KEGG   ENZYME: 1.1.1.270
Entry
EC 1.1.1.270                Enzyme                                 
Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R12402]
Reaction(KEGG)
R12402 > R05691 R07495 R12399 R12400 R12401 R12405;
(other) R04328
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 51478(HSD17B7) 79154(DHRS11)
PTR: 454598(DHRS11) 466046 747814(HSD17B7)
PPS: 100985156 100989828(DHRS11) 117974256(HSD17B7)
GGO: 101133645(DHRS11) 101137638(HSD17B7)
PON: 100446761(HSD17B7) 100450428(DHRS11)
NLE: 100580130(DHRS11) 100587120(HSD17B7)
MCC: 713823(DHRS11) 720399
MCF: 102127673(HSD17B7) 102133734(DHRS11)
CSAB: 103223654(HSD17B7) 103242795(DHRS11)
CATY: 105583369(DHRS11) 105589219(HSD17B7)
PANU: 101007886(DHRS11) 101019563(HSD17B7)
TGE: 112610332(DHRS11)
RRO: 104656967(HSD17B7) 104672997(DHRS11)
RBB: 108526295(DHRS11) 108535633
TFN: 117067355(DHRS11) 117074787(HSD17B7)
PTEH: 111525046(HSD17B7) 111537680(DHRS11)
CJC: 100410416(HSD17B7) 100415468(DHRS11)
SBQ: 101047238(HSD17B7) 101049784(DHRS11)
CSYR: 103250515(HSD17B7) 103269368(DHRS11)
MMUR: 105873582(HSD17B7) 105879451(DHRS11)
OGA: 100950944(DHRS11) 100957601(HSD17B7)
MMU: 15490(Hsd17b7) 192970(Dhrs11)
MCAL: 110292934(Hsd17b7) 110304998(Dhrs11)
MPAH: 110322287(Hsd17b7) 110332326(Dhrs11)
RNO: 29540(Hsd17b7) 360583(Dhrs11)
MCOC: 116078372(Dhrs11) 116103156(Hsd17b7)
MUN: 110550630(Hsd17b7) 110555253(Dhrs11)
CGE: 100763193(Dhrs11) 100767580(Hsd17b7)
PLEU: 114689903(Hsd17b7) 114707715(Dhrs11)
NGI: 103732605(Dhrs11) 103746788(Hsd17b7)
HGL: 101704213(Dhrs11) 101712707(Hsd17b7)
CPOC: 100729809(Hsd17b7) 100733505(Dhrs11)
CCAN: 109690973(Hsd17b7) 109691233(Dhrs11)
DORD: 105983235(Dhrs11) 105989680(Hsd17b7) 106002656
DSP: 122103721(Hsd17b7) 122119919(Dhrs11)
OCU: 100008778(HSD17B7) 100349261 100350282(DHRS11)
OPI: 101524723(HSD17B7) 101526339(DHRS11)
TUP: 102473205(HSD17B7) 102481007(DHRS11)
CFA: 491129(DHRS11) 609364(HSD17B7)
VVP: 112914306(HSD17B7) 112917964(DHRS11)
VLG: 121473558(DHRS11) 121501279(HSD17B7)
AML: 100477716(HSD17B7) 100483445(DHRS11)
UMR: 103658287(HSD17B7) 103667445(DHRS11)
UAH: 113268675(HSD17B7) 113268922(DHRS11)
UAR: 123776919(DHRS11) 123800151(HSD17B7)
ELK: 111151061 111151673
LLV: 125086086 125086982
MPUF: 101688526(DHRS11) 101689203(HSD17B7)
ORO: 101368538(HSD17B7) 101372465(DHRS11)
EJU: 114210516(HSD17B7) 114213877(DHRS11)
ZCA: 113933397(HSD17B7) 113936410(DHRS11)
MLX: 118014038(HSD17B7) 118025129(DHRS11)
FCA: 101083482(HSD17B7) 101083724(DHRS11)
PYU: 121017066(DHRS11) 121020915(HSD17B7)
PBG: 122475607(HSD17B7) 122485272(DHRS11)
PTG: 102953856(DHRS11) 102968316(HSD17B7)
PPAD: 109251987(DHRS11) 109276652(HSD17B7)
AJU: 106980443(DHRS11) 106986761(HSD17B7)
HHV: 120241069(HSD17B7) 120248116(DHRS11)
BTA: 505212(HSD17B7) 510264(DHRS11)
BOM: 102266348(HSD17B7) 102267490(DHRS11)
BIU: 109574096(DHRS11) 109577890(HSD17B7)
BBUB: 102389083(HSD17B7) 102414485(DHRS11)
CHX: 102176160(DHRS11) 102179058(HSD17B7)
OAS: 101109465(DHRS11) 101110013(HSD17B7)
ODA: 120855521(HSD17B7) 120866412(DHRS11)
CCAD: 122429981(HSD17B7) 122432561 122449929(DHRS11)
SSC: 100155418(HSD17B7) 100513307(DHRS11)
CFR: 102507556(DHRS11) 102512546(HSD17B7)
CBAI: 105064308(DHRS11) 105068038(HSD17B7)
CDK: 105092702(HSD17B7) 105097850(DHRS11)
VPC: 102531229(HSD17B7) 102531560(DHRS11)
BACU: 103011691(DHRS11) 103014331(HSD17B7)
LVE: 103069867(DHRS11) 103084050(HSD17B7)
OOR: 101278328(DHRS11) 101286750(HSD17B7)
DLE: 111163734(DHRS11) 111169243(HSD17B7)
PCAD: 102984493(HSD17B7) 102995379(DHRS11)
PSIU: 116743840(HSD17B7) 116746440(DHRS11)
ECB: 100059061(HSD17B7) 100071416(DHRS11)
EPZ: 103554456(DHRS11) 103559639(HSD17B7)
EAI: 106823694(HSD17B7) 106844689(DHRS11)
MYB: 102251181(HSD17B7) 102262752(DHRS11)
MYD: 102765268(DHRS11) 102767046(HSD17B7)
MMYO: 118671682(DHRS11) 118673077(HSD17B7)
MLF: 102428751(HSD17B7) 102439019(DHRS11)
MNA: 107530816(DHRS11) 107535110(HSD17B7)
PKL: 118712029(HSD17B7) 118726466(DHRS11)
HAI: 109379798(DHRS11) 109392309(HSD17B7)
DRO: 112298817(HSD17B7) 112316505(DHRS11)
SHON: 118979201(HSD17B7) 119003587(DHRS11)
AJM: 119052313(HSD17B7) 119062640(DHRS11)
PDIC: 114502689(DHRS11) 114511975(HSD17B7)
PHAS: 123817235(DHRS11) 123818535(HSD17B7)
MMF: 118633927(DHRS11) 118637572(HSD17B7)
RFQ: 117013304(DHRS11) 117015421(HSD17B7)
PALE: 102892079(HSD17B7) 102894290(DHRS11)
PGIG: 120584178(HSD17B7) 120620857(DHRS11)
PVP: 105303413(HSD17B7) 105305000(DHRS11)
RAY: 107510114(DHRS11)
MJV: 108383263(DHRS11) 108396655(HSD17B7)
TOD: 119231930(DHRS11) 119241348(HSD17B7)
SARA: 101551054(HSD17B7) 101551118(DHRS11)
LAV: 100676060 100676239(DHRS11) 100676343(HSD17B7)
TMU: 101350976 101361551
DNM: 101418508(HSD17B7) 101420664(DHRS11)
MDO: 100016071(HSD17B7) 100618596(DHRS11)
GAS: 123243907(DHRS11) 123244846(HSD17B7)
SHR: 100926227(HSD17B7) 100933320(DHRS11)
PCW: 110209887(HSD17B7) 110212020(DHRS11)
OAA: 100077820(DHRS11) 114817513(HSD17B7)
GGA: 395172(DHRS11) 424367(HSD17B7)
PCOC: 116227942(DHRS11) 116230531(HSD17B7)
MGP: 100542399(DHRS11) 100542640(HSD17B7)
CJO: 107317140(HSD17B7) 107322636(DHRS11)
NMEL: 110402344(HSD17B7)
APLA: 101796287(DHRS11) 101799136(HSD17B7)
ACYG: 106041628(HSD17B7) 106046860(DHRS11)
AFUL: 116491836(HSD17B7) 116497443(DHRS11)
TGU: 100222823(HSD17B7) 100230987(DHRS11)
LSR: 110467717(DHRS11) 110478897(HSD17B7)
SCAN: 103820184(DHRS11) 103824326(HSD17B7)
PMOA: 120497588(HSD17B7) 120507831(DHRS11)
OTC: 121344332(HSD17B7) 121347083(DHRS11)
PRUF: 121359833(HSD17B7) 121361824(DHRS11)
GFR: 102031952(DHRS11) 102042580(HSD17B7)
FAB: 101806967(DHRS11) 101818521(HSD17B7)
PHI: 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107213026(DHRS11)
CCAE: 111932684(HSD17B7) 111937859(DHRS11)
CCW: 104690988(DHRS11) 104695594(HSD17B7)
ETL: 114057489(DHRS11) 114067481(HSD17B7)
ZAB: 102061622(DHRS11) 102069841(HSD17B7)
FPG: 101912846(DHRS11) 101919410(HSD17B7)
FCH: 102050282(DHRS11) 102059217(HSD17B7)
CLV: 102090168(DHRS11) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7)
NNI: 104010459(HSD17B7) 104016400(DHRS11)
ACUN: 113483111(HSD17B7) 113487258(DHRS11)
TALA: 104356976(HSD17B7) 104360740(DHRS11)
PADL: 103914076(HSD17B7) 103917037(DHRS11)
ACHC: 115347497(DHRS11) 115349487(HSD17B7)
AAM: 106494687(DHRS11) 106499711(HSD17B7)
AROW: 112968787(DHRS11) 112977170(HSD17B7)
NPD: 112951140(HSD17B7) 112954713(DHRS11)
DNE: 112987422(DHRS11) 112997417(HSD17B7)
ASN: 102374189(HSD17B7) 112551119(DHRS11)
AMJ: 102561890(DHRS11) 102565865(HSD17B7)
CPOO: 109307069(HSD17B7) 109317147(DHRS11)
GGN: 109287068(HSD17B7) 109293262(DHRS11)
PSS: 102452802(DHRS11) 102461698(HSD17B7)
CMY: 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936463(DHRS11) 101953232(HSD17B7)
TST: 117867488(DHRS11) 117881449(HSD17B7)
CABI: 116824223(DHRS11) 116831149(HSD17B7)
MRV: 120370584(HSD17B7) 120387076(DHRS11)
ACS: 100556465(hsd17b7)
PVT: 110075560(DHRS11) 110081655(HSD17B7)
SUND: 121929890(HSD17B7)
PBI: 103063132(HSD17B7) 103065679(DHRS11)
PMUR: 107294873(DHRS11) 107302880(HSD17B7)
TSR: 106539066(DHRS11)
PGUT: 117661207(HSD17B7) 117675673(DHRS11)
VKO: 123023595(DHRS11) 123027952(HSD17B7)
PMUA: 114585448(DHRS11) 114598525(HSD17B7)
ZVI: 118078620 118089365(HSD17B7) 118097242(DHRS11)
GJA: 107108933(DHRS11) 107121042(HSD17B7)
XLA: 108704561(dhrs11.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 496708(dhrs11) 548963(hsd17b7)
NPR: 108801354(HSD17B7)
RTEM: 120945526(HSD17B7)
BBUF: 120979196(HSD17B7)
BGAR: 122943861(HSD17B7)
DRE: 436969(dhrs11b.2) 768185(hsd17b7) 791578(dhrs11a) 791770(dhrs11b.1)
SRX: 107724130 107724135 107725165 107731464 107734374 107752375 107752377 107758362 107758673 107758683
SANH: 107654319 107665172 107672389 107672391 107672392 107683210 107684349(hsd17b7) 107692446 107694033
SGH: 107551038 107562199 107582609 107582610 107591475 107592755 107592792 107594628
CCAR: 109066392 109066456 109067119 109091408
CAUA: 113051185 113058281 113068034 113070053 113073543 113100989 113115232
IPU: 108260417(dhrs11a) 108271889(hsd17b7)
PHYP: 113531061(dhrs11) 113538418(hsd17b7)
SMEO: 124379484(dhrs11a) 124388015(hsd17b7)
AMEX: 103021948 103023849 103035681(hsd17b7) 103042381 103042688 103043000
EEE: 113570462(hsd17b7) 113577576(dhrs11)
TRU: 101072277 101075534 101079626(hsd17b7) 101079674(dhrs11) 115248690
TNG: GSTEN00016280G001 GSTEN00024682G001 GSTEN00030120G001
LCO: 104923446(dhrs11) 104925933 104930791 104933511
NCC: 104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
CGOB: 115007156(hsd17b7) 115017925 115018914(dhrs11)
ELY: 117253561(hsd17b7) 117260047 117268096(dhrs11a) 117271615
PLEP: 121940863(hsd17b7) 121943315 121951731 121952976(dhrs11a) 121963835
SLUC: 116045810 116048477 116058070(dhrs11a) 116063209(hsd17b7)
ECRA: 117942184 117950534(hsd17b7) 117954002 117955964(dhrs11a)
PFLV: 114553336 114561703 114565046 114566471(dhrs11)
GAT: 120816127(hsd17b7) 120822622(dhrs11a)
PPUG: 119202648(hsd17b7) 119215510(dhrs11a) 119216850
MSAM: 119882883 119895317(dhrs11a) 119900960(hsd17b7) 119902362
CUD: 121511992(hsd17b7) 121516037 121516905 121518057 121518430(dhrs11a) 121520534 121521235 121521242
MZE: 101475164(dhrs11) 101475712 101476044 101480987 101482452 101483095 106674540 106675057 106675058 112430056 112435947
ONL: 100694215 100694479 100695275 100695806 100696595 100698653 100698819 100698923 100699728 100701254 100706590(dhrs11) 100708654 102082640 106097863 109194269 112841634
OAU: 116313876 116313883 116316375 116316390 116318426 116321239 116321691(dhrs11a) 116326992 116327922(hsd17b7) 116331994 120432826 120443504 120443558 120443559 120443560 120443564
OLA: 101156119 101158433 101160498 101167642(dhrs11)
OML: 112138999(dhrs11a) 112147206 112149002 112150931(hsd17b7)
XMA: 102219736(dhrs11) 102223080(hsd17b7) 102225591 102238341 102238369
XCO: 114133176 114133177 114146459 114150325 114153301(dhrs11)
XHE: 116708005 116708105 116708307 116721503 116725522 116728461(dhrs11)
PRET: 103463731 103474141 103474142 103476050(dhrs11) 103479029
PFOR: 103133850(dhrs11) 103139996 103148525 103155178
PLAI: 106946498 106949687 106952787 106956657(dhrs11)
PMEI: 106907488 106917775 106922829 106933207(dhrs11)
GAF: 122832192 122832193 122838419(hsd17b7) 122840633 122845217(dhrs11a)
CVG: 107082613 107090012 107090028 107090353(dhrs11) 107099593
CTUL: 119789912 119790042(hsd17b7) 119791476(dhrs11a) 119795338 119795346
GMU: 124866110 124870458 124873591(hsd17b7) 124876497(dhrs11a) 124880193 124880948 124883585 124884217 124884218 124884265
NFU: 107379993 107379994 107384420 107387055(dhrs11) 107393363
KMR: 108230837(hsd17b7) 108233843(dhrs11a) 108235955 108236012 108236013 108238258 108247279
ALIM: 106511588 106525408(dhrs11) 106528419(hsd17b7) 106528841 106529742
NWH: 119407462(hsd17b7) 119411326 119411327 119414502 119420614(dhrs11a)
AOCE: 111563582 111567499 111567500 111572719(dhrs11) 111580065 111586999
CSEM: 103376747 103394917(dhrs11) 103395808
POV: 109625649(hsd17b7) 109628284(dhrs11) 109644359
SSEN: 122779439(dhrs11a) 122780473 122780509(hsd17b7)
HHIP: 117760842(hsd17b7) 117774058(dhrs11a) 117778754
LCF: 108875972 108876053 108879148 108883797 108893892(dhrs11)
SDU: 111222241(dhrs11) 111228986 111231932 111232315
SLAL: 111650668 111653771 111663897(dhrs11) 111670521
XGL: 120790306(hsd17b7) 120792442 120798840 120803065(dhrs11a)
HCQ: 109521128 109521129 109531160(dhrs11) 109532086
BPEC: 110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109960466(dhrs11) 109966957
SASA: 100196011(dhr11) 106567994 106568727 106603495
OTW: 112228556 112257875 112260221(hsd17b7) 112265505
OMY: 110507750 110530031(hsd17b7) 110533618 110537508
OGO: 123993925 123994594 124000655 124009932(hsd17b7)
ONE: 115105516 115114123(hsd17b7) 115135930 115137610
SALP: 111950509 111957119(hsd17b7) 111981656 111982530
SNH: 120018199 120030392 120055749(hsd17b7) 120057046
ELS: 105024805 105025666(dhrs11) 105030986
SFM: 108921710(dhrs11) 108935177(hsd17b7) 108938265
PKI: 111841069(hsd17b7) 111854721(dhrs11) 111859701
AANG: 118209261 118230844(hsd17b7) 118236726(dhrs11a)
LOC: 102694052(dhrs11) 102696390(hsd17b7)
PSPA: 121308431(dhrs11a) 121327382
ARUT: 117400178 117416602 117429929 117430868
LCM: 102348492(HSD17B7) 102362545(DHRS11)
CMK: 103180036(hsd17b7) 103180635(dhrs11a)
RTP: 109920236(dhrs11) 109925128(hsd17b7)
BFO: 118408332 118408333 118408418 118421569 118421586 118426285
BBEL: 109467187 109467200 109482730 109482774
CIN: 100175937 100179068 100180521 100183772 104266129 104266131 104266156
SCLV: 120325859 120336480 120346622
SPU: 574625 574750 574825 588363 752858
APLC: 110976300 110976571 110976608 110976634 110976654 110976655 110976666
SKO: 100374990 100375140 100375283 102804082
ACER: 107993351
BBIF: 117205728
BVK: 117230776
BVAN: 117157352
NMEA: 116424013
CGIG: 122405241
FEX: 115240720
PFUC: 122518089 122523913
CCIN: 107266625
CSET: 123307195
PPYR: 116171680
OTU: 111415407 111416771 111420830 111423098
HHAL: 106680119 106680121 106687257 106687260 106687261 106687264 106691770 106691802 112210398
NLU: 111054592 111054596 111054598
CSEC: 111867801 111868321 111868327 111873476 111873478 111873484 111873485 111873486 111873934 111875540 111875546
FCD: 110845300 110848537
DPX: DAPPUDRAFT_306348
DMK: 116930984
PVM: 113817572 113823180
PJA: 122245754 122247374
HAME: 121862366 121865924
PCLA: 123767671 123767673 123767674 123767675
PTRU: 123515477 123515543 123515544 123515545 123515937 123515938
CSCU: 111616124 111618745 111618759
PTEP: 107437425
SDM: 118180812 118195543
HRO: HELRODRAFT_76698
LGI: LOTGIDRAFT_201976 LOTGIDRAFT_205793
PCAN: 112561798 112564142 112575325
BGT: 106062648 106063212
GAE: 121366783 121376023 121380252 121381187
HRF: 124113772 124114009 124114011 124114013 124114014 124143791 124146728 124146756
HRJ: 124260971 124264874 124288111 124288131 124288132
CRG: 105331538 105332739 105338891 117680536
MYI: 110447365 110457107
PMAX: 117328501 117328541 117343915
MMER: 123524121 123531642 123531798
OBI: 106869005 106869006
OSN: 115223516 115223538 115223587 115231651
LAK: 106150742 106152479 106155453 106155948 106155949 106155960 106157462 106158358 106160574 106162367 106165644 106166261 106166737 106167094 106170933 106170936 106176414
TAD: TRIADDRAFT_53215
AQU: 100632069 100632185 100633565 100638506 100640506
QSU: 111993502 112014247
SCE: YLR100W(ERG27)
AGO: AGOS_AGR068W
ERC: Ecym_4279
KLA: KLLA0_F19756g
KMX: KLMA_40163(ERG27)
LTH: KLTH0G13046g
VPO: Kpol_1033p20
ZRO: ZYRO0D06534g
CGR: CAGL0M11506g
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
TGB: HG536_0C01650
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
ZMK: HG535_0G04170
PPA: PAS_chr2-1_0628
DHA: DEHA2E20130g
PIC: PICST_61325(ERG27)
PGU: PGUG_05066
SPAA: SPAPADRAFT_59939
LEL: LELG_00158
CAL: CAALFM_CR01140CA(ERG27)
CTP: CTRG_00974
COT: CORT_0A01630
CDU: CD36_26140(ERG27)
CTEN: CANTEDRAFT_113050
YLI: YALI0B17644g
CLU: CLUG_05409
CLUS: A9F13_23g00473
CAUR: CJI97_004310
SLB: AWJ20_1569(ERG27)
PKZ: C5L36_0A05120
BNN: FOA43_001771
BBRX: BRETT_004734
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SMP: SMAC_07919
PAN: PODANSg3046
TTT: THITE_164350
MTM: MYCTH_69410
CTHR: CTHT_0040790
TMN: UCRPA7_4666
SSCK: SPSK_07425
FGR: FGSG_13596
FPU: FPSE_10479
FVR: FVEG_04041
FOX: FOXG_06186
NHE: NECHADRAFT_91272
TRE: TRIREDRAFT_2634
TRR: M419DRAFT_72950
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
PLJ: VFPFJ_03970
VAL: VDBG_08048
VDA: VDAG_01545
CFJ: CFIO01_12216
SAPO: SAPIO_CDS8162
ELA: UCREL1_2995
PFY: PFICI_14173
SSL: SS1G_00326
BFU: BCIN_03g05110
MBE: MBM_01041
PSCO: LY89DRAFT_608282
GLZ: GLAREA_07003
ANI: AN5585.2
AFM: AFUA_4G11500
ACT: ACLA_050580
NFI: NFIA_104700
AOR: AO090003001070
ANG: ANI_1_1880184(An04g05000)
AFV: AFLA_000602
ALUC: AKAW2_51484A(ERG27)
ACHE: ACHE_10583S(ERG27)
APUU: APUU_40944S(ERG27)
PCS: Pc22g06030
PDP: PDIP_33960
TMF: PMAA_041550
TRG: TRUGW13939_02849
CIM: CIMG_01575
CPW: CPC735_048910
URE: UREG_05299
PBL: PAAG_02717
PBN: PADG_01744
ABE: ARB_02354
TVE: TRV_04668
AJE: HCAG_01553
BGH: BDBG_07225
PNO: SNOG_06194
PTE: PTT_11743
BZE: COCCADRAFT_22878
BSC: COCSADRAFT_32948
BOR: COCMIDRAFT_4981
AALT: CC77DRAFT_76456
ZTR: MYCGRDRAFT_38293
PFJ: MYCFIDRAFT_82835
NPA: UCRNP2_3103
TML: GSTUM_00003619001
SPO: SPBC1709.07(erg27)
CNE: CND03020
CNB: CNBD3330
CGI: CGB_D5570C
TMS: TREMEDRAFT_43600
TASA: A1Q1_03186
TVS: TRAVEDRAFT_73290
DSQ: DICSQDRAFT_162108 DICSQDRAFT_88133
HIR: HETIRDRAFT_312795
ADL: AURDEDRAFT_80749
FME: FOMMEDRAFT_21336
GTR: GLOTRDRAFT_103653
LBC: LACBIDRAFT_303734
MRR: Moror_13823
CCI: CC1G_09970
SCM: SCHCODRAFT_80561
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
CPUT: CONPUDRAFT_103632
SLA: SERLADRAFT_333162
WSE: WALSEDRAFT_70726
UMA: UMAG_02895
PFP: PFL1_04973
MGL: MGL_2564
MRT: MRET_0524
PGR: PGTG_14396
MLR: MELLADRAFT_64276
 » show all
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5
LinkDB

KEGG   REACTION: R12400
Entry
R12400                      Reaction                               
Name
episterol:NADP+ 3-oxidoreductase
Definition
Episterone + NADPH + H+ <=> Episterol + NADP+
Equation
C22122 + C00005 + C00080 <=> C15777 + C00006
Reaction class
RC00144  C15777_C22122
Enzyme
1.1.1.270
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
LinkDB

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