proteinase-activated receptor 1 isoform X1 [KO:K03914]
113246917  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
113266585  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
113260324  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
113256760  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
113242104  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
113257973  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
113251326  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
113270618  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
113267850  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
113257958  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
113254767  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
113269635  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
113242381  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
113246953  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113258997  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
113254482  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
113242789  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113243396  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113260317  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
113260097  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
113254546  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
113247141  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
113245403  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
113260088  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
113265599  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
113258627  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
113271195  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
113271196  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
113245405  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
113242722  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
113260929  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.11]
113254619  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.11]
113259157  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
113266547  TSC1; hamartin isoform X1 [KO:K07206]
113245080  TSC2; tuberin isoform X1 [KO:K07207]
113241493  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
113245112  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
113270510  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113244532  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
113262099  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
113263893  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
113263123  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
113250342  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
113244028  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
113268897  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
113257571  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
113260592  RPS6; 40S ribosomal protein S6 [KO:K02991]
113265250  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113247145  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
113254445  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
113266480  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
113259468  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
113258622  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
113268043  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113257053  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
113265932  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
113258976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113246173  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
113262137  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113261737  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113260072  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
113247257  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
113269966  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
113252071  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113255341  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113266692  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
113240812  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
113266124  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
113253964  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113250050  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
113250051  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta-like [KO:K11583]
113262671  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
113246276  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
113244148  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
113261281  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
113246356  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
113267251  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
113261246  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
113267248  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
113256067  HSP90B1; endoplasmin [KO:K09487]
113242986  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
113245327  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
113253488  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
113252456  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
113267157  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
113267158  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
113248349  MTCP1; protein p13 MTCP-1 [KO:K16837]
113241474  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
113265384  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
113251972  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113257808  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
113243320  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
113258758  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
113246063  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
113265366  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
113265393  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
113249088  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
113252726  MYC; myc proto-oncogene protein [KO:K04377]
113243982  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113243864  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
113257870  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
113256451  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
113256363  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113259981  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113258003  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
113261302  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
113252919  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
113244704  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
113264764  FOXO3; forkhead box protein O3 [KO:K09408]
113252236  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
113262825  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113242278  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
113269739  YWHAQ; 14-3-3 protein theta [KO:K16197]
113252869  14-3-3 protein zeta/delta [KO:K16197]
113258642  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
113269111  YWHAE; 14-3-3 protein epsilon [KO:K06630]
113267814  YWHAG; 14-3-3 protein gamma [KO:K16198]
113245070  YWHAH; 14-3-3 protein eta [KO:K16198]
113244178  BAD; bcl2-associated agonist of cell death [KO:K02158]
113258461  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
113253490  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113270476  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
113250525  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
113250749  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113241758  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113264990  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
113264732  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
113245324  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
113260470  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
113242823  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
113262153  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
113243741  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
113246198  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
113266584  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
113257593  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
113247832  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113251823  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113245546  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113244102  RELA; transcription factor p65 [KO:K04735]
113263101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113259474  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
113256295  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
113271152  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
uah00010  Glycolysis / Gluconeogenesis
uah04010  MAPK signaling pathway
uah04012  ErbB signaling pathway
uah04062  Chemokine signaling pathway
uah04064  NF-kappa B signaling pathway
uah04068  FoxO signaling pathway
uah04110  Cell cycle
uah04115  p53 signaling pathway
uah04150  mTOR signaling pathway
uah04210  Apoptosis
uah04370  VEGF signaling pathway
uah04510  Focal adhesion
uah04620  Toll-like receptor signaling pathway
uah04630  JAK-STAT signaling pathway
uah04662  B cell receptor signaling pathway
uah04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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