KEGG   ENZYME: 1.1.1.152
Entry
EC 1.1.1.152                Enzyme                                 
Name
3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase;
etiocholanolone 3alpha-dehydrogenase;
etiocholanolone 3alpha-dehydrogenase;
3alpha-hydroxy-5beta-steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase
Reaction(IUBMB)
3alpha-hydroxy-5beta-androstane-17-one + NAD+ = 5beta-androstane-3,17-dione + NADH + H+ [RN:R04309]
Reaction(KEGG)
R04309
Substrate
3alpha-hydroxy-5beta-androstane-17-one;
NAD+ [CPD:C00003]
Product
5beta-androstane-3,17-dione [CPD:C03772];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.1.1.152 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
Reference
1  [PMID:5365796]
  Authors
Roe CR, Kaplan NO.
  Title
Purification and substrate specificities of bacterial hydroxysteroid dehydrogenases.
  Journal
Biochemistry 8:5093-103 (1969)
DOI:10.1021/bi00840a063
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.152
IUBMB Enzyme Nomenclature: 1.1.1.152
ExPASy - ENZYME nomenclature database: 1.1.1.152
BRENDA, the Enzyme Database: 1.1.1.152
CAS: 37250-77-4
LinkDB

KEGG   REACTION: R04309
Entry
R04309                      Reaction                               
Name
3alpha-hydroxy-5beta-androstan-17-one:NAD+ oxidoreductase (B-specific)
Definition
Etiocholanolone + NAD+ <=> 5beta-Androstane-3,17-dione + NADH + H+
Equation
C04373 + C00003 <=> C03772 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00144  C03772_C04373
Enzyme
1.1.1.50        1.1.1.152
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50
     R04309  Etiocholanolone + NAD+ <=> 5beta-Androstane-3,17-dione + NADH + H+
    1.1.1.152
     R04309  Etiocholanolone + NAD+ <=> 5beta-Androstane-3,17-dione + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.50
   R10422  3alpha-Hydroxysteroid <=> 3-Oxosteroid
    R04309  Etiocholanolone <=> 5beta-Androstane-3,17-dione
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Other DBs
RHEA: 10359
LinkDB

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