KEGG   ENZYME: 1.1.1.154
Entry
EC 1.1.1.154                Enzyme                                 
Name
ureidoglycolate dehydrogenase [NAD(P)+];
ureidoglycolate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-ureidoglycolate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(S)-ureidoglycolate + NAD(P)+ = N-carbamoyl-2-oxoglycine + NAD(P)H + H+ [RN:R02935 R02936]
Reaction(KEGG)
R02935 R02936
Substrate
(S)-ureidoglycolate [CPD:C00603];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
N-carbamoyl-2-oxoglycine [CPD:C00802];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in catabolism of purines. The enzyme from the bacterium Arthrobacter allantoicus can use both NAD+ and NADP+ with similar activity. cf. EC 1.1.1.350, ureidoglycolate dehydrogenase (NAD+).
History
EC 1.1.1.154 created 1976, modified 2025
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4399430]
  Authors
van der Drift C, van Helvoort PE, Vogels GD.
  Title
S-ureidoglycolate dehydrogenase: purification and properties.
  Journal
Arch Biochem Biophys 145:465-9 (1971)
DOI:10.1016/S0003-9861(71)80006-1
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.154
IUBMB Enzyme Nomenclature: 1.1.1.154
ExPASy - ENZYME nomenclature database: 1.1.1.154
BRENDA, the Enzyme Database: 1.1.1.154
CAS: 62213-62-1
LinkDB

KEGG   REACTION: R02935
Entry
R02935                      Reaction                               
Name
(S)-ureidoglycolate:NAD+ oxidoreductase
Definition
(S)-Ureidoglycolate + NAD+ <=> Oxalureate + NADH + H+
Equation
C00603 + C00003 <=> C00802 + C00004 + C00080
Comment
NADP+ (see R02936)
Reaction class
RC00001  C00003_C00004
RC00169  C00603_C00802
Enzyme
1.1.1.154       1.1.1.350
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.154
     R02935  (S)-Ureidoglycolate + NAD+ <=> Oxalureate + NADH + H+
    1.1.1.350
     R02935  (S)-Ureidoglycolate + NAD+ <=> Oxalureate + NADH + H+
Orthology
K00073  ureidoglycolate dehydrogenase (NAD+) [EC:1.1.1.350]
Other DBs
RHEA: 15332
LinkDB

KEGG   REACTION: R02936
Entry
R02936                      Reaction                               
Name
(S)-ureidoglycolate:NADP+ oxidoreductase
Definition
(S)-Ureidoglycolate + NADP+ <=> Oxalureate + NADPH + H+
Equation
C00603 + C00006 <=> C00802 + C00005 + C00080
Comment
NAD+ (see R02935)
Reaction class
RC00001  C00005_C00006
RC00169  C00603_C00802
Enzyme
1.1.1.154
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.154
     R02936  (S)-Ureidoglycolate + NADP+ <=> Oxalureate + NADPH + H+
Orthology
K00073  ureidoglycolate dehydrogenase (NAD+) [EC:1.1.1.350]
Other DBs
RHEA: 15336
LinkDB

DBGET integrated database retrieval system