KEGG   ENZYME: 1.1.1.148
Entry
EC 1.1.1.148                Enzyme                                 
Name
estradiol 17alpha-dehydrogenase;
17alpha-estradiol dehydrogenase;
17alpha-hydroxy steroid dehydrogenase;
17alpha-hydroxy steroid oxidoreductase;
17alpha-hydroxysteroid oxidoreductase;
estradiol 17alpha-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase
Reaction(IUBMB)
estradiol-17alpha + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02347 R02349]
Reaction(KEGG)
R02347 R02349
Substrate
estradiol-17alpha [CPD:C02537];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
estrone [CPD:C00468];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.148 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
Reference
1  [PMID:4383682]
  Authors
Renwick AG, Engel LL.
  Title
The partial purification of 17 alpha- and 17 beta-estradiol dehydrogenase activities from chicken liver.
  Journal
Biochim Biophys Acta 146:336-48 (1967)
DOI:10.1016/0005-2744(67)90220-3
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.148
IUBMB Enzyme Nomenclature: 1.1.1.148
ExPASy - ENZYME nomenclature database: 1.1.1.148
BRENDA, the Enzyme Database: 1.1.1.148
CAS: 9044-91-1
LinkDB

KEGG   REACTION: R02347
Entry
R02347                      Reaction                               
Name
estradiol-17alpha:NAD+ 17-oxidoreductase
Definition
Estradiol-17alpha + NAD+ <=> Estrone + NADH + H+
Equation
C02537 + C00003 <=> C00468 + C00004 + C00080
Comment
NADP+ (see R02349)
Reaction class
RC00001  C00003_C00004
RC00127  C00468_C02537
Enzyme
1.1.1.148
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.148
     R02347  Estradiol-17alpha + NAD+ <=> Estrone + NADH + H+
Other DBs
RHEA: 16704
LinkDB

KEGG   REACTION: R02349
Entry
R02349                      Reaction                               
Name
estradiol-17alpha:NADP+ 16-oxidoreductase
Definition
Estradiol-17alpha + NADP+ <=> Estrone + NADPH + H+
Equation
C02537 + C00006 <=> C00468 + C00005 + C00080
Comment
NAD+ (see R02347)
Reaction class
RC00001  C00005_C00006
RC00127  C00468_C02537
Enzyme
1.1.1.148
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.148
     R02349  Estradiol-17alpha + NADP+ <=> Estrone + NADPH + H+
Other DBs
RHEA: 16708
LinkDB

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