KEGG ENZYME: 1.1.1.427

ENZYME: 1.1.1.427

Entry

EC 1.1.1.427                Enzyme

Name

D-arabinose 1-dehydrogenase (NADP+);
AraDH;
adh-4 (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-arabinose:NADP+ 1-oxidoreductase

Reaction(IUBMB)

D-arabinofuranose + NADP+ = D-arabinono-1,4-lactone + NADPH + H+ [RN:R01575]

Reaction(KEGG)

R01575

Substrate

D-arabinofuranose [CPD:C21067];
NADP+ [CPD:C00006]

Product

D-arabinono-1,4-lactone [CPD:C00652];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme from the archaeon Saccharolobus solfataricus is tetrameric and contains zinc. L-fucose also is a substrate. In contrast to EC 1.1.1.116 (D-arabinose 1-dehydrogenase (NAD+)) and EC 1.1.1.117 (D-arabinose 1-dehydrogenase [NAD(P)+]), this enzyme is specific for NADP+.

History

EC 1.1.1.427 created 2022

Pathway

ec00053

Ascorbate and aldarate metabolism

ec01100

Metabolic pathways

Orthology

K19590

D-arabinose 1-dehydrogenase (NADP+)

Genes

SSO:	SSO1300(adh-4)

SOL:

Ssol_2254

SSOA:

SULA_2287

SSOL:

SULB_2288

SSOF:

SULC_2285

SSHI:

J5U23_01598

SCAS:

SACC_26710

SIS:	LS215_1090

SIA:	M1425_0567

SIM:	M1627_0588

SID:

M164_0597

SIN:	YN1551_2256

SII:

LD85_0601

SIH:

SiH_0792

SIR:

SiRe_0562

SIC:

SiL_0583

SULA:

BFU36_12575

SULE:

GFS03_04535

AMAN:

B6F84_05670

SACD:

HS1genome_1982

CSTY:

KN1_28410(adh)

CMA:

Cmaq_1175

VDI:

Vdis_1460

» show all

Reference

1 [PMID:16849334]

Authors

Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J

Title

Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.

Journal

J Biol Chem 281:27378-88 (2006)
DOI:10.1074/jbc.M605549200

Sequence

[sso:SSO1300]

Reference

2 [PMID:17610898]

Authors

Brouns SJ, Turnbull AP, Willemen HL, Akerboom J, van der Oost J.

Title

Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus.