KEGG   ENZYME: 1.1.1.105
Entry
EC 1.1.1.105                Enzyme                                 

Name
all-trans-retinol dehydrogenase (NAD+);
retinol (vitamin A1) dehydrogenase;
MDR;
microsomal retinol dehydrogenase;
retinol dehydrogenase (misleading);
retinal reductase (ambiguous);
retinene reductase;
epidermal retinol dehydrogenase 2;
SDR16C5 (gene name);
RDH16 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
all-trans retinol:NAD+ oxidoreductase
Reaction(IUBMB)
all-trans-retinol---[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal---[cellular-retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R02124
Substrate
all-trans-retinol---[cellular-retinol-binding-protein];
NAD+ [CPD:C00003]
Product
all-trans-retinal---[cellular-retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2].
History
EC 1.1.1.105 created 1972, modified 2011
Pathway
ec00830  Retinol metabolism
ec01100  Metabolic pathways
Orthology
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K15734  all-trans-retinol dehydrogenase (NAD+)
Genes
HSA: 195814(SDR16C5) 8630(HSD17B6)
PTR: 452001 472773(SDR16C5)
PPS: 100993740(SDR16C5) 100996145(HSD17B6)
GGO: 101152181(SDR16C5) 101153072
PON: 100450496(SDR16C5) 100454653 100458219(HSD17B6)
NLE: 100600756(SDR16C5) 100606923
MCC: 696397(SDR16C5) 713549(HSD17B6)
MCF: 101926544(HSD17B6) 101926736(SDR16C5)
CSAB: 103236829(SDR16C5) 103238543(HSD17B6)
CATY: 105587281(HSD17B6) 105592158(SDR16C5)
PANU: 100998417(SDR16C5)
RRO: 104661773(SDR16C5) 104673659(HSD17B6)
RBB: 108516069(HSD17B6) 108538388
TFN: 117078998(SDR16C5) 117089914(HSD17B6)
PTEH: 111524870(SDR16C5) 111541833(HSD17B6)
CJC: 100387390(HSD17B6) 100392998(SDR16C5)
SBQ: 101038570 101054253(HSD17B6)
MMUR: 105865568 105876404(SDR16C5)
MMU: 242285(Sdr16c5) 27400(Hsd17b6)
MCAL: 110293742(Sdr16c5) 110303948
MPAH: 110326955(Hsd17b6) 110338936(Sdr16c5)
RNO: 286964(Hsd17b6) 297805(Sdr16c5)
MCOC: 116076149 116088118(Sdr16c5)
MUN: 110562497
NGI: 103730224(Hsd17b6) 103734179(Sdr16c5)
HGL: 101699287(Hsd17b6) 101723971(Sdr16c5)
CCAN: 109686095 109702463(Sdr16c5)
OCU: 100357209
TUP: 102485005(HSD17B6) 102489556(SDR16C5)
CFA: 477888(SDR16C5) 481118(HSD17B6)
VVP: 112922366(HSD17B6) 112929554(SDR16C5)
VLG: 121491966(HSD17B6) 121499010(SDR16C5)
AML: 100464987(SDR16C5) 100474694
UMR: 103656323(HSD17B6) 103677445(SDR16C5)
UAH: 113256406(HSD17B6) 113268084(SDR16C5)
ORO: 101368715(HSD17B6) 101381803(SDR16C5)
MPUF: 101672306(HSD17B6) 101677841(SDR16C5)
EJU: 114215053(HSD17B6) 114220874(SDR16C5)
MLX: 118008692 118014839(SDR16C5)
FCA: 101082207(SDR16C5) 101088341(HSD17B6)
PYU: 121038246(SDR16C5) 121040906(HSD17B6)
PBG: 122473787(HSD17B6) 122495429(SDR16C5)
PTG: 102959434(SDR16C5) 102971783(HSD17B6)
PPAD: 109250295(SDR16C5) 109270351(HSD17B6)
AJU: 106982532(SDR16C5) 106986922(HSD17B6)
HHV: 120222469(SDR16C5) 120224864(HSD17B6)
BTA: 526726(SDR16C5) 533086(HSD17B6)
BOM: 102278015(SDR16C5) 102283510(HSD17B6)
BIU: 109559345 109568694(SDR16C5)
CHX: 102185066(HSD17B6) 102186703(SDR16C5)
OAS: 100302354(SDR16C5) 101105400
ODA: 120857465 120878592(SDR16C5)
SSC: 100157319(SDR16C5) 100620470
BACU: 103000587(SDR16C5) 103008169(HSD17B6)
LVE: 103076064(HSD17B6) 103076578(SDR16C5)
OOR: 101278484(HSD17B6) 101278906 101289971(SDR16C5)
DLE: 111165821(SDR16C5) 111165839 111173857(HSD17B6)
PCAD: 102974623(SDR16C5) 102988625
EPZ: 103552507(SDR16C5) 103565330(HSD17B6)
EAI: 106832977(HSD17B6) 106841659
MYB: 102260999(SDR16C5)
MYD: 102753241(SDR16C5)
MMYO: 118670855(SDR16C5)
MNA: 107533137(SDR16C5)
HAI: 109394445
DRO: 112315502(SDR16C5)
SHON: 118974971(SDR16C5)
MMF: 118623751
PALE: 102881754(SDR16C5) 102883634(HSD17B6)
RAY: 107521200(HSD17B6)
MJV: 108402619 108407808(SDR16C5)
TOD: 119242981
LAV: 100653594(SDR16C5) 100657790
MDO: 100029976(SDR16C5)
PCW: 110211084 110221381(SDR16C5)
OAA: 100083362(SDR16C5)
GGA: 421130(SDR16C5) 428538(ERD2L)
MGP: 100538468(SDR16C5) 100550995
APLA: 101805250(SDR16C5)
ACYG: 106039064(SDR16C5)
TGU: 100224990(SDR16C5) 100231724
SCAN: 103812390(SDR16C5) 103812400
OTC: 121340184(SDR16C5) 121340263
GFR: 102033253(SDR16C5) 102033420
FAB: 101814462(SDR16C5) 101814732
CCAE: 111924712(SDR16C5) 111924713
CCW: 104690373 104690375(SDR16C5)
ETL: 114060199(SDR16C5) 114060211
CLV: 102083489
EGZ: 104127571(SDR16C5) 104127582
NNI: 104019745(SDR16C5) 104019746
ACUN: 113476203
AAM: 106494376(SDR16C5) 106494442
CPIC: 101934621(SDR16C5) 101952318
PBI: 103063029(SDR16C5) 103063622
PMUR: 107284324(SDR16C5) 107293735
TSR: 106540515(SDR16C5) 106545328(HSD17B6)
PGUT: 117662721 117672813(SDR16C5)
ZVI: 118077226(HSD17B6) 118090083(SDR16C5)
XLA: 444148(sdr16c5.L)
XTR: 100498221 448386(sdr16c5)
NPR: 108789963(SDR16C5)
DRE: 405814(sdr16c5a) 406799(sdr16c5b) 563950(si:dkey-221h15.4)
SANH: 107660835 107676237 107698670(sdr16c5)
IPU: 108268084(sdr16c5) 108280727
TRU: 101062133(sdr16c5)
LCO: 104939798(sdr16c5)
CGOB: 115022156(sdr16c5)
ELY: 117272043
PLEP: 121951102
GAT: 120816204
CUD: 121520026
MZE: 101474670(sdr16c5)
ONL: 100706426(sdr16c5)
OAU: 116334141
OLA: 101174946(sdr16c5)
OML: 112151014
XMA: 102229885(sdr16c5)
XCO: 114146916(sdr16c5)
XHE: 116721391(sdr16c5)
PRET: 103479220(sdr16c5)
CVG: 107099250(sdr16c5)
CTUL: 119781487
NFU: 107395036(sdr16c5)
KMR: 108249507
ALIM: 106510864(sdr16c5)
AOCE: 111575778(sdr16c5)
CSEM: 103396624(sdr16c5)
POV: 109647912(sdr16c5)
SDU: 111233932(sdr16c5)
SLAL: 111648402(sdr16c5)
XGL: 120798871
HCQ: 109524163(sdr16c5)
BPEC: 110175116(sdr16c5)
MALB: 109971387(sdr16c5)
OMY: 110489858(sdr16c5b) 110508828 110529649(si:dkey-221h15.4) 110530198
SNH: 120020430 120024278(si:dkey-221h15.4) 120051101(sdr16c5b) 120055522
ELS: 105008851 105028193(sdr16c5)
AANG: 118225930(sdr16c5b) 118229768(si:dkey-221h15.4) 118234138
LOC: 102691815(sdr16c5) 102698185
PSPA: 121313917(sdr16c5b) 121317492
ARUT: 117394815(sdr16c5b) 117403406 117410685
CMK: 103177053(sdr16c5)
RTP: 109918672
CIN: 100185899
SCLV: 120346389
DME: Dmel_CG15629(CG15629) Dmel_CG9265(CG9265)
DSI: Dsimw501_GD21662(Dsim_GD21662) Dsimw501_GD23300(Dsim_GD23300)
APLN: 108732576
CSEC: 111871510
VDE: 111245087
VJA: 111266766
CEL: CELE_T02E1.5(dhs-3) CELE_T11F9.11(dhs-19)
CBR: CBG03768(Cbr-dhs-4) CBG04146(Cbr-dhs-3) CBG23222(Cbr-dhs-19)
TSP: Tsp_09971
EGL: EGR_00981
MBE: MBM_05882
ANG: ANI_1_1126124(An14g01270)
PTE: PTT_12628
CNE: CNH02090
CNB: CNBL2080
TASA: A1Q1_05574
SMIN: v1.2.025487.t1(symbB.v1.2.025487.t1)
PSHI: SAMEA2665130_1592(fabG_2)
ADI: B5T_04430
APAC: S7S_18390
AXE: P40_21605
DALK: DSCA_16220
ADE: Adeh_2306
ROH: FIU89_04815(sadH)
CPEG: CPELA_00035(fabG1)
CGK: CGERO_00035(fabG1)
CPSO: CPPEL_00035(fabG1)
NFA: NFA_34340
NFR: ERS450000_00613(budC_2)
NAD: NCTC11293_04557(budC_3)
ROP: ROP_35410
AUW: AURUGA1_01569(fabG_2)
ART: Arth_2505
ARM: ART_2310
AAGI: NCTC2676_1_00076(polS)
BLIN: BLSMQ_0754
TBW: NCTC13354_00741(fabG_1)
RXY: Rxyl_2457
SDYN: Mal52_55240(sadH)
LBF: LBF_3161
SGN: SGRA_4013
TMAR: MARIT_1274
RAI: RA0C_1296
RAR: RIA_1196
RAG: B739_0856
RAE: G148_0579
RAT: M949_1320
CTAK: 4412677_00576(acr1)
CANT: NCTC13489_00252(acr1) NCTC13489_01308(fabG_1)
 » show all
Reference
1  [PMID:5972368]
  Authors
Koen AL, Shaw CR.
  Title
Retinol and alcohol dehydrogenases in retina and liver.
  Journal
Biochim Biophys Acta 128:48-54 (1966)
DOI:10.1016/0926-6593(66)90140-8
Reference
2  [PMID:9677409]
  Authors
Gough WH, VanOoteghem S, Sint T, Kedishvili NY
  Title
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids.
  Journal
J Biol Chem 273:19778-85 (1998)
DOI:10.1074/jbc.273.31.19778
Reference
3  [PMID:12372410]
  Authors
Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, Inoko H
  Title
Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.
  Journal
Biochem Biophys Res Commun 297:1171-80 (2002)
DOI:10.1016/S0006-291X(02)02344-6
  Sequence
[hsa:195814]
Reference
4  [PMID:18926804]
  Authors
Lee SA, Belyaeva OV, Kedishvili NY
  Title
Biochemical characterization of human epidermal retinol dehydrogenase 2.
  Journal
Chem Biol Interact 178:182-7 (2009)
DOI:10.1016/j.cbi.2008.09.019
  Sequence
[hsa:195814]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.105
IUBMB Enzyme Nomenclature: 1.1.1.105
ExPASy - ENZYME nomenclature database: 1.1.1.105
BRENDA, the Enzyme Database: 1.1.1.105
CAS: 9033-53-8
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