| Entry |
|
|---|
| Name |
15-hydroxyprostaglandin-I dehydrogenase (NADP+);
prostacyclin dehydrogenase;
PG I2 dehydrogenase;
prostacyclin dehydrogenase;
NADP+-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase;
NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin-I dehydrogenase (NADP+)
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
|---|
| Sysname |
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase
|
|---|
| Reaction(IUBMB) |
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+ [RN: R03520]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [CPD: C01312];
NADP+ [CPD: C00006]
|
|---|
| Product |
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate [CPD: C04835];
NADPH [CPD: C00005];
H+ [CPD: C00080]
|
|---|
| Comment |
Specific for prostaglandin I2.
|
|---|
| History |
EC 1.1.1.231 created 1990
|
|---|
| Pathway |
| ec00590 | Arachidonic acid metabolism |
|
|---|
| Reference |
|
|---|
| Authors |
Korff JM, Jarabak J. |
|---|
| Title |
Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.231 |
|
|---|
| LinkDB |
|
|---|
