KEGG   PATHWAY: vvp04115
vvp04115                    Pathway                                

p53 signaling pathway - Vulpes vulpes (red fox)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
vvp04115  p53 signaling pathway

Vulpes vulpes (red fox) [GN:vvp]
112925961  ATM; serine-protein kinase ATM [KO:K04728] [EC:]
112906959  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:]
112934959  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:]
112920276  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:]
112923476  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
112911644  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
112922285  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:]
112914392  MDM4; protein Mdm4 [KO:K10127]
112924853  TP53; cellular tumor antigen p53 [KO:K04451]
112913942  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112924157  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112917379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112913983  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112922331  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
112923889  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
112931227  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112928464  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112922404  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:]
112931790  SFN; 14-3-3 protein sigma [KO:K06644]
112921925  G2/mitotic-specific cyclin-B1-like [KO:K05868]
112935841  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112917134  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
112931083  CDK1; LOW QUALITY PROTEIN: cyclin-dependent kinase 1 [KO:K02087] [EC:]
112908633  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112910526  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112935608  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112935856  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
112931965  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
112924121  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
112922873  CASP8; caspase-8 [KO:K04398] [EC:]
112917438  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
112931372  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112919301  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
112931366  BBC3; LOW QUALITY PROTEIN: bcl-2-binding component 3 [KO:K10132]
112930309  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
112909902  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112919203  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
112908482  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
112920278  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
112912079  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
112919473  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
112926216  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
112931753  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:]
112916549  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
112915706  cytochrome c [KO:K08738]
112930669  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112929772  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:]
112934766  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:]
112923938  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
112930717  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112935788  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
112909226  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
112924116  CD82; CD82 antigen [KO:K06509]
112919933  THBS1; thrombospondin-1 [KO:K16857]
112919310  SERPINB5; serpin B5 isoform X1 [KO:K10139]
112924073  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112927720  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:]
112916984  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:]
112915770  SESN3; sestrin-3 isoform X1 [KO:K10141]
112925157  SESN1; sestrin-1 isoform X1 [KO:K10141]
112931735  SESN2; sestrin-2 [KO:K20394]
112931976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:]
112909041  TSC2; tuberin isoform X1 [KO:K07207]
112934329  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
112921727  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:]
112915542  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:]
112926540  CCNG1; cyclin-G1 [KO:K10145]
112910878  cyclin-G1 [KO:K10145]
112919717  CCNG2; cyclin-G2 [KO:K10146]
112917953  PPM1D; protein phosphatase 1D [KO:K10147] [EC:]
112924708  TP73; tumor protein p73 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
vvp04110  Cell cycle
vvp04210  Apoptosis
vvp04218  Cellular senescence
KO pathway

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