Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

D-glucose-6-phosphate:NAD(P)+ 1-oxidoreductase

D-glucose 6-phosphate + NAD(P)+ = 6-phospho-D-glucono-1,5-lactone + NAD(P)H + H+ [RN:R00835 R10520]

R00835 > R02736;
R10520 > R10907

D-glucose 6-phosphate [CPD:C00092];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the Gram-positive bacterium Leuconostoc mesenteroides prefers NADP+ while the enzyme from the Gram-negative bacterium Gluconacetobacter xylinus prefers NAD+. cf. EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+) and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).

EC 1.1.1.363 created 2013, modified 2015