KEGG   ENZYME: 1.1.1.288
Entry
EC 1.1.1.288                Enzyme                                 
Name
xanthoxin dehydrogenase;
xanthoxin oxidase;
ABA2
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
xanthoxin:NAD+ oxidoreductase
Reaction(IUBMB)
xanthoxin + NAD+ = abscisic aldehyde + NADH + H+ [RN:R06954]
Reaction(KEGG)
R06954
Substrate
xanthoxin [CPD:C13453];
NAD+ [CPD:C00003]
Product
abscisic aldehyde [CPD:C13455];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.14.137 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3].
History
EC 1.1.1.288 created 2005
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09841  xanthoxin dehydrogenase
Genes
ATH: AT1G52340(ABA2)
ALY: 9327753
CRB: 17896886
CSAT: 104758555 104778156
EUS: EUTSA_v10011636mg
BRP: 103832798 103871215
BNA: 106345736 106390565
BOE: 106300040
RSZ: 108860834
THJ: 104821959
CPAP: 110815871
CIT: 102577974(ABA2)
CIC: CICLE_v10012415mg
PVY: 116143607
MINC: 123215053
TCC: 18585758
GRA: 105783205
GHI: 107920536 107933310
GAB: 108461096
HSYR: 120162557
DZI: 111295129 111310084
EGR: 104454559
GMX: 100786658 100801691
GSJ: 114374582 114376976
PVU: PHAVU_005G031500g PHAVU_005G031600g
VRA: 106760860 106761417
VAR: 108333217 108333278
VUN: 114162538 114176348
VUM: 124842493 124845387
CCAJ: 109809099 109815886
APRC: 113867779
MTR: 11414690
CAM: 101515018
PSAT: 127085747
VVO: 131631924
LJA: 130749186
ADU: 107471843
AIP: 107622404
AHF: 112717010 112782563
LANG: 109335868
PCIN: 129295431 129296353
QSA: O6P43_029656
FVE: 101292810
RCN: 112179057
PPER: 18785370
PMUM: 103343399
PAVI: 110747964 110770832
PDUL: 117620278
MDM: 103431475 103446486 114819149
MSYL: 126600708 126628499 126628501
PXB: 103945571 103957656 103957657
ZJU: 125422308
MNT: 21391964
CSAV: 115698597
CSV: 101219413
CMO: 103503321
BHJ: 120092550
MCHA: 111024504
CMAX: 111489670
CMOS: 111445228
CPEP: 111808179
RCU: 8270915 8280319
MEAN: 126682574
JCU: 105631198
HBR: 110661036
MESC: 110613693
POP: 7487015
PEU: 105107390
PALZ: 118061218
PNZ: 133681164
JRE: 108988748 108988790 108988885 108989891
CILL: 122289539 122294916
CAVE: 132185686
QSU: 112022992 112022997 112023002
QLO: 115986376 115986377 115986378
TWL: 119988731 119989639 119989664 119989851 120006222 120006223
VVI: 100265470
VRI: 117927554
SLY: 101254297 101254591
SPEN: 107015744 107018349 107019321
SOT: 102577811 102584670
SSTN: 125856475 125856853
SDUL: 129902627 129904323
CANN: 107855067 107855068
LBB: 132627371 132627373
NTA: 107760487 107765743 107765752 107778136
NSY: 104235616 104237462
NTO: 104121195 104121196
NAU: 109207455 109209388
INI: 109155970
ITR: 115997558
SIND: 105172159
OEU: 111410241
EGT: 105951798 105957017
SSPL: 121756256 121759247
SMIL: 130994657 131022895
SHIS: 125223514 125223696
APAN: 127261320 127262583
HAN: 110925709
ECAD: 122603241 122605147
LSV: 111876124 111916298
CCAV: 112515797
DCR: 108206649
CSIN: 114297049
RVL: 131334732
AEW: 130783853
BVG: 104888541 104888542 104888543
SOE: 110784079 110784166
CQI: 110697046 110729644
ATRI: 130805838 130805839
MOF: 131163849
NNU: 104612004
MING: 122090896
TSS: 122648330 122672765 122672766
PSOM: 113312628
OSA: 4334535
OBR: 102708142
OGL: 127766755
BDI: 100827045
ATS: 109784728
TDC: 119303737 119312419 119350087
TAES: 123105588 123113898 123123404
TUA: 125511092
LPER: 127292200
LRD: 124701005
SBI: 8057083
ZMA: 100282128
MFLO: 136534305
SITA: 101756331 101757665
SVS: 117836315 117838061
PVIR: 120649344 120687980
PHAI: 112874733 112874734
PDA: 103720715 103720728
EGU: 105045553 105045554 105052461
MUS: 103981080
ZOF: 122041394 122045892
DCT: 110111993
PEQ: 110031715
AOF: 109848475
MSIN: 131250792
NCOL: 116257606 116257618
ATR: 18433242
 » show all
Reference
1  [PMID:16666262]
  Authors
Sindhu RK, Walton DC.
  Title
Xanthoxin Metabolism in Cell-free Preparations from Wild Type and Wilty Mutants of Tomato.
  Journal
Plant Physiol 88:178-182 (1988)
DOI:10.1104/pp.88.1.178
Reference
2  [PMID:9159947]
  Authors
Schwartz SH, Leon-Kloosterziel KM, Koornneef M, Zeevaart JA.
  Title
Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana.
  Journal
Plant Physiol 114:161-6 (1997)
DOI:10.1104/pp.114.1.161
  Sequence
[ath:AT1G52340]
Reference
3  [PMID:12172025]
  Authors
Gonzalez-Guzman M, Apostolova N, Belles JM, Barrero JM, Piqueras P, Ponce MR, Micol JL, Serrano R, Rodriguez PL
  Title
The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde.
  Journal
Plant Cell 14:1833-46 (2002)
DOI:10.1105/tpc.002477
  Sequence
[ath:AT1G52340]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.288
IUBMB Enzyme Nomenclature: 1.1.1.288
ExPASy - ENZYME nomenclature database: 1.1.1.288
BRENDA, the Enzyme Database: 1.1.1.288
CAS: 129204-37-1
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