Ursus maritimus (polar bear): 103661704 Help Entry 103661704         CDS       T03271                                  Gene name ADCY8 Definition (RefSeq) adenylate cyclase 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103661704 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103661704 (ADCY8)    04371 Apelin signaling pathway     103661704 (ADCY8)    04020 Calcium signaling pathway     103661704 (ADCY8)    04072 Phospholipase D signaling pathway     103661704 (ADCY8)    04024 cAMP signaling pathway     103661704 (ADCY8)    04022 cGMP-PKG signaling pathway     103661704 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103661704 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     103661704 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103661704 (ADCY8)    04062 Chemokine signaling pathway     103661704 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     103661704 (ADCY8)    04923 Regulation of lipolysis in adipocytes     103661704 (ADCY8)    04912 GnRH signaling pathway     103661704 (ADCY8)    04913 Ovarian steroidogenesis     103661704 (ADCY8)    04915 Estrogen signaling pathway     103661704 (ADCY8)    04914 Progesterone-mediated oocyte maturation     103661704 (ADCY8)    04921 Oxytocin signaling pathway     103661704 (ADCY8)    04926 Relaxin signaling pathway     103661704 (ADCY8)    04935 Growth hormone synthesis, secretion and action     103661704 (ADCY8)    04918 Thyroid hormone synthesis     103661704 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     103661704 (ADCY8)    04916 Melanogenesis     103661704 (ADCY8)    04925 Aldosterone synthesis and secretion     103661704 (ADCY8)    04927 Cortisol synthesis and secretion     103661704 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103661704 (ADCY8)    04270 Vascular smooth muscle contraction     103661704 (ADCY8)   09154 Digestive system    04970 Salivary secretion     103661704 (ADCY8)    04971 Gastric acid secretion     103661704 (ADCY8)    04972 Pancreatic secretion     103661704 (ADCY8)    04976 Bile secretion     103661704 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     103661704 (ADCY8)    04727 GABAergic synapse     103661704 (ADCY8)    04725 Cholinergic synapse     103661704 (ADCY8)    04720 Long-term potentiation     103661704 (ADCY8)    04723 Retrograde endocannabinoid signaling     103661704 (ADCY8)   09157 Sensory system    04742 Taste transduction     103661704 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     103661704 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     103661704 (ADCY8)    04213 Longevity regulating pathway - multiple species     103661704 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     103661704 (ADCY8)    04714 Thermogenesis     103661704 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103661704 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     103661704 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103661704 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103661704 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103661704 (ADCY8)    05163 Human cytomegalovirus infection     103661704 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103661704 (ADCY8) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103661704 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N DUF1053 TBK1_ULD Motif Other DBs NCBI-GeneID:  103661704 NCBI-ProteinID:  XP_008687606 UniProt:  A0A384BYD8 LinkDB All DBs Position Un AA seq 1127 aa AA seqDB search DLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVM NVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYS GVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVV LQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLET ENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTN LSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEM GLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGI PGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKES VSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPE EINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLF ITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWINETYLAR NVIIFASILINFLGAILNILWCDFDKSIPLKNLAFNSSAVFTDICSYPEYFVFTGVLAMV TCAVFLRLNSVLKLAVLLIMTAIYALLTETIYAGLFLRYDNLNHSGETDFLGTKEASLLL MAVFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFL EKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE DRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNN FELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQG FAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLN RQRQKQLLNEDNNTGIIKAHYNRRTLLAPSGPEPGAPAEGTDKSDLP NT seq 3384 nt NT seq  +upstreamnt  +downstreamnt gatctgggcttcctgcacctcgactgcgccccgagcaactcggatttcttcctcaatggg ggctacagctaccgaggggtcattttccccactctgcgcaactccttcaagtcccgggat ctggagcgcctctaccagcgctatttcctgggccagaggcgcaaatccgaggtggtgatg aacgtgttggatgtgctgaccaaactcaccctcttggtcctgcacttgagcctggcctcg gcccccatggacccgctcaagggcatcctcctgggcttcttcactggcatcgaggtggtg atctgcgccctggtggtggtcaggaaggacaccacctcgcacacgtacctgcagtacagc ggcgtggtcacttgggtggccatgaccacccagatcttggcagcaggcctcggctacggg cttttgggtgatggcatcggctacgttctcttcacgctgttcgccacctacagcatgctg ccgctgccgctcacctgggccatcctggccggcttgggcacctcgctgctgcaggtggtc ctgcaggtggtcatcccccggctagcggtcatttccatcaaccaggtcgtggcccaggca gtattattcatgtgtatgaacacagctggaatcttcatcagttacctgtcagaccgggcc cagcgccaagccttcctggagacgcggaggtgtgtggaggccaggctccgcctggagacg gaaaaccaaagacaggagcgtctcgtgctatctgtgctcccccgctttgtcgtcctggaa atgatcaatgacatgaccaatgttgaagacgagcacttgcagcaccagttccatcggatc tacatccatcgctatgagaacgtcagtattctttttgcagatgttaaaggatttaccaac ctctccacaaccttgtccgcccaggagctggtccggatgctcaacgagctctttgccaga tttgatcgactggcccatgagcatcactgccttcgcattaaaatcctgggggactgttac tactgtgtttcagggcttcctgagccccgccaggaccacgcccactgctgtgttgaaatg ggcctcagcatgatcaaaaccatcaggtatgtgaggtcgaggacgaagcatgatgtggac atgcggatcggaatccactctggctcagtgctatgtggcgtgttgggcctgcggaagtgg cagtttgatgtctggtcttgggatgtggacattgcaaacaaactcgaatctggaggaatc cccgggaggattcacatttccaaagccacgctggactgcctcaacggcgactataacgtg gaagagggtcatggtaaagagagaaacgaattcttgaggaagcataatattgagacctac ttgattaagcagcctgaggaaagtctgctgtcgttgcccgaagacatcgtcaaggagtcg gtgagctcctcagacaggagaaacagtggggcaacattcacagaaggatcctggagcccc gaactgccctttgataacatagtggggaaacagaacactctggctgccctaacaagaaat tcaataaatctacttccaaaccatcttgcacaagctttgcatgtccagtctgggcctgag gaaattaacaagagaatagaacataccatcgacttgcggagtggcgataaattgagaaga gagcatatcaagccattctcactgatgtttaaagactccagcctggagcacaagtattct caaatgagggatgaagtattcaagtcaaacttggtctgtgcatttatcgttcttctattt atcacggcgatacaaagtttgcttccttcctcaagggtgatgccaatggccatccagttt tccatcctgattatgctgcactcggctctggtcctcatcaccacggcggaggattataag tgtttgcccctcgtcctccggaaaacttgctgttggattaacgagacctatttggcccgg aacgtcatcatctttgcatccatcttgattaacttcctgggcgccatcttgaatatcctg tggtgtgattttgacaagtcgatacccttgaagaacctggctttcaattcctcagctgtg tttacagatatctgctcctacccagagtacttcgtcttcaccggggtgctggccatggtg acctgtgcggttttcctccgcctgaactctgtcctgaagctggccgtgctgctgattatg accgccatctacgccctgctcaccgagaccatctacgcgggcctcttcctgcgctacgac aacctgaaccacagtggagagacagatttcctggggaccaaggaggcgtcactgctcctg atggccgtgttcctccttgccgtgttctaccatggacagcagctggagtatacagcccgc cttgacttcctttggcgagtacaggccaaagaggagatcaacgagatgaaggagctgagg gaacacaacgagaacatgctccggaacattctacccagccacgtggcccgccacttcctg gagaaagaccgagacaacgaggagctgtattctcaatcctacgatgccgtcggggtgatg tttgcctccatcccggggttcgcagacttctactctcagaccgaaatgaataaccaggga gtggaatgcctgcgcctgctgaatgagatcatcgctgacttcgatgagctgctcggcgaa gaccggtttcaagacattgaaaagattaagaccattggcagcacctacatggccgtgtca ggcctgtcacccgaaaaacagcaatgcgaagacaagtggggacatttgtgcgccctggcc gacttctccctcgccctgaccgagagcatacaggagatcaacaagcattccttcaacaat ttcgaactccggatcggcatcagccacggctcggtggtagctggcgttatcggcgctaag aaaccgcagtatgacatttggggcaaaaccgtgaacctggcaagtcgaatggacagcacg ggggtcagcggcaggatccaagtccccgaggagacctatctcatcctgaaggaccagggc tttgcctttgactaccgaggggagatctacgtgaagggcatcagtgaacaggaaggaaaa atcaaaacatactttctgctgggaagagtccaacccaacccattcatcctgcccccgaga agactgcccgggcagtactccctggccgcggtcgtcctgggccttgtccagtccctcaac aggcaaaggcagaagcagctgcttaacgaggacaacaacacggggatcatcaaggctcat tacaaccggcggactttgctggcacccagcgggccagagcccggagccccagccgaaggc accgacaagtccgatttgccatga

Ursus maritimus (polar bear): 103668547 Help Entry 103668547         CDS       T03271                                  Gene name ADCY9 Definition (RefSeq) adenylate cyclase 9   KO K08049   adenylate cyclase 9 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04962   Vasopressin-regulated water reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103668547 (ADCY9)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103668547 (ADCY9)    04371 Apelin signaling pathway     103668547 (ADCY9)    04020 Calcium signaling pathway     103668547 (ADCY9)    04072 Phospholipase D signaling pathway     103668547 (ADCY9)    04024 cAMP signaling pathway     103668547 (ADCY9)    04022 cGMP-PKG signaling pathway     103668547 (ADCY9)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103668547 (ADCY9)   09144 Cellular community - eukaryotes    04540 Gap junction     103668547 (ADCY9)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103668547 (ADCY9)    04062 Chemokine signaling pathway     103668547 (ADCY9)   09152 Endocrine system    04911 Insulin secretion     103668547 (ADCY9)    04923 Regulation of lipolysis in adipocytes     103668547 (ADCY9)    04912 GnRH signaling pathway     103668547 (ADCY9)    04913 Ovarian steroidogenesis     103668547 (ADCY9)    04915 Estrogen signaling pathway     103668547 (ADCY9)    04914 Progesterone-mediated oocyte maturation     103668547 (ADCY9)    04921 Oxytocin signaling pathway     103668547 (ADCY9)    04926 Relaxin signaling pathway     103668547 (ADCY9)    04935 Growth hormone synthesis, secretion and action     103668547 (ADCY9)    04918 Thyroid hormone synthesis     103668547 (ADCY9)    04928 Parathyroid hormone synthesis, secretion and action     103668547 (ADCY9)    04916 Melanogenesis     103668547 (ADCY9)    04925 Aldosterone synthesis and secretion     103668547 (ADCY9)    04927 Cortisol synthesis and secretion     103668547 (ADCY9)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103668547 (ADCY9)    04270 Vascular smooth muscle contraction     103668547 (ADCY9)   09154 Digestive system    04970 Salivary secretion     103668547 (ADCY9)    04971 Gastric acid secretion     103668547 (ADCY9)    04972 Pancreatic secretion     103668547 (ADCY9)    04976 Bile secretion     103668547 (ADCY9)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     103668547 (ADCY9)    04961 Endocrine and other factor-regulated calcium reabsorption     103668547 (ADCY9)   09156 Nervous system    04724 Glutamatergic synapse     103668547 (ADCY9)    04727 GABAergic synapse     103668547 (ADCY9)    04725 Cholinergic synapse     103668547 (ADCY9)    04723 Retrograde endocannabinoid signaling     103668547 (ADCY9)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103668547 (ADCY9)   09149 Aging    04211 Longevity regulating pathway     103668547 (ADCY9)    04213 Longevity regulating pathway - multiple species     103668547 (ADCY9)   09159 Environmental adaptation    04713 Circadian entrainment     103668547 (ADCY9)    04714 Thermogenesis     103668547 (ADCY9)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103668547 (ADCY9)   09165 Substance dependence    05032 Morphine addiction     103668547 (ADCY9)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103668547 (ADCY9)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103668547 (ADCY9)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103668547 (ADCY9)    05163 Human cytomegalovirus infection     103668547 (ADCY9)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103668547 (ADCY9) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103668547 (ADCY9) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF512 DUF1053 zf-C2HC_2 AC_N Motif Other DBs NCBI-GeneID:  103668547 NCBI-ProteinID:  XP_008695054 UniProt:  A0A384CKP8 LinkDB All DBs Position Un AA seq 1352 aa AA seqDB search MASPPHQQLLQHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS GGVPRRVGAGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACMERCFPQTQRRFRYAL FYIGFACLLWSIYFGVHVRSKLIVMVAPALCFLVVCVGFFLFTFTKLYARHYVWTSLVLT LLVFALTLAAQFQVLTPLSGRVDSSNHTLAAKPTDTCLSQVGSFSMCIEVLFLLYTVMHL PLYLSLFLGVVYSVLFETFGYHFRDKDCFPPPGAGAPHWELLSRALLHLCIHAIGIHLFI MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIRAIEQFCQEK KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD DRYEMEDGKVTERLGQSVVADQLKGLKTYLIAGQRAKESHCSCSEALLSGFEVIDGSRVS SGPRRQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAVQNGCQEEHKN STKAPGAPNSKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF ASATFSSLLDVFLSTTVFLILSITCFLKYGAATTAPPPAALAVFSAALLLEMLSLVVSIR MVFFLEDVMACTKRLLEWIAGWLPRHFIGAILVSLPALAVYSHVTSEFETNIHFTVFMGS AVLITVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSIVISHLDAGQNFSSEG NPCNSSLPRDGGTASLIGQEVILVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKI QSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKEC YRVLNELIGDFDELLSRPGYSSIEKIKTIGATYMAASGLNGAQCQDGSHPQEHLQVLFEF AKEMMRVVDDFNSNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTG VECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCMDSGAVPQHQLSISPD IRVQVDGSIGRSPTDEIANLVPSVQNADKMSLGSENNVQAKDIHLSSKRPWKEPFKAEER CRFGKAIEKSDCEEAGMEEASELTRLNVSKSV NT seq 4059 nt NT seq  +upstreamnt  +downstreamnt atggcttccccaccccaccagcagctgctgcagcaccacagcaccgaggtgagttgtgac tccagcggagacagcaacagcgtgagggtcaaaattaaccccaagcagctgtcctccaac agccaccccaagcactgcaagtacagcatctcctccagctgtagcagctctggggactca gggggtgtcccccggagagtgggcgctggaggccgcctgcgcaggcagaagaagctgccc cagctgttcgagagggcctccagccgatggtgggaccccaagttcgactccgtgaacctg gaggaggcttgcatggagcgctgcttcccgcagacccagcgccgcttccgatatgcgctc ttctacatcggcttcgcctgccttctgtggagcatctattttggggtccacgtgaggtcc aaactgattgtcatggtagccccagctctgtgcttcctcgtagtgtgtgtgggctttttt ctgtttaccttcaccaagctgtatgcccggcattacgtgtggacctctctggttctcacc ctcctggtgttcgccctgaccctggctgcccagtttcaggttttgacgcctctctcagga cgtgttgacagctccaatcataccctcgcagccaagcccacagacacttgcttatctcaa gtggggagcttttccatgtgcatcgaagtgctctttttactctacacggtcatgcactta cctttgtacttgagcttgtttttgggagtggtctattctgttctctttgagacctttggc tatcatttccgagacaaagactgctttcccccacctggagcaggggcgccacactgggag ttgctgagccgagccctgctccacctctgcattcatgccattgggatccacctatttatc atgtcccaggtgagatctcggagcacctttctcaaggtgggacagtcaattatgcatgga aaggatctggaagtggaaaaagccctgaaagagaggatgattcattctgtgatgccgaga atcatagctgatgacctgatgaaacagggggatgaggagagcgagaattctgtcaaaagg cacgcgacctccagccccaagaacaggaagaaaaagtcttccatacagaaagcccctata gcattccgccctttcaaaatgcagcagatagaagaagtcagtattttatttgcagatatc gtgggcttcacaaagatgagtgccaataagtctgctcacgccctggtgggtctcctcaac gatctgtttggtcgctttgaccggttgtgtgaagagaccaagtgtgagaaaattagtacc ctgggagactgctactattgtgtggcggggtgtccggagccccgggccgaccatgcctac tgctgcattgagatgggcttgggcatgatcagagctatcgagcaattctgccaggagaag aaagagatggtgaacatgcgtgtcggggttcacacggggactgtcttgtgcggcattttg ggcatgaggaggttcaaattcgatgtgtggtccaatgatgtgaacttggccaatctcatg gagcagctgggagtggcgggcaaggttcacatttctgaggccacagcaaaatacctagat gatcggtacgaaatggaagatgggaaagttactgaacgccttggccagagcgttgttgct gaccagttgaaaggtttgaagacatacctgatagcgggtcagagagcgaaggagtctcat tgcagctgctcagaggccttgctttctggctttgaggtcattgacggctcacgggtgtcc tcaggtcctaggagacaggggacagcatcgccagggagtgtcagtgacttggcgcagact gtcaaaacctttgataaccttaagacctgtccttcatgcggaatcacgtttgcccccaaa tcggaagctggtgcagaaggaggagcggtccaaaatggctgtcaagaggagcataaaaac agcaccaaggctcctggagcaccgaattccaaaactcagaatggacttctgagccctccc caagaggaaaagctcaccaacagtcagacctccctgtgtgagatcttacaggaaaaggga aggtgggcaggagtgagcttggaccagtcagctctccttccgctgagattcaagaacatc cgggagaaaacagatgcccattttgtcgatgttatcaaagaagacagcctgatgaaagat tattttttcaagccacccatcaatcagttcagcttgaacttcctggatcaggagctagag cgatcctataggaccagctaccaagaagaggttataaagaattctcccgtgaagactttt gccagtgccaccttcagctccctcctggatgtgtttctttcgacgacagtgtttctaatt ctctctatcacctgcttcctgaagtacggggctgccaccacggctcccccgcctgccgcc ctggcagtcttcagcgccgccctgctgctggagatgctgagccttgtggtctccatcagg atggtgtttttcctggaggatgtgatggcctgtacgaagcgcctgctggagtggatagcc ggctggctcccgcgccatttcattggggccatcctggtgtcactccctgctcttgcagtc tattcacatgtcacctctgaatttgagacaaacatacacttcaccgtgtttatgggctca gccgtcctgatcaccgtcgtgcactactgtaacttctgccagctcagctcctggatgagg tcctccttagccacagtcgtcggggctgggcccctgctcctgctctatgtctccctgtgc cctgacagttccatagtaatttcacaccttgatgcaggacagaatttcagttccgagggg aatccgtgcaatagttccttgccacgtgatggcggaacggccagcctgattggccaggag gtgattcttgtcttctttctcctgctcctgttggtctggttcctgaatcgagaattcgag gtcagctaccgcctgcactaccatggggacgtggaggcggaccttcaccgcaccaagatc cagagcatgagggaccaagctgactggctgctgagaaacatcatcccctaccacgtggcc gagcagctgaaggtctcacagacctactccaagaaccacgacagcggaggcgtcatcttc gccagcatcgtcaacttcagtgagttctacgaggagaactacgaggggggcaaggagtgc taccgggtcctcaacgagctcatcggggacttcgacgagctcctgagcaggccgggctac agcagcatcgagaagatcaagaccattggggccacgtacatggctgcatcgggtctgaac ggcgcccagtgccaggacggcagccacccgcaggagcacctgcaggtcctgtttgagttc gccaaggagatgatgcgtgtggtggacgacttcaacagcaacatgctgtggttcaacttt aagctcagggtcggcttcaaccatgggccgctcacagcgggggtcatcggcaccaccaag ctgctgtatgacatctggggcgacactgtcaacatcgccagcaggatggacagcacaggg gtggagtgccgcatccaggtgagcgaggagagctaccgcgtcctgagcaagatgggctac gacttcgactaccgggggacagtgaacgtgaagggcaagggccagatgaagacctacctg tacccaaagtgcatggacagcggggccgtgccacagcaccagctgtccatctccccggac atccgagtccaggtggacggcagcattgggcggtctcccacggatgagatcgccaacctg gtgccttctgtacagaatgcagacaagatgtctctgggttccgaaaacaacgttcaggcc aaggacattcacctgtcctctaagaggccgtggaaagagcccttcaaagccgaagaaagg tgtcgatttggcaaagccatagagaaaagtgactgtgaagaagctggcatggaggaagcc agcgagctcaccaggctcaatgtttccaagagcgtgtga

Ursus maritimus (polar bear): 103671685 Help Entry 103671685         CDS       T03271                                  Gene name ADCY3 Definition (RefSeq) adenylate cyclase 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04740   Olfactory transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04962   Vasopressin-regulated water reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103671685 (ADCY3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103671685 (ADCY3)    04371 Apelin signaling pathway     103671685 (ADCY3)    04020 Calcium signaling pathway     103671685 (ADCY3)    04072 Phospholipase D signaling pathway     103671685 (ADCY3)    04024 cAMP signaling pathway     103671685 (ADCY3)    04022 cGMP-PKG signaling pathway     103671685 (ADCY3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103671685 (ADCY3)   09144 Cellular community - eukaryotes    04540 Gap junction     103671685 (ADCY3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103671685 (ADCY3)    04062 Chemokine signaling pathway     103671685 (ADCY3)   09152 Endocrine system    04911 Insulin secretion     103671685 (ADCY3)    04923 Regulation of lipolysis in adipocytes     103671685 (ADCY3)    04912 GnRH signaling pathway     103671685 (ADCY3)    04913 Ovarian steroidogenesis     103671685 (ADCY3)    04915 Estrogen signaling pathway     103671685 (ADCY3)    04914 Progesterone-mediated oocyte maturation     103671685 (ADCY3)    04921 Oxytocin signaling pathway     103671685 (ADCY3)    04926 Relaxin signaling pathway     103671685 (ADCY3)    04935 Growth hormone synthesis, secretion and action     103671685 (ADCY3)    04918 Thyroid hormone synthesis     103671685 (ADCY3)    04928 Parathyroid hormone synthesis, secretion and action     103671685 (ADCY3)    04916 Melanogenesis     103671685 (ADCY3)    04925 Aldosterone synthesis and secretion     103671685 (ADCY3)    04927 Cortisol synthesis and secretion     103671685 (ADCY3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103671685 (ADCY3)    04270 Vascular smooth muscle contraction     103671685 (ADCY3)   09154 Digestive system    04970 Salivary secretion     103671685 (ADCY3)    04971 Gastric acid secretion     103671685 (ADCY3)    04972 Pancreatic secretion     103671685 (ADCY3)    04976 Bile secretion     103671685 (ADCY3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     103671685 (ADCY3)   09156 Nervous system    04724 Glutamatergic synapse     103671685 (ADCY3)    04727 GABAergic synapse     103671685 (ADCY3)    04725 Cholinergic synapse     103671685 (ADCY3)    04723 Retrograde endocannabinoid signaling     103671685 (ADCY3)   09157 Sensory system    04740 Olfactory transduction     103671685 (ADCY3)    04750 Inflammatory mediator regulation of TRP channels     103671685 (ADCY3)   09149 Aging    04211 Longevity regulating pathway     103671685 (ADCY3)    04213 Longevity regulating pathway - multiple species     103671685 (ADCY3)   09159 Environmental adaptation    04713 Circadian entrainment     103671685 (ADCY3)    04714 Thermogenesis     103671685 (ADCY3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103671685 (ADCY3)   09165 Substance dependence    05032 Morphine addiction     103671685 (ADCY3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103671685 (ADCY3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103671685 (ADCY3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103671685 (ADCY3)    05163 Human cytomegalovirus infection     103671685 (ADCY3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103671685 (ADCY3) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103671685 (ADCY3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N NCE101 fn3_4 Motif Other DBs NCBI-GeneID:  103671685 NCBI-ProteinID:  XP_008698591 UniProt:  A0A384CUW6 LinkDB All DBs Position Un AA seq 1134 aa AA seqDB search MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCTVVFSSDKLAPLLVAGMGLLLDIL LFVLCKKGLLPDRVTRKVVPYLLWLLITAQIFSYLGLNFARAHSASDTVGWQAFFVFSFF ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDGLKGMHLLREILANVSLYLCAVAVG VMSYYMADRKHRKAFLEAREEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNT MYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDC YYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKR WQYDVWSTDVTVANKMEAGGIPGRVHISQSTLDCLKGEFDVEPGDGGSRCEYLDEKGIET YLIIASKPEVKKTAAQHGLGGRVSPPPAPDRPREGAVSENQELPGQAHAXGSTSEEPEEQ ETQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLL SMRFMDPDMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYMTFVVGEVLL LILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYY TGPTNSTAGLEVEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVAVIN IYAWRPIFDEYDRKRFQEHDFPAVALEKMQGFSTPGLNGTGRLPLVPSKYSMTAMILVMM LSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKR DEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV ITKIKTIGSTYMAASGVTPDVNTNGFASSNKEEKSDKERWQHLADLADFALAMKDTLTNI NNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQ AILREYGFRFVRRGTIFVKGKGELLTFFLKGRDKPAAFPNGSSVTLPHQVVDNS NT seq 3405 nt NT seq  +upstreamnt  +downstreamnt atgccgaggaaccagggcttctccgagcctgagtactcggccgagtactccgccgagtac tcggtcagcctgccctctgaccctgaccgcggggtgggccggacccatgaaatctcggtc cggaactcgggatcctgcctctgcctgcctcggttcatgcggctgaccttcgtgcccgag tccttggagaacctgtaccagacctacttcaaacggcagcgccatgagaccctgctggtg ctggtggtgttcgctgcgctcttcgactgctatgtggtggtcatgtgcacggtggtcttc tccagcgacaagctggctcccctcctcgtagctgggatgggactgctgttggacatcctc ctcttcgtactctgcaaaaaggggctgctcccggaccgggtcacccggaaagtggtgccc tacctgctgtggctactgataactgcccagattttctcttacctgggcctgaactttgcc cgagcccactcggccagtgacacggtgggctggcaggccttctttgtcttctccttcttc atcacgctgccgctcagcctcagccccatcgtcatcatctctgtggtctcctgcgttgtg cacacactcgtcttgggggtcaccgtggcccagcagcagcaggacgggctgaagggcatg cacttgctgagggagatcctggcgaacgtctccctctacctgtgcgccgtcgccgtgggc gtcatgtcctactacatggcggaccgcaagcaccgcaaggccttcctggaggcccgcgag gagcagagccagcagcaggagaaccttatgctctccatcctgcccaagcacgtggctgac gagatgctgaaggacatgaagaaggacgagagccagaaggaccagcagcagttcaacacc atgtacatgtaccggcacgagaacgtcagcatcctctttgcggacatcgtgggcttcacc cagctgtcttctgcctgcagtgcccaggagctcgtgaagctgctcaacgagctctttgcc cgcttcgacaagctggcagccaaataccaccagctgcggattaagatcctaggcgactgt tactactgcatctgcggcctgcccgactaccgggaggaccacgccgtctgctccatcctc atggggctcgccatggtggaggccatctcgtacgtgcgggagaagacgaagactggggtg gacatgcgcgtgggggtgcacacgggcaccgtgctggggggcgtcctgggccagaaacgc tggcagtacgacgtgtggtctaccgacgtcactgtggccaacaagatggaggccggaggc atccccgggcgtgtgcacatctcccagagcaccctggactgcctgaagggcgagttcgat gtggagccgggcgacgggggcagccgctgtgagtacctggacgagaagggcatcgagacc tacctcatcatcgcgtccaagccagaggtgaagaagacagccgcccagcacggcctcggt ggccgggtgagtcccccgcccgccccggacaggccacgggaaggggctgtctcagaaaat caggaactgccaggccaggcccacgcnnncggctccacatcggaggagcccgaggagcag gagacccaggccgacaacccctcgttccccaacccgcgccggaggctgcgccttcaggac ctggctgaccgagtggtggacgcctccgaggatgagcacgagctcaaccagctactcaac gaggccctgctggagcgagagtccgcccaggtggtgaagaagagaaacaccttcctcctt tccatgcggttcatggaccccgacatggaaacccgctactcagtggagaaggaaaagcag agcggggctgccttcagctgctcctgcgtcgtcctgctctgtacggccctggtcgagata ctcatcgacccctggctaatgacaaactacatgacctttgtggttggggaggttctgctt ctgatcctgacaatctgctcgctggccgccatctttccccgggcctttcctaagaagctc gtggccttctccacttggatcgaccggacccgctgggccaggaacacctgggccatgtta gccatcttcattctggttatggcaaatgtcgtggacatgctcagctgtctccagtactac acaggcccaaccaacagcactgcagggctggaggtggaagacggctgcgtcgagaacccc aagtattacaactatgtcgccgtgctgtccctcatcgccaccatcatgctggtgcaggtc agccacatggtgaagctcacactcatgctgctcgtcaccggggctgtggccgtcatcaac atctatgcctggcgccccatctttgatgaatacgaccgcaaacgttttcaggaacatgac ttccctgcagtcgccttagagaagatgcagggattttccacccctgggctcaatggcacc ggcaggctgcccctggtaccttctaagtactccatgaccgcgatgatcctcgtcatgatg ctgagcttctactacttctcacgccacgtggaaaaattggcaaggacactgttcttgtgg aagattgaggtccatgaccagaaggaacgggtctacgagatgcggcgctggaacgaggcc ttggtcaccaacatgttgcctgagcacgtggcacgccatttcctggggtccaagaagaga gatgaggagctgtacagccagtcttacgatgagatcggagtcatgtttgcctccctgccc aacttcgccgacttctacacggaggagagcatcaacaacggcggcattgagtgtctgcgc ttcctcaacgagatcatctccgactttgattctctcctggacaatcccaagttccgggtc atcaccaagatcaaaaccattggcagcacctacatggccgcttccggagtcaccccagat gtcaacaccaacggctttgccagctccaacaaggaggagaagtcagacaaggagcgctgg cagcacctggctgatctggccgacttcgctctggccatgaaggatacgctcacaaacatc aacaaccagtccttcaacaacttcatgctgcgcatcggcatgaacaaaggaggggtcctg gctggggtcattggagcccggaaaccacactatgacatctggggcaacacagtcaatgtg gccagcaggatggagtccacaggggtcatgggcaacattcaggtggtggaagaaacacaa gccatccttcgagagtacggcttccgctttgtgaggcgagggacaatctttgtgaaaggg aaaggggagctgctaacctttttcttgaaggggcgtgataagccagctgccttcccaaat ggctcctcggtcaccctgccccaccaggtggtggacaactcctga

Ursus maritimus (polar bear): 103673916 Help Entry 103673916         CDS       T03271                                  Gene name ADCY7 Definition (RefSeq) adenylate cyclase 7   KO K08047   adenylate cyclase 7 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103673916 (ADCY7)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103673916 (ADCY7)    04371 Apelin signaling pathway     103673916 (ADCY7)    04020 Calcium signaling pathway     103673916 (ADCY7)    04072 Phospholipase D signaling pathway     103673916 (ADCY7)    04024 cAMP signaling pathway     103673916 (ADCY7)    04022 cGMP-PKG signaling pathway     103673916 (ADCY7)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103673916 (ADCY7)   09144 Cellular community - eukaryotes    04540 Gap junction     103673916 (ADCY7)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103673916 (ADCY7)    04062 Chemokine signaling pathway     103673916 (ADCY7)   09152 Endocrine system    04911 Insulin secretion     103673916 (ADCY7)    04923 Regulation of lipolysis in adipocytes     103673916 (ADCY7)    04912 GnRH signaling pathway     103673916 (ADCY7)    04913 Ovarian steroidogenesis     103673916 (ADCY7)    04915 Estrogen signaling pathway     103673916 (ADCY7)    04914 Progesterone-mediated oocyte maturation     103673916 (ADCY7)    04921 Oxytocin signaling pathway     103673916 (ADCY7)    04926 Relaxin signaling pathway     103673916 (ADCY7)    04935 Growth hormone synthesis, secretion and action     103673916 (ADCY7)    04918 Thyroid hormone synthesis     103673916 (ADCY7)    04928 Parathyroid hormone synthesis, secretion and action     103673916 (ADCY7)    04916 Melanogenesis     103673916 (ADCY7)    04925 Aldosterone synthesis and secretion     103673916 (ADCY7)    04927 Cortisol synthesis and secretion     103673916 (ADCY7)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103673916 (ADCY7)    04270 Vascular smooth muscle contraction     103673916 (ADCY7)   09154 Digestive system    04970 Salivary secretion     103673916 (ADCY7)    04971 Gastric acid secretion     103673916 (ADCY7)    04972 Pancreatic secretion     103673916 (ADCY7)    04976 Bile secretion     103673916 (ADCY7)   09156 Nervous system    04724 Glutamatergic synapse     103673916 (ADCY7)    04727 GABAergic synapse     103673916 (ADCY7)    04725 Cholinergic synapse     103673916 (ADCY7)    04723 Retrograde endocannabinoid signaling     103673916 (ADCY7)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103673916 (ADCY7)   09149 Aging    04211 Longevity regulating pathway     103673916 (ADCY7)    04213 Longevity regulating pathway - multiple species     103673916 (ADCY7)   09159 Environmental adaptation    04713 Circadian entrainment     103673916 (ADCY7)    04714 Thermogenesis     103673916 (ADCY7)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103673916 (ADCY7)   09165 Substance dependence    05032 Morphine addiction     103673916 (ADCY7)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103673916 (ADCY7)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103673916 (ADCY7)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103673916 (ADCY7)    05163 Human cytomegalovirus infection     103673916 (ADCY7)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103673916 (ADCY7) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103673916 (ADCY7) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N Motif Other DBs NCBI-GeneID:  103673916 NCBI-ProteinID:  XP_008700992 UniProt:  A0A384D1P9 LinkDB All DBs Position Un AA seq 1092 aa AA seqDB search MPAKGRYFLNEGEEGPDQTALYEKYRLTSQHGPLLLTLLLVAVAACVALIVITFVCGDPS RHQAVLGTAFFTLAVFVALYVLVYVECLVRRWLRAMALFVWVCLMMLGYMLVFDSWMKAT HMGAQVPFFLFIVFVAYTLLPFSMQGAVVAGVVSSLSHLLVLGVLMKAFTTPSVKVGLQL LANAAIFLCGNLTGAFHKHQMQDASRDLFIYTVKCIQIRRKLRIEKRQQGTGSDPIDCSP KELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCEA IKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMDRVHITEATLNH LDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPKPKGDAALKMRASVR MTRYLESWGAARPFAHLNHRESMSSGETPVPSGRRPKTIPLRRHRTPDRNASPKGRSEDD SYDEEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKDFEREVRVPQQPEERGLQARGGVR VQATGWPTVPQPGWLGVMSGAAGARFSEIPFAARRWQSGREGGGRGPENWDAGGWGAHLQ LGPGQVVPQNQGFLLSRMAALGVSFGLVACVLGLVLGLCFAREFPVSERPLTGHLARPRP AGPLRPSCPGDSSRIPVSCPRAASGVALRRALWAGSPLMPLWALGLPAGNQTSPSPSPRA GRSRELTLCELFPYYTCSCILAFIACSVFLRMSLELKVVLLTVALVAYLVLFNISPCWQS GCCGHTVANLTETNGTLSSSFCMWKDPKAMINFYLVLFYVTLLMLSRQIDYYCRLDCLWK TKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDF KVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSSVEKIKTIGSTYMAAAGLSSPSG AENQDLERQHAHIGIMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQ YDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVC TDTAKFQGLGLN NT seq 3279 nt NT seq  +upstreamnt  +downstreamnt atgccggccaaggggcgctatttcctcaacgagggcgaagagggccctgaccagacggcg ctctacgagaagtaccgcctcaccagccagcacgggccgctgctgctcacgctcctgctg gtggccgtcgccgcctgcgtcgccctcatcgtcatcaccttcgtctgtggggacccctcc agacaccaggctgtcctggggacggccttcttcacgcttgccgtgtttgtggctctctac gtgctggtgtatgttgaatgcctcgtccggaggtggctcagggccatggcactgtttgtc tgggtctgcctcatgatgctgggctacatgctggtgttcgactcctggatgaaggccacc catatgggggcgcaggtgcccttcttcctgttcatcgtcttcgtggcatacacgctgctg cccttcagcatgcagggggctgtcgtggccggggtggtctccagcctctcccacctcctg gtgctcggagttctgatgaaggccttcacgacgcccagtgtcaaggtgggactgcagctg ctggccaacgctgccatcttcctgtgcgggaacctcacgggcgccttccacaagcaccag atgcaggatgcctctcgagacctcttcatctacaccgtcaagtgcatccagatccgtcgt aagctgcgtatcgagaagcgccagcaggggacgggatcagatccgattgactgctccccg aaagagctggtggtggtgctgaacgagctcttcggcaagtttgaccagatcgccaaggcc aatgagtgtatgcggatcaagatcctgggggactgctactactgcgtgtcgggtctgccc gtatccctgcccacccatgcccggaactgcgtgaagatgggcctggacatgtgtgaggcc attaagcaggtgcgagaggccacgggtgtggacatcagcatgcgtgtgggcatacactca gggaacgtgctgtgtggggtcattgggttgcgcaagtggcagtacgacgtgtggtcccac gatgtgtccctggccaacaggatggaccgggtgcatatcacggaggcgacgttgaaccac ctggacaaggcgtatgaggtggaggacgggcacgggcagcagcgggacccctacctgaaa gaaatgaacatccgtacctacctggtcatcgacccccggagccagcagccgcccccgccc agccagcacctccccaagcccaagggggatgcggccctgaaaatgcgggcgtccgtgcga atgacccgctacctcgagtcctggggggccgcgcggccctttgcgcacctcaaccaccgt gagagcatgagcagtggcgagacccctgtccccagcgggcggaggcccaagaccattccc ctgcggcgccaccgcacccctgacaggaacgcgtcccccaaggggcggtcggaggacgac tcatacgatgaggagatgctgtcagccatcgaggggctgagctccacgaggccctgctgc tccaagtctgatgacttctacacctttgggtctatcttcctggagaaggacttcgagcga gaggtgagggtcccccagcagcccgaggaacgggggctccaggcccggggtggggtgcgg gtgcaggccacggggtggcccacagtcccacagcccggctggctaggggtcatgagcggg gcagccggagcacggttctcagagatcccctttgctgcgcgtagatggcagtctgggcgg gaaggaggcggccgggggcccgagaattgggatgctgggggttggggagcacacctgcag cttggccctgggcaggtggtcccccagaaccagggttttctgctttccaggatggcggct ctgggtgtgtcctttgggctggtggcctgtgtgctggggctggtgctgggcctgtgcttt gcccgtgagttcccggtgagtgagaggcccctgaccgggcacctggccaggccccgcccc gctggccctctgcgcccctcctgcccgggcgatagttctcgaatcccggtctcctgcccg agagctgcctctggtgtagctctccgcagggccctgtgggcaggctccccgctgatgcct ctctgggccctggggctgcctgcgggcaaccagacgagcccgagcccgagcccgagggct gggagaagcagggagctgacgctgtgcgagctcttcccgtattacacctgtagctgcatc ctggccttcatcgcttgctcggtcttcctgcggatgagcctggagctgaaggtcgtgctg ttgaccgtggctttggtagcttacctggtgctcttcaatatctccccgtgctggcagtcg ggctgctgtggccacactgtggccaacctcactgagaccaacggcaccctcagctcctcg ttctgcatgtggaaggacccgaaggccatgatcaatttctacctggttctgttttacgtc accctgctcatgctctccagacagattgactactactgccgcctggactgtttatggaag acgaagttcaagaaggaacacgaggagtttgagaccatggagaatgtgaaccgccttctt ctggagaatgtcttgccagcccacgtggccgctcacttcattggcgacaagttaaatgag gactggtaccatcagtcctacgactgcgtgtgtgtcatgttcgcgtctgtgccggacttc aaagtcttctacacggagtgcgatgtcaacaaggaggggctggagtgtctgcggctgctg aacgagatcatcgccgacttcgacgagctgctcctgaagcccaagttcagcagcgtggag aagatcaagaccatcggcagcacatacatggcagccgcagggctcagcagcccctcaggg gcggagaaccaggacctggagcgacagcacgcgcacattggcatcatggtggagttcagc atcgccctgatgagcaagctggacggcatcaaccggcactcgttcaactccttccgcctc cgagttggcataaaccacgggcccgtgattgctggagtgattggagcacgaaagcctcag tatgacatctggggaaacacggttaacgtcgccagcaggatggagagcactggagaactt ggcaagatccaggttactgaggagacatgcaccatcctccagggcctaggttattcttgc gaatgccggggactgatcaacgtcaaaggcaaaggcgagctgaggacttactttgtctgt acagacactgccaagttccaggggctggggctgaactga

Ursus maritimus (polar bear): 103675618 Help Entry 103675618         CDS       T03271                                  Gene name ADCY6 Definition (RefSeq) adenylate cyclase 6   KO K08046   adenylate cyclase 6 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04962   Vasopressin-regulated water reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103675618 (ADCY6)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103675618 (ADCY6)    04371 Apelin signaling pathway     103675618 (ADCY6)    04072 Phospholipase D signaling pathway     103675618 (ADCY6)    04024 cAMP signaling pathway     103675618 (ADCY6)    04022 cGMP-PKG signaling pathway     103675618 (ADCY6)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103675618 (ADCY6)   09144 Cellular community - eukaryotes    04540 Gap junction     103675618 (ADCY6)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103675618 (ADCY6)    04062 Chemokine signaling pathway     103675618 (ADCY6)   09152 Endocrine system    04911 Insulin secretion     103675618 (ADCY6)    04923 Regulation of lipolysis in adipocytes     103675618 (ADCY6)    04912 GnRH signaling pathway     103675618 (ADCY6)    04913 Ovarian steroidogenesis     103675618 (ADCY6)    04915 Estrogen signaling pathway     103675618 (ADCY6)    04914 Progesterone-mediated oocyte maturation     103675618 (ADCY6)    04921 Oxytocin signaling pathway     103675618 (ADCY6)    04926 Relaxin signaling pathway     103675618 (ADCY6)    04935 Growth hormone synthesis, secretion and action     103675618 (ADCY6)    04918 Thyroid hormone synthesis     103675618 (ADCY6)    04928 Parathyroid hormone synthesis, secretion and action     103675618 (ADCY6)    04916 Melanogenesis     103675618 (ADCY6)    04924 Renin secretion     103675618 (ADCY6)    04925 Aldosterone synthesis and secretion     103675618 (ADCY6)    04927 Cortisol synthesis and secretion     103675618 (ADCY6)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103675618 (ADCY6)    04270 Vascular smooth muscle contraction     103675618 (ADCY6)   09154 Digestive system    04970 Salivary secretion     103675618 (ADCY6)    04971 Gastric acid secretion     103675618 (ADCY6)    04972 Pancreatic secretion     103675618 (ADCY6)    04976 Bile secretion     103675618 (ADCY6)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     103675618 (ADCY6)    04961 Endocrine and other factor-regulated calcium reabsorption     103675618 (ADCY6)   09156 Nervous system    04724 Glutamatergic synapse     103675618 (ADCY6)    04727 GABAergic synapse     103675618 (ADCY6)    04725 Cholinergic synapse     103675618 (ADCY6)    04723 Retrograde endocannabinoid signaling     103675618 (ADCY6)   09157 Sensory system    04742 Taste transduction     103675618 (ADCY6)    04750 Inflammatory mediator regulation of TRP channels     103675618 (ADCY6)   09149 Aging    04211 Longevity regulating pathway     103675618 (ADCY6)    04213 Longevity regulating pathway - multiple species     103675618 (ADCY6)   09159 Environmental adaptation    04713 Circadian entrainment     103675618 (ADCY6)    04714 Thermogenesis     103675618 (ADCY6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103675618 (ADCY6)   09165 Substance dependence    05032 Morphine addiction     103675618 (ADCY6)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103675618 (ADCY6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103675618 (ADCY6)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103675618 (ADCY6)    05163 Human cytomegalovirus infection     103675618 (ADCY6)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103675618 (ADCY6) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103675618 (ADCY6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N DUF1053 HNOBA TBK1_ULD Motif Other DBs NCBI-GeneID:  103675618 NCBI-ProteinID:  XP_008702957 UniProt:  A0A384D7A3 LinkDB All DBs Position Un AA seq 913 aa AA seqDB search MSWFSGLLVPKVDERKTAWGERNGQKRPRRGTRPGGFCTPRYMSCLRDAQPPSPTPAAPP RCPWQDEAFIRRGGPGNYGTGLWSWITLLGKEELGGGASLHPSTFSLAGQGWLGANVLLF LCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKE DINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAA ENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISSISGEGNGSFFSLCSLG PRQRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQ DALNPEDEVDEFLGRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKADPRFGAYVAC ALLVFCFICFIQLLVFPHSTLMLGTYAGIFLLLLTAVLTCAVSSCGSLFPKALRRLSRSI VRSRAHSTVVGIFSVLLVFTSAIANMFTCNHTPIRTCAARMLNVTPADITACHLQQLNYS LGLDAPLCEGTAPTCSFPEYFVGNMLLSLLASSVFLHISSIGKLAVIFVLGLVYLVLLLL GPPATVFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQ VESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSC ECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGS TYMAASGLNASTYDQAGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAG VIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKG EMTTYFLNGGPPS NT seq 2742 nt NT seq  +upstreamnt  +downstreamnt atgtcatggtttagtggcctcctggtccccaaagtggatgaacggaaaacagcctggggt gagcgcaatgggcagaagcgtccacgccgtgggactcggcccgggggcttctgcacgcct cgctacatgagctgcctccgggatgcgcagccccccagtcccacccctgcagctccgcct cggtgcccctggcaggatgaggccttcatccggaggggcggcccgggtaactatggcact gggctttggagttggattaccctcctggggaaggaggagcttggaggtggtgcctccctt cacccctccaccttctctctggctggccaggggtggctgggtgccaacgtgctgctgttc ctctgcaccaacgtcatcggcatctgcacgcactacccggcggaggtgtctcagcgccag gcctttcaggagacccgcggttacatccaggcccggctgcacctgcagcatgagaatcgg cagcaggaacggctgctgctgtccgtgttgccccagcatgttgccatggagatgaaagaa gatatcaacacaaagaaagaagacatgatgttccacaagatctatatccagaagcatgac aatgtcagcatcctgtttgcagacatcgaaggcttcaccagcctggcatcccagtgcacc gcgcaggagctggtcatgaccctgaacgagctctttgcccggtttgacaagctggctgcg gaaaatcactgcctgagaatcaagatcttaggggactgttactactgtgtgtcggggctg ccggaggcccgggcagaccatgcccactgctgtgtggagatgggggtggacatgatcgag gccatctcatccatcagcggggaggggaatggatctttcttcagcctgtgcagcttaggc ccccgccagaggaaagaggagaaggccatgctggccaagctgcagcggacgcgggccaac tccatggaagggctgatgccgcgctgggtgcccgaccgcgccttctcccggaccaaggac tccaaggctttccgccagatgggcattgatgattccagcaaagacaaccggggtgcccaa gatgccctgaaccccgaggatgaagtagatgagttcctgggccgtgccatcgatgcccgc agcatcgatcagctacggaaggaccacgtgcgccgcttcctgctcaccttccagagagaa gatcttgaaaagaagtactcgcggaaggcggacccccgcttcggagcctacgtggcctgc gcgctgttggtcttctgcttcatctgctttatccagctcctcgtcttcccacactccacc ctgatgcttgggacctatgccggtatcttcctgctgttgctgaccgccgtgctgacctgt gccgtgtcctcctgtggctccctcttccccaaggccctgcgacgcctttcccgcagcatt gtccgctctcgggcgcacagcactgtggttggcatcttttcagtcttgcttgtgttcacc tctgccattgccaacatgttcacctgtaaccacacccccatacggacctgcgcagcccgg atgctgaatgtgacgcccgcggacatcacagcctgccacctgcagcagctcaattactcc ctgggcctggatgctccgctgtgtgagggcaccgcacccacttgcagcttccccgagtac ttcgttgggaacatgctgctgagtctcctggccagctctgtcttcctgcacatcagcagc atcgggaagttggccgtgatctttgtcctggggctcgtctatttggtgctgcttctgctg ggccccccagccaccgtctttgacaactatgacctgctgcttggtgtccatggcttggct tcttccaatgagactttcgacgggctggactgcccagctgcagggagggtggcgctcaaa tacatgacccccgtgattctgctggtgtttgcactggcgttgtatctgcacgcccagcag gtggagtcaactgcacgcctggacttcctctggaaactgcaggcaacaggggagaaggag gagatggaggaactccaggcctacaaccgaagactgctgcataacattctgcccaaggac gtggctgcccacttcctggcccgggagcgccggaatgacgagctctactatcagtcgtgt gagtgtgtggccgtcatgtttgcctccattgccaacttttctgagttctatgtggagctg gaggccaacaacgagggcgttgagtgtctgcggttgctcaacgagatcatcgctgacttc gacgagatcatcagcgaggagcggttccggcagctggagaagatcaaaacgattggtagc acctacatggctgcctcggggctgaacgccagcacctatgatcaggccggccgctcccac atcactgccctggccgactatgccatgcggctcatggagcagatgaaacacatcaatgag cactccttcaacaatttccagatgaagattgggctgaacatgggcccagtcgtggcaggt gtcattggggctcggaagccgcagtatgacatctgggggaacacagtgaatgtctctagc cgtatggacagcacaggggtccctgaccgaatccaggtgaccacggacttgtaccaggtt ctagctgccaaaggctaccagctggagtgtcgaggggtggtcaaggtgaagggcaagggg gagatgaccacctacttcctcaatgggggcccccccagttag

Ursus maritimus (polar bear): 103678826 Help Entry 103678826         CDS       T03271                                  Gene name ADCY5 Definition (RefSeq) adenylate cyclase 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04727   GABAergic synapse umr04728   Dopaminergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05012   Parkinson disease umr05030   Cocaine addiction umr05031   Amphetamine addiction umr05032   Morphine addiction umr05034   Alcoholism umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103678826 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103678826 (ADCY5)    04371 Apelin signaling pathway     103678826 (ADCY5)    04072 Phospholipase D signaling pathway     103678826 (ADCY5)    04024 cAMP signaling pathway     103678826 (ADCY5)    04022 cGMP-PKG signaling pathway     103678826 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103678826 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     103678826 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103678826 (ADCY5)    04062 Chemokine signaling pathway     103678826 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     103678826 (ADCY5)    04923 Regulation of lipolysis in adipocytes     103678826 (ADCY5)    04912 GnRH signaling pathway     103678826 (ADCY5)    04913 Ovarian steroidogenesis     103678826 (ADCY5)    04915 Estrogen signaling pathway     103678826 (ADCY5)    04914 Progesterone-mediated oocyte maturation     103678826 (ADCY5)    04921 Oxytocin signaling pathway     103678826 (ADCY5)    04926 Relaxin signaling pathway     103678826 (ADCY5)    04935 Growth hormone synthesis, secretion and action     103678826 (ADCY5)    04918 Thyroid hormone synthesis     103678826 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     103678826 (ADCY5)    04916 Melanogenesis     103678826 (ADCY5)    04924 Renin secretion     103678826 (ADCY5)    04925 Aldosterone synthesis and secretion     103678826 (ADCY5)    04927 Cortisol synthesis and secretion     103678826 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103678826 (ADCY5)    04270 Vascular smooth muscle contraction     103678826 (ADCY5)   09154 Digestive system    04970 Salivary secretion     103678826 (ADCY5)    04971 Gastric acid secretion     103678826 (ADCY5)    04972 Pancreatic secretion     103678826 (ADCY5)    04976 Bile secretion     103678826 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     103678826 (ADCY5)    04727 GABAergic synapse     103678826 (ADCY5)    04725 Cholinergic synapse     103678826 (ADCY5)    04728 Dopaminergic synapse     103678826 (ADCY5)    04726 Serotonergic synapse     103678826 (ADCY5)    04723 Retrograde endocannabinoid signaling     103678826 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103678826 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     103678826 (ADCY5)    04213 Longevity regulating pathway - multiple species     103678826 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     103678826 (ADCY5)    04714 Thermogenesis     103678826 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103678826 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     103678826 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     103678826 (ADCY5)    05031 Amphetamine addiction     103678826 (ADCY5)    05032 Morphine addiction     103678826 (ADCY5)    05034 Alcoholism     103678826 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103678826 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103678826 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103678826 (ADCY5)    05163 Human cytomegalovirus infection     103678826 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103678826 (ADCY5) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103678826 (ADCY5) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N DUF1053 HNOBA TBK1_ULD Motif Other DBs NCBI-GeneID:  103678826 NCBI-ProteinID:  XP_008706469 UniProt:  A0A384DI42 LinkDB All DBs Position Un AA seq 971 aa AA seqDB search AAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAA VLSGVLLSALHLAIALRTNARDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQE TRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSI LFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEAR ADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVT LANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRK EEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESA NPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASL VFLFICFVQITIVPHSVFMLSFYLTCFLLLTLVVFVSVIYSCVKLFPGPLQTLSRKIVRS KMNSTLVGVFTITLVFLSAFVNMFTCNSNDLFGCLADEHNISTSQVNACHVVESAANYSL GDERGFCSSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELTYVLIVEVP RVTLFDNADLLVTANAIDFNNNGTSQCPEHATKVALKVMTPIVISVFVLALYLHAQQVES TARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECV AVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFKQLEKIKTIGSTYM AASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIG ARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMM TYFLNGGPPLS NT seq 2916 nt NT seq  +upstreamnt  +downstreamnt gccgccttccaccaggaccacatgggcctggcctgctacgcgctcatcgccgtggtgctg gccgtccaggtggtgggcctgctgctgccccagccgcgcagcgcctccgagggcatctgg tggaccgtgttcttcatctacaccatctacacgttgctgcctgtgcgcatgcgggccgcg gtactcagtggagtgctcctttctgcactccacctggccatcgccctgcgcaccaacgcc cgggaccagttcctgctcaagcagcttgtctccaatgtcctcattttctcctgcaccaac attgtgggtgtttgcacccactacccggctgaagtctcccagagacaggccttccaggag acccgggagtgcatccaggcacggctccactcacaacgggagaaccagcaacaggagcgg ctcctgctgtctgtcctgccccgtcatgttgccatggagatgaaagcagacatcaatgcc aagcaggaggatatgatgttccataagatttacatccagaaacacgacaacgtgagcatc ctgtttgctgacatcgagggcttcaccagcctggcatcccagtgcactgcccaggagctg gtcatgaccctcaacgagctcttcgcccgcttcgacaagctggctgcggagaatcactgt ttacgtattaagatcctgggggattgttattactgtgtctctgggctgcctgaagcgagg gctgaccacgcccactgctgcgtggagatgggcatggacatgattgaggccatctcgttg gtccgggaggtgacaggggtgaacgtgaacatgcgcgtgggaattcacagcgggcgagta cactgcggtgtccttggtctcaggaagtggcaattcgacgtctggtctaatgacgtcacg ctggccaaccacatggaagctggaggcaaggcagggcgcatccacatcaccaaggccaca ctcaactacctgaacggggactacgaggtggagccgggctgtgggggcgagcgtaacgcc tacctcaaggaacacagtatcgagaccttcctcatcctgcgctgcacccagaagcggaaa gaagaaaaggccatgatcgccaagatgaatcgccagagaaccaactccattgggcacaac ccgccccactggggggccgagcgtcccttctacaaccacctggggggcaaccaggtgtcc aaggagatgaagcggatgggcttcgaagaccccaaggacaagaacgcccaagaaagcgca aaccctgaggacgaagtggacgaatttctgggccgtgccattgacgccaggagcatcgac aggctgcggtctgagcatgtccgcaagttcctcttgaccttcagggagcctgacttagag aagaagtactccaagcaggtggatgaccgattcggtgcctacgtggcatgtgcctcgctt gtcttcctcttcatctgctttgtccagatcaccatcgtgccccactccgtgttcatgttg agtttctacctaacctgtttcctgctgctgacgttagtggtatttgtgtccgtgatctat tcctgcgtgaagctgttccccggcccactgcagaccctctccaggaagattgtgcggtcc aagatgaacagcactctggttggcgtgttcaccatcaccctcgtgttcctctcggctttt gtcaacatgttcacgtgtaactccaacgacctgttcggctgcctggcggatgagcacaac atcagcaccagccaggtcaacgcgtgccacgtggtggagtcggccgccaactacagcctg ggggacgagcggggcttctgcagcagcccgtggcccaactgcaacttccctgagtacttc acctacagcgtgctgctcagcctgctggcctgctccgtgttcctgcagatcagctgcatt gggaagctggtgctcatgctggccattgagctcacatacgtgctcatcgtcgaggtgccc cgagtcacgctctttgacaatgccgacctgctggttaccgccaatgccatagacttcaac aacaacgggacctcccagtgccctgagcatgcgaccaaggtggcgctgaaggtgatgacg cccatcgtcatctccgtctttgtgctggccctgtacctgcacgcccagcaagtggagtcc accgcccgcctggacttcctctggaaactgcaggccacggaggagaaggaggagatggag gagctgcaggcctacaaccggcggctgctgcacaacatcctgcccaaggacgtggctgcc cacttcctggcccgcgagcggcgcaacgacgagctctactaccagtcgtgcgagtgcgtg gccgtcatgtttgcctccatcgccaacttctccgagttctatgtggagctggaggccaac aatgagggcgtcgagtgcctgcggctgctcaatgagatcatcgccgactttgacgagatc atcagtgaggatcggttcaagcagctggagaagatcaagaccattggcagcacctacatg gccgcctcaggcctcaacgactctacgtatgacaaggtgggcaagacccacatcaaagcc ctggccgacttcgccatgaagctcatggaccaaatgaagtacatcaatgaacactccttc aacaacttccagatgaagatcgggctcaacatcggccctgtggtggccggggtgatcggg gctcgcaagccgcagtacgacatctggggcaatacggtgaacgtggccagccgcatggac agcaccggtgtgcccgaccgcatccaggtcaccacggacatgtaccaggtgctggctgcc aacacataccagctggagtgcaggggtgtggtcaaggtcaagggcaaaggcgagatgatg acctacttcctcaacgggggccccccgctcagttag

Ursus maritimus (polar bear): 103679250 Help Entry 103679250         CDS       T03271                                  Gene name ADCY2 Definition (RefSeq) adenylate cyclase 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04922   Glucagon signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103679250 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103679250 (ADCY2)    04371 Apelin signaling pathway     103679250 (ADCY2)    04020 Calcium signaling pathway     103679250 (ADCY2)    04072 Phospholipase D signaling pathway     103679250 (ADCY2)    04024 cAMP signaling pathway     103679250 (ADCY2)    04022 cGMP-PKG signaling pathway     103679250 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103679250 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     103679250 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103679250 (ADCY2)    04062 Chemokine signaling pathway     103679250 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     103679250 (ADCY2)    04922 Glucagon signaling pathway     103679250 (ADCY2)    04923 Regulation of lipolysis in adipocytes     103679250 (ADCY2)    04912 GnRH signaling pathway     103679250 (ADCY2)    04913 Ovarian steroidogenesis     103679250 (ADCY2)    04915 Estrogen signaling pathway     103679250 (ADCY2)    04914 Progesterone-mediated oocyte maturation     103679250 (ADCY2)    04921 Oxytocin signaling pathway     103679250 (ADCY2)    04926 Relaxin signaling pathway     103679250 (ADCY2)    04935 Growth hormone synthesis, secretion and action     103679250 (ADCY2)    04918 Thyroid hormone synthesis     103679250 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     103679250 (ADCY2)    04916 Melanogenesis     103679250 (ADCY2)    04925 Aldosterone synthesis and secretion     103679250 (ADCY2)    04927 Cortisol synthesis and secretion     103679250 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103679250 (ADCY2)    04270 Vascular smooth muscle contraction     103679250 (ADCY2)   09154 Digestive system    04970 Salivary secretion     103679250 (ADCY2)    04971 Gastric acid secretion     103679250 (ADCY2)    04972 Pancreatic secretion     103679250 (ADCY2)    04976 Bile secretion     103679250 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     103679250 (ADCY2)    04727 GABAergic synapse     103679250 (ADCY2)    04725 Cholinergic synapse     103679250 (ADCY2)    04723 Retrograde endocannabinoid signaling     103679250 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103679250 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     103679250 (ADCY2)    04213 Longevity regulating pathway - multiple species     103679250 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     103679250 (ADCY2)    04714 Thermogenesis     103679250 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103679250 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     103679250 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103679250 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103679250 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103679250 (ADCY2)    05163 Human cytomegalovirus infection     103679250 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103679250 (ADCY2) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103679250 (ADCY2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N HNOBA Motif Other DBs NCBI-GeneID:  103679250 NCBI-ProteinID:  XP_008706979 UniProt:  A0A384DJN7 LinkDB All DBs Position Un AA seq 1028 aa AA seqDB search MGVVFLLWDVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSVVIWICLVAMGY LFLCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPG AKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQER LLLSLLPAHIAMEMKAEIIRRLQGPRAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRL ASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMG LDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVP GRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPHLFRPRHTL DGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTK SQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKILEKEYRATALPAFKYY VTCACLIFFCVFIVQILVLPKTSILGISFGAAFLLLAFILFICFAGQLLQCSKKASASLL WLLKSSGIIADRPWPRVSLTVLTTAIILTMAVFNMFFLSDPEETIPPTANSSNTSLSALS NQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAH VLDDYSQVLFQRPGIWKDLKTMGSVSLFIFFVTLLVLGRQNEYYCRLDFLWKNKFKKERE EIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES DVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEP ERQYMHIGTMVEFAFALVAKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGN TVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGELKTYFVNTEMSRS LSQGNLAS NT seq 3087 nt NT seq  +upstreamnt  +downstreamnt atgggagtagtgttccttttgtgggacgttgaagaccacgtggcatttttaataacggtc ccgacagccctggcgatcttcttcgcgatcttcatcctcgtctgcatcgagtccgtgttc aagaagctcctgcgccttttctccgtcgtgatatggatctgcctcgtggccatgggctac ctgttcctgtgcttcggaggcaccgtctccccctgggaccaggtgtcgttcttcctcttc atcatctttgtggtgtacaccatgctgcccttcaacatgcgggacgccatcatcgccagc gtgctcacctcctcctcccacaccatcgtgctgagcgtctgcctgtctgcgacgccgggg gccaaggagcacctggtctggcagatcctggccaatgtgatcattttcatctgtgggaac ctggcgggagcgtaccacaagcacctcatggagctggccttgcagcagacgtatcaggac acctgcaactgtatcaagtctcggatcaagctggaatttgaaaagcgtcagcaggagcgg cttctgctctccctgctgccggctcacatagccatggaaatgaaagccgagatcatccgg aggctgcagggccccagagccggccaaatggaaaacacaaacaacttccacaacctgtac gtcaagcgccataccaacgtgagcatcctgtatgctgatattgttggcttcacccggctg gccagtgactgctccccaggagaactggtccacatgctgaacgagctctttggaaagttc gaccaaattgcaaaggagaatgaatgcatgagaataaaaattttgggagactgctactac tgtgtgtccggacttcctatatctctcccgaaccatgccaagaactgtgtgaaaatgggg ctggacatgtgtgaagccataaagaaagtgagggatgccactggagtggatatcaacatg cgcgtgggagtgcattctgggaacgtcctctgcggggtgattggtctgcagaagtggcag tacgacgtgtggtcacatgacgttaccttggccaatcacatggaagctggaggggtccct ggacgtgttcacatttcttccgtcaccctggaacacttgaacggcgcttacaaagtggag gaaggagacggtgacatcagagacccgtatttaaaacagcacctggtgaaaacctacttt gtcatcaaccccaagggagaacgaaggagtcctcacctcttcagacctcgccacaccctc gatggagccaagatgagggcctctgtgcgcatgacccggtacctggagtcctggggggcg gccaagccctttgcacacctgcatcaccgagacagcatgaccacggagaatggcaaaatc agcaccacggatgtgccaatgggtcagcataattttcaaaatcgtaccttaagaaccaag tcccaaaagaagagatttgaagaagaattaaatgaaaggatgattcaagcaattgatgga attaacgcacaaaagcagtggctcaagtctgaagacattcagagaatctcactcctgttc tacaataaaatactagaaaaagaataccgagccaccgccctgccagcgtttaagtactac gtgacctgcgcgtgtctcatattcttctgcgtcttcattgtgcagattctggtattacca aaaacgtccattctggggatctcctttggagctgcgtttctcttgctcgcctttatcctc ttcatctgctttgccgggcagcttctgcaatgcagcaagaaggcctccgcctctctcctg tggctgttgaagtcgtcgggcatcatcgcggaccggccctggcctcgtgtctccctcact gtcctcaccacggccatcattctgaccatggccgtgttcaacatgtttttcctgagtgac ccagaggaaacaattcctccaactgccaattcatccaacacaagtctttctgccttaagt aatcaggcagcgattctacgggcacaaaatctgtttttcctcccgtactttatctacagc tgcatcctgggactgatctcctgctcggttttcctgagggtgaattacgagctgaagatg ttgatcatgatggtggcgttggtgggttacaacaccatccttctacacacgcacgcccac gtcctggacgactatagccaggtcttattccagagaccaggcatttggaaagacctgaag accatgggctcagtgtctctctttatattcttcgtcacactgcttgttctgggtagacag aatgaatattactgtaggttagacttcttatggaagaacaagttcaaaaaagagcgggag gagatagaaaccatggaaaacctgaaccgcgtgctgctggagaacgtgctgcccgcgcac gtggcggagcatttcctggcccggagcctgaagaacgaggagttataccaccagtcctat gactgtgtctgcgtcatgtttgcctctattccggatttcaaagaattctacacagaatca gatgtgaacaaggagggcttggaatgccttcggctcctgaatgagatcatcgccgacttt gatgatctgctgtccaagccgaagttcagtggagttgaaaagatcaagaccattggcagc acatacatggcggcgaccggtctgagcgccgtgcccagccaggagcacgcccaggagccg gagaggcagtacatgcacattggcaccatggtggagtttgccttcgcgctggtggcgaag ctggacgccatcaacaagcactccttcaacgacttcaagctgcgagtgggtattaaccac ggacctgtgatagccggtgtgattggagctcagaagccgcagtatgatatctggggcaac actgtaaacgtggccagcaggatggacagcaccggcgtgctggacaagatacaggtcacc gaggagacaagcctcatcctccagacgctggggtacacgtgcacgtgtcgaggaataatt aacgtgaaaggcaagggggagctgaagacgtactttgtaaacacagaaatgtcaaggtcc ctttcccagggcaacttggcatcctga

Ursus maritimus (polar bear): 103679331 Help Entry 103679331         CDS       T03271                                  Gene name ADCY4 Definition (RefSeq) adenylate cyclase 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism umr  Ursus maritimus (polar bear) Pathway umr00230   Purine metabolism umr01100   Metabolic pathways umr01522   Endocrine resistance umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04024   cAMP signaling pathway umr04062   Chemokine signaling pathway umr04072   Phospholipase D signaling pathway umr04114   Oocyte meiosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04713   Circadian entrainment umr04714   Thermogenesis umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04727   GABAergic synapse umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04913   Ovarian steroidogenesis umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04921   Oxytocin signaling pathway umr04923   Regulation of lipolysis in adipocytes umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04976   Bile secretion umr05032   Morphine addiction umr05163   Human cytomegalovirus infection umr05166   Human T-cell leukemia virus 1 infection umr05200   Pathways in cancer umr05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103679331 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103679331 (ADCY4)    04371 Apelin signaling pathway     103679331 (ADCY4)    04020 Calcium signaling pathway     103679331 (ADCY4)    04072 Phospholipase D signaling pathway     103679331 (ADCY4)    04024 cAMP signaling pathway     103679331 (ADCY4)    04022 cGMP-PKG signaling pathway     103679331 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103679331 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     103679331 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103679331 (ADCY4)    04062 Chemokine signaling pathway     103679331 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     103679331 (ADCY4)    04923 Regulation of lipolysis in adipocytes     103679331 (ADCY4)    04912 GnRH signaling pathway     103679331 (ADCY4)    04913 Ovarian steroidogenesis     103679331 (ADCY4)    04915 Estrogen signaling pathway     103679331 (ADCY4)    04914 Progesterone-mediated oocyte maturation     103679331 (ADCY4)    04921 Oxytocin signaling pathway     103679331 (ADCY4)    04926 Relaxin signaling pathway     103679331 (ADCY4)    04935 Growth hormone synthesis, secretion and action     103679331 (ADCY4)    04918 Thyroid hormone synthesis     103679331 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     103679331 (ADCY4)    04916 Melanogenesis     103679331 (ADCY4)    04925 Aldosterone synthesis and secretion     103679331 (ADCY4)    04927 Cortisol synthesis and secretion     103679331 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103679331 (ADCY4)    04270 Vascular smooth muscle contraction     103679331 (ADCY4)   09154 Digestive system    04970 Salivary secretion     103679331 (ADCY4)    04971 Gastric acid secretion     103679331 (ADCY4)    04972 Pancreatic secretion     103679331 (ADCY4)    04976 Bile secretion     103679331 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     103679331 (ADCY4)    04727 GABAergic synapse     103679331 (ADCY4)    04725 Cholinergic synapse     103679331 (ADCY4)    04723 Retrograde endocannabinoid signaling     103679331 (ADCY4)   09157 Sensory system    04742 Taste transduction     103679331 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     103679331 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     103679331 (ADCY4)    04213 Longevity regulating pathway - multiple species     103679331 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     103679331 (ADCY4)    04714 Thermogenesis     103679331 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103679331 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     103679331 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103679331 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103679331 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103679331 (ADCY4)    05163 Human cytomegalovirus infection     103679331 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103679331 (ADCY4) Enzymes [BR:umr01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103679331 (ADCY4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc DUF1053 AC_N CD52 Motif Other DBs NCBI-GeneID:  103679331 NCBI-ProteinID:  XP_008707065 UniProt:  A0A384DJU5 LinkDB All DBs Position Un AA seq 1074 aa AA seqDB search LFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALLAMLAVASASGRDLASDRGFLT TVLCALGGFSLLLGLASREQRLQRWTRPLSVLVWAALLGLGHGFLFTGGLVSAWDQVSFF LFVIFTVYAMLPLGMRDAAAGGLASSLSHLLALGLYLGPQRDSRPALLPQLAANAVLFLC GNVAGAYHKALMERALRATFREALRSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEI MARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFG KFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDI NMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGVYA VEDASMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPQMRPSLLMTRYLE SWGAAKPFAHLSHLESPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDEDLDTGDAKFFQ VIEQLNSQKQWKQSKDFNPLTLYFREKELEKEYRLSALPAFKYYAACTFLVFFSNFIIQM LVANRPPALAITYSITFLLFLLLLFVCFSEHLTKCVLKGPKMLHWLPALSGLVATRPGLR VALGTATILLVFVMAITSLFFLPAATNCPSRASNVSSVASNVSWELPGSLPLISVPYSMH CCVLGFLSCSLFLHMSFELKLLLLLLWLGVSCSLFLHSHAWLSDCLIARLYPDPLDSRPG VLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEQEETETMENLTRLLLE NVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLN EIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATPGQDAQQDAERSCSHLGTMVEFA VALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVVGAQKPQYDIWGNTVNVASRMESTGVL GKIQVTEETARVLQSLGYTCYSRGIIKVKGKGQLCTYFLNTDLTRTGPPSATLG NT seq 3225 nt NT seq  +upstreamnt  +downstreamnt ctcttcagtccccggccgccccccagcgaagacctcttctacgagacctactacagcctg agccagcagtacccactgctgcttctgctgctggtgattgtgctctgtgcgctcctggcg atgctggctgtcgcctccgccagcggcagggatctagcttcagaccggggcttcctgacc accgtgctgtgtgcgctcggtggcttctcgctgctcctgggcctggcttcccgcgagcaa cgactgcagcgctggacacgtcccctgtcagtcctcgtgtgggctgcgctactcgggcta ggccatggcttcctgttcaccgggggcctggtgagcgcctgggaccaggtgtcctttttc ctcttcgtcatcttcaccgtgtacgccatgttgcccttgggcatgcgggatgccgccgcc gggggccttgcctcgtcgctttcccacctgctggcccttgggctgtaccttgggcctcag cgggactccaggccagcgctgctgccgcagctggcagcgaacgccgtgttgttcttgtgc gggaacgtggccggagcgtaccacaaggcgctgatggagcgcgctctgcgcgccacgttc cgggaggctcttcgttccctgcactcgcgccggcggctggacacagagaagaagcaccag gaacaccttctcttgtccattcttcctgcctacctggcccgagagatgaaggcagagatc atggcacggctgcaggctggacaggggtcccggccagagagcaccaacaacttccacagc ctctatgtcaagaggcaccagggagtgagcgtgctgtatgctgacatcgtgggcttcaca cggctggccagtgagtgctcccctaaggagctggtgctcatgctcaacgagctcttcggc aagttcgaccagattgccaaggagcatgaatgcatgcggatcaagatcctgggagactgt tactactgtgtctctggtctaccgctctccctgccagaccacgccatcaactgcgtgcgc atggggctggacatgtgccgggccatcaggaaactccgggcggccactggcgtggacatc aacatgcgtgtgggcgtgcattcgggcagtgtgctctgcggagtcattgggctgcagaag tggcagtatgatgtctggtcccatgatgtcacactggccaaccacatggaggcgggcggc gtgccaggacgagtacatattacaggggctaccctggccctgctggccggggtctatgct gtggaagatgcatcgatggaacaccgggacccataccttcgggagctaggggagcccacc tacctagtcatcgacccccgggctgaggaggaggatgagaagggcactgcgggagggctg ctgtcctctctcgagggcccccagatgcgcccatcactgctgatgacccgctacctggag tcctggggcgcggccaagccttttgcccatctgagccacctagagagccctgtgtccact tccacccctctcccggagaaggccctggcctccttcagcccccagtggagcctggaccgg agccgtaccccccggggactagatgaggacctggacactggggatgccaagttcttccag gtcatcgaacagctcaactctcagaagcagtggaagcagtccaaggacttcaacccactg acactgtacttcagagagaaggagctggagaaagagtatcgactttctgccctccccgcc ttcaaatactatgcggcctgcaccttcctggtcttcttctccaacttcatcatccagatg ctggtggccaacaggccgccagctctggccatcacctatagcatcaccttcctcctcttc ctcctcctcctcttcgtctgcttctcagagcacctgacgaagtgtgtcttgaaaggcccc aagatgctgcactggctgcccgcactgtctggcttggtggccacacggcccggactccga gttgccctgggcactgccaccatcctcctcgtttttgtcatggctattaccagcctgttc ttcttaccggcggcaacaaactgcccttcccgggcttccaatgtgtcctccgtggcttcc aacgtctcctgggagctccctggctccctgcctctcatcagcgtcccatactctatgcac tgctgcgtgctggggttcctgtcctgctccctctttctgcacatgagcttcgagctgaag ttgctgctgctcctgctatggctgggggtctcctgctccctcttcctgcactcccacgcc tggctgtccgactgcctcatcgcccgcctctatccagatcccttggactccaggccaggg gtgctgaaggagcccaaactgatgggagctatctccttcttcatcttcttcttcaccctc cttgtcctggctcggcagaatgagtactactgccgcctggacttcctgtggaagaagaag ctgcggcaggagcaggaggagacagagaccatggagaacctgactcggctgctgctggag aatgtgctccctgcgcacgtggccccccagttcattggccagaaccggcgcaacgaggac ctctaccaccagtcctacgagtgtgtctgtgtcctcttcgcctcagttccagactttaag gagttttactctgaatctaacatcaaccacgagggtctagagtgtctgcggttgctcaat gagatcatcgctgattttgatgagctgctctcaaagcccaagtttagcggcgtggagaag atcaaaaccatcggcagcacctacatggcagccacgggcttaaatgccacccccggacag gacgcacagcaggatgccgagcgaagctgcagccacctgggcaccatggtggagttcgca gtggccctcggatcgaagctggatgtcatcaacaagcactcattcaacaacttccgcctg cgtgtggggttgaaccacggacctgtagtggctggggtggttggggcccagaagcctcag tatgacatctggggcaacacggtgaacgtggccagccgcatggaaagtacgggagtcctg ggcaagatccaagtgactgaagagacagcccgggtgctgcagtccttaggctatacctgc tacagccggggcatcatcaaggtcaaaggcaaagggcagctgtgcacctacttcctgaac acagatttgacacgaactggccctccctcggccaccctaggctga

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