Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

(R)-mandelate:NAD+ 2-oxidoreductase

(R)-mandelate + NAD+ = phenylglyoxylate + NADH + H+ [RN:R03790]

R03790
Reaction

(R)-mandelate [CPD:C01983];
NAD+ [CPD:C00003]

The enzyme, found in bacteria and fungi, can also accept a number of substituted mandelate derivatives, such as 3-hydroxymandelate, 4-hydroxymandelate, 2-methoxymandelate, 4-hydroxy-3-methoxymandelate and 3-hydroxy-4-methoxymandelate. The enzyme has no activity with (S)-mandelate (cf. EC 1.1.99.31, (S)-mandelate dehydrogenase) [1,2]. The enzyme transfers the pro-R-hydrogen from NADH [2].

EC 1.1.1.379 created 2014

1

2  [PMID:1731758]