KEGG   ENZYME: 1.1.1.300
Entry
EC 1.1.1.300                Enzyme                                 

Name
NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
retinol:NADP+ oxidoreductase
Reaction(IUBMB)
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
Reaction(KEGG)
R08379
Substrate
retinol [CPD:C00473];
NADP+ [CPD:C00006]
Product
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
History
EC 1.1.1.300 created 2009
Orthology
K11146  short-chain dehydrogenase/reductase 3
K11152  retinol dehydrogenase 11
K11153  retinol dehydrogenase 12
K11161  retinol dehydrogenase 13
Genes
HSA: 112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 100971367(DHRS3) 100975938(RDH11) 100976717(RDH12) 100995016(RDH13)
GGO: 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 100173396(RDH11) 100443109(RDH13) 100444779(RDH12) 100446028(DHRS3)
NLE: 100590397(RDH11) 100592081(RDH12) 100595824(RDH13) 100599507(DHRS3) 115833951
MCC: 106996362(RDH13) 711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798
MCF: 101865597(RDH12) 101866088(RDH11) 102118061(RDH13) 102142015(DHRS3)
CSAB: 103225584(DHRS3) 103229214(RDH11) 103229215(RDH12) 103235287(RDH13)
CATY: 105580842(DHRS3) 105582866(RDH11) 105582867(RDH12) 105582912(RDH13)
PANU: 101000507(RDH12) 101011773(RDH13) 101025196(DHRS3) 103875541(RDH11)
RRO: 104664937(RDH12) 104664944(RDH11) 104668927(DHRS3) 104674753(RDH13)
RBB: 108533721(RDH11) 108533722(RDH12) 108539385(DHRS3) 108542524(RDH13)
TFN: 117069432(RDH12) 117069434(RDH11) 117091720(RDH13) 117093295(DHRS3)
CJC: 100386416(DHRS3) 100403102(RDH12) 100406713(RDH13) 103787305(RDH11)
SBQ: 101033448(RDH12) 101039627(DHRS3) 101045253(RDH13) 104649866(RDH11)
MMUR: 105877189(RDH13) 105880249(RDH11) 105880251(RDH12) 105882703(DHRS3)
MMU: 108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
MCAL: 110292172(Dhrs3) 110297351(Rdh13) 110307013(Rdh11) 110307230(Rdh12)
MPAH: 110323041(Dhrs3) 110324273(Rdh11) 110324761(Rdh12) 110336860(Rdh13)
RNO: 313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
MCOC: 116079581(Rdh11) 116079825(Rdh12) 116096993(Dhrs3) 116101541(Rdh13)
MUN: 110539426(Dhrs3) 110540988(Rdh13) 110557055(Rdh11) 110563447 110563448
CGE: 100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
PLEU: 114685519(Dhrs3) 114688722 114697773(Rdh11) 114697775(Rdh12)
NGI: 103744827(Rdh13) 103747479(Dhrs3) 103749297(Rdh11) 103749298(Rdh12)
HGL: 101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
CCAN: 109683963(Dhrs3) 109694521(Rdh11) 109694522(Rdh12) 109696274(Rdh13)
OCU: 100337836(RDH12) 100344639(RDH13) 100348969 100353716(RDH11) 103352513(DHRS3)
TUP: 102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3)
CFA: 480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
VVP: 112909346(RDH13) 112927128(RDH12) 112927195(RDH11) 112929696(DHRS3)
VLG: 121475753(RDH13) 121492930(RDH11) 121493408(RDH12) 121496751(DHRS3)
AML: 100468936(RDH12) 100469186(RDH11) 100470711(RDH13) 100481198(DHRS3)
UMR: 103666638(DHRS3) 103671847(RDH12) 103671858(RDH11) 103680271(RDH13)
ORO: 101365883(RDH11) 101366366(RDH12) 101370738(DHRS3) 101383491(RDH13)
MPUF: 101672269(RDH11) 101672924(RDH12) 101678864(RDH13) 101687558(DHRS3)
EJU: 114202039(RDH13) 114207319(RDH11) 114207585(RDH12) 114213406(DHRS3)
MLX: 117997856(RDH13) 118002180(RDH11) 118002451(RDH12) 118019991(DHRS3)
FCA: 101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
PPAD: 109259903(RDH13) 109268278(RDH12) 109268280(RDH11) 109274137(DHRS3)
AJU: 106971557(RDH11) 106971559(RDH12) 106980937(RDH13) 106988168(DHRS3)
HHV: 120224913(DHRS3) 120237433(RDH12) 120237440(RDH11) 120239761(RDH13)
BTA: 281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
BIU: 109564569(RDH12) 109565274(RDH11) 109570447(DHRS3) 109572930(RDH13)
BBUB: 102404826(DHRS3) 102405382(RDH12) 102405721(RDH11) 102411635(RDH13)
CHX: 102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882 114108681(RDH13)
ODA: 120852788(RDH11) 120852789(RDH12) 120871899(RDH13) 120880238(DHRS3)
SSC: 100153020(RDH12) 100154684(RDH11) 100514967(DHRS3) 110261049(RDH13)
CFR: 102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
CDK: 105086164(RDH12) 105086165(RDH11) 105098733(RDH13) 105107044(DHRS3)
BACU: 103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
OOR: 101277554(RDH13) 101283025(RDH11) 101283442(RDH12) 101290385(DHRS3)
DLE: 111173039(RDH11) 111173259(RDH12) 111181006(RDH13) 111187101(DHRS3)
PCAD: 102978048(RDH12) 102978320(RDH11) 102982136(DHRS3) 102987556 114484116
ECB: 100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
EPZ: 103541138(RDH11) 103541139(RDH12) 103552172(DHRS3) 103554723(RDH13)
EAI: 106836659(DHRS3) 106840917(RDH13) 106844772(RDH12) 106844775
MYB: 102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
MMYO: 118655159(RDH13) 118656921(RDH11) 118656932(RDH12) 118676160(DHRS3)
MNA: 107531562(DHRS3) 107541313(RDH13) 107545709(RDH11) 107545710(RDH12)
HAI: 109373731(RDH13) 109381266(DHRS3) 109382035(RDH11) 109382038(RDH12)
DRO: 112299121(DHRS3) 112311390(RDH12) 112311797(RDH11) 112314049(RDH13)
SHON: 118976770(RDH11) 118976801(RDH12) 118981373(RDH13) 118986332(DHRS3)
AJM: 119034814(RDH11) 119034816(RDH12) 119059972(RDH13) 119064076(DHRS3)
MMF: 118627175(DHRS3) 118628327(RDH11) 118628335(RDH12) 118638727(RDH13)
PALE: 102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
RAY: 107503265(RDH11) 107503281(RDH12) 107513138(DHRS3) 107515444(RDH13)
MJV: 108396332(RDH13) 108402930(DHRS3) 108410077(RDH11) 108410078(RDH12)
LAV: 100656973(DHRS3) 100659620(RDH12) 100664643(RDH11) 100668990(RDH13)
MDO: 100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
PCW: 110198918(DHRS3) 110220123(RDH13) 110220578(RDH12) 110220629(RDH11)
GGA: 419480(DHRS3) 423274(RDH12)
PCOC: 116229291 116242686(DHRS3)
MGP: 100540846 100541886(DHRS3)
CJO: 107314931 107323359(DHRS3)
NMEL: 110401302 110408680(DHRS3)
APLA: 101792259(DHRS3) 101793409
ACYG: 106031772 106040190(DHRS3)
TGU: 100221618(DHRS3) 100226769
LSR: 110473996 110476789(DHRS3)
SCAN: 103820840(DHRS3) 103826955
PMOA: 120496756(DHRS3) 120500308
GFR: 102032402(DHRS3) 102032925(RDH12)
FAB: 101814379(DHRS3) 101816060(RDH12)
PHI: 102106104(RDH12) 102110985(DHRS3)
PMAJ: 107205238 107213682(DHRS3)
CCAE: 111930091 111938724(DHRS3)
CCW: 104688342 104693251(DHRS3)
ETL: 114062535 114065123(DHRS3)
FPG: 101916630(RDH12) 101921484(DHRS3)
FCH: 102055890 102058887(DHRS3)
EGZ: 104122065 104133092(DHRS3)
NNI: 104009010(DHRS3) 104020414
ACUN: 113480412 113487888(DHRS3)
PADL: 103914367 103917993(DHRS3)
AAM: 106482457(DHRS3) 106483104(RDH12)
ASN: 102370531(DHRS3) 102373718
AMJ: 102567292(RDH12) 102574201(DHRS3)
CPOO: 109314392(DHRS3) 109321084
GGN: 109293769(DHRS3) 109298864
PSS: 102445977(DHRS3) 102446647
CMY: 102934533 102944040(DHRS3)
CPIC: 101941293(DHRS3) 101950060(RDH12)
TST: 117867783(DHRS3) 117876877
CABI: 116821488 116821896(DHRS3)
PBI: 103054360(DHRS3) 103055029
PMUR: 107284674(DHRS3) 107285841
PGUT: 117656603(DHRS3) 117665566
GJA: 107112214(RDH12) 107124081(DHRS3)
XLA: 108697667(dhrs3.S) 444106(rdh13.L) 444269(dhrs3.L)
XTR: 493258(dhrs3) 496409(rdh13)
NPR: 108783931(DHRS3) 108788946(RDH13)
DRE: 100141353(si:dkey-94e7.2) 100150965(si:dkey-73n8.3) 407663(si:ch211-107o10.3) 436597(rdh12) 445083(dhrs3a) 450050(dhrs3b) 494176(rdh12l) 553712(zgc:112332) 561542(si:dkey-23o4.6) 751745(zgc:153441)
IPU: 100528113(rdh13) 108255144(dhrs3) 108257080 108263330(rdh11) 108268141 108270740(RDH12) 108275517(DHRS3) 108280225
ELY: 117246682 117256430(dhrs3b) 117259970(si:ch211-107o10.3) 117262711 117264433(rdh12l) 117264561(zgc:112332) 117264898(si:dkey-73n8.3) 117266286 117267571(rdh12)
PLEP: 121949987 121950706(dhrs3b) 121953459(rdh12) 121958652 121960539(rdh12l) 121960599(si:dkey-73n8.3) 121960618(zgc:112332) 121961810(si:ch211-107o10.3)
SLUC: 116037906(zgc:112332) 116038040(si:dkey-73n8.3) 116044253 116048580(rdh12l) 116051562(dhrs3b) 116057432(rdh12) 116060464(si:ch211-107o10.3) 116062588
GAT: 120810131 120810820(si:ch211-107o10.3) 120811541 120811542 120811951(rdh12l) 120819324 120832957(rdh12) 120835162(dhrs3b)
MSAM: 119883128(si:dkey-73n8.3) 119886682(dhrs3b) 119887132 119890531(si:ch211-107o10.3) 119893944 119898234 119908538(zgc:112332) 119909958(rdh12) 119916184
CUD: 121507446(dhrs3b) 121509965(si:ch211-107o10.3) 121513629 121515322 121525814(rdh12) 121526968 121527289 121527325(zgc:112332) 121527476(si:dkey-73n8.3) 121528291
OAU: 116310336 116310351 116314699(si:ch211-107o10.3) 116315043(dhrs3b) 116315244(rdh12) 116319932 116326232 116327119 116328260(si:dkey-73n8.3) 116328286(zgc:112332)
OML: 112136602 112144521(dhrs3b) 112147772(rdh12) 112151630(rdh12l) 112152847(si:ch211-107o10.3) 112154587
KMR: 108228975 108230029 108230278(rdh12l) 108231475(dhrs3b) 108232585(rdh12) 108237226 108237291(si:ch211-107o10.3) 108243166(si:dkey-73n8.3) 108243167(zgc:112332)
XGL: 120784530 120789703(si:dkey-73n8.3) 120789704(zgc:112332) 120789809(rdh12l) 120791156(si:ch211-107o10.3) 120793779 120794479 120795187(rdh12) 120807538(dhrs3b)
PSPA: 121299084 121307869(si:dkey-73n8.3) 121308219(zgc:112332) 121314247 121315784 121329268 121329334 121330121(rdh12)
LCM: 102347732(RDH13) 102349654 102353614(RDH12) 102354914 102361459(DHRS3)
DSI: Dsimw501_GD10497(Dsim_GD10497) Dsimw501_GD10498(Dsim_GD10498) Dsimw501_GD10499(Dsim_GD10499) Dsimw501_GD10500(Dsim_GD10500) Dsimw501_GD10501(Dsim_GD10501)
DPE: 6602084
MGEN: 117225076
NMEA: 116428599
ACEP: 105626379
CBR: CBG04620(Cbr-dhs-22) CBG24516(Cbr-dhs-24)
EGL: EGR_02372
PDAM: 113667168
ATH: AT1G64590
ALY: 9323935
CPAP: 110807030
TCC: 18597799
APRC: 113860614
CAM: 101509179
LJA: Lj1g3v0342000.1(Lj1g3v0342000.1)
FVE: 101295243
RCN: 112193888
MCHA: 111014975
RCU: 8269384
JCU: 105636270
HBR: 110672874
MESC: 110622567
POP: 7487251
PEU: 105122473
PALZ: 118053365
JRE: 109006782
TWL: 119992774
VRI: 117920382
SLY: 101258297
ITR: 116030211
DCR: 108215406
BDI: 100827273
TDC: 119297574
SITA: 101786469
PDA: 103710518
EGU: 105056971
DCT: 110107237
PEQ: 110022984
MAJ: MAA_07435
CMT: CCM_01960
MBE: MBM_08426
ANG: ANI_1_1940074(An08g04690)
PTE: PTT_20036
ABP: AGABI1DRAFT59093(AGABI1DRAFT_59093) AGABI1DRAFT70956(AGABI1DRAFT_70956)
ABV: AGABI2DRAFT117623(AGABI2DRAFT_117623) AGABI2DRAFT186625(AGABI2DRAFT_186625) AGABI2DRAFT203820(AGABI2DRAFT_203820)
DFA: DFA_01654
SMIN: v1.2.009977.t1(symbB.v1.2.009977.t1) v1.2.033662.t1(symbB.v1.2.033662.t1)
ALK: ALEK_2395
CCX: COCOR_00754(yciK)
HOH: Hoch_2073
RPB: RPB_3188
RPC: RPC_2983
RPD: RPD_1039
MDI: METDI3947
MEX: Mext_3159
MCH: Mchl_3483
MPO: Mpop_3355
MOR: MOC_4304
META: Y590_15415
RVA: Rvan_0765
BMD: BMD_2832
BMEG: BG04_5337
MANA: MAMMFC1_03177(fabG_2)
MCOO: MCOO_32000
MMAG: MMAD_31940
MCHE: BB28_17475
MSTE: MSTE_03452
HAU: Haur_3830
ATM: ANT_25440
DGE: Dgeo_1140
DFC: DFI_07860
PBOR: BSF38_01904(rhlG)
GAU: GAU_2064
BVU: BVU_1966
SLI: Slin_0197
HSW: Hsw_2466
FLM: MY04_4115
IAL: IALB_0056
TAF: THA_705
NGA: Ngar_c13700(sdr2)
NVN: NVIE_020260(sdr-2)
NEV: NTE_00111
LOKI: Lokiarch_06920(rhlG_1)
 » show all
Reference
1  [PMID:15865448]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
  Title
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
  Journal
Biochemistry 44:7035-47 (2005)
DOI:10.1021/bi050226k
  Sequence
[hsa:145226]
Reference
2  [PMID:18039331]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
  Title
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
  Journal
FEBS J 275:138-47 (2008)
DOI:10.1111/j.1742-4658.2007.06184.x
  Sequence
[hsa:112724]
Reference
3  [PMID:9705317]
  Authors
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
  Title
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
  Journal
J Biol Chem 273:21790-9 (1998)
DOI:10.1074/jbc.273.34.21790
  Sequence
[hsa:9249] [mmu:20148] [bta:281482]
Reference
4  [PMID:12036956]
  Authors
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
  Title
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
  Journal
J Biol Chem 277:28909-15 (2002)
DOI:10.1074/jbc.M202588200
  Sequence
[hsa:51109]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.300
IUBMB Enzyme Nomenclature: 1.1.1.300
ExPASy - ENZYME nomenclature database: 1.1.1.300
BRENDA, the Enzyme Database: 1.1.1.300
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