KEGG   ENZYME: 1.1.1.92
Entry
EC 1.1.1.92                 Enzyme                                 
Name
oxaloglycolate reductase (decarboxylating)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glycerate:NAD(P)+ oxidoreductase (carboxylating)
Reaction(IUBMB)
D-glycerate + NAD(P)+ + CO2 = 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H+ [RN:R01749 R01750]
Reaction(KEGG)
R01749 R01750
Substrate
D-glycerate [CPD:C00258];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
CO2 [CPD:C00011]
Product
2-hydroxy-3-oxosuccinate [CPD:C03459];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces hydroxypyruvate to D-glycerate and glyoxylate to glycolate.
History
EC 1.1.1.92 created 1972
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4385076]
  Authors
Kohn LD, Jakoby WB.
  Title
Tartaric acid metabolism. VI. Crystalline oxaloglycolate reductive decarboxylase.
  Journal
J Biol Chem 243:2486-93 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.92
IUBMB Enzyme Nomenclature: 1.1.1.92
ExPASy - ENZYME nomenclature database: 1.1.1.92
BRENDA, the Enzyme Database: 1.1.1.92
CAS: 37250-28-5
LinkDB

KEGG   REACTION: R01749
Entry
R01749                      Reaction                               
Name
D-glycerate:NAD+ oxidoreductase (carboxylating)
Definition
D-Glycerate + NAD+ + CO2 <=> 2-Hydroxy-3-oxosuccinate + NADH + H+
Equation
C00258 + C00003 + C00011 <=> C03459 + C00004 + C00080
Comment
NADP+ (see R01750)
Reaction class
RC00001  C00003_C00004
RC00129  C00258_C03459
Enzyme
1.1.1.92
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.92
     R01749  D-Glycerate + NAD+ + CO2 <=> 2-Hydroxy-3-oxosuccinate + NADH + H+
Other DBs
RHEA: 13156
LinkDB

KEGG   REACTION: R01750
Entry
R01750                      Reaction                               
Name
D-glycerate:NADP+ oxidoreductase (carboxylating)
Definition
D-Glycerate + NADP+ + CO2 <=> 2-Hydroxy-3-oxosuccinate + NADPH + H+
Equation
C00258 + C00006 + C00011 <=> C03459 + C00005 + C00080
Comment
NAD+ (see R01749)
Reaction class
RC00001  C00005_C00006
RC00129  C00258_C03459
Enzyme
1.1.1.92
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.92
     R01750  D-Glycerate + NADP+ + CO2 <=> 2-Hydroxy-3-oxosuccinate + NADPH + H+
Other DBs
RHEA: 13160
LinkDB

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