KEGG   ENZYME: 1.1.1.404
Entry
EC 1.1.1.404                Enzyme                                 
Name
tetrachlorobenzoquinone reductase;
pcpD (gene name);
TCBQ reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase
Reaction(IUBMB)
2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ [RN:R11585]
Reaction(KEGG)
R11585
Substrate
2,3,5,6-tetrachlorohydroquinone [CPD:C03434];
NAD+ [CPD:C00003]
Product
2,3,5,6-tetrachloro-1,4-benzoquinone [CPD:C18933];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol.
History
EC 1.1.1.404 created 2017
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21607  tetrachlorobenzoquinone reductase
Genes
PAOPat9b_4735
PAEPA3498
PAEVN297_3621
PAEIN296_3621
PAECM802_3620
PAEOM801_3486
PREPCA10_15680
PFUWKF707C_16670
PCQPcP3B5_07920(pobB_1)
PFCPflA506_5354(vanB)
PSVPVLB_18300
PALKPSAKL28_39360
PSILPMA3_18885
PEZHWQ56_28435
PSAMHU731_015665
PSHHHU773_000600
PTKEXN22_08330
EMODM558_02380
HPEGEAO82_07115
AALEP13_18330
AAUSEP12_19110
ADIB5T_04413
AXEP40_21510
RPIRpic_4500
RPFRpic12D_4632
RPJN234_24525
RMNTK49_17075
RINACS15_4618
REHH16_B0739(h16_B0739)
CNCCNE_2c06820(pobB)
CUHBJN34_24895
REUReut_B3579 Reut_B4797 Reut_B5777
RMERmet_5549(pobB)
CTIRALTA_B0575
CBWRR42_m2771 RR42_s1575
CCUPBKK81_20595 BKK81_29830
CUPBKK80_21285 BKK80_26525
CUUBKK79_26500 BKK79_32410
CPAUEHF44_27450
COXE0W60_08555 E0W60_20470
BUUWS70_13205
BCENDM39_1986
BYIBYI23_C004950 BYI23_D008340
BUEBRPE67_CCDS06780 BRPE67_DCDS10270
BGPBGL_2c01180
BPLAbpln_1p1360 bpln_2g01180
BXEBxe_B2369
BXBDR64_4701
BGEBC1002_4697
BPYBphyt_4243
BCAIK788_00002315
PSPWBJG93_04570
PTROG5S35_25095
PACSFAZ98_16390
PDIOPDMSB3_0712.1(pobB)
PPKU875_18000
PPNODA70_10510
PPNMLV28_20550
PRBX636_16120
PPULRO07_06165
PSPUNA29_21435 NA29_22295
PAPISG18_14725
PVEUC34_06025
POXMB84_08065 MB84_10465
PTXABW99_12525
PFGAB870_17050 AB870_18760
PNRAT302_01050 AT302_05955
PANDDRB87_05410 DRB87_13355
PFIBPI93_022220 PI93_023925
BUOBRPE64_DCDS03390
BAVBAV0615
BHZACR54_03867(pobB)
BBROBAU06_03630
BFZBAU07_13835
BPDZBBN53_03795
BGMCAL15_17825
BOJCBF45_01150
ASWCVS48_25005
ACHRC2U31_19590
AFAUZ73_13830
PIGEGT29_10560 EGT29_19400 EGT29_23160
KGYEHF36_01335
PARKLSG25_14010
POLBpro_3680
ACIPCBP36_17870
ACINCBP34_18210
ACISCBP35_01040
VEIVeis_2771
DACDaci_0965
DELDelCs14_5558
DTSBI380_19870
DHKBO996_04910
DLAI6G47_19800 I6G47_32225
VAPVapar_3159
VPEVarpa_3582
VPDVAPA_1c32460 VAPA_2c09730
VBOCKY39_14805
VAMC4F17_30660
CTTCtCNB1_4601
CTESO987_27295 O987_28190
CODOLAD35_19190
HYRBSY239_2702 BSY239_3348
HYBQ5W_01280 Q5W_24670
HYNF9K07_00825 F9K07_07505 F9K07_11515 F9K07_11635 F9K07_30140 F9K07_30190 F9K07_30240 F9K07_30385 F9K07_30435
HTNKI616_03630
DIHG7047_06755
DRGH9K76_11925
STHMIS481_17575
MMSmma_2506
HHTF506_19590
HRBHrubri_1309
HEEhmeg3_00175
HFRG5S34_07830
CARELT85_0544
MUMFCL38_03880
APETToN1_02080
THKCCZ27_15675
MESOBSQ44_11255
AAKAA2016_5653
AOLS58_21520
BRKCWS35_19805
BELBE61_31180 BE61_64930
BDGLPJ38_20665
BSEPHAP48_0032610
BQBJ4P68_0033845
XDIEZH22_10380
HMCHYPMC_3536(pobB)
RHZRHPLAN_44340
DEQXM25_18610
YTIFNA67_00260
AEXAstex_2477
CIDP73_2874
CONTQ29_05730
CBOTATE48_17525
SMAZLH19_26280
SSANNX02_22630
SCHSphch_3460
SBDATN00_07600
SPHRBSY17_2022
SPHTK426_02680
SPYGYGS_C1P1167
AAYWYH_01862(pobB_1) WYH_03339(pobB_2)
CMANA9D14_14475
AACEA0U92_13920
 » show all
Reference
1  [PMID:19325743]
  Authors
Chen L, Yang J
  Title
Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol.
  Journal
Int J Mol Sci 9:198-212 (2008)
DOI:10.3390/ijms9030198
Reference
2  [PMID:23676275]
  Authors
Yadid I, Rudolph J, Hlouchova K, Copley SD
  Title
Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.
  Journal
Proc Natl Acad Sci U S A 110:E2182-90 (2013)
DOI:10.1073/pnas.1214052110
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.404
IUBMB Enzyme Nomenclature: 1.1.1.404
ExPASy - ENZYME nomenclature database: 1.1.1.404
BRENDA, the Enzyme Database: 1.1.1.404
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