KEGG   ENZYME: 1.1.1.24
Entry
EC 1.1.1.24                 Enzyme                                 
Name
quinate/shikimate dehydrogenase (NAD+);
quinate dehydrogenase (ambiguous);
quinic dehydrogenase (ambiguous);
quinate:NAD oxidoreductase;
quinate 5-dehydrogenase (ambiguous);
quinate:NAD+ 5-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-quinate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-quinate + NAD+ = 3-dehydroquinate + NADH + H+ [RN:R01872]
Reaction(KEGG)
R01872
Substrate
L-quinate [CPD:C00296];
NAD+ [CPD:C00003]
Product
3-dehydroquinate [CPD:C00944];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, found mostly in bacteria (mostly, but not exclusively in Gram-positive bacteria), fungi, and plants, participates in the degradation of quinate and shikimate with a strong preference for NAD+ as a cofactor. While the enzyme can act on both quinate and shikimate, activity is higher with the former. cf. EC 1.1.5.8, quinate/shikimate dehydrogenase (quinone), EC 1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+], and EC 1.1.1.25, shikimate dehydrogenase (NADP+).
History
EC 1.1.1.24 created 1961, modified 1976, modified 2004, modified 2021
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
Orthology
K09484  quinate dehydrogenase
Genes
QSU: 112022117 112029077
DHA: DEHA2C03674g
PIC: PICST_30813
CTEN: CANTEDRAFT_91884
CAUR: CJI97_002595
OPA: HPODL_00009
NCR: NCU06025(qa-3)
NTE: NEUTE1DRAFT46730(NEUTE1DRAFT_46730)
SMP: SMAC_07403(qa3)
PAN: PODANSg2393
TTT: THITE_2116892
MTM: MYCTH_2309055
CTHR: CTHT_0047970
MGR: MGG_07781
PPEI: PpBr36_03790
SSCK: SPSK_00849 SPSK_06463
FGR: FGSG_03880 FGSG_05704 FGSG_12357
FPU: FPSE_06307 FPSE_06596 FPSE_06601
FVR: FVEG_05965 FVEG_09879
FOX: FOXG_04621 FOXG_08708 FOXG_10944
NHE: NECHADRAFT_32803 NECHADRAFT_51161
TRE: TRIREDRAFT_109687
TRR: M419DRAFT_131881
MAW: MAC_04533
MAJ: MAA_07943
CMT: CCM_06001
PLJ: VFPFJ_10299
VAL: VDBG_08510
VDA: VDAG_08175
CFJ: CFIO01_01549 CFIO01_09601
CHIG: CH63R_14195
SAPO: SAPIO_CDS6511
ELA: UCREL1_1141 UCREL1_7618
PFY: PFICI_03111 PFICI_14932 PFICI_15086
SSL: SS1G_09188
BFU: BCIN_06g00810
MBE: MBM_00576 MBM_09548
PSCO: LY89DRAFT_635429 LY89DRAFT_680000 LY89DRAFT_698602
GLZ: GLAREA_11530
ANI: AN1137.2
AFM: AFUA_1G11590 AFUA_3G14800
ACT: ACLA_024050
NFI: NFIA_013950
AOR: AO090038000263 AO090103000428 AO090103000431
ANG: ANI_1_1222184(An04g08100) ANI_1_1306034(An03g03710)
AFV: AFLA_008750 AFLA_013099 AFLA_013104
ALUC: AKAW2_30242S AKAW2_50769A
ACHE: ACHE_30247S ACHE_80025A
APUU: APUU_30054A APUU_31273S APUU_50617S
PCS: Pc13g08380
PDP: PDIP_30870
TMF: PMAA_028760 PMAA_038650
TRG: TRUGW13939_02954 TRUGW13939_04943
PNO: SNOG_10413 SNOG_11439
PTE: PTT_10795
BZE: COCCADRAFT_83737
BSC: COCSADRAFT_107251
BOR: COCMIDRAFT_39029
AALT: CC77DRAFT_994183
ZTR: MYCGRDRAFT_84424(qa-3)
PFJ: MYCFIDRAFT_84957
FFU: CLAFUR5_10641
BCOM: BAUCODRAFT_32361
NPA: UCRNP2_4112
SHS: STEHIDRAFT_87473
HIR: HETIRDRAFT_476563
UMA: UMAG_05412
PFP: PFL1_00209
 » show all
Reference
1  [PMID:13208693]
  Authors
MITSUHASHI S, DAVIS BD.
  Title
Aromatic biosynthesis. XIII. Conversion of quinic acid to 5-dehydroquinic acid by quinic dehydrogenase.
  Journal
Biochim Biophys Acta 15:268-80 (1954)
DOI:10.1016/0006-3002(54)90069-4
Reference
2
  Authors
Gamborg, O.L.
  Title
Aromatic metabolism in plants. III. Quinate dehydrogenase from mung bean cell suspension cultures.
  Journal
Biochim Biophys Acta 128:483-491 (1966)
Reference
3  [PMID:7049157]
  Authors
Hawkins AR, Giles NH, Kinghorn JR.
  Title
Genetical and biochemical aspects of quinate breakdown in the filamentous fungus Aspergillus nidulans.
  Journal
Biochem Genet 20:271-86 (1982)
DOI:10.1007/BF00484424
Reference
4  [PMID:18669580]
  Authors
Singh S, Stavrinides J, Christendat D, Guttman DS.
  Title
A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass.
  Journal
Mol Biol Evol 25:2221-32 (2008)
DOI:10.1093/molbev/msn170
Reference
5  [PMID:19376919]
  Authors
Teramoto H, Inui M, Yukawa H.
  Title
Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum.
  Journal
Appl Environ Microbiol 75:3461-8 (2009)
DOI:10.1128/AEM.00163-09
  Sequence
[cgt:cgR_0495]
Reference
6  [PMID:23306642]
  Authors
Kubota T, Tanaka Y, Hiraga K, Inui M, Yukawa H.
  Title
Characterization of shikimate dehydrogenase homologues of Corynebacterium glutamicum.
  Journal
Appl Microbiol Biotechnol 97:8139-49 (2013)
DOI:10.1007/s00253-012-4659-y
  Sequence
[cgt:cgR_0495]
Reference
7  [PMID:25524738]
  Authors
Peek J, Christendat D.
  Title
The shikimate dehydrogenase family: functional diversity within a conserved structural and mechanistic framework.
  Journal
Arch Biochem Biophys 566:85-99 (2015)
DOI:10.1016/j.abb.2014.12.006
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.24
IUBMB Enzyme Nomenclature: 1.1.1.24
ExPASy - ENZYME nomenclature database: 1.1.1.24
BRENDA, the Enzyme Database: 1.1.1.24
CAS: 9028-28-8
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