2-dehydropantolactone reductase (Re-specific);
2-oxopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase (A-specific);
(R)-pantolactone:NADP+ oxidoreductase (A-specific);
2-dehydropantolactone reductase (A-specific)
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
(R)-pantolactone:NADP+ oxidoreductase (Re-specific)
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:
The yeast enzyme differs from that from Escherichia coli [EC
2-dehydropantolactone reductase (Si-specific)], which is specific for the Si-face of NADP+, and in receptor requirements from EC
EC 188.8.131.52 created 1976, modified 1986, modified 1999
King HL Jr, Dyar RE, Wilken DR.
Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase.
J Biol Chem 249:4689-95 (1974)
Wilken DR, King HL Jr, Dyar RE.
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate.
J Biol Chem 250:2311-4 (1975)
ExPASy - ENZYME nomenclature database: 184.108.40.206
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