Vulpes vulpes (red fox): 112922331 Help Entry 112922331         CDS       T05911                                  Gene name CDK4 Definition (RefSeq) cyclin-dependent kinase 4   KO K02089   cyclin-dependent kinase 4 [EC:2.7.11.22] Organism vvp  Vulpes vulpes (red fox) Pathway vvp01522   Endocrine resistance vvp04110   Cell cycle vvp04115   p53 signaling pathway vvp04151   PI3K-Akt signaling pathway vvp04218   Cellular senescence vvp04530   Tight junction vvp04660   T cell receptor signaling pathway vvp04933   AGE-RAGE signaling pathway in diabetic complications vvp04934   Cushing syndrome vvp05160   Hepatitis C vvp05162   Measles vvp05163   Human cytomegalovirus infection vvp05164   Influenza A vvp05165   Human papillomavirus infection vvp05166   Human T-cell leukemia virus 1 infection vvp05167   Kaposi sarcoma-associated herpesvirus infection vvp05169   Epstein-Barr virus infection vvp05200   Pathways in cancer vvp05203   Viral carcinogenesis vvp05212   Pancreatic cancer vvp05214   Glioma vvp05218   Melanoma vvp05219   Bladder cancer vvp05220   Chronic myeloid leukemia vvp05222   Small cell lung cancer vvp05223   Non-small cell lung cancer vvp05224   Breast cancer vvp05225   Hepatocellular carcinoma Brite KEGG Orthology (KO) [BR:vvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     112922331 (CDK4)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     112922331 (CDK4)    04115 p53 signaling pathway     112922331 (CDK4)    04218 Cellular senescence     112922331 (CDK4)   09144 Cellular community - eukaryotes    04530 Tight junction     112922331 (CDK4)  09150 Organismal Systems   09151 Immune system    04660 T cell receptor signaling pathway     112922331 (CDK4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112922331 (CDK4)    05203 Viral carcinogenesis     112922331 (CDK4)   09162 Cancer: specific types    05212 Pancreatic cancer     112922331 (CDK4)    05225 Hepatocellular carcinoma     112922331 (CDK4)    05214 Glioma     112922331 (CDK4)    05220 Chronic myeloid leukemia     112922331 (CDK4)    05218 Melanoma     112922331 (CDK4)    05219 Bladder cancer     112922331 (CDK4)    05224 Breast cancer     112922331 (CDK4)    05222 Small cell lung cancer     112922331 (CDK4)    05223 Non-small cell lung cancer     112922331 (CDK4)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     112922331 (CDK4)    04934 Cushing syndrome     112922331 (CDK4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     112922331 (CDK4)    05160 Hepatitis C     112922331 (CDK4)    05164 Influenza A     112922331 (CDK4)    05162 Measles     112922331 (CDK4)    05163 Human cytomegalovirus infection     112922331 (CDK4)    05167 Kaposi sarcoma-associated herpesvirus infection     112922331 (CDK4)    05169 Epstein-Barr virus infection     112922331 (CDK4)    05165 Human papillomavirus infection     112922331 (CDK4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     112922331 (CDK4)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:vvp01001]     112922331 (CDK4) Enzymes [BR:vvp01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.22  cyclin-dependent kinase      112922331 (CDK4) Protein kinases [BR:vvp01001]  Serine/threonine kinases: CMGC group   CDK family    112922331 (CDK4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like FTA2 Motif Other DBs NCBI-GeneID:  112922331 NCBI-ProteinID:  XP_025857605 UniProt:  A0A3Q7TQY7 LinkDB All DBs Position Unknown AA seq 303 aa AA seqDB search MATPRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALL RRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDL MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR DVSLPRGAFSPRGPRPVQTVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLQKAEG NPE NT seq 912 nt NT seq  +upstreamnt  +downstreamnt atggctactcctcggtacgagccagtggctgagattggggttggtgcctatggaacggtg tacaaggcccgtgatccgcacagcggccacttcgtggccctcaagagcgttagagtccct aatggaggaggtgccggagggggccttcccatcagcacagttcgtgaagtggcattgctg aggcggctggaggcttttgagcatcccaacgttgtccggctgatggacgtctgcgccact gcccgaaccgaccgggagaccaaagtgaccctggtgtttgagcacgtggaccaagacctg agaacgtacctggacaaggcacccccaccgggcttgccagtggagaccatcaaggacctg atgcgccagtttctaagaggcctagatttccttcatgccaactgcatcgttcaccgagac ctgaagcccgagaacattctggtgaccagtggtgggacagtcaagctggctgattttggt ctggccagaatctacagctaccagatggcacttacgcctgtggttgttacactctggtat cgtgctccagaagttcttctgcagtctacgtatgcaacacccgtggacatgtggagtgtc ggctgtatcttcgcagagatgtttcgtcgcaagcctctcttctgtggaaactctgaagct gaccagttaggcaaaatctttgacctgatcgggctgcccccagaggatgactggccccga gatgtgtctctgccccgaggagccttttcccctagagggccccgtccagtacagacagtg gtacctgagatggaggagtctggagcacagctgctgctggagatgctgacttttaaccca cacaagcgaatctctgccttccgagccctgcagcactcttatctacaaaaggcagaaggt aatccagagtga

Vulpes vulpes (red fox): 112923889 Help Entry 112923889         CDS       T05911                                  Gene name CDK6 Definition (RefSeq) cyclin-dependent kinase 6   KO K02091   cyclin-dependent kinase 6 [EC:2.7.11.22] Organism vvp  Vulpes vulpes (red fox) Pathway vvp04110   Cell cycle vvp04115   p53 signaling pathway vvp04151   PI3K-Akt signaling pathway vvp04218   Cellular senescence vvp04934   Cushing syndrome vvp05160   Hepatitis C vvp05162   Measles vvp05163   Human cytomegalovirus infection vvp05164   Influenza A vvp05165   Human papillomavirus infection vvp05167   Kaposi sarcoma-associated herpesvirus infection vvp05169   Epstein-Barr virus infection vvp05200   Pathways in cancer vvp05203   Viral carcinogenesis vvp05206   MicroRNAs in cancer vvp05212   Pancreatic cancer vvp05214   Glioma vvp05218   Melanoma vvp05220   Chronic myeloid leukemia vvp05222   Small cell lung cancer vvp05223   Non-small cell lung cancer vvp05224   Breast cancer vvp05225   Hepatocellular carcinoma Brite KEGG Orthology (KO) [BR:vvp00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     112923889 (CDK6)  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     112923889 (CDK6)    04115 p53 signaling pathway     112923889 (CDK6)    04218 Cellular senescence     112923889 (CDK6)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112923889 (CDK6)    05206 MicroRNAs in cancer     112923889 (CDK6)    05203 Viral carcinogenesis     112923889 (CDK6)   09162 Cancer: specific types    05212 Pancreatic cancer     112923889 (CDK6)    05225 Hepatocellular carcinoma     112923889 (CDK6)    05214 Glioma     112923889 (CDK6)    05220 Chronic myeloid leukemia     112923889 (CDK6)    05218 Melanoma     112923889 (CDK6)    05224 Breast cancer     112923889 (CDK6)    05222 Small cell lung cancer     112923889 (CDK6)    05223 Non-small cell lung cancer     112923889 (CDK6)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     112923889 (CDK6)   09172 Infectious disease: viral    05160 Hepatitis C     112923889 (CDK6)    05164 Influenza A     112923889 (CDK6)    05162 Measles     112923889 (CDK6)    05163 Human cytomegalovirus infection     112923889 (CDK6)    05167 Kaposi sarcoma-associated herpesvirus infection     112923889 (CDK6)    05169 Epstein-Barr virus infection     112923889 (CDK6)    05165 Human papillomavirus infection     112923889 (CDK6)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:vvp01001]     112923889 (CDK6) Enzymes [BR:vvp01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.22  cyclin-dependent kinase      112923889 (CDK6) Protein kinases [BR:vvp01001]  Serine/threonine kinases: CMGC group   CDK family    112923889 (CDK6) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like RIO1 FTA2 Motif Other DBs NCBI-GeneID:  112923889 NCBI-ProteinID:  XP_025859548 UniProt:  A0A3Q7SS30 LinkDB All DBs Position Unknown AA seq 326 aa AA seqDB search MEKDGLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE EDWPRDVALPRQAFHSKSPQPIEKFVTDIDEQGKDLLLKCLTFNPAKRISAYSALSHPYF HDLERCKENLDSHLPPSQNSSEMNTA NT seq 981 nt NT seq  +upstreamnt  +downstreamnt atggagaaggacggcctgagccgcgcggaccagcagtacgagtgcgtggcggagatcggg gagggggcctacgggaaggtgttcaaggcccgggacctgaagaacggaggccgtttcgtg gcgctgaagcgcgtgcgggtgcagacgggcgaggagggcatgccgctctccaccatccgc gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcagattgttt gatgtatgcacagtgtcacgaacagacagagaaacgaaactaacattagtgtttgaacat gttgatcaagacttgaccacttatttggataaagtcccagagccgggagtgcccactgaa accataaaggatatgatgtttcagcttctccgaggcctggactttcttcattctcaccga gtagtgcatcgcgatttaaaaccacagaacattttagtgaccagcagtggacaaataaaa ctggctgacttcggccttgcccgcatctacagttttcagatggctcttacttcagtggtc gtcacactgtggtacagagctccagaagtcctgcttcagtccagctatgccacccccgtg gacctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt ggaagttcagacgtcgatcaacttggaaaaatcttggacgtaattggactcccaggagaa gaggactggcctagagatgtcgccctacccaggcaggctttccactcaaaatctcctcaa ccgattgagaagtttgtgacggacattgatgaacaaggcaaagacctccttctgaagtgc ttaacatttaatccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc catgacctggagaggtgcaaggaaaacttggattcccatctgccgcccagccagaacagc tcagagatgaacacagcctga

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