KEGG   Ursus maritimus (polar bear): 103672573
Entry
103672573         CDS       T03271                                 

Gene name
STAT3
Definition
(RefSeq) signal transducer and activator of transcription 3
  KO
K04692  signal transducer and activator of transcription 3
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr01521  EGFR tyrosine kinase inhibitor resistance
umr04062  Chemokine signaling pathway
umr04066  HIF-1 signaling pathway
umr04068  FoxO signaling pathway
umr04217  Necroptosis
umr04550  Signaling pathways regulating pluripotency of stem cells
umr04630  JAK-STAT signaling pathway
umr04659  Th17 cell differentiation
umr04917  Prolactin signaling pathway
umr04920  Adipocytokine signaling pathway
umr04931  Insulin resistance
umr04933  AGE-RAGE signaling pathway in diabetic complications
umr04935  Growth hormone synthesis, secretion and action
umr05145  Toxoplasmosis
umr05160  Hepatitis C
umr05161  Hepatitis B
umr05162  Measles
umr05163  Human cytomegalovirus infection
umr05167  Kaposi sarcoma-associated herpesvirus infection
umr05169  Epstein-Barr virus infection
umr05200  Pathways in cancer
umr05203  Viral carcinogenesis
umr05205  Proteoglycans in cancer
umr05206  MicroRNAs in cancer
umr05212  Pancreatic cancer
umr05221  Acute myeloid leukemia
umr05223  Non-small cell lung cancer
umr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
umr05321  Inflammatory bowel disease
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    103672573 (STAT3)
   04066 HIF-1 signaling pathway
    103672573 (STAT3)
   04068 FoxO signaling pathway
    103672573 (STAT3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    103672573 (STAT3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    103672573 (STAT3)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    103672573 (STAT3)
   04062 Chemokine signaling pathway
    103672573 (STAT3)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    103672573 (STAT3)
   04917 Prolactin signaling pathway
    103672573 (STAT3)
   04935 Growth hormone synthesis, secretion and action
    103672573 (STAT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103672573 (STAT3)
   05206 MicroRNAs in cancer
    103672573 (STAT3)
   05205 Proteoglycans in cancer
    103672573 (STAT3)
   05203 Viral carcinogenesis
    103672573 (STAT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103672573 (STAT3)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    103672573 (STAT3)
   05221 Acute myeloid leukemia
    103672573 (STAT3)
   05223 Non-small cell lung cancer
    103672573 (STAT3)
  09163 Immune disease
   05321 Inflammatory bowel disease
    103672573 (STAT3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    103672573 (STAT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    103672573 (STAT3)
  09172 Infectious disease: viral
   05162 Measles
    103672573 (STAT3)
   05161 Hepatitis B
    103672573 (STAT3)
   05160 Hepatitis C
    103672573 (STAT3)
   05163 Human cytomegalovirus infection
    103672573 (STAT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103672573 (STAT3)
   05169 Epstein-Barr virus infection
    103672573 (STAT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    103672573 (STAT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103672573 (STAT3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:umr03000]
    103672573 (STAT3)
Transcription factors [BR:umr03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   STAT
    103672573 (STAT3)
SSDB
Motif
Pfam: STAT_alpha STAT_bind STAT_int SH2 E2R135 DUF4795 Syntaxin-6_N AP1AR Fib_alpha
Other DBs
NCBI-GeneID: 103672573
NCBI-ProteinID: XP_008699510
UniProt: A0A384CYE5
LinkDB
Position
Un
AA seq 770 aa
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
NT seq 2313 nt   +upstreamnt  +downstreamnt
atggcccaatggaatcagctccagcagctcgacacacggtacctggagcagcttcatcag
ctgtacagtgacagcttcccgatggagctgcggcagtttctggccccttggattgagagt
caagattgggcatatgcggccagcaaagaatcacatgcgactttggtgtttcataatctc
ttgggtgagattgaccagcagtacagccgcttcctacaggagtcaaatgttctctatcag
cacaatctgcgaaggatcaagcagttccttcagagcagatatctggagaagccaatggag
attgcccgaatcgtggcccggtgcctatgggaagagtcccgcctgctccagactgcagcc
actgcagcccagcaagggggccaggccaaccaccccacagccgctgtggtgacggagaag
cagcagatgctggagcagcacctccaggatgttcggaagcgagtacaggatctagaacag
aaaatgaaagtggtggagaatctccaggatgactttgatttcaactacaaaaccctcaag
agtcaaggagacatgcaggatctgaatggaaacaaccagtcggtgaccaggcagaagatg
cagcagctggagcagatgctcaccgcgctggaccagatgcggcgcagcatcgtgagtgag
ttggcggggctgttgtccgcgatggagtatgtgcagaaaactctcacggacgaagagctg
gctgactggaagaggcggcagcagattgcgtgcatcgggggccctcccaacatctgccta
gatcgcctagaaaattggataacctcattagcagaatctcaacttcagacccgccagcaa
attaagaaactggaggagttgcagcaaaaagtgtcctacaaaggggatcccatcgtacag
caccggccgatgctggaggagaggatcgtagagctgttcagaaacttaatgaaaagtgcc
ttcgtggttgagcggcagccctgcatgcctatgcatcctgaccggcccttagtcatcaag
actggcgtccagttcactaccaaagtcagattgctggtcaaattccctgagttaaattat
cagcttaaaattaaagtgtgcattgacaaagactccggggatgttgcagccctcagagga
tcccggaaatttaacattctgggcacaaacacaaaagtgatgaacatggaagagtccaac
aacggcagcctgtctgcagaattcaaacacctgaccctgagagagcaaagatgtggtaac
gggggccgagccaattgtgacgcctccctgattgtcaccgaggagctgcacctgatcact
tttgagaccgaggtgtatcaccaaggcctcaagatcgaccttgagacccactccttgccg
gtcgtggtgatctccaacatctgtcagatgccaaatgcctgggcatcgatcctgtggtat
aacatgctgaccaacaaccccaagaacgtgaacttcttcaccaagcccccgattggcacc
tgggatcaagtggccgaggtgctgagctggcagttctcctccaccacgaagcgagggctg
agcatcgagcagttgactacgctggcagagaaactcttaggacctggtgtgaactattca
gggtgtcagattacgtgggctaaattttgcaaagaaaacatggctggcaaaggcttctcc
ttctgggtttggctagacaatatcattgaccttgtgaaaaagtacatcctggctctttgg
aatgaagggtacataatgggttttatcagtaaggagcgagagcgggccatcttgagtacc
aagcccccaggcaccttcctgctacggttcagtgaaagcagcaaagaaggaggtgtcacc
ttcacttgggtggagaaggacatcagcggtaagacccagatccagtcggtggaaccatat
accaagcagcagctgaacaacatgtcgtttgctgaaatcatcatgggctataagatcatg
gatgccaccaacatcctggtgtctccgctggtctatctctaccccgacattcctaaggag
gaggcatttggaaagtactgtcgcccagagagccaggagcatcctgaagctgacccaggt
agtgctgccccgtacctgaagaccaagtttatctgtgtgacaccaacgacgtgcagcaat
accattgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataat
ggtgaaggtgctgagccctcagcaggagggcagttcgagtccctcacgttcgacatggag
ttgacctcggagtgcgctacctccccgatgtga

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