KEGG   PATHWAY: van00010Help
Entry
van00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Vibrio anguillarum 775
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
van00010  Glycolysis / Gluconeogenesis
van00010

Ortholog table
Module
van_M00002  Glycolysis, core module involving three-carbon compounds [PATH:van00010]
van_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:van00010]
van_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:van00010]
Other DBs
GO: 0006096 0006094
Organism
Vibrio anguillarum 775 [GN:van]
Gene
VAA_00264  Glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
VAA_02577  6-phosphofructokinase 1 [KO:K00850] [EC:2.7.1.11]
VAA_02726  Fructose-1,6-bisphosphatase [KO:K03841] [EC:3.1.3.11]
VAA_02578  Fructose-1,6-bisphosphatase [KO:K02446] [EC:3.1.3.11]
VAA_00184  Fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
VAA_02595  Triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
VAA_02960  Glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
VAA_00950  Glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
VAA_02344  Glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
VAA_00185  Phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
VAA_00342  Phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
VAA_03764  Enolase [KO:K01689] [EC:4.2.1.11]
VAA_00177  Pyruvate kinase [KO:K00873] [EC:2.7.1.40]
VAA_03328  Pyruvate kinase [KO:K00873] [EC:2.7.1.40]
VAA_01561  Pyruvate kinase [KO:K00873] [EC:2.7.1.40]
VAA_00740  Pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
VAA_00741  Dihydrolipoamide acetyltransferase component of pyruvate [KO:K00627] [EC:2.3.1.12]
VAA_02624  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
VAA_00742  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
VAA_01187  Glutathione-dependent formaldehyde dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
VAA_03354  Alcohol dehydrogenase [KO:K04072] [EC:1.2.1.10 1.1.1.1]
VAA_01457  hypothetical protein [KO:K13954] [EC:1.1.1.1]
VAA_02547  Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
VAA_03420  Phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
VAA_02345  Aldose 1-epimerase family protein [KO:K01792] [EC:5.1.3.15]
VAA_00658  Phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
VAA_01451  6-phospho-beta-glucosidase [KO:K01223] [EC:3.2.1.86]
VAA_01085  PTS system, glucose-specific IIA component [KO:K02777] [EC:2.7.1.-]
VAA_03335  PTS system, glucose-specific IIBC component [KO:K02779] [EC:2.7.1.199]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
van00020  Citrate cycle (TCA cycle)
van00030  Pentose phosphate pathway
van00500  Starch and sucrose metabolism
van00620  Pyruvate metabolism
van00640  Propanoate metabolism
KO pathway
ko00010   
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