KEGG   PATHWAY: ypq00010
Entry
ypq00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Yersinia pseudotuberculosis ATCC 6904
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
ypq00010  Glycolysis / Gluconeogenesis
ypq00010

Module
ypq_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:ypq00010]
ypq_M00002  Glycolysis, core module involving three-carbon compounds [PATH:ypq00010]
ypq_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:ypq00010]
ypq_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ypq00010]
Other DBs
GO: 0006096 0006094
Organism
Yersinia pseudotuberculosis ATCC 6904 [GN:ypq]
Gene
DJ40_3842  glk; glucokinase [KO:K00845] [EC:2.7.1.2]
DJ40_2757  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
DJ40_2349  pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
DJ40_1948  fbp; fructose-1,6-bisphosphatase class 1 [KO:K03841] [EC:3.1.3.11]
DJ40_2338  glpX; fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
DJ40_2592  putative fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
DJ40_3316  fbaA; fructose-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
DJ40_2342  tpiA; triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
DJ40_222  gap; glyceraldehyde-3-phosphate dehydrogenase, type I [KO:K00134] [EC:1.2.1.12]
DJ40_3315  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
DJ40_1077  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DJ40_1773  putative phosphoglycerate mutase gpmB [KO:K15634] [EC:5.4.2.11]
DJ40_2362  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
DJ40_1618  eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
DJ40_261  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
DJ40_4279  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
DJ40_4267  ppsA; phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2]
DJ40_1659  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
DJ40_1658  aceF; dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
DJ40_1657  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DJ40_2305  putative dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
DJ40_55  nifJ; ferredoxin (flavodoxin) oxidoreductase [KO:K03737] [EC:1.2.7.1 1.2.7.-]
DJ40_695  S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
DJ40_201  adhE; aldehyde-alcohol dehydrogenase [KO:K04072] [EC:1.2.1.10 1.1.1.1]
DJ40_110  aldehyde dehydrogenase family protein [KO:K00138] [EC:1.2.1.-]
DJ40_2099  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
DJ40_1075  galM; galactose mutarotase [KO:K01785] [EC:5.1.3.3]
DJ40_2396  yihX; phosphatase yihX [KO:K20866] [EC:3.1.3.10]
DJ40_3566  pgm; phosphoglucomutase, alpha-D-glucose phosphate-specific [KO:K01835] [EC:5.4.2.2]
DJ40_223  aldose 1-epimerase family protein [KO:K01792] [EC:5.1.3.15]
DJ40_2633  pckA; phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
DJ40_2661  hypothetical protein [KO:K01222] [EC:3.2.1.86]
DJ40_943  glycosyl hydrolase 1 family protein [KO:K01223] [EC:3.2.1.86]
DJ40_3818  crr; glucose-specific phosphotransferase enzyme IIA component [KO:K02777] [EC:2.7.1.-]
DJ40_4079  ptsG; PTS system glucose-specific EIICB component [KO:K02779] [EC:2.7.1.199]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
ypq00020  Citrate cycle (TCA cycle)
ypq00030  Pentose phosphate pathway
ypq00500  Starch and sucrose metabolism
ypq00620  Pyruvate metabolism
ypq00640  Propanoate metabolism
KO pathway
ko00010   
LinkDB

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