Xenopus tropicalis (tropical clawed frog): 780264
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Entry
780264 CDS
T01011
Symbol
gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
xtr
Xenopus tropicalis (tropical clawed frog)
Pathway
xtr00270
Cysteine and methionine metabolism
xtr00480
Glutathione metabolism
xtr01100
Metabolic pathways
xtr01240
Biosynthesis of cofactors
xtr04216
Ferroptosis
Module
xtr_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
xtr00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
780264 (gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
780264 (gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
780264 (gclc)
Enzymes [BR:
xtr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
780264 (gclc)
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Motif
Pfam:
GCS
Motif
Other DBs
NCBI-GeneID:
780264
NCBI-ProteinID:
NP_001072803
Xenbase:
XB-GENE-1002435
UniProt:
Q0V9R9
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Position
5:96702141..96730780
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AA seq
637 aa
AA seq
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MGLLSQGSPLSWEETKKYADHVRQHGIVQFLHIYHKLKERQKDVLKWGDEVEYMLVSFDH
ANKKVRLLLKGGEILDTLQDRGEKINPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRQEASSLLSVNDSLCSITTFPRLGCPGFTLPEFPPTPVEQGASKSLFFPDQAI
NIHPRFSTLTRNIRHRRGEKVAINVPIYKDQNTPSPFIERFPNDSNNEAVAAKPDHIYMD
AMGFGMGNCCLQVTFQACSICEARYLYDQLATICPIMMALSAAAPFYRGYVSDIDCRWGV
ISASVDDRTKEERGLEPLKNNKYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYNQLI
KEGIDHLLAQHIAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSD
IGWRVEFRPVEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAV
RQGMFYFRKDISKAGIAVVDGCCSPQNGMETDPEEYTLMSIDTIINGKEGVFPGLIPILN
SYLENMEVDVDTRCTILNYLKLIKKRASGELMTCARWMREFVASHPEYKKDSVITDKINY
DLLMKCNQIANELTTCPELLGTTVNKSKASGSQSVPL
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atgggtctgctgtcacaggggtcccctctaagctgggaagagaccaagaagtatgccgat
catgtccggcagcacggtatcgtccagttcctgcacatctatcacaagttgaaagagcgg
caaaaggacgtgcttaaatggggagacgaggtggaatacatgctggtatcttttgaccat
gccaataaaaaggttcgcttgcttcttaaaggaggagagatactagacactctccaagac
agaggtgaaaaaataaatccaaatcatccaacactttggaggcccgaatatgggagttac
atgattgaaggaacgcctggacaaccttacgggggaaccatgtctgagtttaacacagtg
gaagacaatatgagaaaaaggcgccaagaagcatcatctttgctatcagtaaatgattct
ctctgctccatcaccaccttcccacgattgggatgtccaggattcaccttgcctgagttt
ccaccaacccctgtggaacagggtgcctcaaaatccctattcttcccagatcaggctatc
aatatacatcccaggttcagtacactcactagaaatattcgacacagacggggtgaaaaa
gttgcaattaatgttccaatttataaagaccaaaatacaccatctccatttattgaaagg
tttcccaatgacagtaacaatgaagcagtagctgctaaaccagaccacatttacatggat
gctatgggatttggcatggggaactgctgccttcaggtaacattccaagcctgcagcatt
tgtgaagccaggtatctttatgaccagctagctacaatatgtcctattatgatggctcta
agtgcggcagctccattttacagaggatatgtgtctgatatagattgccgttggggagtg
atctctgcatcagtagatgatcgtaccaaagaagaaagaggattagaacctttgaaaaat
aacaaatatcgaatcagtaagtctcgatatgattccatagacagttatttgtctgaatgc
ggagagaaatacaatgacattgatttgaccattgataaagaaatctacaatcagttaata
aaagaaggtattgatcacctgttagcccagcacattgcacatctctttattagagatcct
ttaacattgtttgaggagaagatacatctagatgatgccaatgaatctgaccattttgag
aacattcaatcaacaaactggcagactatgaggtttaaacctcccccaccaaattctgac
attggatggagggtcgagtttcgtccagtggaggtccaattaacagactttgagaattct
gcatatgttgtatttgtggtgctgcttaccagagtaattctgtcctacaaactggatttc
cttattcccttgtcaaaggttgatgagaacatgaaggtggcacagaaacgagatgcagtg
cgacaaggaatgttttactttaggaaggatatttctaaagctggaattgcagttgttgat
ggctgttgttctccacaaaatggaatggaaactgacccagaagaatacacattgatgagc
attgatacaataatcaatggaaaggaaggagtttttccgggtttaattccaatacttaac
tcataccttgaaaatatggaggttgatgttgatacgcgctgcaccatcttgaattatctt
aaactcattaaaaaaagagcttcaggtgagttaatgacttgtgcaagatggatgcgagaa
tttgttgcaagccacccggagtacaagaaggacagtgtcattactgacaaaatcaattat
gatcttcttatgaaatgtaaccaaattgcaaatgagctgactacttgcccagagcttctt
gggaccacggtcaataaatccaaggcaagcggcagtcagtctgttcctttatga
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