Ursus maritimus (polar bear): 103665244 Help Entry 103665244         CDS       T03271                                  Gene name KRAS Definition (RefSeq) KRAS proto-oncogene, GTPase   KO K07827   GTPase KRas Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04062   Chemokine signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04137   Mitophagy - animal umr04140   Autophagy - animal umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04360   Axon guidance umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04540   Gap junction umr04550   Signaling pathways regulating pluripotency of stem cells umr04625   C-type lectin receptor signaling pathway umr04650   Natural killer cell mediated cytotoxicity umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04714   Thermogenesis umr04720   Long-term potentiation umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04730   Long-term depression umr04810   Regulation of actin cytoskeleton umr04910   Insulin signaling pathway umr04912   GnRH signaling pathway umr04914   Progesterone-mediated oocyte maturation umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr04960   Aldosterone-regulated sodium reabsorption umr05010   Alzheimer disease umr05022   Pathways of neurodegeneration - multiple diseases umr05034   Alcoholism umr05160   Hepatitis C umr05161   Hepatitis B umr05163   Human cytomegalovirus infection umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05205   Proteoglycans in cancer umr05206   MicroRNAs in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05212   Pancreatic cancer umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05216   Thyroid cancer umr05218   Melanoma umr05219   Bladder cancer umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103665244 (KRAS)    04012 ErbB signaling pathway     103665244 (KRAS)    04014 Ras signaling pathway     103665244 (KRAS)    04015 Rap1 signaling pathway     103665244 (KRAS)    04370 VEGF signaling pathway     103665244 (KRAS)    04371 Apelin signaling pathway     103665244 (KRAS)    04068 FoxO signaling pathway     103665244 (KRAS)    04072 Phospholipase D signaling pathway     103665244 (KRAS)    04071 Sphingolipid signaling pathway     103665244 (KRAS)    04151 PI3K-Akt signaling pathway     103665244 (KRAS)    04150 mTOR signaling pathway     103665244 (KRAS)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103665244 (KRAS)    04137 Mitophagy - animal     103665244 (KRAS)   09143 Cell growth and death    04210 Apoptosis     103665244 (KRAS)    04218 Cellular senescence     103665244 (KRAS)   09144 Cellular community - eukaryotes    04540 Gap junction     103665244 (KRAS)    04550 Signaling pathways regulating pluripotency of stem cells     103665244 (KRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103665244 (KRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     103665244 (KRAS)    04650 Natural killer cell mediated cytotoxicity     103665244 (KRAS)    04660 T cell receptor signaling pathway     103665244 (KRAS)    04662 B cell receptor signaling pathway     103665244 (KRAS)    04664 Fc epsilon RI signaling pathway     103665244 (KRAS)    04062 Chemokine signaling pathway     103665244 (KRAS)   09152 Endocrine system    04910 Insulin signaling pathway     103665244 (KRAS)    04929 GnRH secretion     103665244 (KRAS)    04912 GnRH signaling pathway     103665244 (KRAS)    04915 Estrogen signaling pathway     103665244 (KRAS)    04914 Progesterone-mediated oocyte maturation     103665244 (KRAS)    04917 Prolactin signaling pathway     103665244 (KRAS)    04921 Oxytocin signaling pathway     103665244 (KRAS)    04926 Relaxin signaling pathway     103665244 (KRAS)    04935 Growth hormone synthesis, secretion and action     103665244 (KRAS)    04919 Thyroid hormone signaling pathway     103665244 (KRAS)    04916 Melanogenesis     103665244 (KRAS)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     103665244 (KRAS)   09156 Nervous system    04725 Cholinergic synapse     103665244 (KRAS)    04726 Serotonergic synapse     103665244 (KRAS)    04720 Long-term potentiation     103665244 (KRAS)    04730 Long-term depression     103665244 (KRAS)    04722 Neurotrophin signaling pathway     103665244 (KRAS)   09158 Development and regeneration    04360 Axon guidance     103665244 (KRAS)   09149 Aging    04211 Longevity regulating pathway     103665244 (KRAS)    04213 Longevity regulating pathway - multiple species     103665244 (KRAS)   09159 Environmental adaptation    04714 Thermogenesis     103665244 (KRAS)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103665244 (KRAS)    05206 MicroRNAs in cancer     103665244 (KRAS)    05205 Proteoglycans in cancer     103665244 (KRAS)    05203 Viral carcinogenesis     103665244 (KRAS)    05230 Central carbon metabolism in cancer     103665244 (KRAS)    05231 Choline metabolism in cancer     103665244 (KRAS)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103665244 (KRAS)   09162 Cancer: specific types    05210 Colorectal cancer     103665244 (KRAS)    05212 Pancreatic cancer     103665244 (KRAS)    05225 Hepatocellular carcinoma     103665244 (KRAS)    05226 Gastric cancer     103665244 (KRAS)    05214 Glioma     103665244 (KRAS)    05216 Thyroid cancer     103665244 (KRAS)    05221 Acute myeloid leukemia     103665244 (KRAS)    05220 Chronic myeloid leukemia     103665244 (KRAS)    05218 Melanoma     103665244 (KRAS)    05211 Renal cell carcinoma     103665244 (KRAS)    05219 Bladder cancer     103665244 (KRAS)    05215 Prostate cancer     103665244 (KRAS)    05213 Endometrial cancer     103665244 (KRAS)    05224 Breast cancer     103665244 (KRAS)    05223 Non-small cell lung cancer     103665244 (KRAS)   09164 Neurodegenerative disease    05010 Alzheimer disease     103665244 (KRAS)    05022 Pathways of neurodegeneration - multiple diseases     103665244 (KRAS)   09165 Substance dependence    05034 Alcoholism     103665244 (KRAS)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103665244 (KRAS)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103665244 (KRAS)    05170 Human immunodeficiency virus 1 infection     103665244 (KRAS)    05161 Hepatitis B     103665244 (KRAS)    05160 Hepatitis C     103665244 (KRAS)    05163 Human cytomegalovirus infection     103665244 (KRAS)    05167 Kaposi sarcoma-associated herpesvirus infection     103665244 (KRAS)    05165 Human papillomavirus infection     103665244 (KRAS)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103665244 (KRAS)    01522 Endocrine resistance     103665244 (KRAS)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103665244 (KRAS)   09183 Protein families: signaling and cellular processes    04031 GTP-binding proteins [BR:umr04031]     103665244 (KRAS) Membrane trafficking [BR:umr04131]  Endocytosis   Macropinocytosis    Ras GTPases     103665244 (KRAS) GTP-binding proteins [BR:umr04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     103665244 (KRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 G-alpha ATP_bind_1 FeoB_N Gtr1_RagA Septin AAA_25 CbiA Motif Other DBs NCBI-GeneID:  103665244 NCBI-ProteinID:  XP_008691359 UniProt:  A0A384CA71 LinkDB All DBs Position Un AA seq 189 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKINKEEKTPGC VKIKKCIVM NT seq 570 nt NT seq  +upstreamnt  +downstreamnt atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg atacagctaattcagaatcactttgtggatgaatatgatcctacaatagaggattcctac aggaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaata aaaagagttaaagactctgaagatgtacctatggtcctagtaggaaataaatgcgatttg ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg agagagatccgacaatacagattgaaaaaaatcaacaaagaagaaaagactcctggctgt gtgaaaattaaaaaatgcattgtaatgtaa

Ursus maritimus (polar bear): 103669173 Help Entry 103669173         CDS       T03271                                  Definition (RefSeq) GTPase HRas-like   KO K02833   GTPase HRas Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04062   Chemokine signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04137   Mitophagy - animal umr04140   Autophagy - animal umr04144   Endocytosis umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04360   Axon guidance umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04510   Focal adhesion umr04540   Gap junction umr04550   Signaling pathways regulating pluripotency of stem cells umr04625   C-type lectin receptor signaling pathway umr04630   JAK-STAT signaling pathway umr04650   Natural killer cell mediated cytotoxicity umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04714   Thermogenesis umr04720   Long-term potentiation umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04730   Long-term depression umr04810   Regulation of actin cytoskeleton umr04910   Insulin signaling pathway umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr05010   Alzheimer disease umr05022   Pathways of neurodegeneration - multiple diseases umr05034   Alcoholism umr05132   Salmonella infection umr05160   Hepatitis C umr05161   Hepatitis B umr05163   Human cytomegalovirus infection umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05205   Proteoglycans in cancer umr05206   MicroRNAs in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05216   Thyroid cancer umr05218   Melanoma umr05219   Bladder cancer umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103669173    04012 ErbB signaling pathway     103669173    04014 Ras signaling pathway     103669173    04015 Rap1 signaling pathway     103669173    04370 VEGF signaling pathway     103669173    04371 Apelin signaling pathway     103669173    04630 JAK-STAT signaling pathway     103669173    04068 FoxO signaling pathway     103669173    04072 Phospholipase D signaling pathway     103669173    04071 Sphingolipid signaling pathway     103669173    04151 PI3K-Akt signaling pathway     103669173    04150 mTOR signaling pathway     103669173  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     103669173    04140 Autophagy - animal     103669173    04137 Mitophagy - animal     103669173   09143 Cell growth and death    04210 Apoptosis     103669173    04218 Cellular senescence     103669173   09144 Cellular community - eukaryotes    04510 Focal adhesion     103669173    04540 Gap junction     103669173    04550 Signaling pathways regulating pluripotency of stem cells     103669173   09142 Cell motility    04810 Regulation of actin cytoskeleton     103669173  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     103669173    04650 Natural killer cell mediated cytotoxicity     103669173    04660 T cell receptor signaling pathway     103669173    04662 B cell receptor signaling pathway     103669173    04664 Fc epsilon RI signaling pathway     103669173    04062 Chemokine signaling pathway     103669173   09152 Endocrine system    04910 Insulin signaling pathway     103669173    04929 GnRH secretion     103669173    04912 GnRH signaling pathway     103669173    04915 Estrogen signaling pathway     103669173    04917 Prolactin signaling pathway     103669173    04921 Oxytocin signaling pathway     103669173    04926 Relaxin signaling pathway     103669173    04935 Growth hormone synthesis, secretion and action     103669173    04919 Thyroid hormone signaling pathway     103669173    04916 Melanogenesis     103669173   09156 Nervous system    04725 Cholinergic synapse     103669173    04726 Serotonergic synapse     103669173    04720 Long-term potentiation     103669173    04730 Long-term depression     103669173    04722 Neurotrophin signaling pathway     103669173   09158 Development and regeneration    04360 Axon guidance     103669173   09149 Aging    04211 Longevity regulating pathway     103669173    04213 Longevity regulating pathway - multiple species     103669173   09159 Environmental adaptation    04714 Thermogenesis     103669173  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103669173    05206 MicroRNAs in cancer     103669173    05205 Proteoglycans in cancer     103669173    05203 Viral carcinogenesis     103669173    05230 Central carbon metabolism in cancer     103669173    05231 Choline metabolism in cancer     103669173    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103669173   09162 Cancer: specific types    05210 Colorectal cancer     103669173    05225 Hepatocellular carcinoma     103669173    05226 Gastric cancer     103669173    05214 Glioma     103669173    05216 Thyroid cancer     103669173    05221 Acute myeloid leukemia     103669173    05220 Chronic myeloid leukemia     103669173    05218 Melanoma     103669173    05211 Renal cell carcinoma     103669173    05219 Bladder cancer     103669173    05215 Prostate cancer     103669173    05213 Endometrial cancer     103669173    05224 Breast cancer     103669173    05223 Non-small cell lung cancer     103669173   09164 Neurodegenerative disease    05010 Alzheimer disease     103669173    05022 Pathways of neurodegeneration - multiple diseases     103669173   09165 Substance dependence    05034 Alcoholism     103669173   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103669173   09171 Infectious disease: bacterial    05132 Salmonella infection     103669173   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103669173    05170 Human immunodeficiency virus 1 infection     103669173    05161 Hepatitis B     103669173    05160 Hepatitis C     103669173    05163 Human cytomegalovirus infection     103669173    05167 Kaposi sarcoma-associated herpesvirus infection     103669173    05165 Human papillomavirus infection     103669173   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103669173    01522 Endocrine resistance     103669173  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103669173   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:umr04147]     103669173    04031 GTP-binding proteins [BR:umr04031]     103669173 Membrane trafficking [BR:umr04131]  Endocytosis   Macropinocytosis    Ras GTPases     103669173 Exosome [BR:umr04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    103669173   Exosomal proteins of colorectal cancer cells    103669173 GTP-binding proteins [BR:umr04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     103669173 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf MMR_HSR1 Motif Other DBs NCBI-GeneID:  103669173 NCBI-ProteinID:  XP_008695725 UniProt:  A0A384CMQ7 LinkDB All DBs Position Un AA seq 250 aa AA seqDB search MTFRLTKDLPSSLEKLVDDFLAIICLILMSTVVTMIAIIPCVEFEAADSEDNSQEADQNF LQSPRDVRQEWPSGSVLRKVGSGSAGKSALTIQLIQNHFVDEYDHTVXMTLSSCRKQVVI NGETCLLDILDMEGQEEYSSVWYQYMHTGEGFQCLFTIETTKSFRDIHQYREQIKCVKDS CDVPMVLVGNKCDLAAHTVESWQAHDLARTHGIPYMETSTRRTSHSGSGSSSGTLWDPPG PPGTQRHLEL NT seq 753 nt NT seq  +upstreamnt  +downstreamnt atgactttccggctgacgaaagatttaccatcatctctagaaaaactcgttgatgacttc ctagcaataatctgccttatcttgatgtccactgtggtaacaatgatagctattattccc tgtgttgagtttgaggctgctgattcagaggacaatagccaggaggctgaccagaacttt ctccagagtcccagggatgtgaggcaagaatggccttcaggatctgtgttgaggaaggtg ggctctggaagtgcggggaagagtgccctgaccatccagctcatccagaaccacttcgtg gatgaatatgaccacaccgtctagatgacactgtcttcctgcaggaagcaagtggttatc aatggtgagacgtgcctgctagacattttggacatggagggccaggaggagtatagttcc gtatggtatcagtacatgcacaccggagagggtttccagtgtttgtttaccattgaaacc accaagtccttcagggacatccaccagtacagggagcaaatcaagtgcgtaaaggactcc tgtgatgtgcccatggtgctggtagggaacaaatgcgacctggctgcgcacacggtagag tcctggcaggcacatgaccttgcccgcacccatggcatcccctacatggagacctcaacc agacgcaccagccactctggctctggttctagttccgggaccctctgggaccctccggga ccccccgggactcagcgacacctagaactctaa

Ursus maritimus (polar bear): 103669422 Help Entry 103669422         CDS       T03271                                  Gene name NRAS Definition (RefSeq) neuroblastoma RAS viral oncogene homolog   KO K07828   GTPase NRas Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04062   Chemokine signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04137   Mitophagy - animal umr04140   Autophagy - animal umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04360   Axon guidance umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04540   Gap junction umr04550   Signaling pathways regulating pluripotency of stem cells umr04625   C-type lectin receptor signaling pathway umr04650   Natural killer cell mediated cytotoxicity umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04714   Thermogenesis umr04720   Long-term potentiation umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04730   Long-term depression umr04810   Regulation of actin cytoskeleton umr04910   Insulin signaling pathway umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr05010   Alzheimer disease umr05022   Pathways of neurodegeneration - multiple diseases umr05034   Alcoholism umr05160   Hepatitis C umr05161   Hepatitis B umr05163   Human cytomegalovirus infection umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05205   Proteoglycans in cancer umr05206   MicroRNAs in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05216   Thyroid cancer umr05218   Melanoma umr05219   Bladder cancer umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103669422 (NRAS)    04012 ErbB signaling pathway     103669422 (NRAS)    04014 Ras signaling pathway     103669422 (NRAS)    04015 Rap1 signaling pathway     103669422 (NRAS)    04370 VEGF signaling pathway     103669422 (NRAS)    04371 Apelin signaling pathway     103669422 (NRAS)    04068 FoxO signaling pathway     103669422 (NRAS)    04072 Phospholipase D signaling pathway     103669422 (NRAS)    04071 Sphingolipid signaling pathway     103669422 (NRAS)    04151 PI3K-Akt signaling pathway     103669422 (NRAS)    04150 mTOR signaling pathway     103669422 (NRAS)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103669422 (NRAS)    04137 Mitophagy - animal     103669422 (NRAS)   09143 Cell growth and death    04210 Apoptosis     103669422 (NRAS)    04218 Cellular senescence     103669422 (NRAS)   09144 Cellular community - eukaryotes    04540 Gap junction     103669422 (NRAS)    04550 Signaling pathways regulating pluripotency of stem cells     103669422 (NRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103669422 (NRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     103669422 (NRAS)    04650 Natural killer cell mediated cytotoxicity     103669422 (NRAS)    04660 T cell receptor signaling pathway     103669422 (NRAS)    04662 B cell receptor signaling pathway     103669422 (NRAS)    04664 Fc epsilon RI signaling pathway     103669422 (NRAS)    04062 Chemokine signaling pathway     103669422 (NRAS)   09152 Endocrine system    04910 Insulin signaling pathway     103669422 (NRAS)    04929 GnRH secretion     103669422 (NRAS)    04912 GnRH signaling pathway     103669422 (NRAS)    04915 Estrogen signaling pathway     103669422 (NRAS)    04917 Prolactin signaling pathway     103669422 (NRAS)    04921 Oxytocin signaling pathway     103669422 (NRAS)    04926 Relaxin signaling pathway     103669422 (NRAS)    04935 Growth hormone synthesis, secretion and action     103669422 (NRAS)    04919 Thyroid hormone signaling pathway     103669422 (NRAS)    04916 Melanogenesis     103669422 (NRAS)   09156 Nervous system    04725 Cholinergic synapse     103669422 (NRAS)    04726 Serotonergic synapse     103669422 (NRAS)    04720 Long-term potentiation     103669422 (NRAS)    04730 Long-term depression     103669422 (NRAS)    04722 Neurotrophin signaling pathway     103669422 (NRAS)   09158 Development and regeneration    04360 Axon guidance     103669422 (NRAS)   09149 Aging    04211 Longevity regulating pathway     103669422 (NRAS)    04213 Longevity regulating pathway - multiple species     103669422 (NRAS)   09159 Environmental adaptation    04714 Thermogenesis     103669422 (NRAS)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103669422 (NRAS)    05206 MicroRNAs in cancer     103669422 (NRAS)    05205 Proteoglycans in cancer     103669422 (NRAS)    05203 Viral carcinogenesis     103669422 (NRAS)    05230 Central carbon metabolism in cancer     103669422 (NRAS)    05231 Choline metabolism in cancer     103669422 (NRAS)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103669422 (NRAS)   09162 Cancer: specific types    05210 Colorectal cancer     103669422 (NRAS)    05225 Hepatocellular carcinoma     103669422 (NRAS)    05226 Gastric cancer     103669422 (NRAS)    05214 Glioma     103669422 (NRAS)    05216 Thyroid cancer     103669422 (NRAS)    05221 Acute myeloid leukemia     103669422 (NRAS)    05220 Chronic myeloid leukemia     103669422 (NRAS)    05218 Melanoma     103669422 (NRAS)    05211 Renal cell carcinoma     103669422 (NRAS)    05219 Bladder cancer     103669422 (NRAS)    05215 Prostate cancer     103669422 (NRAS)    05213 Endometrial cancer     103669422 (NRAS)    05224 Breast cancer     103669422 (NRAS)    05223 Non-small cell lung cancer     103669422 (NRAS)   09164 Neurodegenerative disease    05010 Alzheimer disease     103669422 (NRAS)    05022 Pathways of neurodegeneration - multiple diseases     103669422 (NRAS)   09165 Substance dependence    05034 Alcoholism     103669422 (NRAS)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103669422 (NRAS)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103669422 (NRAS)    05170 Human immunodeficiency virus 1 infection     103669422 (NRAS)    05161 Hepatitis B     103669422 (NRAS)    05160 Hepatitis C     103669422 (NRAS)    05163 Human cytomegalovirus infection     103669422 (NRAS)    05167 Kaposi sarcoma-associated herpesvirus infection     103669422 (NRAS)    05165 Human papillomavirus infection     103669422 (NRAS)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103669422 (NRAS)    01522 Endocrine resistance     103669422 (NRAS)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103669422 (NRAS)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:umr04147]     103669422 (NRAS)    04031 GTP-binding proteins [BR:umr04031]     103669422 (NRAS) Membrane trafficking [BR:umr04131]  Endocytosis   Macropinocytosis    Ras GTPases     103669422 (NRAS) Exosome [BR:umr04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    103669422 (NRAS)   Exosomal proteins of other body fluids (saliva and urine)    103669422 (NRAS)   Exosomal proteins of breast cancer cells    103669422 (NRAS)   Exosomal proteins of colorectal cancer cells    103669422 (NRAS) GTP-binding proteins [BR:umr04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     103669422 (NRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Septin ParA Ldh_1_N Motif Other DBs NCBI-GeneID:  103669422 NCBI-ProteinID:  XP_008695968 UniProt:  A0A384CMD2 LinkDB All DBs Position Un AA seq 189 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDL PTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQG CMGLPCVVM NT seq 570 nt NT seq  +upstreamnt  +downstreamnt atgactgagtacaaactggtggtggttggagcaggtggtgtcgggaaaagcgcactgaca atccagctaatccagaaccactttgtagatgaatatgatcccaccatagaggattcttac cgaaaacaggtggttatagacggtgaaacctgtctgttggacatactggatacagctggt caagaggagtacagtgccatgagagaccaatacatgaggacaggcgaaggtttcctctgt gtatttgccatcaataatagcaaatcatttgcagatattaacctctacagggaacagatt aagcgagtcaaagattcagatgacgtacctatggtgctagtaggaaataagtgtgatttg ccaacaaggacagtggacacaaaacaagcccacgaactggccaagagttatgggattcca ttcattgaaacctcagccaagaccagacagggtgttgaagatgccttttacacactggta agagaaatacgtcagtaccgaatgaagaaactcaacagcagtgatgatgggactcaaggt tgtatggggttaccatgtgtggtgatgtaa

Ursus maritimus (polar bear): 103671035 Help Entry 103671035         CDS       T03271                                  Gene name HRAS Definition (RefSeq) HRas proto-oncogene, GTPase   KO K02833   GTPase HRas Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr01522   Endocrine resistance umr04010   MAPK signaling pathway umr04012   ErbB signaling pathway umr04014   Ras signaling pathway umr04015   Rap1 signaling pathway umr04062   Chemokine signaling pathway umr04068   FoxO signaling pathway umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04137   Mitophagy - animal umr04140   Autophagy - animal umr04144   Endocytosis umr04150   mTOR signaling pathway umr04151   PI3K-Akt signaling pathway umr04210   Apoptosis umr04211   Longevity regulating pathway umr04213   Longevity regulating pathway - multiple species umr04218   Cellular senescence umr04360   Axon guidance umr04370   VEGF signaling pathway umr04371   Apelin signaling pathway umr04510   Focal adhesion umr04540   Gap junction umr04550   Signaling pathways regulating pluripotency of stem cells umr04625   C-type lectin receptor signaling pathway umr04630   JAK-STAT signaling pathway umr04650   Natural killer cell mediated cytotoxicity umr04660   T cell receptor signaling pathway umr04662   B cell receptor signaling pathway umr04664   Fc epsilon RI signaling pathway umr04714   Thermogenesis umr04720   Long-term potentiation umr04722   Neurotrophin signaling pathway umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04730   Long-term depression umr04810   Regulation of actin cytoskeleton umr04910   Insulin signaling pathway umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04917   Prolactin signaling pathway umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04926   Relaxin signaling pathway umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04935   Growth hormone synthesis, secretion and action umr05010   Alzheimer disease umr05022   Pathways of neurodegeneration - multiple diseases umr05034   Alcoholism umr05132   Salmonella infection umr05160   Hepatitis C umr05161   Hepatitis B umr05163   Human cytomegalovirus infection umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05170   Human immunodeficiency virus 1 infection umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05205   Proteoglycans in cancer umr05206   MicroRNAs in cancer umr05210   Colorectal cancer umr05211   Renal cell carcinoma umr05213   Endometrial cancer umr05214   Glioma umr05215   Prostate cancer umr05216   Thyroid cancer umr05218   Melanoma umr05219   Bladder cancer umr05220   Chronic myeloid leukemia umr05221   Acute myeloid leukemia umr05223   Non-small cell lung cancer umr05224   Breast cancer umr05225   Hepatocellular carcinoma umr05226   Gastric cancer umr05230   Central carbon metabolism in cancer umr05231   Choline metabolism in cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     103671035 (HRAS)    04012 ErbB signaling pathway     103671035 (HRAS)    04014 Ras signaling pathway     103671035 (HRAS)    04015 Rap1 signaling pathway     103671035 (HRAS)    04370 VEGF signaling pathway     103671035 (HRAS)    04371 Apelin signaling pathway     103671035 (HRAS)    04630 JAK-STAT signaling pathway     103671035 (HRAS)    04068 FoxO signaling pathway     103671035 (HRAS)    04072 Phospholipase D signaling pathway     103671035 (HRAS)    04071 Sphingolipid signaling pathway     103671035 (HRAS)    04151 PI3K-Akt signaling pathway     103671035 (HRAS)    04150 mTOR signaling pathway     103671035 (HRAS)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     103671035 (HRAS)    04140 Autophagy - animal     103671035 (HRAS)    04137 Mitophagy - animal     103671035 (HRAS)   09143 Cell growth and death    04210 Apoptosis     103671035 (HRAS)    04218 Cellular senescence     103671035 (HRAS)   09144 Cellular community - eukaryotes    04510 Focal adhesion     103671035 (HRAS)    04540 Gap junction     103671035 (HRAS)    04550 Signaling pathways regulating pluripotency of stem cells     103671035 (HRAS)   09142 Cell motility    04810 Regulation of actin cytoskeleton     103671035 (HRAS)  09150 Organismal Systems   09151 Immune system    04625 C-type lectin receptor signaling pathway     103671035 (HRAS)    04650 Natural killer cell mediated cytotoxicity     103671035 (HRAS)    04660 T cell receptor signaling pathway     103671035 (HRAS)    04662 B cell receptor signaling pathway     103671035 (HRAS)    04664 Fc epsilon RI signaling pathway     103671035 (HRAS)    04062 Chemokine signaling pathway     103671035 (HRAS)   09152 Endocrine system    04910 Insulin signaling pathway     103671035 (HRAS)    04929 GnRH secretion     103671035 (HRAS)    04912 GnRH signaling pathway     103671035 (HRAS)    04915 Estrogen signaling pathway     103671035 (HRAS)    04917 Prolactin signaling pathway     103671035 (HRAS)    04921 Oxytocin signaling pathway     103671035 (HRAS)    04926 Relaxin signaling pathway     103671035 (HRAS)    04935 Growth hormone synthesis, secretion and action     103671035 (HRAS)    04919 Thyroid hormone signaling pathway     103671035 (HRAS)    04916 Melanogenesis     103671035 (HRAS)   09156 Nervous system    04725 Cholinergic synapse     103671035 (HRAS)    04726 Serotonergic synapse     103671035 (HRAS)    04720 Long-term potentiation     103671035 (HRAS)    04730 Long-term depression     103671035 (HRAS)    04722 Neurotrophin signaling pathway     103671035 (HRAS)   09158 Development and regeneration    04360 Axon guidance     103671035 (HRAS)   09149 Aging    04211 Longevity regulating pathway     103671035 (HRAS)    04213 Longevity regulating pathway - multiple species     103671035 (HRAS)   09159 Environmental adaptation    04714 Thermogenesis     103671035 (HRAS)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103671035 (HRAS)    05206 MicroRNAs in cancer     103671035 (HRAS)    05205 Proteoglycans in cancer     103671035 (HRAS)    05203 Viral carcinogenesis     103671035 (HRAS)    05230 Central carbon metabolism in cancer     103671035 (HRAS)    05231 Choline metabolism in cancer     103671035 (HRAS)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103671035 (HRAS)   09162 Cancer: specific types    05210 Colorectal cancer     103671035 (HRAS)    05225 Hepatocellular carcinoma     103671035 (HRAS)    05226 Gastric cancer     103671035 (HRAS)    05214 Glioma     103671035 (HRAS)    05216 Thyroid cancer     103671035 (HRAS)    05221 Acute myeloid leukemia     103671035 (HRAS)    05220 Chronic myeloid leukemia     103671035 (HRAS)    05218 Melanoma     103671035 (HRAS)    05211 Renal cell carcinoma     103671035 (HRAS)    05219 Bladder cancer     103671035 (HRAS)    05215 Prostate cancer     103671035 (HRAS)    05213 Endometrial cancer     103671035 (HRAS)    05224 Breast cancer     103671035 (HRAS)    05223 Non-small cell lung cancer     103671035 (HRAS)   09164 Neurodegenerative disease    05010 Alzheimer disease     103671035 (HRAS)    05022 Pathways of neurodegeneration - multiple diseases     103671035 (HRAS)   09165 Substance dependence    05034 Alcoholism     103671035 (HRAS)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103671035 (HRAS)   09171 Infectious disease: bacterial    05132 Salmonella infection     103671035 (HRAS)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103671035 (HRAS)    05170 Human immunodeficiency virus 1 infection     103671035 (HRAS)    05161 Hepatitis B     103671035 (HRAS)    05160 Hepatitis C     103671035 (HRAS)    05163 Human cytomegalovirus infection     103671035 (HRAS)    05167 Kaposi sarcoma-associated herpesvirus infection     103671035 (HRAS)    05165 Human papillomavirus infection     103671035 (HRAS)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103671035 (HRAS)    01522 Endocrine resistance     103671035 (HRAS)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103671035 (HRAS)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:umr04147]     103671035 (HRAS)    04031 GTP-binding proteins [BR:umr04031]     103671035 (HRAS) Membrane trafficking [BR:umr04131]  Endocytosis   Macropinocytosis    Ras GTPases     103671035 (HRAS) Exosome [BR:umr04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    103671035 (HRAS)   Exosomal proteins of colorectal cancer cells    103671035 (HRAS) GTP-binding proteins [BR:umr04031]  Small (monomeric) G-proteins   Ras Family    Ras [OT]     103671035 (HRAS) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Ras Roc Arf GTP_EFTU RsgA_GTPase MMR_HSR1 FeoB_N Gtr1_RagA ATP_bind_1 G-alpha Septin Ldh_1_N AAA_25 Motif Other DBs NCBI-GeneID:  103671035 NCBI-ProteinID:  XP_008697816 UniProt:  A0A384CSM8 LinkDB All DBs Position Un AA seq 189 aa AA seqDB search MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKVRKLSPPDEGGPG CLSCRCLLS NT seq 570 nt NT seq  +upstreamnt  +downstreamnt atgacggaatataagcttgtggtagtgggcgctggtggtgtggggaagagcgccctgacc atccagctcattcagaaccacttcgtggatgagtacgaccccaccatcgaggactcctat cggaagcaagtggttatcgatggtgagacgtgcctgctggacattttggacacagcgggc caggaagaatatagcgccatgcgggaccagtacatgcgcactggggaaggcttcctgtgt gtgttcgccatcaataacaccaagtccttcgaggacatccaccagtacagggagcagatc aagcgagtgaaggactccgatgacgtgcccatggtgctggtggggaacaagtgtgatctg gctgcgcgcactgtggagtcccggcaggcacaggaccttgcccgcagctatggcatcccc tacatcgagacgtcggccaagacgcgccagggcgtggaggacgccttctacacgctggtg cgagagatccggcagcacaaggtgcggaagctgagcccgcccgacgaggggggtccgggc tgcctgagctgcaggtgcctgctctcctga

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