KEGG   Ursus arctos horribilis: 113254577
Entry
113254577         CDS       T05909                                 

Gene name
JAK1
Definition
(RefSeq) tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
uah  Ursus arctos horribilis
Pathway
uah01521  EGFR tyrosine kinase inhibitor resistance
uah04151  PI3K-Akt signaling pathway
uah04217  Necroptosis
uah04380  Osteoclast differentiation
uah04550  Signaling pathways regulating pluripotency of stem cells
uah04621  NOD-like receptor signaling pathway
uah04630  Jak-STAT signaling pathway
uah04658  Th1 and Th2 cell differentiation
uah04659  Th17 cell differentiation
uah05140  Leishmaniasis
uah05145  Toxoplasmosis
uah05152  Tuberculosis
uah05160  Hepatitis C
uah05161  Hepatitis B
uah05162  Measles
uah05163  Human cytomegalovirus infection
uah05164  Influenza A
uah05165  Human papillomavirus infection
uah05166  Human T-cell leukemia virus 1 infection
uah05167  Kaposi sarcoma-associated herpesvirus infection
uah05168  Herpes simplex virus 1 infection
uah05169  Epstein-Barr virus infection
uah05200  Pathways in cancer
uah05203  Viral carcinogenesis
uah05212  Pancreatic cancer
uah05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    113254577 (JAK1)
   04151 PI3K-Akt signaling pathway
    113254577 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    113254577 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    113254577 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    113254577 (JAK1)
   04658 Th1 and Th2 cell differentiation
    113254577 (JAK1)
   04659 Th17 cell differentiation
    113254577 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    113254577 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113254577 (JAK1)
   05203 Viral carcinogenesis
    113254577 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113254577 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    113254577 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    113254577 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113254577 (JAK1)
   05162 Measles
    113254577 (JAK1)
   05164 Influenza A
    113254577 (JAK1)
   05161 Hepatitis B
    113254577 (JAK1)
   05160 Hepatitis C
    113254577 (JAK1)
   05168 Herpes simplex virus 1 infection
    113254577 (JAK1)
   05163 Human cytomegalovirus infection
    113254577 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113254577 (JAK1)
   05169 Epstein-Barr virus infection
    113254577 (JAK1)
   05165 Human papillomavirus infection
    113254577 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    113254577 (JAK1)
   05140 Leishmaniasis
    113254577 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113254577 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uah01001]
    113254577 (JAK1)
Enzymes [BR:uah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     113254577 (JAK1)
Protein kinases [BR:uah01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   113254577 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2 DUF4079
Other DBs
NCBI-GeneID: 113254577
NCBI-ProteinID: XP_026353695
UniProt: A0A3Q7VNC1
LinkDB
Position
Unknown
AA seq 1153 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL
CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKHKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT
LVDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagaccgaggtgaatctggaggcccccgagccaggggtggaagtgctcttc
tatctttcggacagggagcccctccggctgggcagcggggagtacacggcagaggagctc
tgcatcagggccgcgcaggaatgttgtatctctcctctgtgtcacaacctctttgctctg
tatgatgagaacaccaagctctggtatgccccgaatcgcaccatcactgttgatgacaag
acatcgctccggctccactaccggatgagattctatttcaccaactggcatgggaccaat
gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa
aaaaaagtcccagatgcaacccctctccttgacgccagctctctggagtatctgtttgct
cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag
gatgggcatgatatcgagaatgagtgtctgggaatggcagtcctggccatctcccactac
gctatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata
aataatgttttcaaagatttcttgaaggaatttaacaacaagactatttgtgacagcagt
gtatctactcatgacctgaaggtgaaatacctggccaccttggaaactttgacaaaacat
tatggcgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat
tggtttcatccaaatgacagtggaaatgttctctactatgaagtgatggtaactggaaat
cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaacacaaa
ctgaaacggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgg
gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct
gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcatcccatgaa
gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccat
cattacctctgcaccgatgtggctcccccgttgatcgtccacaacatacagaatggttgt
catggtccaatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggag
gggatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacc
tgctttgaaaaatctgaggtgctgggtggccagaaacagttcaagaactttcagatcgag
gtgcagaaaggccgctacagcctgcacggctcggaccgcagcttccccagcctgggggac
ctgatgagccacctcaagaagcagatcctgcgcacggacaacatcagtttcgtgctgaag
cgctgctgccagcccaagccccgagagatctccaatctgcttgtggctactaagaaagcc
caagagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa
gatattgtgcagggcgagcacctcgggagaggcacacggacacacatctactctggtacc
ctggtggattacaaggatgacgaaggaactgcggaagaaaagagaataaaagtgatcctc
aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg
atgaggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtg
gagaatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccgg
aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggccagtgcc
ctgagttacttggaggataaagacctggtccacggaaacgtgtgcacgaaaaatcttctc
ctggcccgtgagggcattgacagcgagtgcggcccgttcatcaagctcagtgaccctggc
atccccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcca
gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc
acactctgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag
aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct
gaccttatgacccgctgcatgaactatgaccccaaccagagacctttcttccgagccatc
atgagagacatcaataaactggaagagcagaatccagacattgtttctgaaaaaaagccg
gcaaccgaagtggatcccacgcattttgaaaagcggttcttgaagaggatccgtgacttg
ggagagggccacttcgggaaggtcgagctctgcaggtatgaccctgagggggacaatact
ggggagcaggtggcagtcaaatccctgaagcccgagagtggaggtaaccacatagctgat
ctgaagaaggaaattgaaatcctaaggaacctctatcatgagaacattgtgaagtacaaa
ggcatctgtaccgaagatggaggaaatggtattaagctcatcatggaatttctgccttca
ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta
aaatatgccgttcagatttgtaaggggatggactatttgggttctcgtcagtatgttcac
cgggacttggcagcaagaaacgtcctcgttgagagtgagcaccaagtgaaaattggagac
tttggtttgaccaaagccattgaaactgacaaggagtattacacagtcaaggatgatcgg
gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttatatcgcc
tctgacgtctggtcgtttggagtgactctgcacgagctgcttacttactgtgactccgat
tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc
acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca
gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatccaatcggacaact
tttcagaaccttattgaaggatttgaagcacttttaaaataa

KEGG   Ursus arctos horribilis: 113256691
Entry
113256691         CDS       T05909                                 

Gene name
JAK3
Definition
(RefSeq) tyrosine-protein kinase JAK3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
uah  Ursus arctos horribilis
Pathway
uah04062  Chemokine signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04217  Necroptosis
uah04550  Signaling pathways regulating pluripotency of stem cells
uah04630  Jak-STAT signaling pathway
uah04658  Th1 and Th2 cell differentiation
uah04659  Th17 cell differentiation
uah05161  Hepatitis B
uah05162  Measles
uah05166  Human T-cell leukemia virus 1 infection
uah05169  Epstein-Barr virus infection
uah05200  Pathways in cancer
uah05203  Viral carcinogenesis
uah05223  Non-small cell lung cancer
uah05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    113256691 (JAK3)
   04151 PI3K-Akt signaling pathway
    113256691 (JAK3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    113256691 (JAK3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    113256691 (JAK3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    113256691 (JAK3)
   04659 Th17 cell differentiation
    113256691 (JAK3)
   04062 Chemokine signaling pathway
    113256691 (JAK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113256691 (JAK3)
   05203 Viral carcinogenesis
    113256691 (JAK3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    113256691 (JAK3)
  09163 Immune disease
   05340 Primary immunodeficiency
    113256691 (JAK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    113256691 (JAK3)
   05162 Measles
    113256691 (JAK3)
   05161 Hepatitis B
    113256691 (JAK3)
   05169 Epstein-Barr virus infection
    113256691 (JAK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uah01001]
    113256691 (JAK3)
Enzymes [BR:uah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     113256691 (JAK3)
Protein kinases [BR:uah01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   113256691 (JAK3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo Kinase-like APH SH2
Other DBs
NCBI-GeneID: 113256691
NCBI-ProteinID: XP_026356281
UniProt: A0A3Q7V4V1
LinkDB
Position
Unknown
AA seq 1104 aa
MAPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPGPPQRLSFSFGDHSAEELCVWAAKA
SGILPVYHSLFALATEDLSCWFPPSHIFSVEDSGTQVLVYRLRFYFPNWFGLEKCHRFGL
RKDLASAILDLPVLEHLFAQHRNDLVSGRLPVGLSLKEQGECLSLAVLDLARMACEQAQQ
PEELLKTVSYKVCLPPDLRDLIQGLSFVTRKRIRRTVRRALRRVTACQADRHSLMAKYIM
DLERLDPARAVETFLVSLPGAADGQDAQGLLRVAGDSGIAWCPGGQEALQPFCDFPEIVD
ISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTSDSRHFFC
KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDCFLLTVCVQTP
LGPDYKGCLIRCDPTGTFSLAGLGRPHSSLRELLAACWDGGLHVDGVALNLTVCCTPKPK
EKSNLIVVRRGCNPPTSSPVQPQSQCQLSQMTFHKIPPESLEWHENLGHGSFTKIYRGCR
HEVVEGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ
EFVHLGALDTYLLKSGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGA
DGNLPFIKLSDPGVSPTVLNREMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS
GIPMPISTLDPAKKLQFYEEQQQLPAPKWMELATLIQQCMAYESGQRPSFRAIIRDLNSL
ITSDYELLSDPTPGALAPRDGLWNGAQLYAYQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFEREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDASRLLLYASQICKGMEYLGSCRCVHRDLAARNILVESE
THVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYGNKSCSPSAEFLRMMECDRDVPALCRLLELLAEGQRLPAPPACPGEVHELMKLCWAP
SSQDRPTFSALGPQLDALWSASRG
NT seq 3315 nt   +upstreamnt  +downstreamnt
atggcacctccaagcgaggagacacccctgatccctcagcgttcctgcagcctctcgtct
tcagaggctggtgccctgcatgtgctgctgccccctcggggccctggacccccacagcgc
ctatccttctcctttggggaccattcagctgaagagctgtgtgtttgggctgctaaggcc
agtggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc
tggttccccccgagccacatcttctccgtggaggactcaggcacccaagtcctggtctac
aggctccgcttttacttccccaactggtttgggctagagaagtgccaccgctttgggcta
cgaaaggacttggccagcgccatccttgacctgcccgtcctggagcacctcttcgcccag
caccgaaatgacctggtgagcggccgcctccccgtgggcctcagtctcaaggagcagggt
gaatgtctcagcctggcggtgctggacctggcccggatggcctgcgagcaggctcagcag
cctgaggagctgctaaagactgtcagctacaaggtctgcctcccccccgacctgcgcgac
ctgatccaaggcctgagcttcgtgacgcggaagcgcatccggaggaccgtgcgtcgggcc
ctgcgccgcgtgaccgcctgccaggctgacaggcactcgctcatggccaagtacattatg
gacctggagaggctcgacccggccagggcggtcgagaccttcctcgtgagcctccctggg
gctgctgatggtcaagatgcgcaggggctgctccgagtggctggtgacagcggcatcgca
tggtgtccaggaggacaagaggccctccagcccttctgcgactttccagaaattgtggac
atcagcatcaagcaggctccgcgtgttggcccggccggggagcaccgcctggtcaccgtc
accaggacagacaaccagatcctggaggccgagttcccggggctgccggccgcgttgtcc
ttcgtggcgctcgtcgacggctacttccggctgacctccgactccaggcacttcttctgc
aaggaggttgctccgccgcggctgctggaggaggtggcagagcagtgccacggccccatc
accctggattttgccatcaacaagctcaagactgggggttcacgtccgggctcctacgtt
ctccgccgcagtccccaggattttgactgcttcctcctcactgtctgtgtccagaccccc
ctgggtcctgattacaagggctgcctcatccggtgtgaccccacggggaccttctccctg
gctggcctaggccgtccccacagcagtcttcgagagctcttggcagcctgctgggacggc
gggctgcacgtggatggggttgcgctgaacctcacagtctgctgcacccccaaacccaaa
gaaaagtccaacctgattgtggtgcggaggggttgcaacccccccacgtcgtcccctgtt
cagccccaatcccaatgccagctgagtcagatgacgtttcacaagatccctcctgagagc
ctggagtggcatgagaacttgggtcacgggtccttcaccaagatttaccggggttgtcgc
catgaggtcgtggagggcgaggcccgggagacggaggtgctgctcaaagtgatggatgcc
aagcataaaaactgcatggagtcatttctggaagcagcgagtttgatgagccaagtgtca
taccagcatcttgtgttgctccatggcgtgtgcatggctggagacagtatcatggtgcag
gagtttgtacacctgggagctctggacacgtacctgctcaagtctggccacctggtgcca
gccagctggaagctgcaggtgatcaagcagctggcctacgccctcaactacctggaagac
aaaggcctcccccatggcaatgtctcagcccggaaggtgctcctggctcgcgaaggggct
gatgggaacctgcccttcatcaagctgagtgaccctggtgtcagccccactgtgctaaac
cgggagatgctcactgacaggatcccctgggtggcccctgagtgtctccaggaggcccgg
acacttggcttggaagccgacaagtggggttttggtgccacagtctgggaggtgttcagc
gggatcccgatgcccatcagcaccctggatcctgccaagaagctccagttttatgaggaa
cagcagcagctgcctgcccccaagtggatggagctggccacactgatccaacagtgcatg
gcctatgagtcaggccagaggccctccttccgcgccatcatccgtgacctgaacagcctc
atcacttcagattatgagctcctctcagaccccacgcccggtgccttggcgccccgtgac
gggctatggaatggcgcccagctctacgcctaccaggaccctaccatttttgaggagaga
cacctcaagtacatctcacagctgggcaagggtaacttcggcagcgtggaactgtgccgc
tatgacccgctgggtgacaacacgggcgccctagtggcagtgaagcagctgcagcacagc
gggccagaccagcagagggactttgagagggagatccagatcctcaaagcccttcacagc
gacttcatcgtcaagtaccgcggtgtcagctatggcccaggccgtcagagcttgcggctg
gtgatggagtacctgcccagcggctgcctgcgcgacttcctgcagcggcaccgcgcgcgc
ctcgacgccagccgcctgctcctctacgcctcgcagatctgcaagggcatggagtacctg
ggctcctgccgctgcgtgcaccgcgacctggcagcgcgtaacatcctggtggagagcgag
acgcacgtcaagatcgccgactttggcctcgccaagctgctgccactcgacaaagactac
tacgtggtccgcgagcccggccagagccccatcttctggtatgccccagagtccctctct
gacaacatcttctcgcgccagtcggatgtctggagcttcggggtcgtcctgtacgagctt
ttcacctacggcaacaagagttgcagcccctcagccgagttcctgcggatgatggaatgt
gatcgagatgtccccgccctctgccgcctcctggagctgctggctgagggccagaggctg
cccgcgcctcctgcctgccctggtgaggttcatgagctcatgaagctatgctgggcccct
agctcgcaagaccggccaacattcagtgccctgggcccccagctggatgcgctatggagt
gccagccgggggtag

KEGG   Ursus arctos horribilis: 113270160
Entry
113270160         CDS       T05909                                 

Gene name
JAK2
Definition
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
uah  Ursus arctos horribilis
Pathway
uah01521  EGFR tyrosine kinase inhibitor resistance
uah04062  Chemokine signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04217  Necroptosis
uah04550  Signaling pathways regulating pluripotency of stem cells
uah04630  Jak-STAT signaling pathway
uah04658  Th1 and Th2 cell differentiation
uah04659  Th17 cell differentiation
uah04725  Cholinergic synapse
uah04917  Prolactin signaling pathway
uah04920  Adipocytokine signaling pathway
uah04933  AGE-RAGE signaling pathway in diabetic complications
uah04935  Growth hormone synthesis, secretion and action
uah05140  Leishmaniasis
uah05145  Toxoplasmosis
uah05152  Tuberculosis
uah05161  Hepatitis B
uah05164  Influenza A
uah05167  Kaposi sarcoma-associated herpesvirus infection
uah05168  Herpes simplex virus 1 infection
uah05200  Pathways in cancer
uah05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    113270160 (JAK2)
   04151 PI3K-Akt signaling pathway
    113270160 (JAK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    113270160 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    113270160 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    113270160 (JAK2)
   04659 Th17 cell differentiation
    113270160 (JAK2)
   04062 Chemokine signaling pathway
    113270160 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    113270160 (JAK2)
   04917 Prolactin signaling pathway
    113270160 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    113270160 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    113270160 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    113270160 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113270160 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    113270160 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    113270160 (JAK2)
  09172 Infectious disease: viral
   05164 Influenza A
    113270160 (JAK2)
   05161 Hepatitis B
    113270160 (JAK2)
   05168 Herpes simplex virus 1 infection
    113270160 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    113270160 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    113270160 (JAK2)
   05140 Leishmaniasis
    113270160 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    113270160 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uah01001]
    113270160 (JAK2)
Enzymes [BR:uah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     113270160 (JAK2)
Protein kinases [BR:uah01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   113270160 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like APH
Other DBs
NCBI-GeneID: 113270160
NCBI-ProteinID: XP_026375026
UniProt: A0A3Q7WQ56
LinkDB
Position
Unknown
AA seq 1132 aa
MGMACLTMTEMEGTSVSPVHQNGDIPGNANPVKDIEPLLQVYLYHSLEKAEGEYLKFPTG
EYVAEDICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PYWYCNGSNRTYRHGISRGAEAPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggaaggaacatccgtatctcctgtacat
cagaatggtgatattcctggaaacgctaatcccgtgaaggacatagaaccgctcctacag
gtgtatctttatcattctcttgagaaagctgaaggagagtatctgaagtttccaactggg
gagtatgttgcggaagatatttgtgttgctgcttctaaagcttgtggaatcacacctgtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccgcccaaccat
gtcttccatatagatgagtcaaccagacacaatgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgacgactttgtcatggcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaatacctgtgacccatgaaacacaggaagaatgtcttgga
atggctgtgttagatatgatgagactagccaaagagaaggatcaaaccccactggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaaacgaataaggtacaggtttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatattattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaacctggaaattgaacttagctcattaaga
gaagctttgtcctttgtgtcattaattgatggctattatagattaactgcagacgcacat
cattacctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgt
catggcccaattttaatggatttcgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgct
gtcgagcgagaaaatgtcattgaatataagcactgtttgattacgaaaaatgagaatgga
gaatacaacctcagtggaaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccaaatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagttgaaagataaatcaaaccttctggtcttcagaaccaatggtgtttctgatgtt
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatgtttaatgaaagccttggtcaaggcacttttacaaaaattttt
aaaggtataagaagagaagtaggagactatggtcaactccatgaaacagaagttctttta
aaagttctggataaagcacacagaaactactcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggggag
gagaatattctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcacttattcatggaaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaagctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctagggttttccggtgcttttgaagaccgagac
cctacacagtttgaagagagacacttgaaatttctacagcaacttggcaagggtaatttt
ggcagtgtggagatgtgccggtatgaccctctgcaagacaacactggggaggtggtggct
gtgaagaagctccagcacagtactgaagagcacctgagagactttgaaagggaaattgaa
atcctcaaatcgctgcagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagata
tgcaagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaagg
aatatattggtggaaaacgaaaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatattacaaagtaaaagaacctggtgaaagtcccatattctgg
tatgctccggaatcactgacggagagcaagttttctgtggcttcagatgtctggagcttt
ggagtggttctgtatgaacttttcacgtatattgagaagagtaaaagtcccccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa
ctcctaaagaataatggaagattaccaagaccagatggatgcccagatgagatttatttg
atcatgacagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagct
cttcgagttgatcaaataagggacaacatggctggatga

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