KEGG   ENZYME: 1.1.1.367
Entry
EC 1.1.1.367                Enzyme                                 
Name
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase;
WbjC;
Cap5F
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
UDP-2-acetamido-2,6-dideoxy-L-talose:NADP+ oxidoreductase
Reaction(IUBMB)
UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NAD(P)+ = UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NAD(P)H + H+ [RN:R10665]
Reaction(KEGG)
R10665;
(other) R12552 R12553
Substrate
UDP-2-acetamido-2,6-dideoxy-beta-L-talose [CPD:C20768];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Part of the biosynthesis of UDP-N-acetyl-L-fucosamine. Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
History
EC 1.1.1.367 created 2014
Pathway
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K19068  UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
Genes
EOJECO26_2944(fnlB)
ECOOECRM13514_2753(fnlB)
ECOHECRM13516_2621(fnlB)
EABECABU_c23610(fnlB)
ELPP12B_c2137(capF)
SBZA464_2212
SBVN643_09265
ECANCWI88_07915
CUIAFK65_12840
CTUCTU_27300
CFARCI104_16435
CIEAN232_13735 AN232_31060
LEAGNG26_14690
BFTMNO13_08025
YFRAW19_2184
YKRCH54_3602
PALHB1H58_14580
PGZC2E15_13435
PTTVY86_07665
ASYAUT07_00149(fcl)
OPODSM2777_17405
HPASJL26_05870
PMUPM1008(wbjC)
PMVPMCN06_0222(wbjC)
PULNT08PM_0219
PMPPmu_01530(wbjC)
PMULDR93_961
PDAG4362423_00268(wbjC)
LUSE5843_03575
THESFHQ07_00275
THEHG7079_07105
VCZVAB027_3591
VFLAL536_19550
VTAA2995
VFIVF_0192(fnlB)
PMAICF386_03165
PAPPSPA7_1981
PNCNCGM2_4270(wbjC)
PAEBNCGM1900_3148(wbjC)
PSGG655_09070
PAEUBN889_06737
PPGPputGB1_1374
PPUHB479_06960
PMOSO165_002650
PMOLCLJ08_05530
PCIPCH70_40500
PFSPFLU_1658(fnl2)
PMANOU5_1708
PTVAA957_05810
PFWPF1751_v1c16220
PFFPFLUOLIPICF700210
PENPSEEN1501
PBAPSEBR_a1566
PFZAV641_08230
PSECCCOS191_3871
PUMHGP31_08955
PPSHG5J76_11625
PVKEPZ47_08540
PMAOPMYSY11_1868(wbjC)
PTRTHU722_0009235
PXNHU772_006860
PNNKEM63_05740
PFAKKSS94_07160
PORYEJA05_07540
HAESLO767_04840
MBSMRBBS_2501
MLQASQ50_04330
MARAD0851_05375
PALIA3K91_0727
PSYPE5677_09750
ABZABZJ_00088
ABRABTJ_03753
ABADABD1_00590
ABABBJAB0715_00105
ABAUIX87_14885
ABALABLAC_36950
AHLAHTJS_16405
AIDCTZ23_14895
ABERBSR55_00410
AVBRYU24_00890(fnlB)
SBPSbal223_1481
SJASJ2017_1340
PNGPNIG_a0508
PMAACPA52_14015
FTDAS84_1079
FTYCH70_511
FCFFNFX1_1463
FCNFN3523_1490
FPHFphi_1263
FPTBZ13_740
FPIBF30_1511
FPXKU46_48
FHACDV26_09050
FRCKX01_1760(capF)
TXAHQN79_09385
TANIJ8380_09240
TEETel_08635
THIMKFB96_06175
APACS7S_10530
MPRFJ8N69_05375
NIKF5I99_05205
AAJBOQ57_14820
AVRB565_2780
OCEGU3_12825
ZDFAN401_12710
CFONHZU75_02535
CPAUEHF44_09265
PDQCL55_00003260
PPNODA70_17325
PPNMLV28_13500
PRBX636_09595
POXMB84_03550
CABASBC2_28930(wbjC)
AXYAXYL_06295
AISBUW96_24745
AAQUD3M96_17705
ODIODI_R2816
PACRFXN63_16085
PARKLSG25_14390
RACRA876_17040
AJSAjs_3029
ACIPCBP36_03065
ACISCBP35_15875
VBOCKY39_06060
COFFOZ74_09625
CBXCenrod_0493
HYRBSY239_4260
HYBQ5W_21530
HYNF9K07_02085
SIMPC6571_03420
CBAASRAA_0133
CBABSMCB_0540
KIAG8A07_07110
EBAebA5887
AZAAZKH_0898
TMZTmz1t_3802
THKCCZ27_21920
APPCAP2UW1_0113
SULGFJR48_03845
SSEIFJR45_01380 FJR45_04470
SMASHUE87_09305
AMYTAMYT_0911
PACOAACT_2069
GPIGPICK_06385
GURGura_1693
GBMGbem_1622(wbjC)
DEUDBW_1517
DFLDFE_2838
DTOTOL2_C08120(capF)
DMMdnm_096990
DEKDSLASN_12280
SFUSfum_2863
RHTNT26_3156
SZOK8M09_15615
SNOSnov_3210
HDNHden_0186
HDTHYPDE_23133
DEAFPZ08_13245
MARUFIU81_15470
PAMOBAR1_15460
SMAGAN936_18585
SPHOC3E99_07080
SECHB18_28745
SFLASPHFLASMR4Y_02428(wbjC)
SPHLLPB140_06515
BFWB5J99_05775
PHAOHF685_11060
PHZCHX26_09060
BBABd1694(capF)
MFNGa0123462_1142
BCRBCAH187_A5443
BNCBCN_5195
BTHUYBT1518_33541
BACIB1NLA3E_20920
BFDNCTC4823_03153
LYZDCE79_04810
HMNHM131_05135
VILCFK37_02115
VIMGWK91_11145
BMURABE28_016005
PPSRI6J18_19580
PSYOPB01_03865
PRDF7984_17695
GRCGI584_20435
SCIBHUG20_11465
NMKCHR53_26470
BOUI5818_12875
SAUSA0149(capF)
SAVSAV0154(capF)
SAWSAHV_0153(capF)
SAHSaurJH1_0145
SAJSaurJH9_0140
SAMMW0129(cap8F)
SASSAS0129
SARSAR0156(capF)
SACSACOL0141(cap5F)
SAXUSA300HOU_0168(cap5F)
SAASAUSA300_0157(cap5F)
SAOSAOUHSC_00119
SAENWMN_0100(capF)
SADSAAV_0122(cap5F)
SUUM013TW_0144
SUVSAVC_00540
SUESAOV_0101
SUJSAA6159_00138(cap5F)
SUKSAA6008_00132(cap5F)
SUCECTR2_111
SUTSAT0131_00144
SUQHMPREF0772_10344
SUZMS7_0148(capF)
SUDST398NM01_0168
SUXSAEMRSA15_01200(capF)
SUWSATW20_01650(capF)
SUGSAPIG0168
SUFSARLGA251_01280(capF)
SAUASAAG_00637
SAUERSAU_000108(capF)
SAUNSAKOR_00134
SAUSSA40_0121(capF)
SAUUSA957_0136(capF)
SAUGSA268_0133(capF)
SAUZSAZ172_0164
SAUTSAI1T1_2001090(cap5F)
SAUJSAI2T2_1001090(cap5F)
SAUKSAI3T3_1001090(cap5F)
SAUQSAI4T8_1001090(cap5F)
SAUVSAI7S6_1001090
SAUWSAI5S5_1001080
SAUXSAI6T6_1001090
SAUYSAI8T7_1001090
SAUFX998_0137
SABSAB0095(capF)
SUYSA2981_0155(capF)
SAUBC248_0143(capF)
SAUMBN843_1600
SAUCCA347_165
SAURSABB_01687(capF)
SAUIAZ30_00810
SAUDCH52_04955
SAMSNI36_00705
SUHSAMSHR1132_01280
SHASH0393(capF)
SHHShL2_00298(cap5F)
SLGSLGD_00328
SLNSLUG_03250(capF)
SHUSHYC_02145
SAGQEP23_07990
SARLSAP2_22730
SPICSAMEA4384060_1738
SSHNCTC13712_00109
SDBCNQ82_05965
MVTI6J10_00250
MACRBHM04_11830
SHVAAT16_04055
LGZNCTC10812_01730
EATEAT1b_1188
EAPKB235_04665 KB235_04855
PAEHH70357_28055
PAEJH70737_24330
KYRCVV65_01740
SOBCSE16_04875
PLNPlano_2327
PLLI858_011150
PMARB0X71_14590
PLAYDNR44_008530
LLRllh_0475
SPNSP_0359(cps4K)
SNMSP70585_0426
EFDEFD32_1894
EGAAL523_16080
MPXMPD5_1385
VFVK5K99_13355
AUNAWM73_05385
AUIAPT62_03040
ASANAWM72_06995
CARCNY10_927
CARNFPV25_02520
JEPBW721_05895
JARG7057_08180 G7057_08365
CCHVBTM20_03715
CGASJ1C67_09575
CCAAKQH81_02655
GFEGferi_11335
FSAC5Q98_00735
CTHDCDO33_01150
RCHRUM_09630
FPRFP2_31570
BPBbpr_I0350
BHUbhn_I0406
BYLA4V09_01945
CPYCphy_3503
HSDSD1D_1290
PXVFXF36_15580
ACELacsn021_22510 acsn021_22560
ACHTbsdcttw_26930 bsdcttw_26950
RGNRGna_12005
SSUNH9Q77_13985
EACEAL2_c20140
TEBT8CH_2470
SLPSlip_0164
CALKHUE98_16965
DRSDEHRE_09885
DRMDred_3032
AACXDEACI_3856 DEACI_3920 DEACI_3923 DEACI_3975
ELMELI_4558
ELIMB2M23_15715
ALKAJ0B03_04225
CBARPATL70BA_0362(wbjC)
ACAEHYG86_00815
AMICAmi3637_06440
CKICalkr_2280
CLCCalla_0173
TXYThexy_1803
AFTBBF96_11320
PUFUFO1_4150
ERHERH_0859
ERSK210_02150
ERLAOC36_02525
ERIEEI45_05840
ERDG7062_06980
EIOH9L01_07865
EUCEC1_12020
AARGAargi30884_24440
ERMEYR00_04310
LCGL3BBH23_17550
ACLACL_1044
AAXANCTC10138_00337
MBJKQ51_00735
CMDB841_09300
CPEGCPELA_00510
CGKCGERO_00500
CPSOCPPEL_00485
CSURN24_0491
DIZCT688_13275
PSICJ4E96_17160
AGYATC03_14105
MYLC3E77_02890
AGGC1N71_10855
MANTBHD05_03280
ARUASPU41_19425
AJGKKR91_12385
APNAsphe3_25570
PSEYGU243_10715
RSARSal33209_1612(capF)
KSEKsed_18630
CFLCfla_0760
JMEEEW87_010815
DCOSAMEA4475696_2247
AUSIPK37_01965
MICGGJV80_08200
TDFH9L22_12380
NDKI601_1757
NOIFCL41_02135
NOOFE634_12355
NDPE2C04_02755
NSNEXE58_10525
NPIG7071_07150
MCABHXZ27_11020
MSAGGCM10017556_43940
PLKCIK06_10365
PLABC6361_29210
PLATC6W10_06230
PSUUPsuf_011570
FLHEJ997_04865
EGDGS424_003815
CSTCLK434_09630
DMRDeima_2967
DPTDeipr_2059
DPDDeipe_0923
DEZDKM44_11275
DFCDFI_17510
OBGVerru16b_02063
RULUC8_50260
MFFMFFC18_22180
PNDPla175_07580(wbiB)
PBUL21SP3_00953
PBPSTSP1_00660
VBCC5Q97_11320 C5Q97_18390
SPEREW093_13165
SBUSpiBuddy_0258
SASSMUG09_01995
SCDSpica_0525
LILLA_1644
LIELIF_A1330
LICLIC_12140
LISLIL_12274(wcaG3)
LMAYDPV73_15785
LWLFHG68_08490
FNCHMPREF0946_01288
FPDCTM68_07390
FVAFV113G1_07630
FULC4N20_02505
FPEIC4N17_00395
FSUFisuc_2694
FSCFSU_3261
BTHBT_0382
BTHOBtheta7330_02108 Btheta7330_02998
BFRBF1107
BFGBF638R_1089 BF638R_3769
BFBVU15_04775
BHLBache_2245
BCELBcellWH2_04978
BHFC3V43_13540
BUNBun01g_26120
BFEK6V30_14845 K6V30_24440
BNOK8P02_02075
BVUBVU_0694 BVU_1540
PBTING2E5B_0564
PPNPalpr_0958
PDIBDI_3832
PARCCI960_13475
PMERINE87_00424(wbjC)
PGOLK6V26_10520 K6V26_11950
PJOLK449_12390
BUYD8S85_13780
PRUPRU_0102
PCOILK433_14505
ALQC7Y71_007845
RBCBN938_0769 BN938_1959
TTZFHG85_00420
BACCBRDCF_p1467
DORIFH5T_21510
CPICpin_4751
CHIHGWR21_01125
NIAA8C56_07980
PCMAY601_4544
PSTYBFS30_06920
SHTKO02_22560
SPHZE3D81_15985
MDAIPZ59_16905
ALSDJ013_17375
FPSFP1286(fnlB)
FPCFPSM_02198
FPYFPG101_11015
FPQIB65_06065
FPVIA03_06170
FPWIA04_06075
FPKIA06_06110
FBRFBFL15_1033(fnlB)
FINKQS_03315(fnlB)
FGLEM308_00745
FKIFK004_09020
FENJ0383_14325
COCCoch_1111
CCMCcan_23350
CAPHCGC49_04775
MARTBTR34_14765
CLYCelly_2635
CBATM666_12275
KDIKrodi_2767
DDOI597_2182
MLTVC82_2498
NDODDD_3541(fnlB)
POBLPB03_07080
MYRMYRA21_3294
TDIAUW17_02390
MESQC7H62_1057
MARXINR76_09920
SINHLS482_11755
ASAGFGM00_01225
ELZFCS00_14710
CIHATE47_11270
CHHA0O34_14030
CIOCEQ15_13470
CHRYCEY12_09720
CHRZCO230_02260
CARHEGY05_16415
CSHAEG350_15240
CNKEG343_08470
CJTEG359_09455
CILEG358_16295
CGLENCTC11432_02310
CTAINCTC12078_01305
CTAK4412677_01081
CSALNBC122_00352(wbjC_1) NBC122_02873(wbjC_2)
CNPM0D58_15510
CJGNCTC13459_02733
CANTNCTC13489_01522
KHIEG338_06405
CNREB819_08340
ESTEHNV03_12265
BBAUAEM51_06820
CLZBIU88_00470
PPHPpha_0559
THERY592_04250
FPEFerpe_0105
FIANA23_00520
CABYCabys_3398
NMVNITMOv2_3488
NLIG3M70_09945
 » show all
Reference
1  [PMID:12464616]
  Authors
Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS
  Title
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.
  Journal
J Biol Chem 278:3615-27 (2003)
DOI:10.1074/jbc.M203867200
  Sequence
Reference
2  [PMID:15778500]
  Authors
Mulrooney EF, Poon KK, McNally DJ, Brisson JR, Lam JS
  Title
Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11.
  Journal
J Biol Chem 280:19535-42 (2005)
DOI:10.1074/jbc.M500612200
Reference
3  [PMID:18540063]
  Authors
Miyafusa T, Tanaka Y, Kuroda M, Ohta T, Tsumoto K
  Title
Expression, purification, crystallization and preliminary diffraction analysis of CapF, a capsular polysaccharide-synthesis enzyme from Staphylococcus aureus.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:512-5 (2008)
DOI:10.1107/S174430910801213X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.367
IUBMB Enzyme Nomenclature: 1.1.1.367
ExPASy - ENZYME nomenclature database: 1.1.1.367
BRENDA, the Enzyme Database: 1.1.1.367
LinkDB

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