KEGG   Ursus arctos horribilis: 113266343
Entry
113266343         CDS       T05909                                 

Gene name
TLR4
Definition
(RefSeq) toll-like receptor 4
  KO
K10160  toll-like receptor 4
Organism
uah  Ursus arctos horribilis
Pathway
uah04064  NF-kappa B signaling pathway
uah04066  HIF-1 signaling pathway
uah04145  Phagosome
uah04151  PI3K-Akt signaling pathway
uah04217  Necroptosis
uah04620  Toll-like receptor signaling pathway
uah04621  NOD-like receptor signaling pathway
uah05132  Salmonella infection
uah05133  Pertussis
uah05134  Legionellosis
uah05135  Yersinia infection
uah05140  Leishmaniasis
uah05142  Chagas disease (American trypanosomiasis)
uah05144  Malaria
uah05145  Toxoplasmosis
uah05146  Amoebiasis
uah05152  Tuberculosis
uah05161  Hepatitis B
uah05162  Measles
uah05164  Influenza A
uah05170  Human immunodeficiency virus 1 infection
uah05205  Proteoglycans in cancer
uah05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
uah05321  Inflammatory bowel disease (IBD)
uah05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    113266343 (TLR4)
   04066 HIF-1 signaling pathway
    113266343 (TLR4)
   04151 PI3K-Akt signaling pathway
    113266343 (TLR4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    113266343 (TLR4)
  09143 Cell growth and death
   04217 Necroptosis
    113266343 (TLR4)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    113266343 (TLR4)
   04621 NOD-like receptor signaling pathway
    113266343 (TLR4)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    113266343 (TLR4)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    113266343 (TLR4)
  09163 Immune disease
   05323 Rheumatoid arthritis
    113266343 (TLR4)
   05321 Inflammatory bowel disease (IBD)
    113266343 (TLR4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    113266343 (TLR4)
   05135 Yersinia infection
    113266343 (TLR4)
   05133 Pertussis
    113266343 (TLR4)
   05134 Legionellosis
    113266343 (TLR4)
   05152 Tuberculosis
    113266343 (TLR4)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    113266343 (TLR4)
   05162 Measles
    113266343 (TLR4)
   05164 Influenza A
    113266343 (TLR4)
   05161 Hepatitis B
    113266343 (TLR4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    113266343 (TLR4)
   05144 Malaria
    113266343 (TLR4)
   05145 Toxoplasmosis
    113266343 (TLR4)
   05140 Leishmaniasis
    113266343 (TLR4)
   05142 Chagas disease (American trypanosomiasis)
    113266343 (TLR4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uah04131]
    113266343 (TLR4)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:uah04054]
    113266343 (TLR4)
   04090 CD molecules [BR:uah04090]
    113266343 (TLR4)
   00536 Glycosaminoglycan binding proteins [BR:uah00536]
    113266343 (TLR4)
Membrane trafficking [BR:uah04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    113266343 (TLR4)
Pattern recognition receptors [BR:uah04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   113266343 (TLR4)
CD molecules [BR:uah04090]
 Proteins
  113266343 (TLR4)
Glycosaminoglycan binding proteins [BR:uah00536]
 Hyaluronan
  Cell surface receptors
   113266343 (TLR4)
SSDB
Motif
Pfam: LRR_8 TIR LRR_4 TIR_2 LRR_1 LRR_5 LRR_9 LRR_6 DUF1863
Other DBs
NCBI-GeneID: 113266343
NCBI-ProteinID: XP_026369642
UniProt: A0A3Q7Y0J4
LinkDB
Position
Unknown
AA seq 833 aa
MMSPTRLAGMLIPAMAFLSFLRPESWEPCVQVVPNITYKCMELNLDKIPNNIPTSTKELD
LSFNPLRHLDSHSFSNFPELQVLDLSRCEIRIIEDDAYQGLNHLSILILTGNPIQELFPG
AFSGLSNLQTLVVVETNVQSLEDFPIGHLKTLKELNVAHNLIHSFKLPEYFSNMPNLEYL
DLSNNKIQNIYHKDLQVLRQMPLLNLSLDLSLNPLYFIQPGAFKEIKLHELTLRSNFNST
HVMKTCIQGLAGLKIHQLVLGEFKNERKLESFDKSLLEGLCDLTIEKFRIAYFDEFSKDT
TDLFNCLGNVSTISLVHLFLNRPRYLPKNLRWQRLEMVNCGFEEFPTWGLDSLKEFVFTA
NKGVNTFTEMNPNSLEFLDLSRNGLSFKGCCSHSELGTTRLKHLDLSFNDIITMSSNFLG
LEQLEYLDFQHSNLKQASDFSVFLSLRNLRYLDISYTHTQVVFHGIFDGLVRLQVLKMAG
NSFQDNFLPNIFKDLTNLTILDLSKCQLERVSQVAFGSLPKLQLINMSHNNLLSLDTLPY
EPLLSLQILDYSFNRIVASKERERQHFPSNLVSLNLTQNDFACVCEHQNFLQWVKDHRQL
LVEVEEMVCAKPLDMQGMPVLSFRNATCQRSKTIITVSVFTVLMVSLVAVLVYKFYFHLM
LLAGCKKYSKGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA
ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL
RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKQWSPEGTADAENS
NT seq 2502 nt   +upstreamnt  +downstreamnt
atgatgtctcctacccgcctggctgggatgctgatcccagccatggccttcctctccttc
ctgagacccgagagctgggagccttgtgtgcaggtggttcctaacattacttacaaatgc
atggaactgaatctcgacaaaattcccaacaacatccccacgtcaaccaaggaactggac
ctgagctttaaccccctgaggcatttagacagccatagcttctccaacttcccagaactt
caggtgttggatttatccaggtgtgaaattcggataattgaagatgatgcgtatcagggc
ctaaaccacctctccatcttgatattgacaggaaaccctatccaggagttattcccagga
gccttttctggactctcaaatttacagacgctggtggtcgtggagacaaatgtacaatct
ctagaggacttccccattggacatctcaaaaccttgaaggagcttaatgtagctcacaat
cttatccattccttcaagttacctgaatatttttctaacatgcccaacctggagtacttg
gatctttccaataacaagatccaaaatatttatcataaagacttgcaggttctacgtcaa
atgcctctactcaacctttctttagacttgtccctgaaccctttatactttatccaacca
ggtgcctttaaagaaattaaactccatgaactgactttgagaagtaattttaatagtaca
catgtaatgaaaacttgtattcaaggtctggctggtttaaagatccatcagttggttctg
ggagaatttaaaaatgaaaggaagttggaaagctttgataaatctctcctggagggactg
tgtgatttgaccattgaaaaattccggatagcatactttgatgagttctcaaaggatact
actgacttatttaattgtttgggaaatgtttctacaatttctctggtgcatctgttttta
aacaggccaagataccttcctaaaaatctcagatggcaacggttggaaatggttaactgt
ggatttgaagaatttcccacgtgggggctggactctctcaaggagtttgttttcactgcc
aacaaaggcgtgaacacttttactgagatgaacccgaacagccttgagtttctagatctc
agtagaaatggcctgagttttaagggttgctgttctcactctgaattggggacaaccaga
ctgaagcatttagatctgagcttcaatgatattattaccatgagttcaaacttcttgggc
ttagaacaactagaatatctagatttccagcattccaatttgaaacaggctagtgatttt
tcagtattcctatccctcagaaacctccgttaccttgatatttcttatactcacacccaa
gttgtcttccacggcatttttgatggcttggtcagactccaagtcttgaaaatggctggt
aattcttttcaggacaacttccttccaaatattttcaaagacctgactaacttgaccatt
ctagatctctctaagtgtcagctggaacgggtgtcccaggtagcatttggttcacttccg
aaacttcagttgataaatatgagtcacaacaatctcctgtcattggatacactcccttat
gaacctctcctctccctccaaattctggattacagttttaatcgaatagtggcctccaaa
gagcgagaacgacagcattttccaagtaatctagtttccttaaatcttactcagaatgac
tttgcttgtgtttgtgaacaccagaacttcctgcagtgggtcaaggaccacaggcagctc
ttggtggaagttgaagaaatggtgtgtgcaaaacctttagacatgcagggcatgcccgtg
ctgagttttaggaatgccacctgtcagaggagtaagactatcattactgtgtcggtgttc
actgtactcatggtttctctggtagcagttttggtgtataagttctatttccacctgatg
cttcttgctggctgcaaaaagtacagcaaaggcgaaagcacttatgatgccttcgttatc
tactcaagtcaagatgaagactgggtaaggaatgaactggtaaagaacttggaagagggg
gtgcccccctttcagctctgccttcactatagagacttcattcctggtgtggccattgct
gccaacatcatccaggaaggtttccacaaaagccggaaggttattgttgtggtgtcccaa
cacttcatccagagtcggtggtgtatctttgagtatgagattgcccagacctggcagttt
cttagtagtcgtgccggcatcatcttcattgttctgcagaaggtggagaagtccctgctg
cggcagcaggtggagctgtatcggcttcttagcaggaacacttacctagagtgggaagac
agtgtcctggggcggcacatcttctggagacgactccgaaaagccttgctggatggtaaa
cagtggagtccagaaggaacagcagatgcagaaaacagctag

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