Ursus arctos horribilis (North American brown bear): 113257729
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Entry
113257729 CDS
T05909
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
uah
Ursus arctos horribilis (North American brown bear)
Pathway
uah05012
Parkinson disease
uah05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
uah00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
113257729 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
113257729 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
uah01001
]
113257729 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
uah04131
]
113257729 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
uah04147
]
113257729 (LRRK2)
Enzymes [BR:
uah01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
113257729 (LRRK2)
Protein kinases [BR:
uah01001
]
Serine/threonine kinases: TKL group
LRRK family
113257729 (LRRK2)
Membrane trafficking [BR:
uah04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
113257729 (LRRK2)
Exosome [BR:
uah04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
113257729 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_9
Arf
AAA_22
T2SSE
Ank_2
PduV-EutP
ABC_tran
nSTAND3
MMR_HSR1
SRPRB
G-alpha
GTP_EFTU
AAA_7
LRR_6
TniB
Kdo
TsaE
cobW
AAA_16
MobB
Septin
AAA_23
AAA_29
NACHT
TrwB_AAD_bind
Arm
SRP54
Motif
Other DBs
NCBI-GeneID:
113257729
NCBI-ProteinID:
XP_026357878
LinkDB
All DBs
Position
Unknown
AA seq
2534 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEVLGVHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEIQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLQVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAGLSCLALLTETIFLNQDLEEKNENPENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQRHIHSPEVADSGCKMLNHLFEGSSVTLDTM
AAVAPKIITVMKSHEASLSVQLEGLRAVLHFIVPGMPEDSREDTEYQHKLHMVKKQCFKN
DIHKLALAALNRFIGNPGIQKCGLKVISSIARSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLTGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTILGLSV
SFSKLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVLLERACDQN
NSIMVECLLLLGADANGTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIDPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQVKSAVEEGAASGSNGNFPEGVLDKFDEWTFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQHCSPNLQRHSCSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDISPSVVLDSAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKIPEICSPLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAMPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLREILFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGRKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACITKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPVEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKLFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVSRGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDNLNSAELICLMRHITIPKNFSVECMVSTNH
NNKNASIWLGCGHRDKGQLLFLDLNTEKHTSEEVIDSRILCLALVPLPVEKESWIVCGTQ
SGMLLVINTEDGEKRHTLEKMTDSVTCLYCNPFPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAVPLKILNIGNVSTPLMCLSESMNSAEKNIMWGGCGTKLFSFSDDFTIQKRIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEEMVKV
TAESKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLEDSYFFKGSLKNVMLVLGYIRKSTESTQHQKEIQSCLSVWDLNLPHEVQNLEKHIEV
RKELAEKMRRISVE
NT seq
7605 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtacagcag
gtgggttggtcacttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaagatattggacgtgattgggaagtacttggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagtcggactgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatattggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaaatccagaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctcaatgcgttaaaaaattttaaagatgaagag
gaaattgtgcttcaggtcctgcactgtttacactccctagcaattccttgcaataatgtt
gaagtcctcatgagtggcaatgtcaggtgttacaatattgtggtagaagccatgaaagca
ttccctgtcaatgaaaaaattcaagaagtaagttgctgcttgctccataggcttacatta
ggtaatttttttaatattctggtattaaatgaggtgcacgagtttgtggtgaaagctgtg
cggcgatactcagagaacgccacgttacagatcgcggggctcagctgcttagcgcttctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatccggagaatgat
gatgaggaagaagataagttgttctggttggaagcttgttacaaagcattaacgtggcat
aggaagaacaagcacgtgcaggaagctgcatgctgggcccttaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctttccatgctgatgcattcctcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcgactctgttagaacaaaacgttaatttcagaaaaatcctgttgtcaaaagga
atatacctgaatgtattggagttaatgcagaggcatatacattctcctgaagttgctgac
agtggctgtaaaatgctaaatcatctctttgaaggaagcagtgtgactctggatacaatg
gcagcagtggcccccaaaataataacagttatgaaaagtcatgaggcatccttatcagtg
cagctggagggactaagagctgttttacatttcatagttccaggcatgccagaagactcc
agggaagatactgaatatcaacataagctacatatggttaagaaacagtgtttcaagaat
gacattcataaactggccctagcagccttgaacaggttcattggaaatcctgggattcag
aaatgtgggttgaaagtaatttcttctatagcgcgttctcctgatgcgttagaagtatta
tccttggaaggtgctattgattcagtgcttcacacactgcagatgtatccggatgaccaa
gaaattcaatgtctggggttaagtcttacaggatgcttgattacaaagaagaatttatgc
ataggcactggacatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggccgaagtgcagattaaaggatttcagacaatcttgacaatactggggttgtcagtg
tctttttccaagctgctggtgcaccattcctttgattccgtgatattccatcagatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggatgatgagttaaaaagtgtgcttctagagagagcatgcgatcagaat
aacagtatcatggttgaatgcttgcttctcttgggagcggacgccaatggaacaaaggag
gcaacgtctttaatttgtcaggtatgtgagaaagcgagtagtcccaaattggtggaactg
ttactgaatggtggttcccgtgaacaagatgtccggaaagcgctgacaataagcattggc
aaaggtgacagccagatcatcagcttacttttaaggaggcttgccctggatctggccaat
aatagcatttgccttggaggattctgtataggaaaaattgacccttcctggcttggtcct
ttatttccggataagacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcagatatcaggtgaaaagtgctgtggaagaaggagcagcttcaggcagc
aatgggaattttcctgaaggagtacttgataaatttgatgaatggaccttcattccagac
tcctatgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtaggagaattttaccgagatcgt
gccttgcagcattgttcaccaaatttgcaaaggcattcctgttcattgggacctattttt
gatcatgaagatttactgaggcgaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatattacatcattagacctttcagcaaatgaactaagagacattgatgcccta
agccagaaatgctgtatcagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacaactgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaattgtatt
gccaacctcgatgtctctcgaaacgacatcagcccttcagtagttttggactctgcagtg
aagtgcccaaccttgaaacagtttaacttgtcatacaatcagctgtcttcttttcctgag
aaccttggcgatgtggtagagaaattggaacagctcattttagaaggaaataaaatacca
gaaatatgttcccccttaagcctgaaggaactgaagattttaaaccttagtaaaaatcac
attacatccctgtcagaagacttccttgaggcatgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctatgccttttttgccttcttcgctgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgatcc
ttagatatgagcagcaatgaaattgaatatttgccgagtcctgcacactggaaatctttg
aacttaagggaaatcttgttcagttttaatcaaatcagcatcttggacttaagtgaaaaa
gcgtatgtatggtcaagagtagagaaattacatctttctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaacctgacctcccttgatgtcagttacaatttggaa
ctgagatcctttcctaatgaaatggggaagttaagcaaaatatgggatcttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggctgtgccctacaaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaacgaaaaccaagaaatcc
gatcttggggtgcaaagcgccacagttggcatagatgtgaaagactggccaatccaaata
agaggcaaagggaggaaagacctcattctaaacgtgtgggattttgcaggtcgtgaggag
ttctatagcactcatccgcacttcatgacccaacgagccctctaccttgccgtctatgac
ctcagcaaagggcaggctgaagtggacgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcttctcctgtgattcttgttggcacgcatttggatgtttctgatgaaaag
cagcgtaaagcctgcataactaaaatcaccaaggaactcttgaacaagcgggggtttcct
gcaataagggattaccacttcgtgaatgccactgaggagtccgatgccttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgttgttggg
cagctgatcccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccagttgaatttcctgtgatcgaccggaaacgattattacaacttgtaaaagaaaat
cagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctcaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctacccaaaa
catcctaaggggatcatttcacgtagagatgtggaaaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccttg
ccaataggagaagaatatttgcttgttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcattcgactatatgaaatgccttatttt
ccaatgggattttggtcccggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctggattactggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtaaatccagatcaaccaaggctcaccatcccaatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagcttttcaataaacatacatcacttagactgttaagacaggag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaaggaagtctcaccaggaccctgcagcacaggattgcgctacatgtggctgat
ggcttgagatacctccactcggccatgattatataccgtgacttgaagccccacaacgtg
ctgctcttcaccctgtatcccaatgcagccatcatcgcgaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaagacgtcagagggcacaccagggtttcgcgca
cctgaggtttctagaggaaatgttatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggagggagaatagcggagggtttgaagtttcca
aatgagtttgatgagctggcaatacaaggaaaattacctgatccggttaaagaatatggc
tgtgccccatggcccatggttgagaagttaattaaaaagtgtttgaaggaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacaatttgaattcagctgagttaatctgtctg
atgagacatataacaatacctaaaaactttagtgttgagtgcatggtctctacaaatcat
aacaacaagaatgcaagcatctggctgggctgtgggcaccgtgacaaaggacagctctta
tttcttgacttaaatacagaaaaacacacttctgaggaagttattgatagtagaatactg
tgcctggctttggtgcctcttcctgtggaaaaggaaagctggatcgtgtgtgggacacag
tctggcatgctcctggtcatcaataccgaagatggggaaaagagacatactcttgaaaag
atgactgattccgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaaa
aattttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagctgttcctttgaagatactaaatataggaaacgtcagtactccactg
atgtgtttgagtgaatccatgaattcagctgaaaaaaacattatgtggggaggatgtggt
acaaaacttttctcattttctgatgatttcaccattcagaagcgcattgagacaaagaca
aatcagctgttttcttatgcagctttcagtgactccaacatcatagcagtggtggtagac
acggctctctacgttgctaagaaaaatagtccatttgtggaagtatgggataagaaaact
gaaaaactctgtgaactaatagactgcgtgcactttttaaaggaggaaatggtaaaagta
actgcagaatcaaaacacaaactgtcttattctgggagggtaaaaaccctgtgcctccag
aagaacaccgctctctggataggaactggaggaggccatattttactccttgatctttca
actcgtcgaattatacgtataattcacaatttttgtgattctgtcagagtcatgatgaca
gcacaattagaagactcatatttttttaaaggaagccttaaaaatgttatgctggttttg
gggtatatccggaaaagtactgaaagtacacaacaccaaaaagagatacaatcttgttta
tctgtttgggacctcaatcttccacatgaagtgcaaaatttagaaaaacatattgaagtg
agaaaagaattagctgagaaaatgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
