Entry |
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Name |
codeinone reductase (NADPH)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
codeine:NADP+ oxidoreductase
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Reaction(IUBMB) |
codeine + NADP+ = codeinone + NADPH + H+ [RN: R05124]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.
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History |
EC 1.1.1.247 created 1999, modified 2001
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Pathway |
ec00950 | Isoquinoline alkaloid biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
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Genes |
PSOM: | 113293958 113294469 113328200 113328201 |
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Reference |
1 |
Authors |
Lenz R, Zenk MH. |
Title |
Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum. |
Journal |
Tetrahedron Lett 36:2449-2452 (1995) |
Reference |
|
Authors |
Lenz R, Zenk MH. |
Title |
Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.247 |
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LinkDB |
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