Yersinia pestis Z176003: YPZ3_0446
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Entry
YPZ3_0446 CDS
T01210
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
ypz
Yersinia pestis Z176003
Pathway
ypz00260
Glycine, serine and threonine metabolism
ypz00261
Monobactam biosynthesis
ypz00270
Cysteine and methionine metabolism
ypz00300
Lysine biosynthesis
ypz01100
Metabolic pathways
ypz01110
Biosynthesis of secondary metabolites
ypz01120
Microbial metabolism in diverse environments
ypz01230
Biosynthesis of amino acids
Module
ypz_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
ypz_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
ypz_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
ypz00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
YPZ3_0446 (thrA)
00270 Cysteine and methionine metabolism
YPZ3_0446 (thrA)
00300 Lysine biosynthesis
YPZ3_0446 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
YPZ3_0446 (thrA)
Enzymes [BR:
ypz01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
YPZ3_0446 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
YPZ3_0446 (thrA)
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GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
NAD_binding_3
ACT_7
ACT
Motif
Other DBs
NCBI-ProteinID:
ADE63356
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Position
536888..539347
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AA seq
819 aa
AA seq
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MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDI
SPNISDAERIFAELLRGLADTQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINA
SIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHYLESTVDITESTRRIGASGIP
SDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV
PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESI
DEDSPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISF
CVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIISVVGDGMRTLRGISARFFSAL
ARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL
IEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSC
RKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSLSFIFGKLDEGMSLSEATRQA
KALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLA
RLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFY
TRYYQPIPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq
2460 nt
NT seq
+upstream
nt +downstream
nt
atgcgagtgctgaaatttggcgggacatcagtggcaaatgccgagcgctttatgcgtgtt
gccgatatcatcgaaagtaatgcgcgtcagggacaagtggctacggtgttatccgctccc
gcgaagataacgaaccatctcgttgccatgatcgataaaatggtcgcagggcaagatatc
tccccgaacatcagcgatgctgagcggatttttgctgagttattgcgtggattagctgat
actcagccaggctttgattatgatcgcctaaaagccttggtcggccatgagtttgcgcaa
ctcaaacacctgctacacggtatttcgttgttggggcagtgcccagacagcattaatgcc
tcaattatctgccgtggcgaaaaactctccatcgccattatggaggcgttatttcaggct
aagggttatcacgttacggtgattaatccagtcgaaaaattgttggcgcagggccattat
ctcgaatccactgttgatatcacggagtctacccgccgtatcggtgccagcggtattcca
tctgatcacatcatcctgatggctggttttactgcgggtaatgataaaggtgaattggtg
gtgttggggcgtaatggctctgattattccgctgccgtgctggctgcttgcttacgggca
gattgttgtgagatttggaccgatgtcgacggggtctatacttgtgacccgcgtaccgtt
ccagatgccagattactgaaatcgatgtcataccaagaggcaatggagctttcctatttt
ggtgctaaagttcttcaccctcgcactatcgctcctattgcccgcttccaaattccttgt
ctgataaaaaacacctctaacccgcaagcccccggtaccttgattggtggtgaaagcatt
gatgaggattctccggtcaaaggcattaccaacctgaataatatggcgatgattaatgtt
tcagggccaggaatgaaagggatggtcggtatggctgcccgcgtctttgcggtgatgtcg
cgcagcggtatttcagtggtgctaatcactcagtcctcttctgaatacagcatcagtttt
tgtgtgccgcaaggtgagttattgcgcgcccgccgagcgctggaagatgagttttatctg
gagttgaaagacggtgtcttggatcctctggatgtgatggaacatctggcaattatctct
gtggtcggtgacggtatgcgcaccctgcgcggtatttctgcccgtttcttctcggctctg
gcgcgcgccaacatcaatattattgctatcgctcaaggctcgtctgagcgctctatttct
gtggttgtcaataatgatgcggtcactaccggggtgcgagtttgccaccagatgctgttt
aacacggatcaagtcattgaggtgtttgtcattggcgtgggtggtgtggggggcgcatta
atcgaacaaatctatcgccagcaaccgtggttgaaacagcgtcatattgatttacgtgtt
tgtggtatcgcgaattccaaagccatgttgaccaacgtgcatggcattgcattagataac
tggcgtcaggaactggctgaagttcaggagccgtttaacctgagccgcttgatccgtctg
gttaaagagtatcacttactgaacccggtcattgttgactgtacctcaagccaggcggtt
gctgatcaatatgctgatttcctgaccgatggcttccatgtggtgacgccaaacaagaaa
gccaacacttcatcaatgaattattaccgccaaatgcgtgccgctgcgacgaaatcgtgc
cgtaaattcttgtatgacacaaacgttggggcggggctaccggtgatcgagaacttacag
aacctgctcaatgcgggtgatgaactgatgcgcttcaccggtattctgtccggttcactt
tccttcatcttcggtaagctagatgaggggatgtcattgtcagaggcaacacggcaagct
aaggcgttggggtataccgaacccgatccacgtgatgatctctctgggatggatgttgcc
cgtaaattgttgattttggcccgtgaagcagggtacaaacttgagttggctgatatcgag
gttgagtccgtcttaccagcaagctttgatgcttcaggtgatgtggatactttcctggcg
cgcctgccatcattggatgctgaatttacccgcttggtagcgaatgctgcggagcagggc
aaagtgctacgttatgtcggagtgattgaagacgggcgttgtaaagtgcggatggaggca
gttgacggtaacgacccgttgtataaagttaagaatggcgagaatgcgttggctttctat
acccgctattatcagccaattccgttggtgctacgcggttatggcgcaggcaatgatgtg
actgccgctggggtgtttgccgatcttttacgcacattatcatggaagttgggagtttaa
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