KEGG   ENZYME: 1.1.1.401
Entry
EC 1.1.1.401                Enzyme                                 
Name
2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+);
2-keto-3-deoxy-L-rhamnonate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-dehydro-3-deoxy-L-rhamnonate:NAD+ 4-oxidoreductase
Reaction(IUBMB)
2-dehydro-3-deoxy-L-rhamnonate + NAD+ = 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ [RN:R11339]
Reaction(KEGG)
R11339
Substrate
2-dehydro-3-deoxy-L-rhamnonate [CPD:C03979];
NAD+ [CPD:C00003]
Product
2,4-didehydro-3-deoxy-L-rhamnonate [CPD:C20781];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Sphingomonas sp. SKA58 and Sulfobacillus thermosulfidooxidans, is involved in the non-phosphorylative degradation pathway for L-rhamnose. It does not show any detectable activity with NADP+ or with other aldoses.
History
EC 1.1.1.401 created 2016
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21883  2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)
Genes
ASUBNLZ15_08015
XAXXACM_2065
XFUXFF4834R_chr21390
XPEBJD13_06130
XPHXppCFBP6546_02695(XppCFBP6546P_02695)
XANAC801_10760
XTHG4Q83_12700
SMLSmlt2912
SMTSmal_2364
BUJBurJV3_2418
SMZSMD_2548
SRHBAY15_2207
SLMBIZ42_01235
STENCCR98_12530
STEMCLM74_12860
STESMG068_12375
SINCDAIF1_25010(linC)
SPAQSTNY_R25550
STEQICJ04_08505
SGENRKE57_12535
SOUPDM29_18880
SARCPDM28_10845
PPFPput_2199
PPGPputGB1_2345
PPWPputW619_2844
PPIYSA_00165
PPXT1E_2289
PPUTL483_18725
PPUNPP4_22550
PEZHWQ56_14835
PIZLAB08_R21780
PKMPZ739_15810
PTAIICN73_18090
PKKQQ992_11370
PSJYAA098_11880
PFOUOZ911_16040
PSKPKU43P_27860
GAIIMCC3135_16660(fabG_4)
HAAHHALA3H3_360176
HABDOM794_22495
HOLHORIV_71480(fabG_2)
HNPSR894_21870
MMEMarme_1649
LLPGH975_02675
JEUBJP62_03425
REHH16_B1075(h16_B1075)
CNCCNE_2c10320(fabG7) CNE_BB1p11630(fabG16)
CGDCR3_3352(fabG)
CCUPBKK81_19460
CUPBKK80_22485
CUUBKK79_27725
CCAXKZ686_17795
CUKKB879_10140
BACBamMC406_1205
BUGBC1001_3866
BGFBC1003_5542
BYIBYI23_B004390 BYI23_B007570 BYI23_C012390 BYI23_D004990
BUEBRPE67_BCDS07010 BRPE67_BCDS11520 BRPE67_CCDS14200 BRPE67_DCDS06790
BUQAC233_21665
BUMAXG89_17650 AXG89_39135
BUIAX768_21210 AX768_27430
BXEBxe_A2719 Bxe_B1028 Bxe_C0296
BXBDR64_403 DR64_6349 DR64_8137
BPHBphy_3470 Bphy_6096 Bphy_6716
BGEBC1002_4239
BPXBUPH_00440
BPYBphyt_5691
BFNOI25_6822
BCAIK788_0006074 K788_0008440 K788_0008516
PSPWBJG93_25600
PARABTO02_31840
PARBCJU94_23875 CJU94_35365
PHSC2L64_21010 C2L64_22515 C2L64_33470 C2L64_40795
PTERC2L65_25445 C2L65_30060
PGPCUJ91_21865
PCJCUJ87_23080 CUJ87_29425
PTSCUJ90_29515
PCAFDSC91_001130
PMEGFNZ07_09770
PTROG5S35_23000 G5S35_23835
PGISI6I06_22805 I6I06_24305
PACPFAZ97_21170 FAZ97_29965
PACSFAZ98_17360 FAZ98_27105
PEWKZJ38_34640
PDIOPDMSB3_2084.1(LRA)
PBRYNDK50_27185
PSAAQEN71_12650 QEN71_30000 QEN71_31015
PKFRW095_08765 RW095_19215
PHUNU0042_07600
PLADPPGU16_41660(fabG_5) PPGU16_58890 PPGU16_64130(fabG_8) PPGU16_65860 PPGU16_74310(fabG_9)
PPULRO07_13835
CABASBC2_60230(LRA5)
BUOBRPE64_BCDS05680 BRPE64_BCDS08830 BRPE64_CCDS02950
CABKNK8_34370 NK8_37390 NK8_50690 NK8_75990 NK8_76400
TVLFAZ95_33615
TCARU0034_23345
BBROBAU06_17515
BFZBAU07_03410 BAU07_08710
BOHAKI39_16775 AKI39_21445
BOJCBF45_16040
BGVCAL12_18480
PUSCKA81_16410
POLLOEG81_15545
AKATKWG_22980 TKWG_24470
AMIMMIM_c37220 MIM_c39460
PIGEGT29_25860
PACRFXN63_19505
KGYEHF36_16085
PARKLSG25_14995
RHYRD110_04410 RD110_09810 RD110_13105 RD110_25030
RHFEUB48_18795
POLBpro_1491 Bpro_3960
POSDT070_03350
POOF7R28_06085
PVACHC248_01488(lra5)
AMONH9L24_05015
VEIVeis_0638
VAPVapar_0789
VPEVarpa_0812 Varpa_4230
VPDVAPA_1c08500 VAPA_1c34560 VAPA_1c40710
VAAAX767_07345
VBOCKY39_03990 CKY39_23990
VAMC4F17_15270
VAZH7F35_01195 H7F35_16080
VAVIG196_02355 IG196_21190
CODOLAD35_14540
CTEZCT3_13780(fabG_1)
AANTHUK68_21720
RTARta_09040
LIML103DPR2_00634(fabG_5)
LIHL63ED372_02617(fabG_7)
LIMILINBF2_24200
RGUA4W93_06530
JAJEKL02_03045
HSEHsero_0584(fabG) Hsero_1263(fabG)
HSZACP92_02925 ACP92_06345
HHTF506_05085 F506_06205
HRBHrubri_1079(fabG)
HEEhmeg3_06350 hmeg3_20535
HHFE2K99_03270 E2K99_06180
HFRG5S34_03150 G5S34_06475
HEWHBDW_11110
XYKGT347_22460
XYGR9X41_06680
URUDSM104443_01671(lra5)
UPLDSM104440_01594(lra5)
BEBABWI17_18635
MLOmll5243 mlr7680
MLNA9174_01320 A9174_27675
MCIMesci_0269 Mesci_0299
MCICA4R28_26875 A4R28_27025
MOPMesop_0255
MAMMesau_00256
MAMOA6B35_06440
MESWA9K65_001345 A9K65_001495 A9K65_021660
MESMEJ066_10000
MESPC1M53_17335 C1M53_28885
MHUAMCHK_1138 MCHK_6293
MJREB229_01345 EB229_27935
MERDEB233_01420
MOHIHQ72_01000
MMEILRP31_01230
MESJMJ8_51230
MESILGH82_15980
NKIKW403_18990
NRHT8J41_22145
NTUNTH_00683(fabG_2)
MESMeso_0411 Meso_0784
CHEAPVE73_00500
PHTBLM14_17760
PHYLHB779_05315
RPODE0E05_09135
KMNHW532_07945
ATUAtu3813(fabG) Atu4595
AGRAGROH133_09944
ALEGCFBP4996_28050 CFBP4996_28970
AGRCGSF67_20165
RLERL2674
RLGRleg_2210
RLBRLEG3_21705
RGARGR602_PC01505
RIIFFM53_000160
RSULN2599_28435
RLWRlegWSM1455_11140
AROB0909_14590
RBWRLCC275e_11310
RIFU5G49_002225
NENNCHU2750_48930(fabG)
NPMQEO92_32285
RFVRFYW14_03817
ABAWD5400_03555
HOEIMCC20628_00090
KAIK32_02130
OINIAR37_20445
OCRHGK82_17775
OCCKMS41_20075
OCHCES85_3153
BJAbll3655(bll3655) bll3913(fabG) bll6359(bll6359)
BJUBJ6T_59230
BJPRN69_28710
BRABRADO3101
BBTBBta_3549
BRSS23_43210(fabG)
AOLS58_45070
BRCBCCGELA001_16275
BRADBF49_1142
BICLMTR13_23485
BROBRAD285_2845(fabG)
BRKCWS35_27950
BOTCIT37_34445
BRQCIT40_12295
BGQX265_23805
BGZXH91_20995
BSYMCIT39_11545
BBETF8237_02255
BARHWN72_21055
BVZBRAD3257_2220 BRAD3257_5027 BRAD3257_5135(fabG)
BELBE61_63390(fabG)
BDGLPJ38_21680
BSEPHAP48_0034515
BQBJ4P68_0035760
BSEIKMZ68_11205
BBANJ4G43_002850 J4G43_021855
BCANBcanWSM471_16925
BAUTQA635_25450
BBRAQA636_26395
BGKIC762_15070
BCOUIC761_21595
BPAHQA639_18625
BXNI3J27_15605
BROSQUH67_20880
BRAZLRP30_16900
BOYLQG66_01355
BRAYML401_12815
RPATX73_017980
RPBRPB_2093
RPCRPC_3650
RPDRPD_3326
RPERPE_3690
RPTRpal_3964
RPXRpdx1_1900
RBKE0H22_11315 E0H22_14510
RHORONR75_22340
RHOLRBJ75_02445
VGOGJW-30_1_00198(fabG_1)
TRBHB776_05295
TALZRPMA_11635
BVVBHK69_05300 BHK69_29605
BVESQO058_17505 QO058_21335 QO058_28760 QO058_29165
BOPAXW83_06685 AXW83_15660 AXW83_15690 AXW83_20390
BOSBSY19_1292 BSY19_346
BOIBLM15_15895 BLM15_16500 BLM15_19670
BOFFQV39_13175 FQV39_13575 FQV39_14755 FQV39_17890 FQV39_19460 FQV39_30970
BOWNWE53_19285
BOSERMR04_28730 RMR04_30060
XAUXaut_1907
XDIEZH22_08125 EZH22_12750
AZCAZC_2269
STARG3545_16255 G3545_27160
LNEFZC33_13720 FZC33_22295 FZC33_26780
SNOSnov_4089
APRAG3A50_04745 G3A50_07825
AQIJ5J86_02600 J5J86_11530 J5J86_14735
METM446_4913
MNOMnod_2255 Mnod_2895 Mnod_6624
MAQUMaq22A_c13140(fabG)
MEEDA075_05270
MTEADK419_12605
MINDmvi_05200
MOCBB934_14870 BB934_28775
MIVC4E04_19010
MTEZHPT29_003165
MLDU0023_10450
CHELAL346_08150 AL346_11895
CDQBOQ54_01270 BOQ54_04120
DEQXM25_05675
DEIC4375_11170
DEAFPZ08_14720 FPZ08_18035
DSALK1X15_16270
DEVOH4N61_05585
DNPN8A98_21310
DOYJI749_15590
DAGPSQ19_17155 PSQ19_17815
DRPPSQ90_03995
YTIFNA67_09780
MHARL1P08_03275 L1P08_15160
HDIHDIA_4541(fabG_25)
MMEDMame_04374(actIII_3)
AALAIGS74_14650
AALMLUX29_16565
AUZSa4125_39500
AUBLXB15_00395
JIEOH818_11625
PSINCAK95_01485
NOHG5V57_32705
RBMTEF_05635
RPOPK1718_07155 K1718_20950
SIWGH266_15815
PHRC6569_17890
PSTGE8M01_12015
PAQTE8L99_05345
ACUTMRB58_15425 MRB58_21970
CSECseg_1772 Cseg_2744
CFHC1707_14135
BSBBresu_2871
BRDJL11_06970
BRGA4249_07710
BREVE7T10_08355
BNDKWG56_07400
BFQJX001_09260
BRESE4341_07325
AEXAstex_2137
ASTIQ1W73_02980
ASTDATDW_19970
TSVDSM104635_01778(fabG_4)
SILSPO2413
RUAD1823_15630
RUTFIU92_00170(fabG1)
RDERD1_3872
RLIRLO149_c005630
RFUROLI_010170(LRA5)
KROBVG79_p1000086(fabG)
OATOAN307_c00740
CBAKDA792_00670
YPACCEW88_23325
SULIC1J05_04655
SMEDJNX03_16185 JNX03_16965
SPSESULPSESMR1_01364(fabG)
TOMBWR18_20325
AHTANTHELSMS3_00521
SAGUCDO87_12725 CDO87_23165 CDO87_25655
OCDFHY55_06055
MALUKU6B_07020
HATRC74_03370
PALXGQA70_22770 GQA70_22835
LSALKBK07_18480
TRYQF118_02135
PLCGRVY76_11305
RSPRSP_3888(fabG)
RSHRsph17029_4152
RBLB6K69_17915
PYEA6J80_10075
PCONB0A89_00190
PMUTDPM13_08275
PSANHGN31_05485
PSEWJHW44_18645
PTPRCA23_c06680 RCA23_c11890 RCA23_c23530
YPHYAABB29_02455
SALOEF888_07675
LITFPZ52_13135
HDHG5B40_02135
AMAQGO499_10210
FAQG5B39_10225
RBXI3V23_05380
HBAHbal_2758
STAXMC45_07210 MC45_07305
SPHITS85_02210
SSANNX02_22765
SNJA7E77_11695
SMYBJP26_16660
SPANAWL63_05980
SKRBRX40_01505
SPLMBXU08_18015
SPHCCVN68_10775
SARIH5J25_00355
SSUAFPZ54_00330
SBINSBA_ch1_06560
SCABLZK98_19665
SNOSK8P63_02100
SSAGKV697_00815
SABIPBT88_17540
SPHRBSY17_3164
SYAA6768_21740
SPYGYGS_C1P2518
SPAGsphantq_01937(LRA5)
SPCAGL174_11585
BLASBSY18_1711
BFWB5J99_17935
SSAARPR59_02165
SPHSETR14_07005
SFLVIC614_07240
ALTNLBX01_05135
TFVIDJ81_03385
ACRAcry_2467
AMVACMV_27830
GDIGDI3269
GDJGdia_3096
GXYGLX_03410
GXLH845_1309
KNAB0W47_16360
KEUS101446_00441(butA)
KREGWK63_06515
RGIRGI145_21810 RGI145_22280
RMTIAI58_20555
RFLRmf_23290(fabG_5)
SHUMSTHU_24740(fabG_3)
SVCSTVA_30890(fabG_3)
STELSTAQ_22350(fabG_5)
NAOY958_05035
NCBC0V82_17100 C0V82_24305
SKTIGS68_28120
SMUCJL100_031380
SROEJL101_033735 JL101_034715
FERFNB15_04205
HTQFRZ44_47260
HADHFRZ61_45110(fabG)
ELIOKO353_11810
NACINUH88_12625 NUH88_20605
THART8K17_08800
PUBSAR11_0767 SAR11_0846 SAR11_0869
PELSAR11G3_00249
PEGE5R92_01630 E5R92_02215
APMHIMB5_00003580
PAQIKW060_02535
APBSAR116_0926
ANTArnit_0850
ALKALEK_0863
ALPLPB137_03815
HEBRAEBR_0817
PARHI5S86_15670
PSABPSAB_03640
FFELSG31_02495
CMICcaldi_13000(fabG_3)
ERZER308_18945
CGTcgR_2332
CGSC624_11910
CGGC629_11920
CPOYGP475_11700
RHARHA1_ro01856
RERRER_46900
REYO5Y_22145
REBXU06_22260
RQIC1M55_23600
ROPROP_15410
ROAPd630_LPD06026
RAVAAT18_25275
RRZCS378_14855
RHODAOT96_03635
RKOJWS14_09535 JWS14_41825
RGOKYT97_30365
ROZCBI38_24840
RPSKJWS13_36300
RHOORA302_22915
RHOUKZJ41_26755
RHOWA4U64_25895
RHOJJVH1_28050
RHOSQWW67_15740
RHOQQWW98_15745
RHOYQNA09_22365
SKACP970_39490
SLFJEQ17_04865
MHOSCXR34_05710
MPRTET475_04325
MLZF6J85_08210
MELYL2X98_24315
MINVT9R20_14505
MBETN8K70_15840
MALKMalAC0309_0327
MHUMNNL39_05735
LARIKI794_14410
LRPMUN76_05855
ARRARUE_c18400
ARLAFL94_05110
ARYATC04_12775
ARTPE5206_14085
ACAONF551_14240
PNVJMY29_13020
ACHAchl_0572
APNAsphe3_04660
PSULAU252_01350
PSNINIBR502771_02820
GPRJQN66_05550
SATKSA2016_3915
CCYCSCMU_10800
CMUAP8192_01565
BCVBcav_0122 Bcav_2984
PSEKGCM125_12460(fabG_2)
HALTIM660_05995
NROK8W59_08275
AEZC3E78_14060
NALB005_2522
NOABKM31_10155
NOWGBF35_27275
GOBGobs_2441
SACGFDZ84_24815
ARHDVSH64_18520
PAUTPdca_38240(fabG_8)
PBROHOP40_26370
PSUUPsuf_070940
DACTKZZ52_44275
AEYCDG81_10675
PLANA1s21148_00900
PVSA1sIA79_05290
ABAMB1s21122_04950
NHIB1s21160_04755
LMAJGKN94_08460
VABWPS_28450
SLOMPXH66_00685 PXH66_17160
PPHTGA004_12465
MTARDF168_00748(LRA5)
ROOG5S37_23950
SDYNMal52_25750(fabG_5)
GESVT84_10250(fabG_6)
GOGC1280_17780
GMSSOIL9_18330 SOIL9_49820
TIMGMBLW1_14200
LRSPX52LOC_06167
FTJFTUN_1341 FTUN_2607
ULIETAA1_18450(fabG_5)
TSPHKIH39_25055
SACISinac_5872
PBORBSF38_05220(tsaC1)
LPROPQO03_06025
TALBFTW19_10835
ABASACPOL_0913
EDAGWR55_16765
EPLP4G45_11480
NYNU0035_00395
FLASY85_11795
PGOFSB84_30420
FLCKJS93_09855 KJS93_18560
PHEPhep_2313
CMRCycma_1664
CAMUCA2015_1571
SLISlin_0608
SRDSD10_04060 SD10_11620
SMONAWR27_07945
SPIRCWM47_13545
SPIKEXU85_20030 EXU85_24690
SPIBG8759_20310
STAEHNV11_12675
SOQLQ777_09615
SFOLH3H32_05730 H3H32_14585
SENFGJR95_17665
RHOZGXP67_02250
DFEDfer_3040
DYCNFI80_22220
DFQNFI81_23390
DCNMUK70_27735
DPFON006_20660
RSIRunsl_1900
RUNDR864_18425
RUPDTQ70_25050
IRORT717_16260
FBTD770_14490
CHKD4L85_32635
RBIRB2501_01515
AALGAREALGSMS7_01857
ALAMRT761_01057(lRA5)
 » show all
Reference
1  [PMID:19187228]
  Authors
Watanabe S, Makino K
  Title
Novel modified version of nonphosphorylated sugar metabolism--an alternative L-rhamnose pathway of Sphingomonas sp.
  Journal
FEBS J 276:1554-67 (2009)
DOI:10.1111/j.1742-4658.2009.06885.x
  Sequence
Reference
2  [PMID:25617114]
  Authors
Bae J, Kim SM, Lee SB
  Title
Identification and characterization of 2-keto-3-deoxy-L-rhamnonate dehydrogenase  belonging to the MDR superfamily from the thermoacidophilic bacterium Sulfobacillus thermosulfidooxidans: implications to L-rhamnose metabolism in archaea.
  Journal
Extremophiles 19:469-78 (2015)
DOI:10.1007/s00792-015-0731-8
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.401
IUBMB Enzyme Nomenclature: 1.1.1.401
ExPASy - ENZYME nomenclature database: 1.1.1.401
BRENDA, the Enzyme Database: 1.1.1.401
LinkDB

DBGET integrated database retrieval system