KEGG   ENZYME: 1.1.1.19
Entry
EC 1.1.1.19                 Enzyme                                 
Name
glucuronate reductase;
L-hexonate:NADP dehydrogenase;
TPN-L-gulonate dehydrogenase;
NADP-L-gulonate dehydrogenase;
D-glucuronate dehydrogenase;
D-glucuronate reductase;
L-glucuronate reductase (incorrect)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NADP+ 6-oxidoreductase
Reaction(IUBMB)
L-gulonate + NADP+ = D-glucuronate + NADPH + H+ [RN:R01481]
Reaction(KEGG)
R01481
Substrate
L-gulonate [CPD:C00800];
NADP+ [CPD:C00006]
Product
D-glucuronate [CPD:C00191];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].
History
EC 1.1.1.19 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13913518]
  Authors
SIVAK A, HOFFMANN-OSTENHOF O.
  Title
Enzymes of mesoinositol catabolism in the yeast Schwanniomyces accidentalis.
  Journal
Biochim Biophys Acta 53:426-8 (1961)
DOI:10.1016/0006-3002(61)90462-0
Reference
2
  Authors
von Wartburg JP, Wermoth B.
  Title
Aldehyde reductase.
  Journal
In: Jakoby WB (ed). Enzymatic Basis of Detoxication. Vol. 1. New York: Academic Press; 1980. p. 249-260.
Reference
3  [PMID:13787380]
  Authors
YORK JL, GROLLMAN AP, BUBLITZ C.
  Title
TPN-L-gluonate dehydrogenase.
  Journal
Biochim Biophys Acta 47:298-306 (1961)
DOI:10.1016/0006-3002(61)90290-6
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.19
IUBMB Enzyme Nomenclature: 1.1.1.19
ExPASy - ENZYME nomenclature database: 1.1.1.19
BRENDA, the Enzyme Database: 1.1.1.19
CAS: 9028-29-9
LinkDB

KEGG   REACTION: R01481
Entry
R01481                      Reaction                               
Name
L-gulonate:NADP+ 6-oxidoreductase
Definition
L-Gulonate + NADP+ <=> D-Glucuronate + NADPH + H+
Equation
C00800 + C00006 <=> C00191 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00108  C00191_C00800
Enzyme
1.1.1.2         1.1.1.19
Pathway
rn00040  Pentose and glucuronate interconversions
rn00053  Ascorbate and aldarate metabolism
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00014  Glucuronate pathway (uronate pathway)
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.2
     R01481  L-Gulonate + NADP+ <=> D-Glucuronate + NADPH + H+
    1.1.1.19
     R01481  L-Gulonate + NADP+ <=> D-Glucuronate + NADPH + H+
Orthology
K00002  alcohol dehydrogenase (NADP+) [EC:1.1.1.2]
Other DBs
RHEA: 14912
LinkDB

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