KEGG   Vulpes vulpes (red fox): 112911512
Entry
112911512         CDS       T05911                                 

Gene name
IKBKG
Definition
(RefSeq) NF-kappa-B essential modulator isoform X1
  KO
K07210  inhibitor of nuclear factor kappa-B kinase subunit gamma
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp01523  Antifolate resistance
vvp04010  MAPK signaling pathway
vvp04014  Ras signaling pathway
vvp04062  Chemokine signaling pathway
vvp04064  NF-kappa B signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04210  Apoptosis
vvp04380  Osteoclast differentiation
vvp04620  Toll-like receptor signaling pathway
vvp04621  NOD-like receptor signaling pathway
vvp04622  RIG-I-like receptor signaling pathway
vvp04623  Cytosolic DNA-sensing pathway
vvp04625  C-type lectin receptor signaling pathway
vvp04657  IL-17 signaling pathway
vvp04658  Th1 and Th2 cell differentiation
vvp04659  Th17 cell differentiation
vvp04660  T cell receptor signaling pathway
vvp04662  B cell receptor signaling pathway
vvp04668  TNF signaling pathway
vvp04920  Adipocytokine signaling pathway
vvp05132  Salmonella infection
vvp05135  Yersinia infection
vvp05142  Chagas disease
vvp05145  Toxoplasmosis
vvp05160  Hepatitis C
vvp05161  Hepatitis B
vvp05162  Measles
vvp05163  Human cytomegalovirus infection
vvp05164  Influenza A
vvp05165  Human papillomavirus infection
vvp05166  Human T-cell leukemia virus 1 infection
vvp05167  Kaposi sarcoma-associated herpesvirus infection
vvp05168  Herpes simplex virus 1 infection
vvp05169  Epstein-Barr virus infection
vvp05170  Human immunodeficiency virus 1 infection
vvp05171  Coronavirus disease - COVID-19
vvp05200  Pathways in cancer
vvp05203  Viral carcinogenesis
vvp05212  Pancreatic cancer
vvp05215  Prostate cancer
vvp05220  Chronic myeloid leukemia
vvp05221  Acute myeloid leukemia
vvp05222  Small cell lung cancer
vvp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vvp05340  Primary immunodeficiency
vvp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112911512 (IKBKG)
   04014 Ras signaling pathway
    112911512 (IKBKG)
   04064 NF-kappa B signaling pathway
    112911512 (IKBKG)
   04668 TNF signaling pathway
    112911512 (IKBKG)
   04151 PI3K-Akt signaling pathway
    112911512 (IKBKG)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    112911512 (IKBKG)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    112911512 (IKBKG)
   04621 NOD-like receptor signaling pathway
    112911512 (IKBKG)
   04622 RIG-I-like receptor signaling pathway
    112911512 (IKBKG)
   04623 Cytosolic DNA-sensing pathway
    112911512 (IKBKG)
   04625 C-type lectin receptor signaling pathway
    112911512 (IKBKG)
   04660 T cell receptor signaling pathway
    112911512 (IKBKG)
   04658 Th1 and Th2 cell differentiation
    112911512 (IKBKG)
   04659 Th17 cell differentiation
    112911512 (IKBKG)
   04657 IL-17 signaling pathway
    112911512 (IKBKG)
   04662 B cell receptor signaling pathway
    112911512 (IKBKG)
   04062 Chemokine signaling pathway
    112911512 (IKBKG)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    112911512 (IKBKG)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112911512 (IKBKG)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112911512 (IKBKG)
   05203 Viral carcinogenesis
    112911512 (IKBKG)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112911512 (IKBKG)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    112911512 (IKBKG)
   05221 Acute myeloid leukemia
    112911512 (IKBKG)
   05220 Chronic myeloid leukemia
    112911512 (IKBKG)
   05215 Prostate cancer
    112911512 (IKBKG)
   05222 Small cell lung cancer
    112911512 (IKBKG)
  09163 Immune disease
   05340 Primary immunodeficiency
    112911512 (IKBKG)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    112911512 (IKBKG)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112911512 (IKBKG)
   05135 Yersinia infection
    112911512 (IKBKG)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112911512 (IKBKG)
   05170 Human immunodeficiency virus 1 infection
    112911512 (IKBKG)
   05161 Hepatitis B
    112911512 (IKBKG)
   05160 Hepatitis C
    112911512 (IKBKG)
   05171 Coronavirus disease - COVID-19
    112911512 (IKBKG)
   05164 Influenza A
    112911512 (IKBKG)
   05162 Measles
    112911512 (IKBKG)
   05168 Herpes simplex virus 1 infection
    112911512 (IKBKG)
   05163 Human cytomegalovirus infection
    112911512 (IKBKG)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112911512 (IKBKG)
   05169 Epstein-Barr virus infection
    112911512 (IKBKG)
   05165 Human papillomavirus infection
    112911512 (IKBKG)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112911512 (IKBKG)
   05142 Chagas disease
    112911512 (IKBKG)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    112911512 (IKBKG)
Protein kinases [BR:vvp01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   112911512 (IKBKG)
SSDB
Motif
Pfam: CC2-LZ NEMO zf_C2H2_10 Filament LLC1
Other DBs
NCBI-GeneID: 112911512
NCBI-ProteinID: XP_025843886
UniProt: A0A3Q7RNR1
LinkDB
Position
Unknown
AA seq 457 aa
MFTRAQTFSVTRGWMSPPGMFEEQQGDHYSWSRTLTCWMSRAPWKSQPSEMVQPSGGPAG
DQDVLGEESSLGKPAMLHLPSEQGTPETYQRCLEENQELRDAIRQSNQMLRERCEELQRF
QGSQRKEKEFLMQKFQEARKLVERLSLEKLDLRTQREQALQEVEHLKRCQQQMAEDKASV
KAQVTSLLGELQESQSRLEAATKERQALEGRARAASEQARQLESEREALQQQHSVQVDQL
RMQSQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKSSMVSSERNRGMQLED
LKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAREKL
AEKKEILQDQLEQLQREYSRLKASCQESARIEDLRKRHVEVSQAPLPVTPVHASFHVPVS
IQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
NT seq 1374 nt   +upstreamnt  +downstreamnt
atgtttacccgagctcagaccttttctgtgacccgaggatggatgagccctcctggtatg
ttcgaggaacagcaaggagaccactatagctggagcagaaccctgacttgttggatgagc
agggccccctggaagagtcagccaagtgagatggtgcagcccagtggcggcccggccggg
gaccaggacgtgctgggtgaagagtcttctttggggaagccagctatgctccacctacct
tctgagcagggcactcctgagacctaccaacgctgtctggaggagaatcaagagctccga
gatgccatccggcagagcaaccagatgctccgggagcgctgtgaggagctgcagcgtttc
cagggcagccagaggaaggagaaggagttcctcatgcagaagttccaggaagccaggaaa
ctggtggagagactgagtctggagaagctcgacctgaggacgcagagggagcaggccctg
caggaggtggaacacctgaagcgatgtcagcagcagatggctgaagacaaggcttccgtg
aaagcccaggtgacgtccctgctgggggagctccaggagagccagagtcgtttggaggcc
gccaccaaggagcggcaggctttggagggcagggcccgggctgccagcgagcaggcccgg
cagctggagagtgagcgggaggcgctgcagcagcagcacagcgtgcaggtggaccagctg
cgcatgcagagccagagcgtggaggcggccctgcgcatggagcgccaggctgcctcggag
gagaagcggaagctggcccagctacaggtggcctatcaccagctcttccaggagtatgac
aaccacatcaagagcagcatggtgagcagcgagcgaaaccgaggaatgcagctggaggat
ctcaagcagcagctccagcaggccgaggaggccctggtggccaaacaggaagtgatcgac
aagctgaaggaagaggctgagcagcacaagatcgtgatggagaccgtccctgtgctaaag
gctcaggcggatatctacaaggccgacttccaggccgagaggcaggcccgggagaagctg
gccgagaagaaggagatcctgcaggatcagctggagcagctgcagagggagtacagcagg
ctgaaggccagctgtcaggagtcggccaggattgaagatctgaggaagcggcacgtggag
gtctcccaggctcccttacctgtcaccccagttcacgcctcctttcacgtgcccgtgtcc
atccagaggagaagcccccctgaggagccgccggacttctgctgccccaagtgccagtat
caggcccctgatatggacaccctgcagatacacgtcatggagtgcatcgagtag

KEGG   Vulpes vulpes (red fox): 112914804
Entry
112914804         CDS       T05911                                 

Gene name
CHUK
Definition
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp01523  Antifolate resistance
vvp04010  MAPK signaling pathway
vvp04014  Ras signaling pathway
vvp04062  Chemokine signaling pathway
vvp04064  NF-kappa B signaling pathway
vvp04068  FoxO signaling pathway
vvp04150  mTOR signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04210  Apoptosis
vvp04380  Osteoclast differentiation
vvp04620  Toll-like receptor signaling pathway
vvp04621  NOD-like receptor signaling pathway
vvp04622  RIG-I-like receptor signaling pathway
vvp04623  Cytosolic DNA-sensing pathway
vvp04625  C-type lectin receptor signaling pathway
vvp04657  IL-17 signaling pathway
vvp04658  Th1 and Th2 cell differentiation
vvp04659  Th17 cell differentiation
vvp04660  T cell receptor signaling pathway
vvp04662  B cell receptor signaling pathway
vvp04668  TNF signaling pathway
vvp04920  Adipocytokine signaling pathway
vvp05010  Alzheimer disease
vvp05132  Salmonella infection
vvp05135  Yersinia infection
vvp05142  Chagas disease
vvp05145  Toxoplasmosis
vvp05160  Hepatitis C
vvp05161  Hepatitis B
vvp05162  Measles
vvp05163  Human cytomegalovirus infection
vvp05164  Influenza A
vvp05165  Human papillomavirus infection
vvp05166  Human T-cell leukemia virus 1 infection
vvp05167  Kaposi sarcoma-associated herpesvirus infection
vvp05168  Herpes simplex virus 1 infection
vvp05169  Epstein-Barr virus infection
vvp05170  Human immunodeficiency virus 1 infection
vvp05171  Coronavirus disease - COVID-19
vvp05200  Pathways in cancer
vvp05212  Pancreatic cancer
vvp05215  Prostate cancer
vvp05220  Chronic myeloid leukemia
vvp05221  Acute myeloid leukemia
vvp05222  Small cell lung cancer
vvp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vvp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112914804 (CHUK)
   04014 Ras signaling pathway
    112914804 (CHUK)
   04064 NF-kappa B signaling pathway
    112914804 (CHUK)
   04668 TNF signaling pathway
    112914804 (CHUK)
   04068 FoxO signaling pathway
    112914804 (CHUK)
   04151 PI3K-Akt signaling pathway
    112914804 (CHUK)
   04150 mTOR signaling pathway
    112914804 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    112914804 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    112914804 (CHUK)
   04621 NOD-like receptor signaling pathway
    112914804 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    112914804 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    112914804 (CHUK)
   04625 C-type lectin receptor signaling pathway
    112914804 (CHUK)
   04660 T cell receptor signaling pathway
    112914804 (CHUK)
   04658 Th1 and Th2 cell differentiation
    112914804 (CHUK)
   04659 Th17 cell differentiation
    112914804 (CHUK)
   04657 IL-17 signaling pathway
    112914804 (CHUK)
   04662 B cell receptor signaling pathway
    112914804 (CHUK)
   04062 Chemokine signaling pathway
    112914804 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    112914804 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112914804 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112914804 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112914804 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    112914804 (CHUK)
   05221 Acute myeloid leukemia
    112914804 (CHUK)
   05220 Chronic myeloid leukemia
    112914804 (CHUK)
   05215 Prostate cancer
    112914804 (CHUK)
   05222 Small cell lung cancer
    112914804 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112914804 (CHUK)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    112914804 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112914804 (CHUK)
   05135 Yersinia infection
    112914804 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112914804 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    112914804 (CHUK)
   05161 Hepatitis B
    112914804 (CHUK)
   05160 Hepatitis C
    112914804 (CHUK)
   05171 Coronavirus disease - COVID-19
    112914804 (CHUK)
   05164 Influenza A
    112914804 (CHUK)
   05162 Measles
    112914804 (CHUK)
   05168 Herpes simplex virus 1 infection
    112914804 (CHUK)
   05163 Human cytomegalovirus infection
    112914804 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112914804 (CHUK)
   05169 Epstein-Barr virus infection
    112914804 (CHUK)
   05165 Human papillomavirus infection
    112914804 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112914804 (CHUK)
   05142 Chagas disease
    112914804 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    112914804 (CHUK)
Enzymes [BR:vvp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     112914804 (CHUK)
Protein kinases [BR:vvp01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   112914804 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 112914804
NCBI-ProteinID: XP_025847770
UniProt: A0A3Q7SYZ6
LinkDB
Position
Unknown
AA seq 745 aa
MERRPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDVKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDITLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVRDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEMALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQASAWLPPNSAEREHPLSCVVTPQDGETIVQMIEENLNCLGHL
STIIHEANEEQGSRMMNLDWSWLTE
NT seq 2238 nt   +upstreamnt  +downstreamnt
atggagcggcgcccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcactggcggctttgggaacgtctgtctgtaccagcatcgggaacttgatgttaaa
atagcaattaaatcatgtcgcctagaactaagtaccaaaaacagagaacggtggtgtcat
gaaatccagatcatgaagaagttgaaccacgccaatgttgtaaaggcctgtgatgtacct
gaggaattgaattttttaattaatgatgtacctcttctagcaatggaatactgttctgga
ggagatctccggaagctactcaataaaccagaaaattgctgtggacttaaagaaagccag
atactttctttactgagtgatatagggtctgggatccgatatttgcatgaaaacaaaata
atacatcgtgatctaaaacctgaaaacatagttcttcaggatgttggtggaaagattatg
cataaaataattgatctaggatatgccaaagatgttgatcaaggaagtctgtgtacatct
tttgtgggaacactgcagtatctggccccagagctctttgagaataagccttatacagct
actgttgattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacttggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagaaatgacaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagaacccatggaaaactggcttcagttgatgctg
aattgggatcctcagcaaagaggaggacctgttgatattactttgaagcaaccaagatgt
tttgtattaatggatcacattctcaatttgaagatagtacacatcctaaatatgacttct
gcaaagataatttcttttttgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaataccggttctcaagagcttctttcagagacaggaatt
tctctggatcctcggaaaccggcctctcaatgtgttctagatggagtaagaggctgtgat
agctatatggtgtatttgtttgataaaagtaagactgtatatgaaggaccatttgcttcc
agaagtttatctgactgtgtaaattatattgtacgggacagcaaaattcagcttccaatt
atacagctgcgtaaagtatgggctgaagcagtgcactatgtgtctgggctgaaagaagac
tacagcaggctctttcagggacaaagagcagcaatgttaagtcttcttagatataacgct
aacctgacaaaaatgaagaacactttgatctcagcatctcagcaactaaaagctaaattg
gagtttttccacaaaagcattcagcttgacttggaaagatacagtgagcagatgacttat
gggatatcctcagaaaaaatgttaaaagcatggaaggaaatggaagaaaaggctatccac
tatgccgaggtgggtgtcattggttacctggaggatcagatcatgtctctgcacactgaa
atcatggagctgcagaagagcccttatggaagacgtcagggagacttgatggaatctctg
gaacagcgtgctattgatctgtataagcagttaaagcacagaccttcagatcactcctat
agcgacagcacggaaatggtgaagatcattgtgcatactgttcagagtcaggaccgggtt
ctcaaggagctgtttggtcatctgagcaagttattgggctgtaagcagaagattattgat
ctactgcccaaggtggaaatggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagagacagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccgttccctcgtaggatccagtctagaaggtgcagtaacccctcaggcatca
gcatggcttcctccaaattcagcagaacgtgaacatcctctgtcatgcgtggtaactcct
caagatggggagactatagtacaaatgatagaagaaaatttgaactgtcttggccattta
agcactattattcatgaagcaaatgaggaacagggcagtagaatgatgaatcttgattgg
agttggttaacagaatga

KEGG   Vulpes vulpes (red fox): 112916156
Entry
112916156         CDS       T05911                                 

Gene name
IKBKB
Definition
(RefSeq) inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
  KO
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Organism
vvp  Vulpes vulpes (red fox)
Pathway
vvp01523  Antifolate resistance
vvp04010  MAPK signaling pathway
vvp04014  Ras signaling pathway
vvp04062  Chemokine signaling pathway
vvp04064  NF-kappa B signaling pathway
vvp04068  FoxO signaling pathway
vvp04150  mTOR signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04210  Apoptosis
vvp04380  Osteoclast differentiation
vvp04620  Toll-like receptor signaling pathway
vvp04621  NOD-like receptor signaling pathway
vvp04622  RIG-I-like receptor signaling pathway
vvp04623  Cytosolic DNA-sensing pathway
vvp04625  C-type lectin receptor signaling pathway
vvp04657  IL-17 signaling pathway
vvp04658  Th1 and Th2 cell differentiation
vvp04659  Th17 cell differentiation
vvp04660  T cell receptor signaling pathway
vvp04662  B cell receptor signaling pathway
vvp04668  TNF signaling pathway
vvp04722  Neurotrophin signaling pathway
vvp04910  Insulin signaling pathway
vvp04920  Adipocytokine signaling pathway
vvp04930  Type II diabetes mellitus
vvp04931  Insulin resistance
vvp04932  Non-alcoholic fatty liver disease
vvp05010  Alzheimer disease
vvp05132  Salmonella infection
vvp05135  Yersinia infection
vvp05142  Chagas disease
vvp05145  Toxoplasmosis
vvp05160  Hepatitis C
vvp05161  Hepatitis B
vvp05162  Measles
vvp05163  Human cytomegalovirus infection
vvp05164  Influenza A
vvp05165  Human papillomavirus infection
vvp05166  Human T-cell leukemia virus 1 infection
vvp05167  Kaposi sarcoma-associated herpesvirus infection
vvp05168  Herpes simplex virus 1 infection
vvp05169  Epstein-Barr virus infection
vvp05170  Human immunodeficiency virus 1 infection
vvp05171  Coronavirus disease - COVID-19
vvp05200  Pathways in cancer
vvp05206  MicroRNAs in cancer
vvp05212  Pancreatic cancer
vvp05215  Prostate cancer
vvp05220  Chronic myeloid leukemia
vvp05221  Acute myeloid leukemia
vvp05222  Small cell lung cancer
vvp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
vvp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:vvp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112916156 (IKBKB)
   04014 Ras signaling pathway
    112916156 (IKBKB)
   04064 NF-kappa B signaling pathway
    112916156 (IKBKB)
   04668 TNF signaling pathway
    112916156 (IKBKB)
   04068 FoxO signaling pathway
    112916156 (IKBKB)
   04151 PI3K-Akt signaling pathway
    112916156 (IKBKB)
   04150 mTOR signaling pathway
    112916156 (IKBKB)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    112916156 (IKBKB)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    112916156 (IKBKB)
   04621 NOD-like receptor signaling pathway
    112916156 (IKBKB)
   04622 RIG-I-like receptor signaling pathway
    112916156 (IKBKB)
   04623 Cytosolic DNA-sensing pathway
    112916156 (IKBKB)
   04625 C-type lectin receptor signaling pathway
    112916156 (IKBKB)
   04660 T cell receptor signaling pathway
    112916156 (IKBKB)
   04658 Th1 and Th2 cell differentiation
    112916156 (IKBKB)
   04659 Th17 cell differentiation
    112916156 (IKBKB)
   04657 IL-17 signaling pathway
    112916156 (IKBKB)
   04662 B cell receptor signaling pathway
    112916156 (IKBKB)
   04062 Chemokine signaling pathway
    112916156 (IKBKB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112916156 (IKBKB)
   04920 Adipocytokine signaling pathway
    112916156 (IKBKB)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    112916156 (IKBKB)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112916156 (IKBKB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112916156 (IKBKB)
   05206 MicroRNAs in cancer
    112916156 (IKBKB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112916156 (IKBKB)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    112916156 (IKBKB)
   05221 Acute myeloid leukemia
    112916156 (IKBKB)
   05220 Chronic myeloid leukemia
    112916156 (IKBKB)
   05215 Prostate cancer
    112916156 (IKBKB)
   05222 Small cell lung cancer
    112916156 (IKBKB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112916156 (IKBKB)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    112916156 (IKBKB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    112916156 (IKBKB)
   04932 Non-alcoholic fatty liver disease
    112916156 (IKBKB)
   04931 Insulin resistance
    112916156 (IKBKB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112916156 (IKBKB)
   05135 Yersinia infection
    112916156 (IKBKB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112916156 (IKBKB)
   05170 Human immunodeficiency virus 1 infection
    112916156 (IKBKB)
   05161 Hepatitis B
    112916156 (IKBKB)
   05160 Hepatitis C
    112916156 (IKBKB)
   05171 Coronavirus disease - COVID-19
    112916156 (IKBKB)
   05164 Influenza A
    112916156 (IKBKB)
   05162 Measles
    112916156 (IKBKB)
   05168 Herpes simplex virus 1 infection
    112916156 (IKBKB)
   05163 Human cytomegalovirus infection
    112916156 (IKBKB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112916156 (IKBKB)
   05169 Epstein-Barr virus infection
    112916156 (IKBKB)
   05165 Human papillomavirus infection
    112916156 (IKBKB)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    112916156 (IKBKB)
   05142 Chagas disease
    112916156 (IKBKB)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    112916156 (IKBKB)
Enzymes [BR:vvp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     112916156 (IKBKB)
Protein kinases [BR:vvp01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   112916156 (IKBKB)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo ubiquitin APH YrbL-PhoP_reg Med20 Glyco_hydro_65m
Other DBs
NCBI-GeneID: 112916156
NCBI-ProteinID: XP_025849449
UniProt: A0A3Q7RVJ0
LinkDB
Position
Unknown
AA seq 755 aa
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPYPNNLNSILAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLVHILNMVTGIIHTYPVTEDESLQNLKARIQHDTGIPEKDQELLQEAGLA
LIPDKPAAQCISDGKLNEGRTLDMDLVFLFDNSKIAYETQISPRPQPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHSGQLLAQPSPAPSSLPEAIKKSEELVAEAHTLCTQLE
NAMQDTIKEQDQSLRSLDWSWLQTEEEQNSLEQAS
NT seq 2268 nt   +upstreamnt  +downstreamnt
atgagctggtcaccttctctgccaacccaaacatgtggggcctgggagatgaaagaacga
cttgggacagggggatttggaaacgtgatccgctggcacaatcaggaaacaggtgagcag
attgctatcaagcagtgccggcaggagctcagcccccggaatcgagagcggtggtgcctg
gagattcagatcatgagaaggctgaaccaccccaatgtggtggctgcccgggatgtccct
gaggggatgcagaacttggctcccaatgacctgcccctgctggccatggagtactgccaa
ggaggagatctccgaaagtacctgaaccagtttgagaactgctgtggcctgcgggaagga
gccatcctcaccctgctgagtgacatcgcctctgcacttagataccttcatgaaaacaga
atcatacatcgggatctaaagccagaaaacatcgtcctgcagcaaggagagcaaagatta
atacacaaaattattgacctaggatatgccaaggaactggatcagggcagtctttgtact
tcctttgtggggaccctgcaatacttggccccggaactcctggagcagcagaagtacacg
gtgaccgtggattactggagctttggcaccttggcttttgagtgcatcacgggcttccga
ccttttctccctaactggcagcccgtgcagtggcattccaaagtccggcagaagagtgag
atggacattgtcgtcagtgaggacttgaatggagcggtgaagttttcaagctccttaccc
tatcccaataatctgaacagcatcctggcacagcgactggagaagtggctgcagctcatg
ttgatgtggcacccacggcaaaggggcaccgaccctgtgtacgggcccaatggttgcttc
aaggccctggatgacatcttaaacctaaagctggttcatatcttgaacatggtcacaggc
atcattcacacctatccagtgactgaggacgagagcctgcagaacttgaaggcccgaatc
cagcatgacacaggaatccccgagaaggaccaggagctgctgcaggaagccgggctggca
ctgatccctgacaagcccgccgctcagtgcatttcagacggcaagctgaatgagggccgc
acactggatatggaccttgtctttctctttgacaacagtaaaatcgcctatgagactcag
atctccccacggccccaacctgaaagtgtcagctgtattcttcaagagcccaagaggaac
ctgtctttcttccagctgaggaaagtgtggggccaggtctggcacagcatccagaccctg
aaggaagactgtaaccggctgcagcagggacagcgcgctgccatgatgaatctccttcgg
aataatagctgcctctccaagatgaagaattctatggcttccatgtctcagcagctcaaa
gccaaattggatttctttaaaaccagcatccagattgacctggagaagtacagtgagcaa
actgagtttggaatcacatcagataaacttctgctggcctggagggaaatggaacaggcc
gtggagctctgtgggcgggagaatgaagtgaagcacctggtggaacgcatgatggcactg
cagacggacatcgtggacctgcagaggagcccgatggggcggaagcagggggggacgctg
gatgacctagaagagcaggcgagggagctttataggaggcttcgggaaaagcccagagac
cagcgaactgatggcgacagtcaggagatggtccggctgctcctgcaggccatccaaggt
tttgagaagaaagtgcgagtgatttatacgcagctcagtaaaactgtggtttgtaagcag
aaggctctggaactgttgcccaaggtggaagaagtggtgagtttaatgaacgaagatgag
aagactgttgtccggcttcaggagaagcggcagaaggagctctggaacctcctaaagatt
gcttgtagcaaagtccgtggtcctgtcagcggcagcccagacagcatgaatgcctctcgc
cttagtcactctggtcagctgctggctcagccttcaccagcccccagcagcttgcccgag
gccatcaagaaaagtgaagaactggtggctgaagcacatactctctgcacccagctagaa
aatgcaatgcaagacaccatcaaagaacaggaccagagtttgaggtctctagactggagc
tggttacagacggaagaagagcagaatagcctggaacaggcctcttga

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