Ursus maritimus (polar bear): 103673552 Help Entry 103673552         CDS       T03271                                  Gene name PLCB2 Definition (RefSeq) phospholipase C beta 2   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism umr  Ursus maritimus (polar bear) Pathway umr00562   Inositol phosphate metabolism umr01100   Metabolic pathways umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04062   Chemokine signaling pathway umr04070   Phosphatidylinositol signaling system umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04310   Wnt signaling pathway umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04621   NOD-like receptor signaling pathway umr04713   Circadian entrainment umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04728   Dopaminergic synapse umr04730   Long-term depression umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04922   Glucagon signaling pathway umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05016   Huntington disease umr05017   Spinocerebellar ataxia umr05022   Pathways of neurodegeneration - multiple diseases umr05142   Chagas disease umr05143   African trypanosomiasis umr05146   Amoebiasis umr05163   Human cytomegalovirus infection umr05200   Pathways in cancer Module umr_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103673552 (PLCB2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103673552 (PLCB2)    04310 Wnt signaling pathway     103673552 (PLCB2)    04371 Apelin signaling pathway     103673552 (PLCB2)    04020 Calcium signaling pathway     103673552 (PLCB2)    04070 Phosphatidylinositol signaling system     103673552 (PLCB2)    04072 Phospholipase D signaling pathway     103673552 (PLCB2)    04071 Sphingolipid signaling pathway     103673552 (PLCB2)    04022 cGMP-PKG signaling pathway     103673552 (PLCB2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     103673552 (PLCB2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103673552 (PLCB2)    04621 NOD-like receptor signaling pathway     103673552 (PLCB2)    04062 Chemokine signaling pathway     103673552 (PLCB2)   09152 Endocrine system    04911 Insulin secretion     103673552 (PLCB2)    04922 Glucagon signaling pathway     103673552 (PLCB2)    04929 GnRH secretion     103673552 (PLCB2)    04912 GnRH signaling pathway     103673552 (PLCB2)    04915 Estrogen signaling pathway     103673552 (PLCB2)    04921 Oxytocin signaling pathway     103673552 (PLCB2)    04926 Relaxin signaling pathway     103673552 (PLCB2)    04935 Growth hormone synthesis, secretion and action     103673552 (PLCB2)    04918 Thyroid hormone synthesis     103673552 (PLCB2)    04919 Thyroid hormone signaling pathway     103673552 (PLCB2)    04928 Parathyroid hormone synthesis, secretion and action     103673552 (PLCB2)    04916 Melanogenesis     103673552 (PLCB2)    04924 Renin secretion     103673552 (PLCB2)    04925 Aldosterone synthesis and secretion     103673552 (PLCB2)    04927 Cortisol synthesis and secretion     103673552 (PLCB2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103673552 (PLCB2)    04270 Vascular smooth muscle contraction     103673552 (PLCB2)   09154 Digestive system    04970 Salivary secretion     103673552 (PLCB2)    04971 Gastric acid secretion     103673552 (PLCB2)    04972 Pancreatic secretion     103673552 (PLCB2)    04973 Carbohydrate digestion and absorption     103673552 (PLCB2)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     103673552 (PLCB2)   09156 Nervous system    04724 Glutamatergic synapse     103673552 (PLCB2)    04725 Cholinergic synapse     103673552 (PLCB2)    04728 Dopaminergic synapse     103673552 (PLCB2)    04726 Serotonergic synapse     103673552 (PLCB2)    04720 Long-term potentiation     103673552 (PLCB2)    04730 Long-term depression     103673552 (PLCB2)    04723 Retrograde endocannabinoid signaling     103673552 (PLCB2)   09157 Sensory system    04742 Taste transduction     103673552 (PLCB2)    04750 Inflammatory mediator regulation of TRP channels     103673552 (PLCB2)   09159 Environmental adaptation    04713 Circadian entrainment     103673552 (PLCB2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103673552 (PLCB2)   09164 Neurodegenerative disease    05010 Alzheimer disease     103673552 (PLCB2)    05016 Huntington disease     103673552 (PLCB2)    05017 Spinocerebellar ataxia     103673552 (PLCB2)    05022 Pathways of neurodegeneration - multiple diseases     103673552 (PLCB2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103673552 (PLCB2)    04934 Cushing syndrome     103673552 (PLCB2)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     103673552 (PLCB2)   09174 Infectious disease: parasitic    05146 Amoebiasis     103673552 (PLCB2)    05142 Chagas disease     103673552 (PLCB2)    05143 African trypanosomiasis     103673552 (PLCB2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103673552 (PLCB2) Enzymes [BR:umr01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      103673552 (PLCB2) Membrane trafficking [BR:umr04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     103673552 (PLCB2)  Endocytosis   Macropinocytosis    Phospholipase C     103673552 (PLCB2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y C2 EF-hand_like Gp58 Lectin_N Motif Other DBs NCBI-GeneID:  103673552 NCBI-ProteinID:  XP_008700556 UniProt:  A0A384D0K9 LinkDB All DBs Position Un AA seq 1093 aa AA seqDB search MSLLSPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE NVGQNWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFAPLVFSKVE AALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLT KFINQKQRDPRLNSLLFPPARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSV LAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDCWK GKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAE YCRMMFGDMLLTEPLEKFPLSPGTPLPSPEDLRGKILIKNKKNQFSGPAAPSTEPGEEAS VGDDTVWAGEEGAEPEEEEEEEEEEEEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYE EMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIY PKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRP DKQFNPFSVDRIDVVVATTLSITVISGQFLSDRSVRTYVEVELFGLPGDPKRRYRTKLSP SANSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHS ESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFSAQDKKSVKLKEAMGGLPEKP FPPGSPVVGPVNGTLAPTSNGSADFHLGWDPLCRKPWRLESALKGAHTATPPRGAGRSLP EPGAPGAPVSPPSCPCTTPQQISKMMELAREKQAAELKTLKETLETDTKEMKKKLEAKSL ERIQAMVKITSDKMAQERLKREINNSHIQEVVQVIKQMTENLEKHQEKLEEKQAACLEQI REMEKQFQQEALAEYEARMKGLEAEVKESVKACLRDCLPSQAKDKPERPCEAFRELCEQD PLTVKTGAQESRL NT seq 3282 nt NT seq  +upstreamnt  +downstreamnt atgtctctgctcagcccggtcctgctgccccccaaggtgaaggcttatctgagccaaggg gagcgcttcatcaaatgggacgatgaaaccacaatagcctccccggttatcctccgtgtg gatcccaagggctactacttatattggacatatcagagtaaggagatggagtttctggat atcaccagcatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag ctccgggatgtcttcaacatggacttccctgacaacaacttcctgcttaagacgctcact gtggtgtccggccctgacatggtggacctcaccttccacaacttcgtctcctacaaggag aatgtgggccagaactgggccgaagatgtgctggctctggtcaagcacccgctgacagcc aatgcctcccgcagcaccttcttggacaaaatcctggtcaagctcaagatgcagctcaac cctgaagggaagattcctgtgaaaaatttctttgctcctttagttttttccaaagtggaa gctgccctcagcgcctgccacctcccaaaaggcaagaatgatgccatcaatcctgaggac ttcccagaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaaatagac gagatcttcacttcctaccatgccaaggccaaaccctacatgaccaaggagcacttgacc aagttcatcaaccagaaacagagggacccccgtctcaactctttgctgtttccgccggcg cggcctgaccaggtgcggggcctcatcgacaagtatgagcccagtggcatcaacgtgcag aggggccagctctccccggagggcatggtgtggttcctctgtgggcccgagaacagcgtg ctggcccaggacaagctgcttctccaccatgacatgactcagccactcaaccattacttc atcaactcctcacacaacacctacctgacagccggccagttctctggcctttcctcggcc gagatgtaccgccaggtgctgctcgctggctgccgctgtgtggagctggactgctggaag ggcaagccccctgacgaggagcccattatcacccacggcttcaccatgaccacggacatc tacttcaaggaagcaattgaagccatcgcagaaagtgcctttaagacctccccctatcct gtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatggctgag tactgccggatgatgtttggggatatgctgctcacagagcccctggaaaagttcccgttg agcccaggcacccccctgcccagccctgaggatctccgaggcaagatcctcatcaagaat aaaaagaaccagttttctggcccagcggcccccagcacggagcctggagaggaggcctct gtgggggacgacacagtgtgggctggcgaggaaggggcagagccggaggaggaagaggag gaagaggaggaggaggaggaggaggaggaggaggaagagtcgggaaacctggatgaggag gagatcaagaagatgcagtcggatgagggcacagcgggcctggaggtgacagcttatgag gagatgtccagcctagtgaattacatccagcccaccaagttcatctcctttgagttctct gcccagaagaaccgaagttatgtcatctcgtctttcacagagctcaaggcctatgacctg ctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatgagccgcatttac cctaagggcacccgcatggactcctccaactacatgccccagatgttctggaacgccggt tgccagatggttgccctcaacttccagacgatggacctgcccatgcagcagaacatggcg ctgtttgagttcaatgggcagagtggctacctgctcaagcatgagttcatgcggcggcca gacaagcagttcaaccccttctccgtggaccgcatcgacgtggtggtagccaccaccctt tccatcacggtgatctctgggcagttcctgtcggatcgcagtgtgcgcacgtatgtggaa gtggaactgtttggccttcctggggaccccaagaggcgctatcgcaccaagctgtcaccc agcgccaactccatcaatcctgtctggaaggaggagccttttgtctttgagaagatcttg atgcctgagctggcctccctcagggtggctgtaatggaagaaggcaacaaatttcttggg caccgcatcatccccattaacgccctgaattctggctaccaccacctgtgcctgcacagc gagagcaacatgccccttaccatgcctgcactttttgtcttcctggagatgaaggactat gtacctgacacctgggcagatctcaccgtagctctcgccaatcccatcaagttcttcagt gcccaggataagaagtctgtgaagctcaaggaagccatgggaggtctgcccgagaaaccc ttcccacctgggagtccagttgtcggcccggtcaacgggacattggccccaacgagcaac gggtctgcagactttcacctgggatgggacccactgtgtcggaagccttggcgcttggaa agtgcgctaaagggggcccatactgccacacccccccggggggcggggaggagcctgcca gaaccaggggcccccggggcacctgtcagcccaccctcctgtccctgcaccaccccgcag caaatctccaagatgatggagctggccagagagaagcaggctgcagagctgaagaccctc aaggagaccttggagactgacaccaaagagatgaagaaaaagctggaggccaagagcctg gagcggattcaggccatggtcaaaatcacctcagacaagatggctcaggaaaggctgaag agagagattaacaactctcacatccaggaggtggtgcaagtcattaagcagatgacagag aacctggagaagcaccaggagaagctagaggagaagcaggcagcctgcctggaacagatc cgggagatggaaaagcagttccagcaggaggcgctggcagaatacgaggccaggatgaag ggcctggaggctgaggtgaaggagtcagtgaaggcctgcctcagggactgcttaccctct caggccaaggacaagcctgagaggccctgtgaggccttcagggagctgtgtgagcaggac ccactcacagtaaagacgggcgcccaggagagccgcctctga

Ursus maritimus (polar bear): 103674425 Help Entry 103674425         CDS       T03271                                  Gene name PLCB1 Definition (RefSeq) phospholipase C beta 1   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism umr  Ursus maritimus (polar bear) Pathway umr00562   Inositol phosphate metabolism umr01100   Metabolic pathways umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04062   Chemokine signaling pathway umr04070   Phosphatidylinositol signaling system umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04310   Wnt signaling pathway umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04621   NOD-like receptor signaling pathway umr04713   Circadian entrainment umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04728   Dopaminergic synapse umr04730   Long-term depression umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04922   Glucagon signaling pathway umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05016   Huntington disease umr05017   Spinocerebellar ataxia umr05022   Pathways of neurodegeneration - multiple diseases umr05142   Chagas disease umr05143   African trypanosomiasis umr05146   Amoebiasis umr05163   Human cytomegalovirus infection umr05200   Pathways in cancer Module umr_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103674425 (PLCB1)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103674425 (PLCB1)    04310 Wnt signaling pathway     103674425 (PLCB1)    04371 Apelin signaling pathway     103674425 (PLCB1)    04020 Calcium signaling pathway     103674425 (PLCB1)    04070 Phosphatidylinositol signaling system     103674425 (PLCB1)    04072 Phospholipase D signaling pathway     103674425 (PLCB1)    04071 Sphingolipid signaling pathway     103674425 (PLCB1)    04022 cGMP-PKG signaling pathway     103674425 (PLCB1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     103674425 (PLCB1)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103674425 (PLCB1)    04621 NOD-like receptor signaling pathway     103674425 (PLCB1)    04062 Chemokine signaling pathway     103674425 (PLCB1)   09152 Endocrine system    04911 Insulin secretion     103674425 (PLCB1)    04922 Glucagon signaling pathway     103674425 (PLCB1)    04929 GnRH secretion     103674425 (PLCB1)    04912 GnRH signaling pathway     103674425 (PLCB1)    04915 Estrogen signaling pathway     103674425 (PLCB1)    04921 Oxytocin signaling pathway     103674425 (PLCB1)    04926 Relaxin signaling pathway     103674425 (PLCB1)    04935 Growth hormone synthesis, secretion and action     103674425 (PLCB1)    04918 Thyroid hormone synthesis     103674425 (PLCB1)    04919 Thyroid hormone signaling pathway     103674425 (PLCB1)    04928 Parathyroid hormone synthesis, secretion and action     103674425 (PLCB1)    04916 Melanogenesis     103674425 (PLCB1)    04924 Renin secretion     103674425 (PLCB1)    04925 Aldosterone synthesis and secretion     103674425 (PLCB1)    04927 Cortisol synthesis and secretion     103674425 (PLCB1)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103674425 (PLCB1)    04270 Vascular smooth muscle contraction     103674425 (PLCB1)   09154 Digestive system    04970 Salivary secretion     103674425 (PLCB1)    04971 Gastric acid secretion     103674425 (PLCB1)    04972 Pancreatic secretion     103674425 (PLCB1)    04973 Carbohydrate digestion and absorption     103674425 (PLCB1)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     103674425 (PLCB1)   09156 Nervous system    04724 Glutamatergic synapse     103674425 (PLCB1)    04725 Cholinergic synapse     103674425 (PLCB1)    04728 Dopaminergic synapse     103674425 (PLCB1)    04726 Serotonergic synapse     103674425 (PLCB1)    04720 Long-term potentiation     103674425 (PLCB1)    04730 Long-term depression     103674425 (PLCB1)    04723 Retrograde endocannabinoid signaling     103674425 (PLCB1)   09157 Sensory system    04742 Taste transduction     103674425 (PLCB1)    04750 Inflammatory mediator regulation of TRP channels     103674425 (PLCB1)   09159 Environmental adaptation    04713 Circadian entrainment     103674425 (PLCB1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103674425 (PLCB1)   09164 Neurodegenerative disease    05010 Alzheimer disease     103674425 (PLCB1)    05016 Huntington disease     103674425 (PLCB1)    05017 Spinocerebellar ataxia     103674425 (PLCB1)    05022 Pathways of neurodegeneration - multiple diseases     103674425 (PLCB1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103674425 (PLCB1)    04934 Cushing syndrome     103674425 (PLCB1)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     103674425 (PLCB1)   09174 Infectious disease: parasitic    05146 Amoebiasis     103674425 (PLCB1)    05142 Chagas disease     103674425 (PLCB1)    05143 African trypanosomiasis     103674425 (PLCB1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103674425 (PLCB1) Enzymes [BR:umr01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      103674425 (PLCB1) Membrane trafficking [BR:umr04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     103674425 (PLCB1)  Endocytosis   Macropinocytosis    Phospholipase C     103674425 (PLCB1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X PLC-beta_C PI-PLC-Y EF-hand_like PH_14 C2 DUF1154 Motif Other DBs NCBI-GeneID:  103674425 NCBI-ProteinID:  XP_008701560 UniProt:  A0A384D493 LinkDB All DBs Position Un AA seq 1072 aa AA seqDB search MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN NSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCK KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTK SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYE YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRI LPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME QRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHS QPAPGSVKAPAKTEDLIQSVLTEVEAQTIDELKQQKSFVKLQKKHYKEMKDLVKRHHRKT TDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSDPSSPDHGSSTIEQDLAALDAEM TQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQMKKLKEIC EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ EKLVEKHKEIRQQILDEKPKGDGSSSFLSETCHEDPSVSPNFTPPNPQALKW NT seq 3219 nt NT seq  +upstreamnt  +downstreamnt atgataacagtggtgtatgggcctgacttggttaacatctcccacttgaatctcgtggct ttccaagaagaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctg ctggcccaaaacatgtcaagagatgcatttctggaaaaagcctatactaagcttaagctg caagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagcagac cggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaacgattca atacctcaagaagatttcactccagaagtgtacagagttttcctgaacaatctttgccct cgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccataccttacc gtcgatcagatgatggactttatcaatcttaagcagagagatccccggctaaatgaaata ctttatccacctttaaagcaagaacaagtccaagtattgattgagaagtatgagcccaac aatagcctcgccaaaaaaggacagatatcagtggatggctttatgcgctatctaagtgga gaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcagccc ctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagttggct ggaaactcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggag ttggactgctggaagggacggactgctgaagaggaaccagtcatcacccatgggttcacc atgacaactgaaatatccttcaaggaagtgatagaagcaatcgctgagtgtgcatttaag acatcaccttttccaattctgctttcatttgagaaccacgtagattctccaaagcagcaa gccaagatggcggagtattgccgactgatctttggagatgctcttctcatggaaccactg gaaaaatacccactggaatctggagttcctcttccaagtcctatggatttaatgtacaaa attttggtgaaaaataagaagaaatcgcacaagtcatcagaaggaagtggcaaaaagaag ctctcggaacaagcctccaacacgtacagtgactcctccagcgtgtttgaaccctcgtct ccaggagccggggaagctgataccgagagtgatgatgatgatgatgatgatgactgtaaa aaatcttcaatggatgaggggactgctgggagtgaggccatggccaccgaagagatgtct aacctggtgaactatattcagccagtcaagtttgagtcatttgaaatttcaaaaaagaga aatagaagttttgaaatgtcttccttcgtggaaaccaaaggtctcgagcagctgacgaaa tcgccagtggaatttgtagaatacaacaaaatgcagcttagcaggatatatccaaaagga acccgtgtggattcatctaactacatgcctcagctcttctggaatgcgggttgccaaatg gttgcacttaattttcaaactgtggacctggctatgcagataaatatggggatgtacgaa tacaatgggaaaagtggctacagattaaagccagagttcatgaggagacctgacaagcat tttgatccattcaccgaaggcatcgtggatgggatagtggccaacactttatctgtcaag attatttcaggtcagtttctttctgataagaaagttgggacttacgtggaagtggatatg tttggtttgcctgtggacacgaggaggaaggcgtttaagaccaaaacatcacaaggaaat gctgtaaatcctgtctgggaagaggagcccattgtgttcaaaaaggtggttcttccttcg ctggcctgtttgaggatagcagtttatgaagaagggggtaaatttatcggtcaccggatc ttgccagtacaggcgattcggccaggctatcactacatctgtctgaggaatgagaggaac cagcctctgacgctcccagctgtctttgtctacatagaggtgaaagactatgtcccagat acatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggag caaagagctaaacagttggctgctttgacactggaagatgaagaagaagtaaagaaagag gccgatcctggggaaacaccgtcagaagctccaagtgaagccaggacaacgccagcagaa aatggagtgaatcacactacgtccctggcacccaaaccaccttcccaggctctccacagc caaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgtt ttaacagaagtggaagcccagaccatcgacgagctaaagcagcagaaatcgtttgtgaaa cttcaaaagaaacactacaaagaaatgaaagacctggttaaaagacaccacaggaaaacc actgaccttatcaaggagcacactacaaaatataatgaaattcagaatgattacttgagg aggagggcagctttggagaagacagccaaaaaggacagtaagaaaaaatcagatcctagc agtcctgaccatggttcgtcaacgattgagcaagatcttgctgccctagatgccgaaatg acccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgacaa gagcagtattacagtgaaaaataccagaagcgagagcatattaaactgcttattcaaaag ttgacggatgttgctgaagaatgtcagaacaatcagatgaagaagctcaaagaaatctgt gagaaagagaagaaggaattaaagaagaagatggacaaaaaaaggcaggagaagataaca gaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccggtca tacatccaggaggtggtgcagtacatcaagaggttagaagaggcccaaagtaaacggcaa gaaaaacttgtagagaaacacaaggagatacgtcagcagatcctggacgaaaagcccaag ggggacggttcctcctcattcttgtcggaaacttgccatgaggatccctctgtttccccc aactttactccccccaaccctcaagctctcaagtggtga

Ursus maritimus (polar bear): 103674426 Help Entry 103674426         CDS       T03271                                  Gene name PLCB4 Definition (RefSeq) phospholipase C beta 4   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism umr  Ursus maritimus (polar bear) Pathway umr00562   Inositol phosphate metabolism umr01100   Metabolic pathways umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04062   Chemokine signaling pathway umr04070   Phosphatidylinositol signaling system umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04310   Wnt signaling pathway umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04621   NOD-like receptor signaling pathway umr04713   Circadian entrainment umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04728   Dopaminergic synapse umr04730   Long-term depression umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04922   Glucagon signaling pathway umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05016   Huntington disease umr05017   Spinocerebellar ataxia umr05022   Pathways of neurodegeneration - multiple diseases umr05142   Chagas disease umr05143   African trypanosomiasis umr05146   Amoebiasis umr05163   Human cytomegalovirus infection umr05200   Pathways in cancer Module umr_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103674426 (PLCB4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103674426 (PLCB4)    04310 Wnt signaling pathway     103674426 (PLCB4)    04371 Apelin signaling pathway     103674426 (PLCB4)    04020 Calcium signaling pathway     103674426 (PLCB4)    04070 Phosphatidylinositol signaling system     103674426 (PLCB4)    04072 Phospholipase D signaling pathway     103674426 (PLCB4)    04071 Sphingolipid signaling pathway     103674426 (PLCB4)    04022 cGMP-PKG signaling pathway     103674426 (PLCB4)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     103674426 (PLCB4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103674426 (PLCB4)    04621 NOD-like receptor signaling pathway     103674426 (PLCB4)    04062 Chemokine signaling pathway     103674426 (PLCB4)   09152 Endocrine system    04911 Insulin secretion     103674426 (PLCB4)    04922 Glucagon signaling pathway     103674426 (PLCB4)    04929 GnRH secretion     103674426 (PLCB4)    04912 GnRH signaling pathway     103674426 (PLCB4)    04915 Estrogen signaling pathway     103674426 (PLCB4)    04921 Oxytocin signaling pathway     103674426 (PLCB4)    04926 Relaxin signaling pathway     103674426 (PLCB4)    04935 Growth hormone synthesis, secretion and action     103674426 (PLCB4)    04918 Thyroid hormone synthesis     103674426 (PLCB4)    04919 Thyroid hormone signaling pathway     103674426 (PLCB4)    04928 Parathyroid hormone synthesis, secretion and action     103674426 (PLCB4)    04916 Melanogenesis     103674426 (PLCB4)    04924 Renin secretion     103674426 (PLCB4)    04925 Aldosterone synthesis and secretion     103674426 (PLCB4)    04927 Cortisol synthesis and secretion     103674426 (PLCB4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103674426 (PLCB4)    04270 Vascular smooth muscle contraction     103674426 (PLCB4)   09154 Digestive system    04970 Salivary secretion     103674426 (PLCB4)    04971 Gastric acid secretion     103674426 (PLCB4)    04972 Pancreatic secretion     103674426 (PLCB4)    04973 Carbohydrate digestion and absorption     103674426 (PLCB4)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     103674426 (PLCB4)   09156 Nervous system    04724 Glutamatergic synapse     103674426 (PLCB4)    04725 Cholinergic synapse     103674426 (PLCB4)    04728 Dopaminergic synapse     103674426 (PLCB4)    04726 Serotonergic synapse     103674426 (PLCB4)    04720 Long-term potentiation     103674426 (PLCB4)    04730 Long-term depression     103674426 (PLCB4)    04723 Retrograde endocannabinoid signaling     103674426 (PLCB4)   09157 Sensory system    04742 Taste transduction     103674426 (PLCB4)    04750 Inflammatory mediator regulation of TRP channels     103674426 (PLCB4)   09159 Environmental adaptation    04713 Circadian entrainment     103674426 (PLCB4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103674426 (PLCB4)   09164 Neurodegenerative disease    05010 Alzheimer disease     103674426 (PLCB4)    05016 Huntington disease     103674426 (PLCB4)    05017 Spinocerebellar ataxia     103674426 (PLCB4)    05022 Pathways of neurodegeneration - multiple diseases     103674426 (PLCB4)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103674426 (PLCB4)    04934 Cushing syndrome     103674426 (PLCB4)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     103674426 (PLCB4)   09174 Infectious disease: parasitic    05146 Amoebiasis     103674426 (PLCB4)    05142 Chagas disease     103674426 (PLCB4)    05143 African trypanosomiasis     103674426 (PLCB4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103674426 (PLCB4) Enzymes [BR:umr01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      103674426 (PLCB4) Membrane trafficking [BR:umr04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     103674426 (PLCB4)  Endocytosis   Macropinocytosis    Phospholipase C     103674426 (PLCB4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X PH_14 PI-PLC-Y DUF1154 EF-hand_like C2 EF-hand_7 EF-hand_6 Motif Other DBs NCBI-GeneID:  103674426 NCBI-ProteinID:  XP_008701564 UniProt:  A0A384D446 LinkDB All DBs Position Un AA seq 1187 aa AA seqDB search MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL ECSLINSVRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM MEAGESTAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ SSSELRPTTTVALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLISAHEQQTQQLKLS HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK QSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV NT seq 3564 nt NT seq  +upstreamnt  +downstreamnt atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga gctgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta gaatgctccctcatcaacagtgttcgcctgggagccaccccaaaggatcccaaaatcctg gccgctcttgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtc tgcagtggcacggatctggtgaacatcagtttcacatacatggtggctgaaaatccggaa gtaactaagcaatgggtagaaggactgagatcaatcatacacaacttcagggccaacaat gtcagtccaatgacctgcctcaagaagcactggatgaaattggcgtttatgaccaacaca aacggtaaaattccagttaggagcattactagaacctttgcatcggggaaaacagaaaag gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag cctacagcctttacatacgaaaagttctatgaactgacacaaaagatttgtcctcggaca gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc ccattttatgatgctaaaagggcaatgcagatcatcgagatgtatgagcctgatgaagac ttgaagaaaaaaggcctcatatcaagcgacgggttttgcagatatctgatgtccgatgaa aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcccctggcc cactacttcatcagttcttcccacaacacctatctcacgggccgacagtttggcgggaaa tcttcagtagaaatgtacagacaggtgctcctggctggttgcagatgtgttgaacttgac tgttgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacgtcc gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg tccaaatattgcgaagatctatttggggacctcctgttgaaacaagcacttgaatcacat ccacttgaaccaggcaggcccttaccatcccccaatgacctcaaaagaaaaatactcatc aaaaataaacggctgaaacctgaggttgaaaaaaaacagctcgaagctttgaaaagcatg atggaagctggagaatccactgccccagttagcatcctagaggacgataatgaagaggag atagaaagtgctgaccaagaggaggaggctcacccggaatacaaatttggaaacgaactt tctgctgatgacttgggccacaaggaggctgttgccaatagtgtcaagaaggcttcagat gaccttgaacatgaaatcaacaaaaagggcctggtcactgtggaagatgaacaggcatgg atggcatcgtataaatacgtaggtgctaccactaatatccatccgtatttgtctacaatg atcaactatgcacagcctgtaaagttccaaggtttccatgtggctgaagagcgcaatatc cattataacatgtcttcttttaatgagtccgtcggtctgggctatttgaagacacacgcg attgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaagggaggccgg gtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttcg ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat ggatcgtgcgggtacctcctcaaaccagatttcatgagacggccggatcgaacgttcgat cccttctctgaaactcctgttgatggggttattgcagccacttgctcagtgcaggtcata tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtacggg ttgcccactgacaccatacgtaaggaattccgaactcgcatggtgatgaacaacggactc aatccagtttacaatgaagaatcctttgtgtttcggaaggtaatcctccctgacctggca gtcttgagaatagcagtgtatgatgacaacaacaggctgataggccagaggattcttcca ctggatggcctccaagcaggctatcgacacatttctcttcgaaatgagggaaataaacca ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgacggattt ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgaccccacag agcagctccgagctcagaccaaccaccacggtggccctggggtctggcgtggaagccaag aaaggtatcgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac ttgaagcatttaaagaaacaacagaaggagctaaattctttaaagaagaaacatgcaaag gagcacagcacaatgcagaagttgcactgcacgcaagttgacaaaattgtggcccagtat gacaaagagaagtcaacgcatgagaaaatcctagagaaggcgatgaagaagaagggggga agtaattgtctcgaaatgaaaaaagaaaccgaaattaaaattcagacactgacatcagat cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc aacacccacagtgctgaggagcaagagatccgggacctccacctcagccagcagtgtgag ctcctgcgaaagctactgatcagtgcccacgagcagcaaacccagcagctcaaactgtcc catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc aaagccatcagccaagataaatctatcaagaacaaagcagaacgggaaaggcgagtcagg gaattaaatagcagcaacaccaaaaagtttctggaagaaagaaagagactcgcaatgaaa cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctcgagttcctagag aaacagaatgaacaggcgaaggagatgcagcagatggtgaagttggaagccgagatggac cgcaggccagcaacagtagtgtga

Ursus maritimus (polar bear): 103679549 Help Entry 103679549         CDS       T03271                                  Gene name PLCB3 Definition (RefSeq) phospholipase C beta 3   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism umr  Ursus maritimus (polar bear) Pathway umr00562   Inositol phosphate metabolism umr01100   Metabolic pathways umr04015   Rap1 signaling pathway umr04020   Calcium signaling pathway umr04022   cGMP-PKG signaling pathway umr04062   Chemokine signaling pathway umr04070   Phosphatidylinositol signaling system umr04071   Sphingolipid signaling pathway umr04072   Phospholipase D signaling pathway umr04261   Adrenergic signaling in cardiomyocytes umr04270   Vascular smooth muscle contraction umr04310   Wnt signaling pathway umr04371   Apelin signaling pathway umr04540   Gap junction umr04611   Platelet activation umr04621   NOD-like receptor signaling pathway umr04713   Circadian entrainment umr04720   Long-term potentiation umr04723   Retrograde endocannabinoid signaling umr04724   Glutamatergic synapse umr04725   Cholinergic synapse umr04726   Serotonergic synapse umr04728   Dopaminergic synapse umr04730   Long-term depression umr04742   Taste transduction umr04750   Inflammatory mediator regulation of TRP channels umr04911   Insulin secretion umr04912   GnRH signaling pathway umr04915   Estrogen signaling pathway umr04916   Melanogenesis umr04918   Thyroid hormone synthesis umr04919   Thyroid hormone signaling pathway umr04921   Oxytocin signaling pathway umr04922   Glucagon signaling pathway umr04924   Renin secretion umr04925   Aldosterone synthesis and secretion umr04926   Relaxin signaling pathway umr04927   Cortisol synthesis and secretion umr04928   Parathyroid hormone synthesis, secretion and action umr04929   GnRH secretion umr04933   AGE-RAGE signaling pathway in diabetic complications umr04934   Cushing syndrome umr04935   Growth hormone synthesis, secretion and action umr04961   Endocrine and other factor-regulated calcium reabsorption umr04970   Salivary secretion umr04971   Gastric acid secretion umr04972   Pancreatic secretion umr04973   Carbohydrate digestion and absorption umr05010   Alzheimer disease umr05016   Huntington disease umr05017   Spinocerebellar ataxia umr05022   Pathways of neurodegeneration - multiple diseases umr05142   Chagas disease umr05143   African trypanosomiasis umr05146   Amoebiasis umr05163   Human cytomegalovirus infection umr05200   Pathways in cancer Module umr_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:umr00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103679549 (PLCB3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103679549 (PLCB3)    04310 Wnt signaling pathway     103679549 (PLCB3)    04371 Apelin signaling pathway     103679549 (PLCB3)    04020 Calcium signaling pathway     103679549 (PLCB3)    04070 Phosphatidylinositol signaling system     103679549 (PLCB3)    04072 Phospholipase D signaling pathway     103679549 (PLCB3)    04071 Sphingolipid signaling pathway     103679549 (PLCB3)    04022 cGMP-PKG signaling pathway     103679549 (PLCB3)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     103679549 (PLCB3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103679549 (PLCB3)    04621 NOD-like receptor signaling pathway     103679549 (PLCB3)    04062 Chemokine signaling pathway     103679549 (PLCB3)   09152 Endocrine system    04911 Insulin secretion     103679549 (PLCB3)    04922 Glucagon signaling pathway     103679549 (PLCB3)    04929 GnRH secretion     103679549 (PLCB3)    04912 GnRH signaling pathway     103679549 (PLCB3)    04915 Estrogen signaling pathway     103679549 (PLCB3)    04921 Oxytocin signaling pathway     103679549 (PLCB3)    04926 Relaxin signaling pathway     103679549 (PLCB3)    04935 Growth hormone synthesis, secretion and action     103679549 (PLCB3)    04918 Thyroid hormone synthesis     103679549 (PLCB3)    04919 Thyroid hormone signaling pathway     103679549 (PLCB3)    04928 Parathyroid hormone synthesis, secretion and action     103679549 (PLCB3)    04916 Melanogenesis     103679549 (PLCB3)    04924 Renin secretion     103679549 (PLCB3)    04925 Aldosterone synthesis and secretion     103679549 (PLCB3)    04927 Cortisol synthesis and secretion     103679549 (PLCB3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103679549 (PLCB3)    04270 Vascular smooth muscle contraction     103679549 (PLCB3)   09154 Digestive system    04970 Salivary secretion     103679549 (PLCB3)    04971 Gastric acid secretion     103679549 (PLCB3)    04972 Pancreatic secretion     103679549 (PLCB3)    04973 Carbohydrate digestion and absorption     103679549 (PLCB3)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     103679549 (PLCB3)   09156 Nervous system    04724 Glutamatergic synapse     103679549 (PLCB3)    04725 Cholinergic synapse     103679549 (PLCB3)    04728 Dopaminergic synapse     103679549 (PLCB3)    04726 Serotonergic synapse     103679549 (PLCB3)    04720 Long-term potentiation     103679549 (PLCB3)    04730 Long-term depression     103679549 (PLCB3)    04723 Retrograde endocannabinoid signaling     103679549 (PLCB3)   09157 Sensory system    04742 Taste transduction     103679549 (PLCB3)    04750 Inflammatory mediator regulation of TRP channels     103679549 (PLCB3)   09159 Environmental adaptation    04713 Circadian entrainment     103679549 (PLCB3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103679549 (PLCB3)   09164 Neurodegenerative disease    05010 Alzheimer disease     103679549 (PLCB3)    05016 Huntington disease     103679549 (PLCB3)    05017 Spinocerebellar ataxia     103679549 (PLCB3)    05022 Pathways of neurodegeneration - multiple diseases     103679549 (PLCB3)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     103679549 (PLCB3)    04934 Cushing syndrome     103679549 (PLCB3)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     103679549 (PLCB3)   09174 Infectious disease: parasitic    05146 Amoebiasis     103679549 (PLCB3)    05142 Chagas disease     103679549 (PLCB3)    05143 African trypanosomiasis     103679549 (PLCB3)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:umr04131]     103679549 (PLCB3) Enzymes [BR:umr01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      103679549 (PLCB3) Membrane trafficking [BR:umr04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     103679549 (PLCB3)  Endocytosis   Macropinocytosis    Phospholipase C     103679549 (PLCB3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 EF-hand_like C2 BPL_N Motif Other DBs NCBI-GeneID:  103679549 NCBI-ProteinID:  XP_008707335 UniProt:  A0A384DKL7 LinkDB All DBs Position Un AA seq 1255 aa AA seqDB search MSGLTGCHGALRDTKAEASSRNLVTLRVDSNGFFLYWTGPNMEVDTLDISSIRDTRTGRY ARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNFMAVQDDTAKVWTEELFK LAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNF NRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDP RLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLST DMTQPLSSYFINSSHNTYLTGREQETPWWCSSAGRRPEAGRVLGQVEALLGGCRCVELDV WKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKM AEYWRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPNSSVRKR PLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGPEKPSLEPQKSLGEDGLPR GPDALGSADREDEEEEEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSF EAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFW NVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVA NALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK ALHVSGSGSGSWPSVVFEKRTRSLRPFISLVVVPTAPCDRRGAQARRAEGSRPGALGSPG RLEPAFLGKSLLLSPRQAQAGPETCQETQSQQLGSQLTPNPTPSPRGTSPRRPPGPVTSP TSPSLSSPGQRDDLIASLLSEVAPTPLDELRGHKALVKLRSRQERGLHSVPPSLPGCQAA VEVPHEERVCPETVAPTGSQRLHGANGPRCWHPRPCPHPSRGWCPPLPVGICPVRPCPPS PSPCDNQRVTQRGSSYRGGENEKEEEEEVRRYQEFQKRQVQSLLELREAQVDTEAERRLE HLRQAQQRLREIVLDFHTTQFKRLKEMNEREKKELQKILDRKRHNSISEAKTREKHKKEA ELTEINRRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQ RARLPQEIRRSLLGDTPEGLGDGRLVACASNGHAPGSGGHLSGADSESQEENTKL NT seq 3768 nt NT seq  +upstreamnt  +downstreamnt atgtcagggctgactggttgtcatggggccctgagggacacaaaagcggaggcctccagt cggaacctggtaaccctgcgtgtggactcgaatggcttctttctgtactggaccggaccc aacatggaggtggacacactggacatcagttccatcagggacacgcggacggggcgttac gcccgcctgcccaaggaccccaagatccgggaggtgctgggctttgggggccctgacgcc cggctggaggagaagttgatgacggtggtggctgggccagacccagtgaatacaacgttc ttgaacttcatggccgtgcaggatgacacagccaaggtctggaccgaggagctgttcaag ctggctatgaacatcctggctcagaacgcctcccggaacaccttcctgcgaaaagcatac acaaagctgaagctgcaagtgaaccaggacggacggatcccggtgaagaatatcctgaag atgttttcagcagataaaaagcgagtagagactgcactggaatcctgtggcctcaatttc aaccggagtgagtccatccggccggacgaattttccttggaaatcttcgagcggttcctg aataagttgtgtttgcggccagacattgacaagatcctgctggagataggcgccaagggc aagccgtatctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccg aggctcaacgaagtgctgtacccacccctgcggccctcgcaggcccggctgctcattgag aagtatgagcccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagc cgctacctgggaggtgaggagaacggcatcctgcctctggaggccctggatctgagcaca gacatgacccagccgctgagctcctacttcatcaactcctcgcacaacacctatctcaca ggccgggagcaggagactccttggtggtgctcttcggcgggaaggaggccggaggccggg cgggtgctggggcaggtggaggcgctgctggggggctgccgctgcgtggagctggatgtg tggaaagggcggccgcccgaggaggagcccttcatcacccacggcttcaccatgaccacc gaggtgccgctgcgagatgtgctcgaggccatcgcggaaaccgccttcaagacctcgccc taccccgtcatcctctccttcgagaaccacgtggactcggcaaagcagcaggccaagatg gccgagtactggcgttccatctttggggacgcgctgctcattgacccactggacaagtac ccgctggccccaggcgtccccctgcccagcccccaggacctgatgggccgcatcctggtg aagaacaaaaagcgacaccggcccagcactggtgtccccaacagctctgtgcgtaagcgg ccgctggagcagagcaactcggccctgagcgagagctctgccgccaccgagccctcctca cctcagctcgggtcccccagttctgacagctgcccaggcctgagcaacggggaagaggtg ggcccggagaagcccagcctggagcctcaaaagtctctgggcgaggacgggctaccgagg ggccctgatgctcttgggtctgctgaccgtgaggacgaggaggaagaggaggaagaggag gaacagacagatcctaaaaagccgaccacagatgagggcactgctagcagtgaggtcaat gccaccgaggaaatgtcaacactcgtcaactacatcgagcctgtcaagttcaagtccttt gaggctgctcgaaaaaggaacaaatgcttcgagatgtcatccttcgtggaaaccaaggcc atggagcagctgaccaagagccccatggagtttgtggaatacaataagcagcagctcagc cggatctaccccaagggcacccgcgtggactcgtccaactacatgccccagctcttctgg aacgtcggctgccagcttgtcgcgctcaacttccagaccctggacgtggcgatgcagctc aacgcgggcgtgttcgagtacaacgggcgcagcggctacctgctcaagcccgagttcatg cggcggccagacaagtccttcgatcccttcaccgaggtcatcgtggacggcatcgtggcc aatgccttgcgggtcaaggtgatctcggggcagttcctgtccgacaggaaggtgggcatc tacgtggaggtggacatgttcggcctccccgtggacacgcggcgcaagtaccgcactcgg acctctcaggggaactccttcaatcctgtgtgggacgaggagccctttgacttccccaag gccctgcatgtgtcagggtcgggctcgggctcctggccctctgtagtcttcgagaagagg acaagaagtttgagaccttttatttctctcgtagttgttccaacagccccatgtgataga cgtggagcccaggccagaagggctgagggaagccggccgggggcactggggagccccggg aggttagaaccagcatttctaggaaagagccttctgctttctccccgtcaggctcaggcc ggcccagagacctgccaggagactcagtctcagcagctggggtcccagctgaccccaaac cccacacccagccctcggggcacctccccgcgccggcccccaggccctgtcacgtcccct accagcccctcgctcagcagtccagggcagcgggacgacctcatcgccagtctcctgtca gaggtggccccgaccccgctggatgagctccgaggccacaaggcgctggtgaagctccgg agccggcaggagagggggctacactcggtcccaccctctctgccagggtgccaggccgct gttgaagtcccccacgaggagcgtgtatgtccagagactgttgcccctacaggctcccag cgtttgcacggagcgaatgggcctcgttgttggcatcctagaccctgcccccacccctcc cggggctggtgtcctccgttgcctgttgggatctgccctgtccgcccctgccctcccagc ccaagtccatgtgacaaccagagagtcacccagaggggttcttcctacagaggcggggaa aacgagaaggaggaggaggaagaggtgaggcggtatcaagagttccagaagagacaggtg cagagtctgctggagctgagggaggcccaggtagatacagaggctgagcggaggctggag cacctgagacaggctcagcagcggctcagggagattgtcctggattttcacacaactcag ttcaagaggctgaaggagatgaacgagagggagaagaaggaactgcagaagattctggac aggaagcgccacaacagtatctcagaggccaagacaagggagaaacataagaaggaggcg gaactgacagagattaaccggcggcatatcaccgagtcggtcaactccatccgccggctg gaggaggcccagaagcagcggcatgagcgccttgtggccgggcagcagcaggtcctacag cagctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcag cgggcgaggctgccccaggagatccgccggagcctgctgggcgacacgccggaggggctg ggggacgggcgtctggtggcctgtgccagcaacggtcacgcacccgggagcggcgggcac ctgtctggcgctgactcggagagccaagaggagaatacgaagctctga

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