KEGG   ENZYME: 1.1.1.141
Entry
EC 1.1.1.141                Enzyme                                 

Name
15-hydroxyprostaglandin dehydrogenase (NAD+);
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I);
PGDH;
11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase;
15-OH-PGDH;
15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostanoic dehydrogenase;
NAD+-specific 15-hydroxyprostaglandin dehydrogenase;
prostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NAD+);
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
Reaction(IUBMB)
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ [RN:R02580]
Reaction(KEGG)
R02580;
(other) R02683
Substrate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate;
NAD+ [CPD:C00003]
Product
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Acts on prostaglandin E2, F2alpha and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).
History
EC 1.1.1.141 created 1972
Orthology
K00069  15-hydroxyprostaglandin dehydrogenase (NAD)
Genes
HSA: 3248(HPGD)
PTR: 461613(HPGD)
PPS: 100987384(HPGD)
GGO: 101132897(HPGD)
PON: 100172788(HPGD)
NLE: 100591825(HPGD)
MCC: 697864(HPGD)
MCF: 102140664(HPGD)
CSAB: 103236551(HPGD)
CATY: 105597786(HPGD)
PANU: 101003374(HPGD)
RRO: 104659921(HPGD)
RBB: 108534045(HPGD)
TFN: 117086147(HPGD)
PTEH: 111554049(HPGD)
CJC: 100398196(HPGD)
SBQ: 101040274(HPGD)
MMUR: 105874653(HPGD)
MMU: 15446(Hpgd)
MCAL: 110300059(Hpgd)
MPAH: 110336583(Hpgd)
RNO: 79242(Hpgd)
MCOC: 116069301(Hpgd)
MUN: 110558708(Hpgd)
CGE: 100755116(Hpgd)
PLEU: 114686247(Hpgd)
NGI: 103745222(Hpgd)
HGL: 101714528(Hpgd)
OCU: 100348968(HPGD)
TUP: 102495551(HPGD)
CFA: 486073(HPGD)
VVP: 112934163(HPGD)
VLG: 121497246(HPGD)
AML: 100476658(HPGD)
UMR: 103675927(HPGD)
UAH: 113269915(HPGD)
ORO: 101372450(HPGD)
ELK: 111153747
MPUF: 101671285(HPGD)
EJU: 114217472(HPGD)
MLX: 118022147(HPGD)
FCA: 101087832(HPGD)
PYU: 121027067(HPGD)
PTG: 102970212(HPGD)
PPAD: 109262400(HPGD)
AJU: 106975814(HPGD)
HHV: 120239114(HPGD)
BTA: 512259(HPGD)
BOM: 102269812(HPGD)
BIU: 109562773(HPGD)
BBUB: 102414891(HPGD)
CHX: 102172997(HPGD)
OAS: 101112958(HPGD)
ODA: 120856684(HPGD)
CCAD: 122453165(HPGD)
SSC: 100156186(HPGD)
CFR: 102514446(HPGD)
CBAI: 105083366(HPGD)
CDK: 105101863(HPGD)
BACU: 102998492(HPGD)
LVE: 103089783(HPGD)
OOR: 101282003(HPGD)
DLE: 111185362(HPGD)
PCAD: 102987038(HPGD)
ECB: 100009687(HPGD)
EPZ: 103564977(HPGD)
EAI: 106831730(HPGD)
MYB: 102255162(HPGD)
MYD: 102760950(HPGD)
MMYO: 118658123(HPGD)
MNA: 107527507(HPGD)
HAI: 109379564(HPGD)
DRO: 112312365(HPGD)
SHON: 118984312(HPGD)
AJM: 119048222(HPGD)
MMF: 118615570(HPGD)
PALE: 102884381(HPGD)
PGIG: 120613358(HPGD)
RAY: 107497813(HPGD)
MJV: 108391441(HPGD)
TOD: 119257986(HPGD)
LAV: 100667134(HPGD)
TMU: 101341700
MDO: 100018659(HPGD)
SHR: 100932040(HPGD)
PCW: 110215988(HPGD)
OAA: 100089678(HPGD)
GGA: 422567(HPGD)
PCOC: 116237988(HPGD)
MGP: 100550540(HPGD)
CJO: 107313471(HPGD)
NMEL: 110398268(HPGD)
APLA: 101795486(HPGD)
ACYG: 106041765(HPGD)
TGU: 100229877(HPGD)
LSR: 110482168(HPGD)
SCAN: 103825862(HPGD)
PMOA: 120497956(HPGD)
GFR: 102037923(HPGD)
FAB: 101819475(HPGD)
PHI: 102100222(HPGD)
PMAJ: 107203319(HPGD)
CCAE: 111927925(HPGD) 111928519
CCW: 104690551(HPGD)
ETL: 114058991(HPGD)
FPG: 101913041(HPGD)
FCH: 102048817(HPGD)
CLV: 102089275(HPGD)
EGZ: 104131081(HPGD)
NNI: 104021374(HPGD)
ACUN: 113479421(HPGD)
PADL: 103922575(HPGD)
AAM: 106484005(HPGD)
NPD: 112953160(HPGD)
ASN: 102375779(HPGD)
AMJ: 102566187(HPGD)
CPOO: 109309761(HPGD)
GGN: 109300906(HPGD)
PSS: 102457970(HPGD)
CMY: 102935920(HPGD)
CPIC: 101947637(HPGD)
TST: 117877701(HPGD)
CABI: 116824694(HPGD)
ACS: 100557290(hpgd)
PVT: 110084316(HPGD)
PBI: 103049168(HPGD)
PMUR: 107286508(HPGD)
TSR: 106540211(HPGD)
PGUT: 117680193(HPGD)
PMUA: 114604322(HPGD)
ZVI: 118083952(HPGD)
GJA: 107107799(HPGD)
XLA: 108706627(hpgd.S) 446811(hpgd.L)
XTR: 493354(hpgd)
NPR: 108795296(HPGD)
DRE: 393297(zgc:56585) 565975(hpgd)
CCAR: 109078451(hpgd) 109086746
IPU: 108263011(hpgd) 108278852
PHYP: 113525423 113543131(hpgd)
AMEX: 103022606 103025346(hpgd)
EEE: 113568377 113584231(hpgd)
ELY: 117255195(hpgd) 117261587(zgc:56585)
PLEP: 121941530(hpgd) 121952409(zgc:56585) 121952738
SLUC: 116045746(hpgd) 116056093(zgc:56585)
ECRA: 117955851(zgc:56585) 117957508(hpgd)
PFLV: 114562071(hpgd) 114566922
CUD: 121508908(hpgd) 121519031(zgc:56585)
OML: 112142444(zgc:56585) 112142759 112142761 112157398(hpgd)
XMA: 102219275 102223588(hpgd)
XCO: 114144305(hpgd) 114152922
XHE: 116720545(hpgd) 116727810
PRET: 103460018 103472159(hpgd)
CVG: 107082642(hpgd) 107090678
CTUL: 119785546(hpgd) 119786893(zgc:56585)
NFU: 107386695 107394274(hpgd)
KMR: 108229147(hpgd) 108238042
CSEM: 103384297(hpgd) 103394939
SDU: 111234399 111239681(hpgd)
XGL: 120800828(hpgd) 120802214(zgc:56585)
HCQ: 109518149 109521693(hpgd)
MALB: 109952108(hpgd)
SASA: 100196521(pgdh) 106602382(PGDH) 106610167(PGDH)
OMY: 110491079(zgc:56585) 110497391 110534489
SNH: 120035153 120053034 120066045(zgc:56585)
ELS: 105011191 105020908(hpgd)
SFM: 108919973 108924388(hpgd)
PKI: 111837389(hpgd) 111860928
LOC: 102689930 102697547(hpgd)
PSPA: 121297312(hpgd) 121297577(zgc:56585)
LCM: 102348458 102352839(HPGD)
CMK: 103180222(hpgd) 103180223
SPU: 591898
DSI: Dsimw501_GD12481(Dsim_GD12481) Dsimw501_GD14635(Dsim_GD14635) Dsimw501_GD14636(Dsim_GD14636)
OBB: 114878271
CFO: 105258944
FEX: 115246410
PCF: 106785219
BTAB: 109038900
PVM: 113810768
HAME: 121871797
HAZT: 108665629
PDAM: 113674010
SPIS: 111341552
MBE: MBM_02495
 » show all
Reference
1
  Authors
Anggaard, E. and Samuelsson, B.
  Title
Purification and properties of a 15-hydroxyprostaglandin dehydrogenase from swine lung.
  Journal
Prostaglandins 25:293-300 (1996)
Reference
2  [PMID:1117007]
  Authors
Braithwaite SS, Jarabak J.
  Title
Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization.
  Journal
J Biol Chem 250:2315-8 (1975)
Reference
3  [PMID:234431]
  Authors
Lee SC, Levine L.
  Title
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
  Journal
J Biol Chem 250:548-52 (1975)
Reference
4  [PMID:803247]
  Authors
Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
  Title
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
  Journal
Biochemistry 14:142-5 (1975)
DOI:10.1021/bi00672a024
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.141
IUBMB Enzyme Nomenclature: 1.1.1.141
ExPASy - ENZYME nomenclature database: 1.1.1.141
BRENDA, the Enzyme Database: 1.1.1.141
CAS: 9030-87-9
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