KEGG   Ursus maritimus (polar bear): 103665736
Entry
103665736         CDS       T03271                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr01521  EGFR tyrosine kinase inhibitor resistance
umr01522  Endocrine resistance
umr04010  MAPK signaling pathway
umr04012  ErbB signaling pathway
umr04014  Ras signaling pathway
umr04062  Chemokine signaling pathway
umr04068  FoxO signaling pathway
umr04072  Phospholipase D signaling pathway
umr04150  mTOR signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04380  Osteoclast differentiation
umr04510  Focal adhesion
umr04540  Gap junction
umr04550  Signaling pathways regulating pluripotency of stem cells
umr04630  JAK-STAT signaling pathway
umr04650  Natural killer cell mediated cytotoxicity
umr04660  T cell receptor signaling pathway
umr04662  B cell receptor signaling pathway
umr04664  Fc epsilon RI signaling pathway
umr04714  Thermogenesis
umr04722  Neurotrophin signaling pathway
umr04910  Insulin signaling pathway
umr04912  GnRH signaling pathway
umr04915  Estrogen signaling pathway
umr04917  Prolactin signaling pathway
umr04926  Relaxin signaling pathway
umr04935  Growth hormone synthesis, secretion and action
umr05034  Alcoholism
umr05160  Hepatitis C
umr05161  Hepatitis B
umr05163  Human cytomegalovirus infection
umr05165  Human papillomavirus infection
umr05200  Pathways in cancer
umr05203  Viral carcinogenesis
umr05205  Proteoglycans in cancer
umr05206  MicroRNAs in cancer
umr05210  Colorectal cancer
umr05211  Renal cell carcinoma
umr05213  Endometrial cancer
umr05214  Glioma
umr05215  Prostate cancer
umr05220  Chronic myeloid leukemia
umr05221  Acute myeloid leukemia
umr05223  Non-small cell lung cancer
umr05224  Breast cancer
umr05225  Hepatocellular carcinoma
umr05226  Gastric cancer
umr05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103665736 (GRB2)
   04012 ErbB signaling pathway
    103665736 (GRB2)
   04014 Ras signaling pathway
    103665736 (GRB2)
   04630 JAK-STAT signaling pathway
    103665736 (GRB2)
   04068 FoxO signaling pathway
    103665736 (GRB2)
   04072 Phospholipase D signaling pathway
    103665736 (GRB2)
   04151 PI3K-Akt signaling pathway
    103665736 (GRB2)
   04150 mTOR signaling pathway
    103665736 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103665736 (GRB2)
   04540 Gap junction
    103665736 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    103665736 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103665736 (GRB2)
   04660 T cell receptor signaling pathway
    103665736 (GRB2)
   04662 B cell receptor signaling pathway
    103665736 (GRB2)
   04664 Fc epsilon RI signaling pathway
    103665736 (GRB2)
   04062 Chemokine signaling pathway
    103665736 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103665736 (GRB2)
   04912 GnRH signaling pathway
    103665736 (GRB2)
   04915 Estrogen signaling pathway
    103665736 (GRB2)
   04917 Prolactin signaling pathway
    103665736 (GRB2)
   04926 Relaxin signaling pathway
    103665736 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    103665736 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    103665736 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103665736 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    103665736 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103665736 (GRB2)
   05206 MicroRNAs in cancer
    103665736 (GRB2)
   05205 Proteoglycans in cancer
    103665736 (GRB2)
   05203 Viral carcinogenesis
    103665736 (GRB2)
   05231 Choline metabolism in cancer
    103665736 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103665736 (GRB2)
   05225 Hepatocellular carcinoma
    103665736 (GRB2)
   05226 Gastric cancer
    103665736 (GRB2)
   05214 Glioma
    103665736 (GRB2)
   05221 Acute myeloid leukemia
    103665736 (GRB2)
   05220 Chronic myeloid leukemia
    103665736 (GRB2)
   05211 Renal cell carcinoma
    103665736 (GRB2)
   05215 Prostate cancer
    103665736 (GRB2)
   05213 Endometrial cancer
    103665736 (GRB2)
   05224 Breast cancer
    103665736 (GRB2)
   05223 Non-small cell lung cancer
    103665736 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    103665736 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103665736 (GRB2)
   05160 Hepatitis C
    103665736 (GRB2)
   05163 Human cytomegalovirus infection
    103665736 (GRB2)
   05165 Human papillomavirus infection
    103665736 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103665736 (GRB2)
   01522 Endocrine resistance
    103665736 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103665736 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:umr04990]
    103665736 (GRB2)
Membrane trafficking [BR:umr04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    103665736 (GRB2)
Domain-containing proteins not elsewhere classified [BR:umr04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   103665736 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 103665736
NCBI-ProteinID: XP_008691983
UniProt: A0A384CAV1
LinkDB
Position
Un
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgctgacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagaa
ctcaatgggaaagatggcttcattcccaagaattatatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcatgac
ggggcctttcttatccgagagagtgagagtgccccgggggacttctccctctctgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggagctgggaagtatttcctc
tgggtggtgaaattcaattctctgaacgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatattcctccgggacatagaacaggtgccacagcaaccgacgtac
gtccaggccctctttgactttgatccccaggaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcctgccacggg
cagaccggcatgtttccccgcaattacgtcacccccgtgaaccggaacgtctaa

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