KEGG   PATHWAY: xla04115
xla04115                    Pathway                                

p53 signaling pathway - Xenopus laevis (African clawed frog)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
xla04115  p53 signaling pathway

Xenopus laevis (African clawed frog) [GN:xla]
398148  atm.L; ATM serine/threonine kinase L homeolog [KO:K04728] [EC:]
398179  chek2.L; checkpoint kinase 2 L homeolog [KO:K06641] [EC:]
398197  atr.L; ATR serine/threonine kinase L homeolog [KO:K06640] [EC:]
398191  chek1.S; checkpoint kinase 1 S homeolog [KO:K02216] [EC:]
108696394  chek1.L; checkpoint kinase 1 L homeolog [KO:K02216] [EC:]
108715743  gorab.S; golgin, RAB6-interacting S homeolog [KO:K19748]
108715744  RAB6-interacting golgin-like [KO:K19748]
108706001  RAB6-interacting golgin-like [KO:K19748]
108714491  gorab.L; golgin, RAB6-interacting L homeolog [KO:K19748]
108713153  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:]
108711092  mdm2.L; MDM2 proto-oncogene, E3 ubiquitin protein ligase L homeolog [KO:K06643] [EC:]
398466  mdm4.S; MDM4, p53 regulator S homeolog [KO:K10127]
397926  tp53.L; tumor protein p53 L homeolog [KO:K04451]
108703451  tp53.S; tumor protein p53 S homeolog [KO:K04451]
492305  cdkn1a.L; cyclin-dependent kinase inhibitor 1A (p21, Cip1) L homeolog [KO:K06625]
108709405  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
379161  ccnd1.S; cyclin D1 S homeolog [KO:K04503]
379937  ccnd1.L; cyclin D1 L homeolog [KO:K04503]
108697837  G1/S-specific cyclin-D1-like [KO:K04503]
447748  ccndx.L; cyclin Dx L homeolog [KO:K04503]
447541  MGC83948 protein [KO:K04503]
734882  ccnd2.S; cyclin D2 S homeolog [KO:K10151]
373667  ccnd2.L; cyclin D2 L homeolog [KO:K10151]
379406  cdk4.L; cyclin-dependent kinase 4 L homeolog [KO:K02089] [EC:]
496334  cdk6.L; cyclin-dependent kinase 6 L homeolog [KO:K02089] [EC:]
108705492  cyclin-dependent kinase 4-like [KO:K02089] [EC:]
108718479  cyclin-dependent kinase 6-like [KO:K02091] [EC:]
108719900  cyclin-dependent kinase 6 [KO:K02091] [EC:]
380219  ccne2.L; cyclin E2 L homeolog [KO:K06626]
397840  ccne1.L; cyclin E1 L homeolog [KO:K06626]
495419  ccne2.S; cyclin E2 S homeolog [KO:K06626]
397841  ccne1.S; cyclin E1 S homeolog [KO:K06626]
432036  cdk2.L; cyclin-dependent kinase 2 L homeolog [KO:K02206] [EC:]
399314  cdk2.S; cyclin-dependent kinase 2 S homeolog [KO:K02206] [EC:]
108702018  protein reprimo-like [KO:K10128]
108702402  protein reprimo-like [KO:K10128]
397742  ccnb1.2.S; cyclin B1 S homeolog [KO:K05868]
379888  ccnb1; cyclin B1 [KO:K05868]
398163  ccnb1.S; cyclin B1 S homeolog [KO:K05868]
108718066  ccnb1.L; cyclin B1 L homeolog [KO:K05868]
397743  ccnb2.S; cyclin B2 S homeolog [KO:K21770]
398888  ccnb2.L; cyclin B2 L homeolog [KO:K21770]
398162  cyclin B5 [KO:K21770]
380246  cdk1.S; cyclin-dependent kinase 1 S homeolog [KO:K02087] [EC:]
379785  cdk1.L; cyclin-dependent kinase 1 L homeolog [KO:K02087] [EC:]
379224  gadd45a.L; growth arrest and DNA damage inducible alpha L homeolog [KO:K04402]
399196  gadd45g.L; growth arrest and DNA damage inducible gamma L homeolog [KO:K04402]
379285  gadd45g.S; growth arrest and DNA damage inducible gamma S homeolog [KO:K04402]
101027271  gadd45b.S; growth arrest and DNA damage inducible beta S homeolog [KO:K04402]
108714209  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
108712402  gadd45b.L; growth arrest and DNA damage inducible beta L homeolog [KO:K04402]
447452  gtse1.S; G2 and S-phase expressed 1 S homeolog [KO:K10129]
734417  gtse1.L; G2 and S-phase expressed 1 L homeolog [KO:K10129]
108697171  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
108696050  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
108713866  pidd1.L; p53-induced death domain protein 1 L homeolog [KO:K10130]
404687  tnfrsf10b.S; tumor necrosis factor receptor superfamily member 10b S homeolog [KO:K04722]
404688  tnfrsf10b.L; tumor necrosis factor receptor superfamily member 10b L homeolog [KO:K04722]
373559  casp8.L; caspase 8 L homeolog [KO:K04398] [EC:]
724076  bid.S; BH3 interacting domain death agonist S homeolog [KO:K04726]
108704383  bid.L; BH3 interacting domain death agonist L homeolog [KO:K04726]
373637  bax.L; BCL2-associated X protein L homeolog [KO:K02159]
108696744  apoptosis regulator BAX-like [KO:K02159]
100049128  uncharacterized LOC100049128 [KO:K22744]
100037065  siva1.L; SIVA1, apoptosis-inducing factor L homeolog [KO:K22744]
398251  bcl2l1.L; BCL2-like 1 L homeolog [KO:K04570]
108700971  apoptosis regulator R11-like [KO:K04570]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
108719105  apoptosis regulator Bcl-2-like [KO:K02161]
444383  tp53i3.S; tumor protein p53 inducible protein 3 S homeolog [KO:K10133] [EC:1.-.-.-]
495297  ei24.S; etoposide induced 2.4 S homeolog [KO:K10134]
108696395  ei24.L; etoposide induced 2.4 L homeolog [KO:K10134]
444660  perp.S; PERP, TP53 apoptosis effector S homeolog [KO:K10136]
734854  zmat3.L; zinc finger, matrin-type 3 L homeolog [KO:K10137]
108718092  zmat3.S; zinc finger, matrin-type 3 S homeolog [KO:K10137]
443864  siah1.L; siah E3 ubiquitin protein ligase 1 L homeolog [KO:K04506] [EC:]
108715479  E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:]
444530  cycs.S; cytochrome c, somatic S homeolog [KO:K08738]
443888  cyct.L; cytochrome c, testis L homeolog [KO:K08738]
414705  cyct.S; cytochrome c, testis S homeolog [KO:K08738]
108718882  cytochrome c, testis-specific [KO:K08738]
444261  apaf1.L; apoptotic peptidase activating factor 1 L homeolog [KO:K02084]
373560  casp9.S; caspase 9 S homeolog [KO:K04399] [EC:]
397720  casp3.S; caspase 3 S homeolog [KO:K02187] [EC:]
100036910  casp3.L; caspase 3 L homeolog [KO:K02187] [EC:]
108696268  aifm2.L; apoptosis inducing factor, mitochondria associated 2 L homeolog [KO:K22745]
100049086  aifm2.S; apoptosis inducing factor, mitochondria associated 2 S homeolog [KO:K22745]
378699  igf1.S; insulin like growth factor 1 S homeolog [KO:K05459]
108712492  insulin-like growth factor I-A [KO:K05459]
108711020  igf1.L; insulin like growth factor 1 L homeolog [KO:K05459]
779433  serpine1.L; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog [KO:K03982]
100049768  serpine1.S; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 S homeolog [KO:K03982]
108719769  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
108695463  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
108718612  brain-specific angiogenesis inhibitor 1-like [KO:K04596]
444244  cd82.S; CD82 molecule S homeolog [KO:K06509]
432226  uncharacterized protein MGC79057 [KO:K06509]
379508  thbs1.S; thrombospondin 1 S homeolog [KO:K16857]
779026  thbs2.L; thrombospondin 2 L homeolog [KO:K16857]
444699  serpinb5.S; serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog [KO:K10139]
108718725  serpinb5.L; serpin peptidase inhibitor, clade B (ovalbumin), member 5 L homeolog [KO:K10139]
108713786  ddb2.L; damage-specific DNA binding protein 2 L homeolog [KO:K10140]
108715228  ddb2.S; damage-specific DNA binding protein 2 S homeolog [KO:K10140]
443815  rrm2.1.L; ribonucleotide reductase M2, gene 1 L homeolog [KO:K10808] [EC:]
380465  rrm2.2.L; ribonucleotide reductase M2, gene 2 L homeolog [KO:K10808] [EC:]
379056  rrm2b.S; ribonucleotide reductase M2 B (TP53 inducible) S homeolog [KO:K10808] [EC:]
108695407  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:]
379559  sesn1.L; sestrin 1 L homeolog [KO:K10141]
443904  sesn3.L; sestrin 3 L homeolog [KO:K10141]
108717942  sesn1.S; sestrin 1 S homeolog [KO:K10141]
108710010  sesn3.S; sestrin 3 S homeolog [KO:K10141]
414641  sesn2.L; sestrin 2 L homeolog [KO:K20394]
443672  sesn2.S; sestrin 2 S homeolog [KO:K20394]
399142  pten.L; phosphatase and tensin homolog L homeolog [KO:K01110] [EC:]
100505440  pten.S; phosphatase and tensin homolog S homeolog [KO:K01110] [EC:]
108703213  tuberin-like [KO:K07207]
108701656  tuberin-like [KO:K07207]
108701235  steap3.L; STEAP3 metalloreductase L homeolog [KO:K10142] [EC:1.16.1.-]
100158422  rfwd2.L; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog [KO:K10143] [EC:]
108715625  rfwd2.S; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase S homeolog [KO:K10143] [EC:]
496013  rchy1.L; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase L homeolog [KO:K10144] [EC:]
379404  ccng1.L; cyclin G1 L homeolog [KO:K10145]
779347  ccng1.S; cyclin G1 S homeolog [KO:K10145]
431934  ccng2.S; cyclin G2 S homeolog [KO:K10146]
444607  ccng2.L; cyclin G2 L homeolog [KO:K10146]
443988  ppm1d.L; protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog [KO:K10147] [EC:]
380383  ppm1d; protein phosphatase 1D magnesium-dependent, delta isoform [KO:K10147] [EC:]
108696624  tumor protein p73-like [KO:K10148]
108697705  tumor protein p73-like [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
xla04110  Cell cycle
xla04210  Apoptosis
xla04218  Cellular senescence
KO pathway

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